Jianwei Jiang

Zhejiang Cancer Hospital

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Gen-Cheng Wu

State Key Laboratory of Medical Neurobiology

Wen‐Li Mi

Shanghai Medical College of Fudan University

Xiao-Ding Cao

Shanghai Medical College of Fudan University

Qi‐Liang Mao‐Ying

Shanghai Medical College of Fudan University

Zhifu Wang

Fujian University of Traditional Chinese Medicine

Yan-Qing Wang

Shanghai Medical College of Fudan University

G C Wu

Tumor Hospital of Guangxi Medical University

Amber Giles

National Cancer Institute

Xiaoxia Cao

University of Wisconsin–Milwaukee

Alexei Kharitonenkov

Novo Nordisk (United States)

Cooperative Institutions

Fudan University

Nanjing Medical University

Shanghai Medical College of Fudan University

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

State Key Laboratory of Medical Neurobiology

University of Chinese Academy of Sciences

Harbin Medical University

Jiangsu Province Hospital

Harvard University

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[Modulatory effect of orphanin FQ on the IL-1beta transcripts in hippocampus].

PubMed (2001)

Hui Zhao L N Du Jianwei Jiang G C Wu Xiaoxia Cao

Using in situ hybridization and immuno-fluorescent double labeling method, we investigated the function of orphanin FQ on interlenkin-lbeta (IL-lbeta) transcripts in hippocampus. Intracerebroventricularly (icv) administrated IL-lbeta antibody reduced IL-l and TNF-alpha secreted from peritoneal macrophage. The high level of IL-lbeta transcript in hippocampus elicited by traumatic stress was blocked by icv injection of orphanin FQ (0.55 nmol), which was reversed by orphanin FQ receptor antagonist ([phe(1)Psi(CH(2)-NH)Gly(2)] nociceptin-(1-l3)-NH(2)). Opioid receptor-like receptor transcripts were found in neuron, astrocyte and microglia. Based on the results, we conclude that orphanin FQ functions as a neuroimmune modulator, and provokes immune response via mediation of IL-lbeta derived from neuron, astrocyte and microglia in hippocampus.

Nociceptin receptor

NOP

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Citations (3)

[Potentiation of electroacupuncture analgesia by l-tetrahydropalmatine and its analogues in rabbits].

PubMed (1990)

Gang Wu Jianwei Jiang Gen-Cheng Wu Xiao-Ding Cao

l-Tetrahydropalmatine (l-THP), tetrahydroberberine (THB) and l-stepholidine (l-SPD) are the homologues of tetrahydroproto berberines and have a common antagonistic effect to central dopamine receptors. In the present experiment, the potassium iontophoretic dolorimetry was used to determine the pain threshold of rabbits. Unilateral "Hegu" point (the dorsum of the front paw, between 1st and 2nd metacarpals) and "Waiguan" point (the dorsum of the foreleg, between radius and ulna, 2 cm above the wrist joint) of each rabbit were electrically needled. The effects of iv l-THP 8 mg/kg, THB 16 mg/kg or l-SPD 4 mg/kg on electroacupuncture analgesia were investigated. The experimental results indicated that these 3 agents enhanced the potency of electroacupuncture analgesia and prolonged the duration as well. This investigation gives the evidence that the drug possessing antagonistic effect to central dopamine receptors could be used as a synergist of acupuncture analgesia.

Tetrahydropalmatine

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Molecular Mechanism of Inducing GLC-82 Cells Apoptosis by Ethanol Extract from Wedelia prostrate (Hook.et Arn.) Hemsl

Zhongguo shengwu gongcheng zazhi (2017)

Dai Li-ting Huilan Zeng Huang Xiang Jianwei Jiang Zhongnan Wu

Hook

10.13523/j.cb.20170801

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Citations (0)

Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors

Frontiers of Medicine (2012)

Qing-gang Hu Shanglong Liu Jianwei Jiang Chen Zhang Xiaowei Liu

Mitotic index

10.1007/s11684-012-0203-9

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Effects of Electroacupuncture on Uterine Morphology and Expression of Oestrogen Receptors in Ovariectomised Rats

Acupuncture in Medicine (2016)

