Xinming Chen

Henan Polytechnic University

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Jiali Zhang

Wuhan University

Shaodong Yang

Wuhan University

Zhi‐Jun Sun

Wuhan University

Huazhe Jiao

Henan Polytechnic University

Yi‐Fang Zhao

University of Science and Technology of China

Liuhua Yang

Henan Polytechnic University

Wen‐Feng Zhang

Yancheng Institute of Technology

Mingwen Fan

Wuhan University

Hongkai Zhuang

Sun Yat-sen University

Ming Zeng

Southern Medical University

Cooperative Institutions

Wuhan University

156

Chinese Academy of Sciences

103

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

Sun Yat-sen University

Zhejiang University

Taiwan Semiconductor Manufacturing Company (Taiwan)

Huazhong University of Science and Technology

Sichuan University

Southern Medical University

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Preclinical study on induction of pluripotent stem cells from urine of dilated cardiomyopathy patients.

PubMed (2016)

Y-H. Lin Xinming Chen Zhang Jw He Xq Dai Wj

Dilated cardiomyopathy (DCM) is featured by left or bilateral ventricular dilation combined with systolic dysfunction. Its clinical manifestations include heart enlargement, cardiac failure, arrhythmia and cardiac arrest. Medication and heart transplantation have but only limited treatment effect on DCM.Induced pluripotent stem cell (iPSC) treatment provides a new solution for DCM treatment. Human renal epithelial cells were extracted from the urine of patients with DCM and transfected with Sendai virus carrying OCT3/4, Sox2, Klf4 and c-Myc gene to generate iPSCs by reprogramming.The morphology and pluripotency of iPSCs obtained from the renal epithelial cells from patients with DCM were confirmed, as well as the growth characteristics, immunohistochemical features and surface markers of embryonic stem cells. Teratoma was formed in vivo.We demonstrated that it was feasible to obtain iPSCs from the urine of patients with DCM. This technique lays down the cytological foundation for understanding the pathogenesis and for drug screening and gene therapy for DCM.

KLF4

Dilated Cardiomyopathy

Reprogramming

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Effect of the JAK2/STAT3 signaling pathway on nerve cell apoptosis in rats with white matter injury.

PubMed (2019)

Xinming Chen Y-H Yu L Wang X-Y Zhao J-R Li

The Janus activated kinase 2 (JAK2)/signal transducer and the activator of transcription 3 (STAT3) pathway are involved in many physiological processes, such as cell survival, inflammation, development, proliferation and differentiation. Increasing evidence has shown that this pathway also has neuron-specific functions in the central nervous system. In this study, the functional significance of the JAK2/STAT3 signaling pathway in nerve cell apoptosis in rats with white matter injury was evaluated.The rat model of white matter injury was established by ligating bilateral common carotid arteries, and the changes of the JAK2 and STAT3 phosphorylation in hippocampal neurons were evaluated using the immunohistochemistry. In addition, the effects of JAK2 inhibitor AG490 and STAT3 small interfering ribonucleic acids (siRNAs) on the expression of phosphorylated-JAK2 (pJAK2), STAT3 messenger RNAs (mRNAs) and pSTAT3 in hippocampal neurons of white matter injury rats were studied. The effects of both on cerebral infarction volume and neuron apoptosis in white matter injury rats were also investigated.The expression of pJAK2 and pSTAT3 were significantly increased after white matter injury in rats (p<0.05). JAK2 inhibitor AG490 markedly decreased the phosphorylation of JAK2 and STAT3 in hippocampal neurons in the model group (p<0.05). STAT3 siRNAs remarkably reduced the expression levels of STAT3 mRNA and protein in hippocampus neurons in the model group (p<0.05), while having no effect on the expression level of pJAK2 protein. AG490 and STAT3 siRNAs notably attenuated the volume of cerebral infarction in the model group, as well as reduced neuron apoptosis after white matter injury.The inhibition of the JAK2/STAT3 signaling pathway contributed to reducing the volume of cerebral infarction and neuron apoptosis in rats with white matter injury.

Janus kinase 2

10.26355/eurrev_201901_16779

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Citations (17)

Orthokeratinized odontogenic cyst: a clinicopathological and immunocytochemical study of 15 cases

Histopathology (1998)

Li Kitano Xinming Chen Itoh Kawashima

Intraosseous jaw cysts with a solely orthokeratinized lining epithelium have been suggested to differ from the typical odontogenic keratocysts (OKC) by exhibiting a less aggressive behaviour. We report 15 cases of such cyst type under the term of 'orthokeratinized odontogenic cyst (OOC)' and compared their clinical, histological and immunocytochemical features with that of OKC.The cysts of the present series were all solitary lesions, occurred mostly in young male patients, and showed a predilection for the posterior mandible areas. Follow-up of 14 patients, nine of whom were treated by simple enucleation, revealed no recurrence over a period of 3.5-12 years after surgery. None of the patients had any association with the naevoid basal cell carcinoma syndrome. Furthermore, histological and immunocytochemical comparison between OOC and OKC revealed marked differences in their morphology and epithelial expression. The lining epithelium of OOC lacked the typical features of OKC and appeared to show a lower proliferative activity.These findings suggest that OOC is clinicopathologically separate from other types of odontogenic cysts and may thus constitute a distinct clinical entity.

Basal (medicine)

Odontogenic cyst

Mandible (arthropod mouthpart)

10.1046/j.1365-2559.1998.00380.x

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Citations (104)

Epithelial expression of SHH signaling pathway in odontogenic tumors

Oral Oncology (2005)

Lu Zhang Xinming Chen Zhi‐Jun Sun Zhuan Bian Mingwen Fan

Expression (computer science)

10.1016/j.oraloncology.2005.09.008

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Citations (51)

Combining a Fuzzy Matter-Element Model with a Geographic Information System in Eco-Environmental Sensitivity and Distribution of Land Use Planning

International Journal of Environmental Research and Public Health (2011)

Jing Zhang Ke Wang Xinming Chen Wenjuan Zhu

Sustainable ecological and environmental development is the basis of regional development. The sensitivity classification of the ecological environment is the premise of its spatial distribution for land use planning. In this paper, a fuzzy matter-element model and factor-overlay method were employed to analyze the ecological sensitivity in Yicheng City. Four ecological indicators, including soil condition,, water condition,, atmospheric conditions and biodiversity were used to classify the ecological sensitivity. The results were categorized into five ranks: insensitive, slightly sensitive, moderately sensitive, highly sensitive and extremely sensitive zones. The spatial distribution map of environmental sensitivity for land use planning was obtained using GIS (Geographical Information System) techniques. The results illustrated that the extremely sensitive and highly sensitive areas accounted for 14.40% and 30.12% of the total area, respectively, while the moderately sensitive and slightly sensitive areas are 25.99% and 29.49%, respectively. The results provide the theoretical foundation for land use planning by categorizing all kinds of land types in Yicheng City.

10.3390/ijerph8041206

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Citations (22)

[Suppressive effect of mizoribine on progression of bovine serum albumin nephritis in mice].

PubMed (1987)

Xinming Chen S Aozuka Yumiko Kobayashi

Mizoribine

Bovine serum albumin

Nephritis

Serum Albumin

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