Joana Ferrer

Hospital Clínic de Barcelona

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Juan Carlos García‐Valdecasas

Hospital Clínic de Barcelona

Josep Fuster

Universitat de Barcelona

Constantino Fondevila

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

Santiago Sánchez-Cabús

Hospital de Sant Pau

J. Fuster

Universitat de Barcelona

Pedro Ventura‐Aguiar

Hospital Clínic de Barcelona

Enric Esmatjes

Hospital Clínic de Barcelona

Víctor Molina

Universidad Tecnológica del Sur de Sonora

Fritz Diekmann

Hospital Clínic de Barcelona

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Ángeles García‐Criado

Universitat de Barcelona

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Hospital Clínic de Barcelona

362

Universitat de Barcelona

347

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

283

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

176

Instituto de Salud Carlos III

121

Centro de Investigación Biomédica en Red

114

Fundació Clínic per a la Recerca Biomèdica

Universitat Autònoma de Barcelona

Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer

Centre for Biomedical Network Research on Rare Diseases

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MRI AS A NOVEL TOOL TO OPTIMIZE ENZYME DISTRIBUTION AND PANCREAS DISTENSION FOR SUCCESSFUL ISLET ISOLATION

Pancreas (2008)

William E. Scott Joana Ferrer Ronald S. Chamberlain Takayuki Anazawa Bradley P. Weegman

Background: A thorough, homogeneous enzyme distribution during pancreas distension is desirable to obtain maximum yields of isolated islets. It is thought that some regions of the pancreas do not consistently receive adequate enzyme to properly digest the extracellular matrix and release the islets. Aim: To develop a tool to investigate the homogeneity of classic and novel methods of enzyme delivery for porcine and ultimately human islet isolation. Methods: Pancreata were procured from adult (>18 month) female Landrace pigs via en bloc viscerectomy. The main pancreatic duct was then cannulated with 18g winged catheter and MRI performed at 1.5T. Images were collected before and after ductal infusion of chilled gadolinium-doped saline. Results: It was observed that regions of the distal aspect of the splenic lobe and portions of the connecting lobe and bridge exhibit reduced delivery of solution when traditional methods of distension are utilized. Conclusion Presently utilized methods of enzyme distension do not consistently deliver adequate enzyme uniformly to all regions of the pancreas. Novel methods of enzyme delivery such as selective recannulation and distension of identified problem regions should be investigated for improved enzyme distribution. MRI serves as a valuable tool to visualize and evaluate the efficiency of varying methods of enzyme distension.

10.1097/01.mpa.0000335384.14896.d0

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Experimental Porcine Model in Pancreas Transplantation.

HPB (2019)

Joana Ferrer Víctor Molina Judit Hidalgo Roger Pujol Laura Nuño Gómez

Abdominal aorta

10.1016/j.hpb.2019.10.698

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Unveiling prognostic factors in patients with hepatic metastases from colorectal cancer: pushing beyond boundaries

HPB (2024)

G. Chullo R. García V. Gonzabay C. Arrocha C. Robles

10.1016/j.hpb.2024.03.340

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Usefulness of liver metastases ablation in colorectal cancer

HPB (2024)

Rocío García-Pérez M Llompart G. Chullo Ana M. Briones Javier Moreno

10.1016/j.hpb.2024.03.304

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Influencia del octreótido sobre la secreción exocrina pancreática después de la duodenopancreatectomía

Laureano Fernández Cruz Enrique Jiménez Chavarría Pilar Taurá Daniel Closa Santiago Sánchez-Cabús

Trabajo presentado en la XIII Reunion del Club Espanol Pancreatico, celebrada en Alicante, Espana, del 19 al 21 de septiembre de 2013

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Total duodenopancreatectomy and splenectomy with portal vein resection for borderline pancreatic cancer after neoajuvant chemoradiotherapy

HPB (2019)

Joana Ferrer C. Muñoz Castro R. Diaz del Gobo Esther Delgado J.C. Garciá-Valdecasas

Chemoradiotherapy

Neoadjuvant Therapy

Superior mesenteric vein

10.1016/j.hpb.2019.10.1167

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Impact of endoscopic ultrasonography (EUS) and EUS-guided fine-needle aspiration on the management of pancreatic cystic lesions

European Journal of Gastroenterology & Hepatology (2016)

Antonio Rodríguez-D’Jesús Glòria Fernández‐Esparrach Jaume Boadas Juli Busquets Laureano Fernández‐Cruz

