Aim. To study influence of simvastatin application on clinic, the laboratory and tool data, and as the remote forecast at patients with ischemic heart disease of senile age (75 years and are more senior) with clinic of chronic heart failure. Material and methods. . 60 men were included in research and women in the age of from 75 till 85 years, hearts suffering by ischemic illness with display of intimate insufficiency and divided on 2 equal groups a method of random numbers. Ill control group received standard therapy concerning ischemic heart disease and chronic heart failure, and ill groups of research, in addition to standard therapy, received simvastatin in a doze 20 mg / days. The period of supervision - 12 months. Results. On the termination of the period of supervision there was an authentic divergence of curves survivals in observably groups for the benefit of the patients accepting simvastatin; authentic improvement of function vascular endothelium, reduction of a class of a stenocardia in group of intervention is marked. Clinical results are confirmed with decrease of level СRP, TNFa. Authentic growth of level NO of plasma in group of simvastatin application was not observed, and this fact in the given research contacts additional reception or a cancellation of prolonged nitrates patients during treatment. С onclusion. By results of the executed research positive influence simvastatin on clinic and the forecast of outcome of disease at patients of the senile age, suffering is confirmed with ischemic illness of heart. Significant growth of the by-effects limiting application simvastatin in a daily doze of 20 mg at patients to the given age group, is not marked. Research will be continued.
Major death cause among occupational diseases patients is cardiovascular disorder. Early diagnosis is required to predict heart disorders in occupational risk group. Rhythmocardiography helped to define autonomous cardioneuropathy on background of vibration disease, pneumoconiosis, chronic occupational fluorine-manganese intoxication--this is a pathogenetic basis for early clinical manifestation of CHD.
It is known that the immunological component of nearly any dysregulatory pathology is manifested by the development of new functional systems providing adaptation reactions, as well as by the presence of allostasis, reflecting other forms that are different from the normal parameters, and variants of mutually supporting relationships that occur at different structural and functional levels of the body. A long stay in the areas of military campaigns inevitably has a negative impact on the re-adaptation for civilian life, and it is accompanied by occurence of pathological functional connections that lead to dysregulation of the basic functions, including those of nervous and immune systems. In this regard, we studied the features of immune cell functioning in the patients with early forms of chronic cerebral ischemia accompanied by hyperlipoproteinemia, and we have made a comprehensive assessment of the factors characterizing morphological and functional state of endothelium. A representative survey included 87 patients who participated in the Afghan campaign with early forms of cerebral circulatory failure. The subjects exhibited objective and subjective signs of underlying vascular disease, typical to the earliest manifestations of chronic cerebrovascular insufficiency (CVVN) manifesting as headache, dizziness, noise in the head, memory impairment, decreased performance. All the patients underwent a comprehensive examination, i.e., expanded lipidogram, determination of vasoactive factors in the blood and cultural fluid, the number of circulating desquamated endotheliocytes, thus reflecting morphological signs of endothelial damage, additional ultrasound Doppler sonography of the main vessels, transcranial Doppler and electroencephalography were carried out. It is known that endothelial cells are independently capable of modulating vascular tone, depending on the current clinical condition, and it may be also subjected to remodeling rearrangements with involvement into the pathological process, e.g., in atheromatosis. In this regard, endothelial dysfunction is a key factor in developing vascular pathology, affecting the systemic level. According to results of the study, it has been established that the main progression mechanism for the early forms of CVVN is the development of endothelial dysfunction. The condition has multifactorial genesis in which immune mechanisms are directly involved. Hyperlipoproteinemia established in more than 90% of cases, is one of the most important metabolic triggering factors for development of immune reactions, which is also promoted by imbalance of vasoform and thrombogenic factors, by presence of oxidative and nitrosative cellular stress markers which generally contribute to increase in cerebral vascular remodeling and the basis for the formation of organic pathology of the central nervous system.
Прогрессия ранних форм хронической ишемии мозга на фоне артериальной гипертензии сопровождается увеличением в системном кровотоке нейронспецифических белков, дисбалансом регуляторных цитокинов и вазоформных пептидов. Артериальная гипертензия способствует повышению проницаемости гематоэнцефалического барьера, включению каскада аутоиммунных реакций к тканям мозга, что приводит к структурным повреждениям нейронов и появлению очаговой неврологической микросимптоматики при переходе от начальных проявлений недостаточности кровоснабжения мозга в 1 стадию дисциркуляторной энцефалопатии.
