By combining the precisely sized cavity of pillar[5]arene and photodynamic properties of porphyrin derivatives, novel COMs (P5COMs) as an efficient cancer therapy platform from aldehyde-modified pillar[5]arene (P5CHO) and tetra-(4-aminophenyl)porphyrin (TAPP) were fabricated successfully.
Abstract Recently, nitrogen-doped graphene quantum dots (NGQDs), as a new type of quantum semiconductor and photoelectrochemical material, are promising candidates in photoelectric sensing, water splitting, and biological imaging and have various potential application prospects. In this work, NGQDs were prepared by a simple calcination method, and then a photoelectrochemical sensing platform based on the NGQDs electrode with superior photoelectrochemical activity was designed and fabricated for the detection of dopamine (DA). Benefitting from the quantum effect and size effect, NGQDs displayed an enhanced photocurrent effective within ultra-low detection limit (0.03 μ m ), wide detection range (0.03–450 and 450–9680 μ m ), and high sensitivity in detecting DA with the assistance of ultraviolet light irradiation. The NGQDs electrode also showed continuous and stable photocurrent densities after long-term experiment, indicating the excellent durability of NGQDs for DA detection.
A glucose oxidase-amplified CO gas-releasing nanoplatform was designed using a manganese carbonyl-caged metal–organic framework for synergistic gas/chemodynamic therapy of cancer cells.
A new water-soluble pillar[6]arene was successfully prepared. It complexed with a sodium p-hydroxybenzoate derivative to form a supra-amphiphile. The controllable self-assembly and application in controlled release of this supra-amphiphile in water were investigated.
Abstract Despite the intense progress of photodynamic and chemotherapy, however, they cannot prevent solid tumor invasion, metastasis, and relapse, along with inferior efficacy and severe side effects. The hypoxia‐responsive nanoprodrugs integrating photodynamic functions are highly sought to address the above‐mentioned problems and overcome the tumor hypoxia‐reduced efficacy. Herein, a hypoxia‐responsive tetrameric supramolecular polypeptide nanoprodrug (SPN‐TAPP‐PCB4) is constructed from the self‐assembly of tetrameric porphyrin‐central poly( l ‐lysine‐azobenzene‐chlorambucil) (TAPP‐(PLL‐Azo‐CB)4) and an anionic water‐soluble [2]biphenyl‐extended‐pillar[6]arene (AWBpP6) via the synergy of hydrophobic, π – π stacking, and host–guest interactions. Upon laser irradiation, the central TAPP can convert oxygen to generate single oxygen ( 1 O 2 ) to kill tumor cells. Furthermore, under the acidic and PDT‐aggravated hypoxia tumor cell microenvironment, SPN‐TAPP‐PCB4 is rapidly disassembled, and then efficiently releases activated CB through the hypoxic‐responsive cleavage of azobenzene linkages. Both in vitro and in vivo biological studies showcase synergistic cancer‐killing actions between photodynamic therapy (PDT) and chemotherapy (CT) with negligible toxicity. Consequently, this supramolecular polypeptide nanoprodrug offers an effective strategy to design a hypoxia‐responsive nanoprodrug for a potential combo PDT‐CT transition.
Pillar[5]arenes are a new type of supramolecular hosts constructed from hydroquinone and their derivatives linked by methylene units. Searching new host-guest interaction between pillar[5]arenes and neutral guests are thus great interesting. Here, four neutral guests (AA0, AA2, AA4 and AA6) with both amino and amide groups were prepared from phenol by two steps. The host-guest interactions between perethylated pillar[5]arene (EtP5) and guest molecules were investigated in detail by various technologies, including 1H NMR, 13C NMR, 2D NOESY NMR, MS analysis and DFT calculation. We found that the guests (AA4 and AA6) with longer alkyl chain can form a stable inclusion complex with EtP5 through C–H···O, N–H···O, C–H···N and C–H···π interactions while shorter guests (AA0 and AA2) could not.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
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