Xiang Hao

Zhejiang University

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Cuifang Kuang

Zhejiang University

Xü Liu

Zhejiang University

Xu Liu

Zhejiang University

Yubing Han

Zhejiang University

Wenjuan Zhang

Third Affiliated Hospital of Zhengzhou University

Wen‐Hua Sun

Beijing National Laboratory for Molecular Sciences

Xin Liu

Hebei North University

Shuai Li

Women's Hospital, School of Medicine, Zhejiang University

Yanghui Li

Dalian University of Technology

Wenjie Liu

Zhejiang Lab

Cooperative Institutions

Zhejiang University

156

Chinese Academy of Sciences

122

State Key Laboratory of Modern Optical Instruments

University of Chinese Academy of Sciences

Beijing National Laboratory for Molecular Sciences

Institute of Chemistry

Huazhong University of Science and Technology

Peking University

Zhejiang Lab

Shanghai Jiao Tong University

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Poisson noise image restoration method based on variational regularization

Signal Image and Video Processing (2022)

Jianhong Xiang Xiang Hao Linyu Wang

Regularization

Peak signal-to-noise ratio

Image noise

10.1007/s11760-022-02364-3

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Citations (9)

Modeling off-axis diffraction with the least-sampling angular spectrum method

Optica (2023)

Haoyu Wei Xin Liu Xiang Hao Edmund Y. Lam Yifan Peng

Accurately yet efficiently simulating off-axis diffraction is vital to design large-scale computational optics, but existing rigid sampling and modeling schemes fail to address this. Herein, we establish a universal least-sampling angular spectrum method that enables efficient off-axis diffraction modeling with high accuracy. Specifically, by employing the Fourier transform’s shifting property to convert off-axis diffraction to quasi-on-axis, and by linking the angular spectrum to the transfer function, essential sampling requirements can be thoroughly optimized and adaptively determined across computation. Leveraging a flexible matrix-based Fourier transform, we demonstrate the off-axis point spread function of exemplary coded-aperture imaging systems. For the first time, to our knowledge, a significant speed boost of around 36× over the state of the art at 20° is demonstrated, and so is the viability of computing ultra-large angles such as 35° within seconds on a commercial computer. The applicability to high-frequency modulation is further investigated.

Angular spectrum method

Aperture (computer memory)

10.1364/optica.490223

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Citations (11)

Coarse-to-Fine Recursive Speech Separation for Unknown Number of Speakers

arXiv (Cornell University) (2022)

Zhenhao Jin Xiang Hao Xiangdong Su

The vast majority of speech separation methods assume that the number of speakers is known in advance, hence they are specific to the number of speakers. By contrast, a more realistic and challenging task is to separate a mixture in which the number of speakers is unknown. This paper formulates the speech separation with the unknown number of speakers as a multi-pass source extraction problem and proposes a coarse-to-fine recursive speech separation method. This method comprises two stages, namely, recursive cue extraction and target speaker extraction. The recursive cue extraction stage determines how many computational iterations need to be performed and outputs a coarse cue speech by monitoring statistics in the mixture. As the number of recursive iterations increases, the accumulation of distortion eventually comes into the extracted speech and reminder. Therefore, in the second stage, we use a target speaker extraction network to extract a fine speech based on the coarse target cue and the original distortionless mixture. Experiments show that the proposed method archived state-of-the-art performance on the WSJ0 dataset with a different number of speakers. Furthermore, it generalizes well to an unseen large number of speakers.

Separation (statistics)

Distortion (music)

Source Separation

10.48550/arxiv.2203.16054

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Citations (1)

Superresolution confocal technology for displacement measurements based on total internal reflection

Review of Scientific Instruments (2010)

Cuifang Kuang Mohammod Ali Xiang Hao Tingting Wang Xü Liu

In order to achieve a higher axial resolution for displacement measurement, a novel method is proposed based on total internal reflection filter and confocal microscope principle. A theoretical analysis of the basic measurement principles is presented. The analysis reveals that the proposed confocal detection scheme is effective in enhancing the resolution of nonlinearity of the reflectance curve greatly. In addition, a simple prototype system has been developed based on the theoretical analysis and a series of experiments have been performed under laboratory conditions to verify the system feasibility, accuracy, and stability. The experimental results demonstrate that the axial resolution in displacement measurements is better than 1 nm in a range of 200 nm which is threefold better than that can be achieved using the plane reflector.

