Riki Okeda

Yokufukai Hospital

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Toshihiko Kuroiwa

Osaka University of Pharmaceutical Sciences

Nobuaki Funata

Tokyo Metropolitan Komagome Hospital

Takashi Matsuo

The University of Tokyo

Makoto Shibutani

Tokyo University of Agriculture and Technology

Hidehiro Mizusawa

National Center of Neurology and Psychiatry

Fumio Higashino

Tokyo University of Agriculture and Technology

Masahito Yamada

Kanazawa University

Tayoko Tajima

Tokyo Medical and Dental University

Osamu Matsubara

Hiratsuka Kyosai Hospital

Shinobu Okada

Chiba University

Cooperative Institutions

Tokyo Medical and Dental University

120

The University of Tokyo

Osaka University

Kawasaki Hospital

Musashino Red Cross Hospital

Hokkaido University

National Center of Neurology and Psychiatry

University of Tsukuba

National Hospital Organization

Teikyo University

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Primary granulomatous angiitis of the CNS preferentially involving small veins with a granulomatous leukoencephalitis‐like lesion in the cerebrum

Neuropathology (2012)

Riki Okeda Keisuke Ito Koutaro TSUMURA Yoshinobu Eishi

We have reported an autopsy case of primary granulomatous angiitis of the CNS preferentially involving the small veins with a granulomatous leukoencepalitis‐like lesion in the cerebral white matter of a 48‐year‐old man. The latter lesion was ischemic necrosis due to circumferential multiple perivenous granulomas in the adjacent V irchow‐ R obin space. Multifocal progressive involvement of venular adventitia by granulomas, leaving behind mural fibrosis and luminal stenosis, was related clinically to the prolonged stepwise deterioration observed in the patient, and pathologically to diffuse loosening with dilated veins in the deep cerebral white matter and subcortical hemorrhagic infarction in the left parietal lobe through chronic venous stagnation. PCR demonstrated negativity for M ycobacterium tuberculosis and P ropionibacterium acnes , and in situ hybridization with EBV ‐encoded small nuclear RNA probe was also negative. The possibility of subarachnoidal latent infection with an unknown avirulent agent causing exclusively perivascular granulomas is proposed. It will be necessary to examine by autopsy whether the type (artery or vein) and size of the involved vessels and the pathological subtype of angiitis is related to the etiopathogenesis and prognosis. It is also pointed out that the entity of lymphocytic angiitis is problematic.

10.1111/neup.12006

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Citations (3)

Fetal globoid cell leukodystrophy in one of twins

Acta Neuropathologica (1979)

Riki Okeda Y. Suzuki S Horiguchi T. Fujii

Krabbe disease

10.1007/bf00717039

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Citations (19)

An experimental model for anaplastic astrocytomas and glioblastomas using adult F344 rats and N‐methyl‐N‐nitrosourea

Acta Pathologica Japonica (1993)

Makoto Shibutani Akihiko Maekawa Riki Okeda Kunitoshi Mitsumori Takayoshi Imazawa

An experimental model for induction of gliomas corresponding to human anaplastic astrocytomas and glioblastomas is reported. Eleven week old F344 and ACI rats were given 100 or 200 p.p.m. N ‐methyl‐ N ‐nitrosourea (MNU) solution as their drinking water for 42 weeks. Gliomas were induced at very high incidences (82.5‐92.5%) in each group. Induced gliomas showed apparent evidence of morphologic malignancy by an analysis based on diagnostic criteria of human astrocytomas. All of the gliomas from the killed animals were classified histologically into subtypes according to the classification scheme used in the diagnosis of human gliomas. The majority of macrotumors more than 1 mm in diameter in both strains were diagnosed as anaplastic astrocytomas and glioblastomas. lmmunohistochemically, tumor cells in these tumors were almost negative for glial fibrillary acidic protein, while ultrastructurally neoplastic astrocytes contained glial filaments. A strain difference was observed in the ratio of histological subtypes of macrotumors. In F344 rats, astrocytic tumors diagnosed as anaplastic astrocytomas and glioblastomas of an astrocytic type formed the majority, whereas glioblastomas of mixed oligo‐astrocytic type predominated in ACI rats. The results indicate that MNU‐administration to adult F344 rats may provide a suitable experimental model for gliomas which occur in adult humans.

