JŠ

Ján Šoltés

General University Hospital in Prague

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Co-Authors

MŠ

Martin Švaňa

University of Pavol Jozef Šafárik

Jan Bruthans

Czech Technical University in Prague

Pavel Michálek

Charles University

MČ

Martin Čaprnda

Comenius University Bratislava

Luı́s Rodrigo

Universidad de Oviedo

Peter Kružliak

Masaryk University

KČ

Kristína Čurgali

University of Pavol Jozef Šafárik

M. Maretta

University of Pavol Jozef Šafárik

Jan Bělohlávek

General University Hospital in Prague

Daniel Rob

Charles University

Cooperative Institutions

University of Pavol Jozef Šafárik

Charles University

General University Hospital in Prague

University of Veterinary Medicine in Košice

St. Anne's University Hospital Brno

Masaryk University

Institute of Animal Physiology of the Slovak Academy of Sciences

Czech Academy of Sciences, Institute of Physiology

Institute of Clinical and Experimental Medicine

Comenius University Bratislava

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Parallel intubation technique with the Vie Scope® laryngoscope

Canadian Journal of Anesthesia/Journal canadien d anesthésie (2024)

Tomáš Henlín Pavel Michálek Tomasz Gaszyński Ján Šoltés

Scope (computer science)

Laryngoscopes

Video laryngoscope

10.1007/s12630-023-02683-0

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Citations (2)

Growing Evidence for LV Unloading in VA ECMO

Journal of Clinical Medicine (2023)

Ján Šoltés Daniel Rob Petra Kaválková Jan Bruthans Jan Bělohlávek

Impressively increasing availability of mechanical circulatory/cardiac support systems (MCSs) worldwide, together with the deepening of the knowledge of critical care medical practitioners, has inevitably led to the discussion about further improvements of intensive care associated to MCS. An appealing topic of the left ventricle (LV) overload related to VA ECMO support endangering myocardial recovery is being widely discussed within the scientific community. Unloading of LV leads to the reduction in LV end-diastolic pressure, reduction in pressure in the left atrium, and decrease in the LV thrombus formation risk. Consequently, better conditions for myocardial recovery, with comfortable filling pressures and a better oxygen delivery/demand ratio, are achieved. The combination of VA ECMO and Impella device, also called ECPELLA, seems to be a promising strategy that may bring the improvement of CS mortality rates. The series of presented trials and meta-analyses clearly showed the potential benefits of this strategy. However, the ongoing research has brought a series of new questions, such as whether Impella itself is the only appropriate unloading modality, or any other approach to unload LV would be beneficial in the same way. Benefits and potential risks of LV unloading and its timing are being discussed in this current review.

Impella

Pressure overload

10.3390/jcm12186069

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Citations (2)

Quercetin protects jejunal mucosa from experimental intestinal ischemia reperfusion injury by activation of CD68 positive cells

Acta Histochemica (2017)

Kristína Čurgali Štefan Tóth Zuzana Jonecová M. Maretta Theodoros Kalpakidis

Lamina propria

CD68

Intestinal mucosa

Jejunum

10.1016/j.acthis.2017.11.001

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Citations (11)

Update on Anticoagulation Strategies in Patients with ECMO—A Narrative Review

Journal of Clinical Medicine (2023)

Ján Šoltés Michal Skribuckij Hynek Říha Michal Lipš Pavel Michálek

The use of extracorporeal membrane oxygenation (ECMO) has recently increased exponentially. ECMO has become the preferred mode of organ support in refractory respiratory or circulatory failure. The fragile balance of haemostasis physiology is massively altered by the patient’s critical condition and specifically the aetiology of the underlying disease. Furthermore, an application of ECMO conveys another disturbance of haemostasis due to blood-circuit interaction and the presence of an oxygenator. The purpose of this review is to summarise current knowledge on the anticoagulation management in patients undergoing ECMO therapy. The unfractionated heparin modality with monitoring of activated partial thromboplastin tests is considered to be a gold standard for anticoagulation in this specific subgroup of intensive care patients. However, alternative modalities with other agents are comprehensively discussed. Furthermore, other ways of monitoring can represent the actual state of coagulation in a more complex fashion, such as thromboelastometric/graphic methods, and might become more frequent. In conclusion, the coagulation system of patients with ECMO is altered by multiple variables, and there is a significant lack of evidence in this area. Therefore, a highly individualised approach is the best solution today.

