ÖÖ

Özkan Öztürk

The Centre for Reproductive & Genetic Health

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Eric Jauniaux

University College London

Siladitya Bhattacharya

University of Aberdeen

Paul Serhal

The Centre for Reproductive & Genetic Health

Asıf Muneer

University College London

Gamal I. Serour

The Egyptian IVF-ET Center

Gulam Bahadur

North Middlesex Hospital

MÖ

Mahmut Özdemir

Yüksek İhtisas Üniversitesi

Zabeena Pandian

NHS Grampian

Allan Templeton

Aberdeen Maternity Hospital

Allan Templeton

Royal College of Obstetricians and Gynaecologists

Cooperative Institutions

University College London

Sağlık Bilimleri Üniversitesi

University College Hospital

MRC Centre for Reproductive Health

The Royal Free Hospital

S.B. Keçiören Eğitim ve Araştırma Hastanesi

Hacettepe University

The Centre for Reproductive & Genetic Health

Military Medical Academy

Ankara University

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A Comparative Analysis of Outcomes Between Two Different Intramuscular Progesterone Preparations in Women Undergoing Frozen Embryo Transfer Cycles

Journal of Reproduction & Infertility (2022)

Srividya Seshadri Rabi Odia Özkan Öztürk Wiam Saab Ali Alchami

Background: The purpose of the current study was to assess if luteal support with intramuscular (IM) 17 alpha-hydroxyprogesterone caproate (17-OHPC) (Lentogest, IBSA, Italy) improves the pregnancy outcome in comparison to natural intramuscu-lar progesterone (Prontogest, AMSA, Italy) when administered to recipients in a frozen embryo transfer cycle. Methods: A retrospective comparative study was performed to evaluate outcomes between two different intramuscular regimens used for luteal support in frozen embryo transfer cycles in patients underwent autologous in vitro fertilization (IVF) cycles (896 IVF cycles) and intracytoplasmic sperm injection (ICSI) who had a blastocyst transfer from February 2014 to March 2017 at the Centre for Reproduct-ive and Genetic Health (CRGH) in London. Results: The live birth rates were significantly lower for the IM natural progesterone group when compared to 17-OHPC group (41.8% vs. 50.9%, adjusted OR of 0.63 (0.31-0.91)). The miscarriage rates were significantly lower in the 17-OHPC group compared to the IM natural progesterone group (14.5% vs. 19.2%, OR of 1.5, 95% CI of 1.13-2.11). The gestational age at birth and birth weight were similar in both groups (p=0.297 and p=0.966, respectively). Conclusion: It is known that both intramuscular and vaginal progesterone prepar-ations are the standard of care for luteal phase support in women having frozen embryo transfer cycles. However, there is no clear scientific consensus regarding the optimal luteal support. In this study, it was revealed that live birth rates are sig-nificantly higher in women who received artificial progesterone compared to women who received natural progesterone in frozen embryo transfer cycles.

Live birth

Intramuscular injection

10.18502/jri.v23i1.8452

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Citations (1)

Impact of double trophectoderm biopsy on reproductive outcomes following single euploid blastocyst transfer

European Journal of Obstetrics & Gynecology and Reproductive Biology (2024)

Efstathios Theodorou Elpiniki Chronopoulou Özkan Öztürk Xavier Orriols Brunetti Paul Serhal

Blastocyst Transfer

10.1016/j.ejogrb.2024.04.033

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Citations (2)

Relationship between male reproductive hormones, sperm DNA damage and markers of oxidative stress in infertility

Reproductive BioMedicine Online (2007)

Malathy Appasamy Shanthi Muttukrishna Arnold Pizzey Özkan Öztürk NP Groome

Semen Analysis

10.1016/s1472-6483(10)60783-3

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Citations (111)

The impact of the COVID-19 pandemic on the orthopaedics outpatient clinic.

PubMed (2023)