Shulan Ma Dongju Li Yi Feng Jianwei Jiang Bo Shen

To observe the effects of electroacupuncture (EA) on uterine morphology and expression of oestrogen receptor (ER) α and β in ovariectomised (OVX) rats.Thirty female Sprague-Dawley rats with regular 4-day oestrus cycles were divided into a sham operation group (Control, n=10) and two OVX groups that remained untreated (OVX group, n=10) or received EA treatment (OVX+EA group, n=10). In the latter group, EA was applied at CV4, CV3, SP6 and bilateral Zigong (30 min per day) for 3 days. The effects of EA on uterine morphology were observed by H&E staining. Quantitative real-time reverse transcription-PCR (qRT-PCR) and Western blotting were used to measure ERα and ERβ mRNA and protein expression, respectively.Relative to the (untreated) OVX group, EA treatment significantly increased the uterine wet weight to body weight (UWW/BW) ratio (0.47±0.04 vs 0.31±0.03 g/kg, p=0.04), and myometrial thickness (109.39±10.71 vs 60.81±8.1 μm, p=0.016) of OVX rats. Similarly, the total number of endometrial glands per cross section and endometrial thickness in the OVX +EA group was significantly increased compared to the (untreated) OVX group. EA treatment also increased protein (but not mRNA) expression of both ERα and ERβ in the uteri of OVX rats.This study has demonstrated that EA treatment decreases uterine atrophy in OVX rats. This unique effect of EA on the uterus may be due to upregulation of serum levels of E2 and differential regulation of sex steroid receptors ERα and ERβ.

10.1136/acupmed-2016-011093

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Citations (10)

Involvement of Spinal Neurotrophin-3 in Electroacupuncture Analgesia and Inhibition of Spinal Glial Activation in Rat Model of Monoarthritis

Journal of Pain (2011)

Wen‐Li Mi Qi‐Liang Mao‐Ying Xiaowei Wang Xiu Li Chang-Jiang Yang

Proinflammatory cytokine

Monoarthritis

10.1016/j.jpain.2011.03.002

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Citations (38)

Nucleotide Sequence and Expression of the Genes for the [alpha] and [beta] Subunits of Phycocyanin in Cyanidium caldarium

PLANT PHYSIOLOGY (1995)

Robert F. Troxler Yu Yan Jianwei Jiang Bingya Liu

The nucleotide sequence of the plastid-encoded operon containing genes for the alpha (cpcA) and beta (cpcB) subunits of phycocyanin in the unicellular red alga Cyanidium caldarium is described. cpcB is located 5' to cpcA and the two genes are separated by a 102-bp spacer region. The transcription start site of cpcBA was mapped to 80 bp upstream of the ATG initiation codon of cpcB. Promoter-like elements similar to the -10 (TATAAT) and -35 (TTGACA) consensus promoters in bacteria were found 6 and 31 bp upstream of the transcription initiation site. Northern blotting revealed an abundant 1.3-kb cpcBA transcript in illuminated cells, but this transcript was undetectable in dark-grown cells. Expression levels of cpcBA in cells incubated with 10(-6) M heme in the dark were similar to those in cells illuminated for 24 h. Cells illuminated with 150 microM gabaculine (an inhibitor of delta-aminolevulinate synthesis) or 10 mM levulinic acid (an inhibitor of delta-aminolevulinate dehydrase) lacked detectable cpcBA transcripts. In cells illuminated with 200 microM N-methyl-mesoporphyrin IX (an inhibitor of ferrocheletase), inhibition of cpcBA expression and phycocyanin synthesis was similar. These results provide strong evidence that light induction of the cpcBA operon is dependent on synthesis of heme.

