Melvin J. Bryson

University of Utah

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Max L. Sweat

University of Utah

Richard B. Young

University of Utah

Leo T. Samuels

University of Utah

Morton A. Stenchever

University of Washington

Harvey A. Gabert

Louisiana State University Health Sciences Center New Orleans

Mary F. Paul

Eaton (United States)

L. E. Harris

General Electric (United States)

D. A. Greenwood

University of Bristol

Joseph R. Harris

The Kids Research Institute Australia

Merthyr L. Miner

Utah State University

Cooperative Institutions

University of Utah

Utah Agricultural Experiment Station

Arkansas Agricultural Experiment Station

Utah State University

Texas College

Norwich University

Eaton (United States)

Cornell University

Eaton (Taiwan)

Case Western Reserve University

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Biosynthesis of steroid hormones in a human feminizing adrenal carcinoma

Cancer (1968)

Melvin J. Bryson Richard B. Young William A. Reynolds Max L. Sweat

Pregnenolone-4-14C, progesterone-4-14C, 17α-hydroxyprogesterone-4-14C, 11-deox-ycorticosterone-4-14C, androstenedione-4-14C and testosterone-4-14C were incubated with a homogenate of a feminizing human adrenocortical carcinoma. Estrone, 17β-estradiol were isolated and identified in the phenolic fraction from substrates: pregnenolone, progresterone, androstenedione and testosterone. From androstenedione 19-hydroxyandrostenedione and 19-nortestosterone were identified as metabolic products. Hydroxylation reactions were active for carbons 6, 17 and 21 and appeared to proceed at rates normal to adrenal gland tissue; 16-hydroxylation was not observed. In the tissue homogenates 11β-hydroxylation was not observed; however, it could be demonstrated when supported with the addition of components from bovine adrenocortical mitochondria, thus indicating the presence of only part of the 11β-hydroxylating system.

Hydroxylation

Hydroxyprogesterone

10.1002/1097-0142(196803)21:3<501::aid-cncr2820210321>3.0.co;2-e

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Citations (5)

DDT in Milk and Tissues of Dairy Cows Fed DDT-Dusted Alfalfa Hay

Advances in chemistry series (1950)

Clyde Biddulph G. Q. Bateman Melvin J. Bryson Joseph R. Harris D. A. Greenwood

Untreated alfalfa hay and hay dusted with technical DDT were fed to 16 Holstein cows during 2 years DDT appeared in the milk within 4 days after the feeding of DDT-treated hay and the amount gradually increased until a fairly constant level was reached. More DDT was found in milk and tissues of cows that consumed hay treated with higher levels of DDT. DDT persisted in the milk for 4 months and disappeared approximately 6.5 months after feeding of DDT-treated hay was discontinued.

Alfalfa hay

10.1021/ba-1950-0001.ch044

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Citations (16)

Preparation of a soluble progesterone 17α-hydroxylating system

Archives of Biochemistry and Biophysics (1965)

Richard B. Young Melvin J. Bryson Max L. Sweat

10.1016/0003-9861(65)90357-7

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Citations (13)

Is mevalonic acid a precursor of the corticosteroids?

Archives of Biochemistry and Biophysics (1962)

Melvin J. Bryson Max L. Sweat

Mevalonic acid

10.1016/0003-9861(62)90440-x

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Citations (27)

Complexing of DDT and o,p'DDD with adrenal cytochrome P-450 hydroxylating systems

Journal of Steroid Biochemistry (1973)

Richard B. Young Melvin J. Bryson Max L. Sweat Joseph C. Street

10.1016/0022-4731(73)90033-2

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Citations (50)

Steroid 11β-Oxygenation, Ascorbic Acid, Epinephrine and Adrenochrome Interrelations in the Adrenal Gland

Endocrinology (1965)

Max L. Sweat Melvin J. Bryson

Journal Article Steroid 11β-Oxygenation, Ascorbic Acid, Epinephrine and Adrenochrome Interrelations in the Adrenal Gland Get access MAX L. SWEAT, MAX L. SWEAT 1Department of Obstetrics and Gynecology, University of Utah College of Medicine Salt Lake City, Utah Search for other works by this author on: Oxford Academic Google Scholar MELVIN J. BRYSON MELVIN J. BRYSON 1Department of Obstetrics and Gynecology, University of Utah College of Medicine Salt Lake City, Utah Search for other works by this author on: Oxford Academic Google Scholar Endocrinology, Volume 76, Issue 4, 1 April 1965, Pages 773–775, https://doi.org/10.1210/endo-76-4-773 Published: 01 April 1965 Article history Received: 10 August 1964 Published: 01 April 1965

10.1210/endo-76-4-773

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Citations (12)

EFFECT OF FURACIN ON PYRUVATE METABOLISM

Journal of Biological Chemistry (1956)

Mary F. Paul Melvin J. Bryson Catherine Harrington

10.1016/s0021-9258(18)65812-0

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Citations (22)

The role of phosphopyridinenucleotides in the metabolism of cortisol by peripheral tissue

Biochimica et Biophysica Acta (1960)

Max L. Sweat Melvin J. Bryson

Corticosterone

Liver tissue

Muscle tissue

10.1016/0006-3002(60)91556-0

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Citations (22)

INHIBITION BY FURACIN OF CITRATE FORMATION IN TESTIS PREPARATIONS

Journal of Biological Chemistry (1954)

Mary F. Paul Henry Paul F. Kopko Melvin J. Bryson Catherine Harrington

10.1016/s0021-9258(19)50817-1

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Citations (46)

Adrenal gland steroid C-21 cytochrome P-450 reductase

Biochemistry (1969)

Max L. Sweat John S. Dutcher Richard B. Young Melvin J. Bryson

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdrenal gland steroid C-21 cytochrome P-450 reductaseMax L. Sweat, John S. Dutcher, Richard B. Young, and Melvin J. BrysonCite this: Biochemistry 1969, 8, 12, 4956–4963Publication Date (Print):December 1, 1969Publication History Published online1 May 2002Published inissue 1 December 1969https://pubs.acs.org/doi/10.1021/bi00840a045https://doi.org/10.1021/bi00840a045research-articleACS PublicationsRequest reuse permissionsArticle Views23Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

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10.1021/bi00840a045

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Citations (16)