59 patients with pathologically confirmed thyroid cancer underwent biphase scintigraphy with application of 99mTc-pertechnetate and 99mTc-MIBI prior to operation. The true positive results were detected in 35 patients (59.32 %). It was found, that one of the most significant factors which effected the quality of radionuclide imaging was the size of the cancer nodule: images of nodules with diameter g1 cm were of higher quality. As the factor, promoting positive radionuclide diagnostics, serves biological activity of thyroid cancer, which was shown by invasion of increased cancer nodules to surrounding tissues and/or the presence of metastases. The factor, complicating radionuclide diagnostics of cancer nodules, was the presence of accompanying non-cancer thyroid diseases.
Введение. Изолированные переломы бедренной кости (ИПБК) составляют более 10% от числа всех дорожных травм. Реакция организма в ответ на травму сопровождается нарушением гомеостаза, активацией процессов свободно-радикального окисления. Одним из перспективных направлений коррекции метаболических нарушений при хирургической патологии является озонотерапия. Цель исследования - оценка в динамике показателей свободно-радикального окисления в плазме крови у пациентов с изолированным переломом бедренной кости в условиях применения системной озонотерапии. Методика. Исследование выполнено на 36 пациентах с ИПБК и 20 условно здоровых лицах. Содержание изопропанол- и гептан-растворимых первичных, вторичных и конечных продуктов перекисного окисления липидов (ПОЛ) в плазме оценивали на 5-7-е сут после травмы до начала хирургического лечения, а также на 18-е сут после травмы, хирургического лечения и стандартного курса терапии, в том числе дополненного курсом малой аутогемотерапии (МАГТ), - 7-9 инъекций с озонированием крови (концентрация озона 20 мг/л). Результаты. Ранний посттравматический период у пациентов с ИПБК до оперативного лечения сопровождается накоплением первичных (диеновые конъюгаты), вторичных (ацилгидроперекиси, кетодиены и сопряженные триены) и конечных (основания Шиффа) продуктов ПОЛ в гептановой фазе липидного экстракта плазмы, а также вторичных и конечных продуктов ПОЛ в изопропанольной фазе липидного экстракта плазмы. У пациентов с ИПБК после оперативного лечения на фоне стандартной консервативной терапии сохраняется высокий уровень продуктов ПОЛ в гептановой и изопропанольной фазах липидного экстракта плазмы, что свидетельствует об эскалации окислительного стресса. Применение процедуры МАГТ с озонированием крови приводит к снижению и полному восстановлению уровня продуктов ПОЛ в изопропанольной фазе, снижению и частичному восстановлению продуктов ПОЛ в гептановой фазе липидного экстракта плазмы. Заключение. Применение МАГТ с озонированием крови оптимизирует состояние про- и антиоксидантных систем крови и ограничевает эскалацию окислительного стресса. Introduction. Isolated femoral fractures (IFF) account for more than 10% of all road injuries. The body responds to trauma with homeostatic disorders and activation of free radical oxidation. The ozone therapy is one of promising directions for correction of metabolic disorders in surgical pathology due to the pleiotropic effects of reactive oxygen species. The aim of the study was to evaluate changes in indexes of free radical oxidation in plasma of patients with isolated femoral fracture during the systemic ozone therapy. Methods. The study included 36 patients with IFF and 20 healthy individuals. Plasma concentrations of isopropanol and heptane-soluble primary, secondary, and end products of lipid peroxidation (LPO) were measured at 5-7 days after the injury, prior to the surgical treatment, and at 18 days after the injury following the surgical treatment and a standard therapy, including a course of minor autohemotherapy (7-9 injections of ozonated blood with ozone concentration of 20 mg/l). Results. The early post-traumatic period preceding the surgical treatment was associated with accumulation of LPO primary (conjugated dienes), secondary (ketodienes, and conjugated trienes) and end (Schiff bases) products in the heptane phase of plasma lipid extract, as well as LPO secondary and end products in the isopropanol phase of plasma lipid extract. In patients with IFF after the surgical treatment in combination with a standard, conservative therapy, high levels of LPO products remained in the heptane and isopropanol phases of plasma lipid extract, which indicated escalation of oxidative stress. The use of minor autohemotherapy with blood ozonation resulted in a decrease and complete restoration of the level of LPO products in the isopropanol phase and a decrease and partial return to the normal level of LPO products in the heptane phase of plasma lipid extract. Conclusions. The use of minor autohemotherapy with blood ozonation improved the condition of pro- and antioxidant blood systems and restricted the escalation of oxidative stress.