Transcription

10.1104/pp.107.3.985

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Citations (7)

Overcoming Multidrug Resistance by On-Demand Intracellular Release of Doxorubicin and Verapamil

Journal of Nanomaterials (2018)

Jianwei Jiang Shaojuan Liu Chunlei Wang Hong-yan Zhang

Multidrug resistance (MDR) is one of the major obstacles to the successful application of cancer chemotherapy. Herein, we developed light-responsive doxorubicin-and-verapamil-coencapsulated gold liposomes to overcome MDR. Upon ns-pulsed laser irradiation, the highly confined thermal effect increased the permeability of the phospholipid bilayer, triggering the release of doxorubicin and verapamil, leading to high concentrations in cells. Free verapamil efficiently inhibited the membrane multidrug resistance proteins (MRPs), while the high concentration of doxorubicin saturated MRPs, thus overcoming MDR. We showed that nanosecond- (ns-) pulsed laser- (532 nm, 6 ns) induced doxorubicin release from gold liposomes depended on laser fluence and pulse number. More than 58% of the doxorubicin was released with a 10-pulse irradiation (100 mJ/cm 2 ). Furthermore, ns laser pulses also liberated doxorubicin from endocytosed gold liposomes into the cytosol in MDA-MB-231-R cancer cells. The cytotoxicity of doxorubicin coencapsulated with verapamil was significantly enhanced upon laser irradiation. This study suggested that light-triggered on-demand release of chemotherapeutic agents and MRP inhibitors could be used advantageously to overcome multidrug resistance.

Membrane permeability

10.1155/2018/3568190

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Citations (3)

The Analgesic and Antineuroinflammatory Effect of Baicalein in Cancer-Induced Bone Pain

Evidence-based Complementary and Alternative Medicine (2015)

Shan Hu Yu Chen Zhifu Wang Qi‐Liang Mao‐Ying Wen‐Li Mi

Cancer-induced bone pain (CIBP) is a severe type of chronic pain. It is imperative to explore safe and effective analgesic drugs for CIBP treatment. Baicalein (BE), isolated from the traditional Chinese herbal medicine Scutellaria baicalensis Georgi (or Huang Qin), has been demonstrated to have anti-inflammatory and neuroprotective effects. In this study, we examined the effect of BE on CIBP and the mechanism of this effect. Intrathecal and oral administration of BE at different doses could alleviate the mechanical allodynia in CIBP rats. Intrathecal 100 μ g BE could inhibit the production of IL-6 and TNF- α in the spinal cord of CIBP rats. Moreover, intrathecal 100 μ g BE could effectively inhibit the activation of p-p38 and p-JNK MAPK signals in CIBP rats. The analgesic effect of BE may be associated with the inhibition of the expression of the inflammatory cytokines IL-6 and TNF- α and through the activation of p-p38 and p-JNK MAPK signals in the spinal cord. These findings suggest that BE is a promising novel analgesic agent for CIBP.

Baicalein

Bone pain

10.1155/2015/973524

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Citations (23)

Effects of Chronic Electroacupuncture on Depression- and Anxiety-like Behaviors in Rats with Chronic Neuropathic Pain

Journal of Acupuncture and Meridian Studies (2015)

Qian Li Na Yue Shenbin Liu Zhifu Wang Wen‐Li Mi

Growing evidence indicates that chronic neuropathic pain is frequently accompanied by an array of psychiatric diseases, such as depression and anxiety. Electroacupuncture (EA), as one therapy of traditional Chinese medicine, has displayed potent antidepressant-like effects in numerous clinical studies. The present study was designed to examine the possible effects of EA on the depressive and anxiety disorders induced by neuropathic pain. A classic rat model of neuropathic pain was produced by chronic constriction injury (CCI) of the sciatic nerve. EA was performed on acupoints “Bai-Hui” (GV20) and unilateral “Yang-Ling-Quan” (GB34). The antidepressive and anxiolytic effects of EA treatment were analyzed using the forced swimming test (FST) and the elevated plus maze (EPM) test, respectively. CCI resulted in remarkable depression- and anxiety-like behaviors, whereas the chronic EA treatment significantly improved the behavioral deficits of CCI rats. Moreover, the phosphorylation level of the NMDA receptor type 1 (NR1) subunit was decreased in the hippocampus of CCI rats. Intriguingly, continuous EA treatment effectively blocked this decrease in the levels of pNR1. These results suggested that EA has antidepressive and anxiolytic effects on rats with neuropathic pain and that this might be associated with restoring the phosphorylation of NR1 in the hippocampus.

Elevated plus maze

Depression

10.1016/j.jams.2015.07.007

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Citations (3)