Rongfeng Hu

Anhui University of Traditional Chinese Medicine

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Song Gao

Ministry of Education of the People's Republic of China

Wenjie Lu

China Pharmaceutical University

Wenyou Fang

Innovation Team (China)

Shengqi Chen

Ministry of Education of the People's Republic of China

Jihui Tang

Anhui Medical University

Zhipeng Chen

South China Agricultural University

Xiangjiang Nie

Anhui University of Traditional Chinese Medicine

Qianqian Zhang

Anhui Medical University

Bin Wang

Anhui University of Traditional Chinese Medicine

Chaojie Sun

China General Nuclear Power Corporation (China)

Cooperative Institutions

Anhui University of Traditional Chinese Medicine

Chinese Academy of Sciences

Anhui Medical University

China Pharmaceutical University

Nanjing University of Chinese Medicine

Ministry of Education of the People's Republic of China

Sun Yat-sen University

Shanghai Jiao Tong University

Nanjing Medical University

Shanghai University of Traditional Chinese Medicine

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In vivo pharmacokinetics and biodistribution of novel all-trans retinoic acid derivative-loaded, folate-modified poly ( l -amino acid) micelles

Journal of Drug Delivery Science and Technology (2017)

Wenxiu Hong Rongfeng Hu Xuechao Huang Xiaoqian Lu Tori Czech

Biodistribution

10.1016/j.jddst.2017.09.007

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Citations (3)

Design, synthesis and biological evaluation of novel furoxan-based coumarin derivatives as antitumor agents

Medicinal Chemistry Research (2018)

Zhuo Zhang Zhi-Wei Bai Yong Ling Liqin He Peng Huang

Furoxan

HeLa

IC50

10.1007/s00044-018-2140-x

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Citations (40)

[Applicability of a natural swelling matrix as the propellant of osmotic pump tablets].

PubMed (2013)

Li Wu Haiyan Li Xianzhen Yin Ying Li Jianxiu Chen

The purpose of this study is to investigate the applicability of a natural swelling matrix derived from boat-fruited sterculia seed (SMS) as the propellant of osmotic pump tablets. The sugar components, static swelling, water uptake and viscosity of SMS were determined and compared with that of polythylene oxide (WSR-N10 and WSR-303). Both ribavirin and glipizide were used as water-soluble and water-insoluble model drugs. Then, the monolayer osmotic pump tablets of ribavirin and the bilayer osmotic pump tablets of glipizide were prepared using SMS as the osmotically active substance and propellant. SMS was mainly composed of rhamnose, arabinose, xylose and galactose and exhibited relatively high swelling ability. The area of the disintegrated matrix tablet was 20.1 times as that at initial after swelling for 600 s. SMS swelled rapidly and was fully swelled (0.5%) in aqueous solution with relative low viscosity (3.66 +/- 0.03) mPa x s at 25 degrees C. The monolayer osmotic pump tablets of ribavirin and the bilayer osmotic pump tablets of glipizide using SMS as propellant exhibited typical drug release features of osmotic pumps. In conclusion, the swelling matrix derived from boat-fruited sterculia seed, with low viscosity and high swelling, is a potential propellant in the application of osmotic pump tablets.

Glipizide

Osmotic pressure

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Citations (1)

Preparation of Sustained-release Silybin Microspheres by Spherical Crystallization Technique

Journal of Chinese Pharmaceutical Sciences (2006)

Rongfeng Hu Zhu Jia-bi MA Feng-yu XU Xiang-yang Sun Yu-liang

Aim To improve the dissolution rate and bioavailability of silybin. Methods Sustained-release silybin microspheres were prepared by the spherical crystallization technique with solid-dispersing and release-retarding polymers. A differential scanning calorimeter and an X-ray diffractometer were used to investigate the dispersion state of silybin in the microspheres. The shape, surface morphology, and internal structure of the microspheres were observed using a scanning electron microscope. Characterization of the microspheres, such as average diameter, size distribution and bulk density of the microspheres was investigated. Results The particle size of the microspheres was determined mainly by the agitation speed. The dissolution rate of silybin from microspheres was enhanced by increasing the amount of the dispersing agents, and sustained by the retarding agents. The release rate of microspheres was controlled by adjusting the combination ratio of the dispersing agents to the retarding agents. The results of X-ray diffraction and differential scanning calorimetry analysis indicated that silybin was highly dispersed in the microspheres in amorphous state. The release profiles and content did not change after a three-month accelerated stability test at 40 ℃ and 75% relative humidity. Conclusion Sustained-release silybin microspheres with a solid dispersion structure were prepared successfully in one step by a spherical crystallization technique combined with solid dispersion technique. The preparation process is simple, reproducible and inexpensive. The method is efficient for designing sustained-release microspheres with water-insoluble drugs.