Reflection

10.1063/1.3492075

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Citations (4)

CCDC 1037563: Experimental Crystal Structure Determination

The Cambridge Structural Database (2015)

Yingying Ning Meng Gao Kunyi Zheng Zongyao Zhang Jiang Zhou

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Crystal (programming language)

10.5517/cc13tnsc

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Citations (0)

Freeform surface lens for LED uniform illumination

Applied Optics (2009)

Zheng Zhen-rong Xiang Hao Xü Liu

A method using a freeform surface lens for LED secondary optic design is proposed in this paper. By Snell's Law, the differential equations are given to build the relationship between the normal direction of a freeform surface and its input/output ray vectors. Runge-Kutta formulas are used to calculate the differential equations to design the freeform surface. Moreover, the optical model for uniform illumination is simulated and optical performance is analyzed. A practical freeform surface lens for LED uniform illumination is fabricated using an injection molding method. By the process, our system demonstrates a uniform illumination with a divergence half-angle of 6 degrees and an efficiency of 78.6%.

LED lamp

10.1364/ao.48.006627

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Citations (137)

Super Resolution Microscopy of Offline g-STED Nanoscopy Based on Time-Correlated Single Photon Counting

Chinese Journal of Lasers (2013)

Xiang Hao 匡翠方 Kuang Cuifang 顾兆泰 Gu Zhaotai 李帅 Li Shuai 刘旭 Liu Xu

STED microscopy

Photon Counting

Two-photon excitation microscopy

Temporal resolution

10.3788/cjl201340.0104001

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Citations (3)

Fluorescence interference structured illumination microscopy for 3D morphology imaging with high axial resolution

Advanced Photonics (2023)

Yile Sun Hongfei Zhu Lu Yin Hanmeng Wu Mingxuan Cai

Imaging three-dimensional, subcellular structures with high axial resolution has always been the core purpose of fluorescence microscopy. However, trade-offs exist between axial resolution and other important technical indicators, such as temporal resolution, optical power density, and imaging process complexity. We report a new imaging modality, fluorescence interference structured illumination microscopy (FI-SIM), which is based on three-dimensional structured illumination microscopy for wide-field lateral imaging and fluorescence interference for axial reconstruction. FI-SIM can acquire images quickly within the order of hundreds of milliseconds and exhibit even 30 nm axial resolution in half the wavelength depth range without z-axis scanning. Moreover, the relatively low laser power density relaxes the requirements for dyes and enables a wide range of applications for observing fixed and live subcellular structures.

Interference microscopy

Fluorescence-lifetime imaging microscopy

STED microscopy

10.1117/1.ap.5.5.056007

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Citations (9)

CCDC 755621: Experimental Crystal Structure Determination

The Cambridge Structural Database (2012)

Xia Chen Liping Zhang Tongling Liang Xiang Hao Wen‐Hua Sun

10.5517/cctc8w9

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Breaking the Diffraction Barrier Using Fluorescence Emission Difference Microscopy

Scientific Reports (2013)

Cuifang Kuang Shuai Li Wei Liu Xiang Hao Zhaotai Gu

We propose a novel physical mechanism for breaking the diffraction barrier in the far field. Termed fluorescence emission difference microscopy (FED), our approach is based on the intensity difference between two differently acquired images. When fluorescence saturation is applied, the resolving ability of FED can be further enhanced. A detailed theoretical analysis and a series of simulation tests are performed. The validity of FED in practical use is demonstrated by experiments on fluorescent nanoparticles and biological cells in which a spatial resolution of <λ/4 is achieved. Featuring the potential to realize a high imaging speed, this approach may be widely applied in nanoscale investigations.

Fluorescence-lifetime imaging microscopy

Saturation (graph theory)

10.1038/srep01441

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Citations (148)