Kumar Vanka

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2d9zrg

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CCDC 2170505: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Bhupendra P. Mali Soumya Ranjan Dash Mari Annadhasan Anupam Biswas K. Manoj

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2bvl93

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CCDC 2282077: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

V. S. Ajithkumar Pratiksha B. Ghanwat K. Vipin Raj Kumar Vanka Rajesh G. Gonnade

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2glpd5

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CCDC 2214134: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Milan Kumar Bisai V. S. Ajithkumar K. Vipin Raj Kumar Vanka Rajesh G. Gonnade

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2d9zpd

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CCDC 2055790: Experimental Crystal Structure Determination

The Cambridge Structural Database (2021)

Gargi Kundu V. S. Ajithkumar Milan Kumar Bisai Srinu Tothadi Tamal Das

10.5517/ccdc.csd.cc2706t9

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CCDC 1868733: Experimental Crystal Structure Determination

The Cambridge Structural Database (2019)

Moumita Pait Gargi Kundu Srinu Tothadi Suvendu Karak Shailja Jain

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc20qkq1

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CCDC 1528709: Experimental Crystal Structure Determination

The Cambridge Structural Database (2017)

Suvendu Karak Sushil Kumar Saibal Bera David Díaz Díaz Subhrashis Banerjee

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc1n9r6x

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Studies on the Stereoselective Synthesis of Sacubitril via a Chiral Amine Transfer Approach

Chemistry - An Asian Journal (2024)

Ravindar Kontham Megha V Sadanande Sagar S. Thorat Himanshu Sharma Geetika Singh

We present a comprehensive account of our efforts directed towards the synthesis of sacubitril, a neprilysin inhibitor used in combination with valsartan and marketed as Entresto™. Our initial approach to the formal synthesis of sacubitril employed a chiral pool strategy, utilizing (S)-pyroglutamic acid as a key building block and Cu(I)-mediated Csp2-Csp3 cross-coupling as a key transformation. Further investigations led to the development of chiral amine transfer (CAT) reagents-based stereoselective synthesis. This involved the E-selective construction of γ-ylidene-butenolide from readily available biphenyl bromide and 4-pentynoic acid, the conversion of this butenolide to its ene-lactam using chiral amine, and substrate-controlled diastereoselective reduction of ene-lactam using Et3SiH or Pd/C, H2 (overall chiral amine transfer) as key transformations. Antipodal lactam intermediates were synthesized using corresponding chiral amines, and the stereochemical outcomes during the ene-lactam reduction with Et3SiH were rationalized by DFT studies.

10.1002/asia.202401223

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Substitution at sp³ boron of a six-membered NHC·BH₃: convenient access to a dihydroxyborenium cation

Chemical Communications (2022)

Gargi Kundu V. S. Ajithkumar K. Vipin Raj Kumar Vanka Srinu Tothadi

Herein, we have undertaken the synthesis and investigated the reactivity of a 6-membered saturated NHC borane adduct (1). Direct electrophilic halogenation of 1 with a stoichiometric amount of I2 led to NHC boryl iodides, 6-SIDipp·BH2I (2) and 6-SIDipp·BHI2 (3), which were further reacted with various nucleophiles to give novel 6-SIDipp based mono and disubstituted boranes with OTf (4 and 6) or ONO2 (5 and 7) functional groups. The addition of Br2/H2O to 1 smoothly results in a dihydroxyborenium cation (8).

Boranes

Reactivity

Stoichiometry

Substitution reaction

10.1039/d1cc06816d

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CCDC 1423294: Experimental Crystal Structure Determination

The Cambridge Structural Database (2016)

Shrikant M. Khake Rahul A. Jagtap Yuvraj B. Dangat Rajesh G. Gonnade Kumar Vanka

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc1js1q2

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