Leon Barnes

University of Pittsburgh

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Alfio Ferlito

Istituto di Genomica Applicata

Alessandra Rinaldo

University of Udine

Kenneth O. Devaney

Henry Ford Allegiance Health

Jennifer L. Hunt

IZA - Institute of Labor Economics

Pieter J. Slootweg

Radboud University Nijmegen

Julia A. Woolgar

University of Birmingham

Silloo B. Kapadia

Inter-University Centre for Astronomy and Astrophysics

Asterios Triantafyllou

University of Liverpool

Douglas R. Gnepp

Brown University

Carl E. Silver

University of Arizona

Cooperative Institutions

University of Pittsburgh

University of Pittsburgh Medical Center

UPMC Presbyterian

Johns Hopkins University

The University of Texas MD Anderson Cancer Center

Eye and Ear Foundation

Yale University

UPMC Hillman Cancer Center

University of Michigan–Ann Arbor

Memorial Sloan Kettering Cancer Center

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Surgical margins in head and neck cancer: A contemporary review

Head & Neck (2012)

Michael L. Hinni Alfio Ferlito Margaret Brandwein‐Gensler Robert P. Takes Carl E. Silver

Abstract Adequate resection margins are critical to the treatment decisions and prognosis of patients with head and neck squamous cell carcinoma (HNSCC). However, there are numerous controversies regarding reporting and interpretation of the status of resection margins. Fundamental issues relating to the basic definition of margin adequacy, uniform reporting standards for margins, optimal method of specimen dissection, and the role of intraoperative frozen section evaluation, all require further clarification and standardization. Future horizons for margin surveillance offer the possible use of novel methods such as “molecular margins” and contact microscopic endoscopy, However, the limitations of these approaches need to be understood. The goal of this review was to evaluate these issues to define a more rational, standardized approach for achieving resection margin adequacy for patients with HNSCC undergoing curative resection. © 2012 Wiley Periodicals, Inc. Head Neck, 2013

Margin (machine learning)

Neck dissection

Resection margin

10.1002/hed.23110

Cite

Citations (294)

Recommendations for the Reporting of Larynx Specimens Containing Laryngeal Neoplasms

American Journal of Clinical Pathology (1998)

Douglas R. Gnepp Leon Barnes John D. Crissman Richard J. Zarbo

The Association of Directors of Anatomic and Surgical Pathology have developed recommendations for the surgical pathology report for common malignant tumors. The recommendations for carcinoma of the larynx are reported herein.

Laryngeal Diseases

10.1093/ajcp/110.2.137

Cite

Citations (9)

Angiolymphoid hyperplasia with eosinophilia: A disease that may be confused with malignancy

Head & Neck Surgery (1980)

Leon Barnes William Koss Michael L. Nieland

Twelve new cases of an unusual, benign vasoproliferative and inflammatory disorder of unknown etiology, angiolymphoid hyperplasia with eosinophilia (ALHE), are described and contrasted clinically and pathologically with those appearing in the literature. Only recently recognized in the United States, the disease is of singular importance because the vascular component may be confused histologically with angiosarcoma, thereby resulting in unwarranted aggressive therapeutic measures. ALHE characteristically affects adults and presents in the head and neck region as either solitary or multiple cutaneous tumors. The lesions are pruritic, frequently bleed after minor trauma, and may be associated with peripheral eosinophilia and regional lymphadenopathy. On rare occasions, the disease may masquerade as a salivary-gland tumor, cause stenosis of the external auditory canal, or present as an osseous lesion of the skull. Extrafacial tumors are uncommon. Excision is the most frequent form of therapy; however, local irradiation, corticosteroids, electrodessication with curettage, and chemotherapy have also had varying degrees of success.

Etiology

Work-up

10.1002/hed.2890020512

Cite

Citations (40)

Allelic loss of tumor suppressor genes in ameloblastic tumors

Modern Pathology (2004)

Laurentia Nodit Leon Barnes Esther L.B. Childers Sydney Finkelstein Patricia A. Swalsky

Ameloblastoma is an odontogenic tumor with a variety of histologic appearances and an unpredictable biologic behavior. Little is known about allelic losses of tumor suppressor genes in ameloblastomas. This study surveyed DNA damage in ameloblastomas and correlated this with histologic sub-type and clinical outcome. There were 12 ameloblastomas (two peripheral, eight solid, and two unicystic) and three ameloblastic carcinoma studied for loss of heterozygosity of tumor suppressor genes on chromosomes 1p, 3p, 9p,10q, and 17p (L-myc, hOGG1, p16, pten, and p53). The frequency of allelic loss and the intratumoral heterogeneity were calculated. L-myc (71% frequency of allelic loss) and pten (62% frequency of allelic loss) had the most frequent allelic losses. Overall frequency of allelic loss and intratumoral heterogeneity were higher in mandibular and in unicystic tumors and lower in tumors that recurred/metastasized. The rate of allelic loss in the three carcinomas was similar to that seen in benign tumors. The frequency of allelic loss and intratumoral heterogeneity did not correlate with age, gender, histologic subtype, or prognosis. Since tumors that behaved aggressively did not harbor more allelic losses, it is likely that DNA damage in ameloblastomas and ameloblastic carcinomas is sporadic and cumulative. We conclude that other genetic or epigenetic mechanisms may be responsible for malignant behavior in ameloblastic carcinomas.

Odontogenic tumor

10.1038/modpathol.3800147

Cite

Citations (53)

Preface

ORL (1991)

Alfio Ferlito J. Rosai Adel K. El‐Naggar J.G. Batsakis James M. Woodruff

10.1159/000276216

Cite

Citations (0)

Schneiderian Papillomas and Nonsalivary Glandular Neoplasms of the Head and Neck

Modern Pathology (2002)

Leon Barnes

Confusion

10.1038/modpathol.3880524

Cite

Citations (172)

God's Plan for Growing Churches

Leon Barnes

Source

Cite

Citations (0)

Pathology & Genetics Head and Neck Tumours

Leon Barnes J.W. Eveson Peter A. Reichart David Sidransky

Source

Cite

Citations (167)

Vagal paragangliomas: a clinical, pathological, and DNA assessment

Clinical Otolaryngology (2009)

Leon Barnes Suzanne R. Taylor

Ten vagal paragangliomas were studied by image analysis and the results correlated with clinicopathologic features to determine if the DNA ploidy pattern could be used to separate benign from malignant paragangliomas. The tumours occurred in 8 women and 2 men ranging in age from 23 to 75 years (average 54 years). Follow-up was available in all 10 patients and ranged from 3 months to 27 years (average 7.8 years). Of the 10 tumours examined for DNA, 5 were diploid, 4 diploid-tetraploid, and 1 aneuploid. Two patients experienced local recurrences. One of these had a diploid tumour that recurred 22 years after excision and the other had an aneuploid tumour which recurred 4 years 4 months later and was associated with cervical lymph node metastasis. Two patients had malignant tumours with histologically confirmed metastases to noncontiguous cervical lymph nodes. One of the malignant tumours was diploid and the other aneuploid. This study concludes that DNA abnormalities are common in vagal paragangliomas and that tumour ploidy can not be used to assess malignant potential.

Cervical lymph nodes

10.1111/j.1365-2273.1991.tb02074.x

Cite

Citations (14)

Contributors

Elsevier eBooks (2006)

Leon Barnes Nancy J. Barr Deborah Belchis Parul Bhargava David Bosler

10.1016/b978-0-443-06652-8.50001-6

Cite

Citations (0)