Mahmut Özdemir Y U Yaradilmis A S Targal Özkan Öztürk B Birinci

The COVID-19 pandemic has significantly impacted orthopaedic practice since it started. In our study, we aimed to examine these effects on outpatient services.The patients who applied to the orthopedic outpatient clinic (n=1,518) in six months period under the effect of the COVID-19 pandemic (September 2020-March 2021) and patients (n=1,207) who applied during the same period before the pandemic (September 2019-March 2020) were analyzed according to the demographic characteristics (age, gender), reasons for admission, duration of complaints, treatments applied, surgical acceptance rate, and compliance with treatment.The mean age in the pre-pandemic outpatient clinic admissions was 39.1 years (1-91 years), the gender ratio was 635/572 (Female/Male), the mean age of the patients was 38.1 years (1-95), and the sex ratio was 793/725 (F/M) during the pandemic. Admissions of patients with acute complaints decreased after the pandemic, and applications for subacute or chronic complaints increased. Applications for sports medicine, pediatrics, and hand surgery increased, applications for trauma, foot and ankle surgery decreased, and applications for oncology and spine did not change. Conservative treatment recommendations decreased, the surgical treatment recommendation did not change, and the rate of patients who were given only follow-up decisions increased. There was no significant difference in the treatment rejection and surgical acceptance rate.We observed that the number of traumas decreased, and the hospital admission duration extended. The increase in the consultation rate and follow-up preference indicates that the treatment is more conservative in this period. In this process, patients should be adequately informed about the precautions taken, and their treatment should not be interrupted.

Pandemic

Outpatient clinic

10.26355/eurrev_202301_30899

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Citations (1)

Exact positioning of intra-aortic balloon catheter

European Journal of Cardio-Thoracic Surgery (1993)

Harun Tatar S RICEK Ufuk Demirkılıç Hikmet Süer Mehmet Aslan

The positioning of the intra-aortic balloon catheter in the descending aorta is vital for successful balloon pumping. With transesophageal echocardiography, the catheter could be properly and rapidly positioned in the descending aorta.

Descending aorta

Balloon catheter

10.1016/1010-7940(93)90150-a

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Citations (13)

Semen quality before and after gonadotoxic treatment

Human Reproduction (2005)

Gulam Bahadur Özkan Öztürk Asıf Muneer Raheala Wafa Ale Yasin Ashraf

The aim of this study was to analyse the semen quality of patients before and after gonadotoxic therapy.We evaluated semen quality in 314 patients over a 26 year period. The diagnostic categories were leukaemia (n = 13); lymphoma (n = 128); testicular cancer (n = 102); benign conditions (n = 13); and other malignant neoplasms (n = 58). The degree of azoospermia or oligozoospermia for each disease category was recorded. We then analysed the recovery in semen quality over time for each disease category.The mean patient age was 27.9 years (range 13-65 years). A total of 1115 post-treatment semen samples were analysed from 314 patients. There was a significant reduction in the post-treatment sperm concentration, sperm motility and semen volume compared with pre-treatment levels (P < 0.05) in the entire cohort. However, the sperm movement and motility grade remained unaffected. Patients with testicular carcinoma had the lowest pre-treatment sperm concentrations but also the lowest incidence of azoospermia after cancer treatment. Patients with lymphoma and leukaemia had the highest incidence of post-treatment azoospermia and oligospermia. Patients having the largest reductions in their sperm concentration after treatment required the longest recovery period for spermatogenesis. The diagnostic category was the only significant predictor of post-treatment azoospermia.Gonadotoxic treatment results in a significant reduction in sperm quality. The type of cancer or disease, and the pre-treatment sperm concentrations were found to be the most significant factors governing post-treatment semen quality and recovery of spermatogenesis. All categories of patients displayed varying degrees of azoospermia and oligozoospermia, and recovery of gonadal function from these states was not significant. This highlights the importance of ensuring sperm banking before treatment, including for patients with benign conditions. Several factors and associations are discussed further in order to give an insight into the pre- and post-gonadotoxic treatment effects.

Semen quality

Semen Analysis

10.1093/humrep/deh671

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Citations (124)

In-vivo measurement of intrauterine gases and acid–base values early in human pregnancy

Human Reproduction (1999)

E. Jauniaux Adrian Watson Özkan Öztürk Devon Quick Graham J. Burton

A new multiparameter sensor that combines electrochemical and fibre-optic technology was used for continuous in-vivo investigation of pH, carbon dioxide partial pressure (PCO2), oxygen partial pressure (PO2), bicarbonate concentration (HCO3–), base excess, and oxygen saturation (O2Sat) early in human pregnancy. The sensor was inserted into the amniotic cavity and the placental bed of 16 pregnancies at 10–15 weeks gestation, before termination under general anaesthesia. Amniotic fluid and retroplacental blood from the same site were also aspirated and analysed by means of cartridges and a portable blood gas analyser. Eleven series of measurements were obtained. The variation in measurements over the 5 min of monitoring was ≤10% for all parameters. The sensor was damaged during insertion into the amniotic cavity in one case and in the placental bed in four cases. Measurements of PO2 in both the amniotic cavity and the placental bed and of pH in the placental bed were higher using the cartridges than in vivo. The results indicated that in-vivo monitoring of fetoplacental gas and acid–base with a sensor is stable and accurate. Such technology will be helpful in improving our understanding of the fetoplacental metabolism in normal and complicated pregnancies.

