Thomas Höfer

Research Field

Lymphopoiesis

10.1038/nature14242

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Citations (688)

Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma

Nature Genetics (2021)

Selina Jansky Ashwini Kumar Sharma Verena Körber Andrés Quintero Umut H. Toprak

Neuroblast

10.1038/s41588-021-00806-1

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Citations (218)

Detecting and quantifying clonal selection in somatic stem cells

bioRxiv (Cold Spring Harbor Laboratory) (2021)

Verena Körber Naser Ansari‐Pour Niels Asger Jakobsen Rachel Moore Nina Claudino

Abstract As DNA variants accumulate in somatic stem cells, become selected or evolve neutrally, they may ultimately alter tissue function. When, and how, selection occurs in homeostatic tissues is incompletely understood. Here, we introduce SCIFER, a scalable method that identifies selection in an individual tissue, without requiring knowledge of the underlying driver event. Moreover, SCIFER infers the self-renewal and mutation dynamics of the tissue’s stem cells, and, if selection is present, the size and growth rate of the largest selected clone. We benchmark SCIFER with published data and then probe bone marrow of 22 non-leukemic individuals for clonal hematopoiesis (CH), identifying CH with known and unknown driver events. Unexpectedly, we find accelerated division of all stem cells in CH, compared to age-matched non-CH individuals, suggesting that the bone marrow environment alters stem cell dynamics in individuals with CH. SCIFER is broadly applicable to renewing somatic tissues to detect and quantify selection.

clone (Java method)

Negative selection

10.1101/2021.12.15.472780

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Citations (1)

Novel Tumor-Targeted, Engineered IL-2 Variant (IL2v)-Based Immunocytokines For Immunotherapy Of Cancer

Blood (2013)

Christian Klein Inja Waldhauer Valeria Nicolini Claire Dunn Anne Freimoser–Grundschober

Cancer Immunotherapy

Carcinoembryonic antigen

10.1182/blood.v122.21.2278.2278

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Citations (15)

Dictyostelium discoideum: cellular self-organisation in an excitable biological medium

Proceedings of the Royal Society of London (1995)

Jonathan A. Sherratt Thomas Höfer Philip K. Maini

Source

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Citations (9)

Table S5 from Integrative Genome-Scale Analysis Identifies Epigenetic Mechanisms of Transcriptional Deregulation in Unfavorable Neuroblastomas

Kai‐Oliver Henrich Sebastian Bender Maral Saadati Daniel Dreidax Moritz Gartlgruber

<p>Genes whose hypermethylation and downregulation are associated with high-risk disease (HyperDownHR) are repressed by MYCN in vitro</p>

Table (database)

Deregulation

10.1158/0008-5472.22408911

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Citations (0)

Effects of Hormonal Changes on the Selenium and Glutathione Peroxidase Levels in the Rat

Springer eBooks (1981)

D. Behne Thomas Höfer W. Wolters R. von Berswordt-Wallrabe W. Elger

10.1007/978-3-642-68269-8_10

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Supplementary Figure 2 from Chromothripsis in Human Breast Cancer

Michiel Bolkestein John Wong Verena Thewes Verena Körber Mario Hlevnjak

<p>Copy-number differences between cases with and without chromothripsis in the CATCH cohort</p>

Chromothripsis

10.1158/0008-5472.22426263

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Modelling Single Cell B-Cell Receptor Signaling Reveals Enhanced Activity in Primary CLL Cells Compared to Non-Malignant Cells While Fundamental Network Circuit Topology Remains Stable Even with Novel Therapeutic Inhibitors

Blood (2019)

Daniel Mertens Christine Wolf Carsten Maus Michael R. O. Persicke Katharina Filarsky

breakpoint cluster region

IGHV@

10.1182/blood-2019-127837

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Citations (0)

Simultaneous exposure of rats to dioxin and carbon monoxide reduces the xenobiotic but not the hypoxic response

Biological Chemistry (2004)

Thomas Höfer Raimo Pohjanvirta Patrick Spielmann Matti Viluksela D. P. Buchmann

Aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor-1alpha (HIF-1alpha) are conditionally regulated transcription factor subunits that form heterodimeric complexes with their common partner, AhR nuclear translocator (ARNT/HIF-1beta). Whereas the environmentally toxic compound 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD) initiates the trans-activation activity of AhR:ARNT/HIF-1beta, hypoxic exposure stabilizes HIF-1alpha and functionally activates the HIF-1alpha:ARNT/HIF-1beta complex. To analyze a possible crosstalk between these two pathways in vivo, rats were given dioxin orally and/or were exposed to carbon monoxide (CO), causing functional anemia. We found that exposure to CO inhibited the xenobiotic response while dioxin application had no significant negative impact on hypoxia-mediated gene transcription.

Hypoxia-Inducible Factors

Xenobiotic

Hypoxia-Inducible Factor 1

Hypoxia

HIF1A

10.1515/bc.2004.024

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Citations (24)

Papers

Citation

H-Index

i-10 index

Papers

Citation

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