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Citations (3)

Chinese traditional formula Kaixin San suppressed ferroptosis of hippocampal neurons and cardiomyocytes in mice with paradoxical sleep deprivation

Journal of Ethnopharmacology (2022)

Yin Cao Mingrui Li Lihua Gu Xin Zhao An Zhou

10.1016/j.jep.2022.116034

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Citations (12)

Morphological transformation enhances Tumor Retention by Regulating the Self-assembly of Doxorubicin-peptide Conjugates

Theranostics (2020)

Xu Liu Yutong Wang Chenqi Zhu Shujing Ren Yurou Shao

Both spatial accuracy and temporal persistence are crucial in drug delivery, especially for anti-tumor intravenous nanomedicines, which have limited persistence due to their small particle sizes and easy removal from tumors. The present study takes advantage of morphological transformation strategy to regulate intravenous nanomedicines to display different sizes in different areas, achieving high efficient enrichment and long retention in lesions.

Conjugate

Biodistribution

10.7150/thno.45088

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Citations (22)

Self-assembled hexagonal liquid crystalline gels as novel ocular formulation with enhanced topical delivery of pilocarpine nitrate

International Journal of Pharmaceutics (2019)

Xingqi Wang Yong Zhang Jie Huang Mengqiu Xia Liu Liu

Ex vivo

10.1016/j.ijpharm.2019.02.033

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Citations (18)

Studies on drug release in vitro and rat intestinal absorption of tashinone II_A solid lipid nanoparticles

Zhongguo yaolixue tongbao (2005)

Rongfeng Hu

Aim To study release feature of tashinone Ⅱ A solid lipid nanoparticles(TA-SLN) in vitro,and clarify the differenc e in absorption of TA-SLN from varied intestinal segments and absorptive mechan ism in vivo.Methods Dialytic method was used to determine t ashinone Ⅱ A release rate of nanoparticles in vitro. An in situ rat perfusion method was used to investigate the intestinal absorption of TA-SLN.Resu lts Tashinone Ⅱ A release from TA-SLN in vitro fit the Weibull e quation well and had a property of sustained release. The absorption rate of tas hinone Ⅱ A solution from varied intestinal segments had no significant differe nce(P0.05). However,compared with others segments, significantly high per centage of TA-SLN was absorbed in colon(P0.05). The absorption of tashino ne Ⅱ A tended to be saturated with the high concentration of TA-SLN. It did n ot increase significantly when blank nanoparticles were added to the perfusion s olution(P0.05). With the decrease of Na+ or existence of deoxycholate, T ween 80,SLS or DNP in the perfusion solution, the absorption rate increased rem arkably(P0.05). Conclusion TA-SLN could sustain to relea se drug. The colon was the most potentest site of TA-SLN absorption in intestin al tract.

Solid lipid nanoparticle

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Preparation and Dissolution of Gliclazide Sustained Release Tablets in Vitro

Zhongguo yaofang (2006)

Li Shi Rongfeng Hu Zhao Li-hua

OBJECTIVE:To prepare gliclazide sustained release tablets,and to evaluate its dissolution in vitro.METHODS:Mixed matrix materials was used to prepare the tablet.According to the standard of imported Gliclazide sustained release tablets,the dissolution was determined by UV-absorption spectrometry in release medium of900ml of phosphate buffer with pH value of7.4(paddle method).The results were compared with those of the reference preparation.RESULTS:The dissolution of the prepared tablet in vitro accorded with the first order kinetics law.The release curve was similar to that of reference preparation judging from similar agent(f 2 ).CONCLUSION:The formula of this preparation is stable in technology,good in reproduction quality,and presents a standard cumulative dissolution in vitro.

Gliclazide

Phosphate buffered saline

Matrix (chemical analysis)

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Dual-targeted enzyme-sensitive hyaluronic acid nanogels loading paclitaxel for the therapy of breast cancer

Carbohydrate Polymers (2022)

Dan Gao Sajid Asghar Junxiu Ye Mei Zhang Rongfeng Hu

Hyaluronidase

Nanogel

10.1016/j.carbpol.2022.119785

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Citations (28)