Anaplastic astrocytoma

Nitrosourea

10.1111/j.1440-1827.1993.tb01159.x

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Citations (8)

Mitochondrial Dysfunction and Maturation Phenomenon in Ischemic Gerbil Cortex

Springer eBooks (1999)

Toshihiko Kuroiwa G. Mies Yoji Hakamata S. Hanyu Riki Okeda

Gerbil

10.1007/978-3-642-58602-6_28

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Citations (5)

Regional cerebral blood flow of acute carbon monoxide poisoning in cats

Acta Neuropathologica (1987)

Riki Okeda Takashi Matsuo Toshihiko Kuroiwa M. Nakai Tayoko Tajima

CO poisoning

Carbon monoxide poisoning

10.1007/bf00687271

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Citations (12)

Meningio-angiomatosis in a patient with focal epilepsy: value of PET in diagnoses and preoperative planning of surgery

Acta Neurochirurgica (2003)

Yoshihisa Ohta Tadashi Nariai Kenji Ishii Kiichi Ishiwata Michio Senda

Angiomatosis

Neuroradiology

Interventional radiology

10.1007/s00701-003-0047-9

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Citations (8)

Delayed recovery of auditory cortical evoked potentials is correlated with cortical neuronal death after transient cerebral ischemia in awake gerbils

Brain Research (1998)

Hiroto Ichiki Toshihiko Kuroiwa Ikuo Taniguchi Riki Okeda

Gerbil

10.1016/s0006-8993(98)00757-4

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Citations (5)

Morphometrische Vergleichsuntersuchungen an Hirnarterien bei Binswangerscher Encephalopathie und Hochdruckencephalopathie

Acta Neuropathologica (1973)

Riki Okeda

Hypertensive encephalopathy

10.1007/bf00685521

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Citations (59)

A revised model of regional cerebral ischemia by a middle cerebral artery occlusion in awake cat

Nosotchu (1987)

Toshihiko Kuroiwa Shuuichi Tomida Mitsuru Seida Riki Okeda Yutaka Inaba

脳虚血のモデルとしては現在に至るまで数多くのモデルが用いられているが, 中でも経眼窩的中大脳動脈閉塞モデルは, その病態がヒトの脳梗塞に近いため広く用いられている.我々はその原法を改良して良好な成績を収めている.即ち, 実験2～7日前に中大脳動脈を経眼窩的に露出し, ナイロン糸をその周囲にかけ, その糸を眼窩内にレジンで固定したチューブを介して眼窩皮下に誘導しておく.実験の際はその糸を牽引することにより中大脳動脈を閉塞し, 糸を抜去することにより再疎通をはかる.我々の改良したモデルは脳内の単一血管の閉塞により脳梗塞が生じ, 必要に応じて再開通が可能である.また脳虚血発症時に麻酔剤を使用する必要がなく, 髄液の漏出等によるartifactの可能性が最小限である等の優れた点があり, 今後の脳虚血の研究に有用であると思われる.

Artifact (error)

10.3995/jstroke.9.193

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Citations (0)

An Autopsy Case of Amyotrophic Lateral Sclerosis with Diaphragm Pacing

Internal Medicine (2016)

Hisashi Ito Tetsumasa Kamei Sanae Odake Masayuki Nakano Riki Okeda

Respiratory insufficiency is a critical problem in amyotrophic lateral sclerosis (ALS) patients. We herein present the case of an autopsied patient with sporadic ALS who underwent diaphragm pacing (DP). The pathology showed several localized adhesions with a markedly atrophied diaphragm. A marked loss of motor neurons with Bunina bodies and phosphorylated TDP-43 positive inclusions was found in the spinal cord and primary motor cortex. Mild hyalinization and a few multinucleated giant cells were present around the electrode tracks in the diaphragm. However, no infiltration of inflammatory cells was detected. Our findings suggest that full-time DP might not cause severe damage to adjacent diaphragm tissue.

Diaphragm (acoustics)

10.2169/internalmedicine.55.7130

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Citations (5)