B. A. Reikhardt

Research Field

Effect of etimizole structural analogues on protein kinase CK2, protein phosphorylation and transcription of chromatin in rat brain cortex and hippocampus

Biomeditsinskaya Khimiya (2020)

B. A. Reikhardt П. Д. Шабанов

Protein kinase CK2 is an important enzyme in the nervous system. The nuclear forms of CK2 regulate chromatin structure and gene expression, the key processes for long-term memory formation. Memory modulators, the Structural Analogues of Etimizole (SAE), were able to increase or decrease the activity of chromatin-associated CK in the cortex and hippocampus of rat brain in vitro. In vivo memory enhancers from SAE-group (3 mg/kg) stimulated CK2 activity and the transcriptional ability of chromatin in the cortex and hippocampus, starting from 30 min with a peak for 60 min and a duration up to 180 min. At these periods the memory inhibitor from the SAE-group reduced CK2 activity and chromatin transcription. It is assumed that the modulating effect of SAE on CK2 activity and transcription underlies the effects of these compounds on long-term memory.Mnogofunktsional'naia proteinkinaza CK2 – vazhnyĭ ferment v nervnoĭ sisteme. Iadernye formy SK2 reguliruiut strukturu khromatina i ékspressiiu genov, igraiushchikh kliuchevuiu rol' v formirovanii dolgovremennoĭ pamiati. Ustanovleno, chto moduliatory pamiati iz gruppy strukturnykh analogov étimizola (SAÉ) sposobny povyshat' ili snizhat' aktivnost' SK2 khromatina kory i gippokampa mozga krys in vitro. In vivo usiliteli pamiati iz gruppy SAÉ (3 mg/kg), nachinaia s 30 min, stimulirovali aktivnost' SK2 i transkriptsiiu khromatina kory i gippokampa s pikom na 60 min i prodolzhitel'nost'iu do 180 min. V éti sroki ingibitor pamiati iz gruppy SAÉ snizhal aktivnost' SK2 i transkriptsiiu khromatina. Predpolagaetsia, chto éffekty SAÉ na dolgovremennuiu pamiat' sviazany s moduliruiushchim deĭstviem étikh soedineniĭ na aktivnost' SK2 i transkriptsiiu.

Transcription

10.18097/pbmc20206602130

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Protein kinase CK2 and regulation of Ca2+-ATPase activity in brain neuron chromatin in rats during aging.

Bulletin of Experimental Biology and Medicine (2002)

B. A. Reikhardt O. G. Kulikova Н. С. Сапронов

Brain Aging

10.1023/a:1020277607879

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Ghrelin-dependent mechanisms of food reward. Part 1. Ghrelin and dopamine

Reviews on Clinical Pharmacology and Drug Therapy (2022)

B. A. Reikhardt Петр Д. Шабанов

Feeding behavior includes both the satisfaction of metabolic nutrient requirements and the hedonic aspects of pleasure. The orexigenic hormone ghrelin increases motivation to food intake. In addition, by modulating the reward system, ghrelin enhances the rewarding properties of non-food stimuli. The dopaminergic mesolimbic system plays a key role in the mechanisms of reward. Ghrelin regulates the activity of this system by acting on several levels of brain organization. The hierarchy of ghrelin-sensitive neural networks, as well as afferent connections and reciprocal interactions between its components, mediating the effect of ghrelin on the process of motivation in metabolic and hedonic type of feeding are considered.

Orexigenic

Reward system

10.17816/rcf20129-54

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The Effect of Structural Analogues of Etimizole on Protein Kinase CK2, Protein Phosphorylation, and Transcription of Chromatin in Rat Cortical and Hippocampal Neurons

Biochemistry (Moscow) Supplement Series B Biomedical Chemistry (2020)

B. A. Reikhardt П. Д. Шабанов

Transcription

10.1134/s1990750820040101

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