Marta López‐Fraga

Conseil de L'Europe

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i-10 index

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Beatriz Domínguez‐Gil

Organización Nacional de Trasplantes

Kristof Van Assche

University of Antwerp

Dominique Martin

Providence College

Francis L. Delmonico

Massachusetts General Hospital

Elmi Muller

Stellenbosch University

Mar Lomero

Universidad Rovira i Virgili

Alexander Morgan Capron

University of Southern California

John Forsythe

Department of Health and Social Care

Jacinto Sánchez Ibáñez

Complexo Hospitalario Universitario A Coruña

Emanuele Cozzi

University of Padua

Cooperative Institutions

RELX Group (United States)

Consejo Superior de Investigaciones Científicas

Universidad Autónoma de Madrid

Organización Nacional de Trasplantes

Centro Nacional de Biotecnología

NHS Blood and Transplant

Inserm

University of the Witwatersrand

Deakin University

University of Melbourne

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Strengthening Global Efforts to Combat Organ Trafficking and Transplant Tourism: Implications of the 2018 Edition of the Declaration of Istanbul

Transplantation Direct (2019)

Dominique Martin Kristof Van Assche Beatriz Domínguez‐Gil Marta López‐Fraga Rudolf García Gallont

Abstract The 2018 Edition of the Declaration of Istanbul on Organ Trafficking and Transplant Tourism (DoI) provides an updated set of principles and definitions to guide policymakers and health professionals working in organ donation and transplantation. A draft of the new edition was circulated to the public and transplant professionals through an online consultation process, which also sought feedback on a draft explanatory article that explained the principles and discussed some of their practical implications. Both drafts were revised in response to feedback from participants in the consultation. We present here the discussion article, which is intended to assist stakeholders in applying the principles of the DoI by providing more detailed information about the meaning and potential implications of implementing the DoI in various contexts.

Declaration

10.1097/txd.0000000000000872

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Citations (33)

Differential expression of chemokine receptors and CD95 in porcine CD4+ T cell subsets

Veterinary Immunology and Immunopathology (2005)

Concepción Revilla Belén Álvarez Marta López‐Fraga Sonia Chamorro Paloma Martínez

CXCR3

CCR4

CXCL16

CC chemokine receptors

10.1016/j.vetimm.2005.03.004

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Citations (6)

Physical Examination of Potential Deceased Organ and Tissue Donors: An Overview of the European Landscape

Transplant International (2023)

Akila Chandrasekar Richard Lomas Jacinto Sánchez Ibáñez Mar Lomero Arlinke Bokhorst

Physical examination (PE) of donors is essential to identify potential risks to the safety and efficacy of donated organs and tissues and is mandatory in the EU. However, no detailed guidance is available as to how PE should be performed. Health authorities (HA) and health professionals (HP) in member states of the European Committee on Organ Transplantation of the Council of Europe (CD-P-TO) and observer countries completed surveys relating to the regulatory requirements for PE and the professional practice of PE in their countries for organ and tissue donors. The HA survey addressed regulatory aspects, and the HP survey addressed professional practices, training, and respondents' opinions on the value of PE. These surveys revealed significant inter-country variation in the regulatory approach to PE and the performance of PE by professionals. Most respondents opined that PE was important and yielded valuable information in identifying contraindications to donation. There is no consensus at a regulatory or professional level as to how PE should be performed on organ and tissue donors. There is a requirement for agreed best practice guidelines in this area.