Partial pressure

pCO2

Bicarbonate

10.1093/humrep/14.11.2901

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Citations (83)

Testicular versus epididymal spermatozoa in intracytoplasmic sperm injection treatment cycles.

PubMed (2010)

Nadia Hameed Özkan Öztürk

Normal fertilization and ongoing pregnancy can be achieved using intracytoplasmic sperm injection (ICSI), even with severely immature spermatozoa. However, the published literature documents conflicting results as to the outcome of ICSI.Surgical extraction of spermatozoa in 111 ICSI treatment cycles performed over five years at the Assisted Conception Unit (ACU), University College Hospital (UCH), was retrospectively evaluated to compare the outcome of ICSI treatment using either testicular or epididymal spermatozoa.A higher normal fertilization rate and lower abnormal fertilization rate was observed in the epididymal spermatozoa group than in the testicular spermatozoa group. Embryo development on day 3 after fertilization and implantation was significantly better in the epididymal spermatozoa group. Clinical and ongoing pregnancy rates were higher and the spontaneous miscarriage rate lower in the epididymal spermatozoa group, but only the clinical pregnancy rate reached statistical significance.The origin of surgically extracted spermatozoa has an effect on the success of assisted reproduction using ICSI, and the immaturity of testicular spermatozoa may affect fertilization, embryo development, implantation and pregnancy.

Testicular sperm extraction

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Citations (5)

Diz Eklem Yüzeyi Yenileme Kayıtları

Uğur Yaradılmış Mustafa Caner Okkaoğlu Özkan Öztürk Ahmet Ateş Hakan Şeşen

p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 7.5px Helvetica; color: #7a7a79} Amac Kayit sistemleri epidemiyolojik verilerin toplanmasi, implant sag kalimlarinin ortaya konmasi ve basarisizlikla iliskili etmenlerin anlasilmasi icin gereklidir. Kayit sistemleri; ulusal olabilecegi gibi bolgesel veya hastane bazli da olabilir. Bu calismada klinigimizin diz artroplastisi kayit sisteminin degerlendirilmesi amaclanmistir. Gerec ve Yontem 2011-2017 yillari arasinda klinigimizde diz osteoartriti nedeniyle artroplasti uygulanan 2252 hastanin kayitlari incelendi. Diz artroplastisi verileri degerlendirildi ve yillara gore dagilimi arastirildi. Diz artroplastisi; arka capraz bag korunmasi, unikompartmantal artroplasti, patellar yuzey degisimi, cimentosuz artroplasti acisindan siklik ve yillar ici kullanim tercih degisimleri acisindan kaydedildi. Revizyon artroplastisi kayitlari ise; yuk, etyoloji ve yillar ici degisim acisindan degerlendirildi. Klinik verilerimiz uluslararasi veriler ile karsilastirildi. Bulgular Diz artroplastisi yapilan 2252 hastanin 130'u (% 5.8) revizyon cerrahisi ve 52'si (%2.3) unikompartmantal diz artroplastisi idi. Total diz artroplastisinin 2026'si (%97.8) cimentolu, 44'u (%2.1) cimentosuz olarak uygulandi. Cimentosuz diz protezi 2014 yilinda hastalarin %0.6'sinda kullanilirken 2017 yilinda %6 oranina artis gosterdi. Total diz artroplastisi yapilan 2070 hastanin 450'si (%21) bag kesen, 1620'si (%79) bag koruyan diz protezi idi. 2011 yilinda bag kesen orani %4 iken, 2017 yilinda bu oran %46'ya cikmistir. Diz artroplastisinde revizyonun en sik nedeni %38 oraniyla aseptik gevseme idi. Diz revizyon yuku %5.8 olarak saptandi. Tartisma Diz artroplastisi cerrahisi teknolojinin ilerlemesi, hasta memnuniyetinin artmasi ve olum yasinin artisi ile birlikte yillar icinde artis gostermistir. Klinigimizde; diz protezi seciminde unikompartmantal protezler ve patellar yuzey degisimi acisindan yillar icinde fark yok iken, bag kesen protez tercihinde yillar icerisinde artis saptanmistir. Revizyon cerrahisi nedenleri ve revizyon yuku ulusal kayitlarla paralellik gostermektedir.

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Number of embryos for transfer following in vitro fertilisation or intra-cytoplasmic sperm injection: summary of a Cochrane review

Fertility and Sterility (2014)

Zabeena Pandian Jane Marjoribanks Özkan Öztürk Gamal I. Serour Siladitya Bhattacharya

Live birth

Single Embryo Transfer

Odds

Assisted Reproductive Technology

10.1016/j.fertnstert.2014.04.029

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Citations (7)