Background and study aims Endoscopic ultrasonography (EUS) and EUS-guided fine-needle aspiration (EUS-FNA) are well-recognized techniques for the study of pancreatic cystic lesions (PCLs). However, little evidence exists on their impact on clinical care. The aim of this study is to determine how often EUS and EUS-FNA alter the diagnosis and management of patients with PCLs. Patients and methods Eight physicians expert in pancreatic diseases were asked to report their diagnoses and management recommendations for 49 different PCLs. Clinical information was sequentially disclosed in a stepwise manner – progressively from clinical data plus computed tomography or MRI (level 1), to EUS (level 2) and EUS-FNA results including cytology, carcinoembryonic antigen, and amylase levels (level 3). Results EUS led to a change in the diagnosis and management in 30% [95% confidence interval (CI): 26–35%] and 19% (95% CI: 16–23%) of cases, respectively, usually to a more intensive approach (14%; 95% CI: 11–18%). EUS-FNA altered the diagnosis and management in an additional 39% (95% CI: 34–44%) and 21% (95% CI: 17–25%) of the evaluations, respectively. EUS-FNA also increased the consensus in the diagnosis among the specialists that ranged from fair with computed tomography/MRI ( κ -index=0.32) to substantial with EUS-FNA ( κ -index=0.43). Conclusion EUS and EUS-FNA impact the diagnosis and management of patients with PCLs; therefore, both are necessary in the workup of these patients. EUS-FNA markedly improves the agreement between physicians in terms of diagnosis, but not management. This study highlights the need for more research and standardization in the field.

Endoscopic ultrasonography

Endoscopic Ultrasound

Carcinoembryonic antigen

10.1097/meg.0000000000000678

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Preemptive simultaneous pancreas kidney transplantation has survival benefit to patients

Kidney International (2022)

Enrique Montagud‐Marrahí Elena Cuadrado Evelyn Hermida Judit Cacho David Cucchiari

Pancreas transplantation

10.1016/j.kint.2022.04.032

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Outcomes From Brain Death Donors With Previous Cardiac Arrest Accepted for Pancreas Transplantation

Annals of Surgery (2019)

Pedro Ventura‐Aguiar Joana Ferrer David Paredes Camino Rodrı́guez-Villar Ángel Ruíz

Objective: The aim of the study was to evaluate the effect of cardiac arrest time (CAT) in donors after brain death (DBD) donors on pancreas transplant outcome. Summary of Background Data: Results from donors after circulatory death report good outcomes despite warm ischemia times up to 57 minutes. Previous cardiac arrest in DBD has been addressed as a potential risk factor, but duration of the CAT has never been evaluated. Methods: We conducted a retrospective analysis including 342 pancreas transplants performed at our center from 2000 to 2016, and evaluated the effect of previous cardiac arrest in DBD (caDBD) on pancreas transplant outcomes. Results: A total of 49 (14.3%) caDBD were accepted for transplantation [median CAT of 5.0 min (IQR 2.5–15.0)]. Anoxic encephalopathy was most frequent and P-PASS higher (16.9 vs 15.6) in caDBD group when compared with other DBD. No differences were found in all other characteristics evaluated. Graft survival was similar between both groups, as was the incidence of early graft failure (EGF). CAT increased the risk for EGF [OR 1.09 (95% CI, 1.01–1.17)], and the duration of CPR discriminated for EGF [AUC of 0.86 (95% CI, 0.74–0.98)], with a sensitivity and specificity of 100% and 75% at a cutoff of 15 minutes. When evaluated separately, caDBD >15 min increased over 5 times the risk for EGF [HR 5.80 (95% CI, 1.82–18.56); P = 0.003], and these presented fewer days on the ICU (1.0 vs 3.0 d). Conclusion: CaDBD donors are suitable for routine pancreas transplantation without increasing EGF risk, and in those with longer CAT it may be prudent to postpone donation a few days to allow a thorough evaluation of organ damage following cardiac arrest.

Pancreas transplantation

10.1097/sla.0000000000003218

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Citations (9)

A rare cause of systemic inflammatory response syndrome

Gastroenterología y Hepatología (English Edition) (2019)

Berta Caballol Pablo Ruíz Joana Ferrer Alba Díaz Alejandro Forner

Inflammatory response

10.1016/j.gastre.2018.07.010

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