Tissue Donation

Professional association

Health Professionals

Best practice

10.3389/ti.2023.11394

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Citations (0)

Access of non‐residents to transplantation of deceased donor organs: practices and strategies in the European setting

Transplant International (2021)

Alicia Pérez‐Blanco Marta López‐Fraga John Forsythe Ana M. Pires Silva Massimo Cardillo

Vulnerability

10.1111/tri.14113

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Citations (6)

Protection of haematopoietic progenitor cell donors: an updated overview of the European landscape

Bone Marrow Transplantation (2023)

Jacinto Sánchez Ibáñez Arlinke Bokhorst Akila Chandrasekar Beatriz Domínguez‐Gil Jorge Gayoso

10.1038/s41409-023-01982-w

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Citations (2)

Silencing human genetic diseases with oligonucleotide-based therapies

Human Genetics (2013)

Tamara Martı́nez Natalia Wright Marta López‐Fraga Ana I. Jiménez Covadonga Pañeda

Human genetics

Identification

10.1007/s00439-013-1288-1

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Citations (49)

Table of Contents

Kidney International (2017)

Beatriz Domínguez‐Gil Marta López‐Fraga Elmi Muller M. John Gill Madhav C. Menon

Table (database)

10.1016/s0085-2538(17)30743-3

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Citations (0)

Molecular cloning, characterization and tissue expression of porcine Toll-like receptor 4

Developmental & Comparative Immunology (2005)

Belén Álvarez Concepción Revilla Sonia Chamorro Marta López‐Fraga Fernando Sánchez‐Alonso

Ectodomain

10.1016/j.dci.2005.06.020

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Citations (24)

An Analysis by the European Committee on Organ Transplantation of the Council of Europe Outlining the International Landscape of Donors and Recipients Sex in Solid Organ Transplantation

Transplant International (2022)

Emanuele Cozzi Marina Álvarez Benito Mar Carmona Beatriz Mahíllo John Forsythe

Discrepancies in donation and transplantation by sex and gender have previously been reported. However, whether such differences are invariably the inevitable, unintended outcome of a legitimate process has yet to be determined. The European Committee on Organ Transplantation of the Council of Europe (CD-P-TO) is the committee that actively promotes the development of ethical, quality and safety standards in the field of transplantation in Europe. Whilst the ultimate objective is to shed light on the processes underlying potential gender inequities in transplantation, our initial goal was to represent the distribution by sex among organ donors and recipients in the CD-P-TO Member States and observer countries. Our survey confirms previous evidence that, in most countries, men represent the prevalent source of deceased donors (63.3% in 64 countries: 60.7% and 71.9% for donation after brain and circulatory death, respectively). In contrast, women represent the leading source of organs recovered from living kidney and liver donors (61.1% and 51.2% in 55 and 32 countries, respectively). Across countries, most recovered organs are transplanted into men (65% in 57 countries). These observations may be explained, at least in part, by the higher burden of certain diseases in men, childbearing related immune sensitization in women, and donor-recipient size mismatch. Future research should establish whether gender-related socially-constructed roles and socioeconomic status may play a detrimental role reducing the access of women to transplantation.

10.3389/ti.2022.10322

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Citations (9)

Prevention of Trafficking in Organs, Tissues, and Cells

Transplantation (2024)

Dominique Martin Alexander Morgan Capron Riadh Fadhil John Forsythe Benita Padilla

Trafficking in human organs, cells, and tissues has long been a source of concern for health authorities and professionals, and several international ethical guidance documents and national laws have affirmed the prohibition of trade in these substances of human origin (SoHOs). However, despite considerable attention to the issue of organ trafficking, this remains a substantial and widespread problem internationally. In contrast, trafficking in cells, tissues, and medical products derived from SoHOs has received comparatively little attention, and the extent and nature of such trafficking remain largely unknown. Consequently, as part of the 2023 Global Summit on Convergence in Transplantation held in Santander, Spain, an ethics working group was assigned the task of formulating actionable recommendations to support the prevention of trafficking in all SoHOs. In reporting on this work, we review factors that may influence the persistent trafficking of SoHOs, explore the potential difficulties associated with the collection and reporting of data about suspected trafficking activities, and argue that more practical and consistent guidance, training, and regulatory frameworks are needed internationally to support effective reporting, sharing of data, and collaborative responses to suspected trafficking cases. We also discuss the importance of psychosocial evaluation of living donors as a strategy to detect and prevent organ trafficking and strive to advance the implementation of this well-established recommendation by outlining minimum standards for psychosocial evaluation of living donors.

Summit

10.1097/tp.0000000000005212

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Citations (2)