Extracorporeal

Modalities

10.3390/jcm12186067

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Citations (3)

Quercetin attenuates the ischemia reperfusion induced COX-2 and MPO expression in the small intestine mucosa

Biomedicine & Pharmacotherapy (2017)

Štefan Tóth Zuzana Jonecová Kristína Čurgali M. Maretta Ján Šoltés

Lamina propria

Intestinal mucosa

10.1016/j.biopha.2017.08.038

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Citations (28)

Growing Evidence for LV Unloading in VA ECMO

Ján Šoltés Daniel Rob Petra Kaválková Jan Bruthans Jan Bělohlávek

Impressively increasing availability of the mechanical circulatory/cardiac support systems (MCS) worldwide, together with the deepening of the knowledge of critical care medical practitioners, have inevitably led to the discussion about further improvements of intensive care associated to MCS. An appealing topic of the left ventricle (LV) overload related to VA ECMO support endangering myocardial recovery is being widely discussed within the scientific community. Unloading of LV leads to the reduction of LV end-diastolic pressure, reduction of pressure in the left atrium and decrease of the LV thrombus formation risk. Consequently, better conditions for myocardial recovery, with comfortable filling pressures and better oxygen delivery/demand ratio are achieved. The combination of VA ECMO and Impella device, also called ECPELLA seems to be a promising strategy which may bring the improvement of CS mortality rates. The series of presented trials and meta-analyses clearly showed potential benefits of this strategy. However, the ongoing research has brought a series of new questions, as whether Impella itself is the only appropriate unloading modality, or any other approach to unload LV would be beneficial in the same way? Benefits and potential risks of LV unloading and its timing are being discussed in current review.

Impella

10.20944/preprints202308.1784.v1

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Citations (1)

Using the national electronic prescription system to determine the primary non-adherence to medication in the Czech Republic

Frontiers in Pharmacology (2023)

Jan Bruthans Jiří Berger Ján Šoltés Pavel Michálek

The primary medication non-adherence occurs when a patient does not collect his or her newly prescribed medication. Various studies give estimates that this occurs between 0.2 percent and 74 percent. Recently, this topic has been researched by analyzing data in national electronic prescription systems. The database of the Czech electronic prescription system was used to obtain the number of all prescriptions issued and collected in 2021 for fifty particular substances (associated with six medication groups). Additionally, a similar query was performed with an additional criterion that the same substance had not been prescribed within the last 365 days. The data were obtained separately in five age categories. The total number of prescriptions analyzed in this study was over 21 million, which represents almost 30 percent of all prescriptions issued in the Czech Republic in 2021. The primary medication non-adherence in the selected substances was 4.56 percent, which negatively correlates (rxy = 0.707) with the age of a patient. There is a higher primary non-adherence in the Psychoanaleptics and Lipid modifying medication groups than in the whole studied sample (p < 0.05). Lipid-modifying medication group and several other particular substances showed a larger difference between primary non-adherence and overall non-adherence, indicating issues in the initiation of these drugs. The results of our study are following earlier studies with similar methodologies from other countries. However, the difference between primary non-adherence and overall non-adherence had not been observed in other studies before. The electronic prescription system proved to be a valuable tool for conducting this type of research.

Medication Adherence

10.3389/fphar.2023.1128457

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Citations (4)

The effect of R-(-)-deprenyl administration on reproductive parameters of rat males

European Journal of Pharmacology (2015)

Jozef Mihálik Jana Mašlanková Peter Solár Františka Horváthová Beáta Hubková

10.1016/j.ejphar.2015.02.030

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Citations (16)