Faranak Kazerouni

Shahid Beheshti University of Medical Sciences

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Ali Rahimipour

Shahid Beheshti University of Medical Sciences

Mehrnoosh Shanaki

Shahid Beheshti University of Medical Sciences

Seyedeh Zahra Shahrokhi

Aja University of Medical Sciences

Hamid Ghaedi

Shahid Beheshti University of Medical Sciences

Saeed Namaki

Shahid Beheshti University of Medical Sciences

Mehdi Hedayati

Shahid Beheshti University of Medical Sciences

Houshang Amirrasouli

Shahid Beheshti University of Medical Sciences

Fatemeh Gharishvandi

Tehran University of Medical Sciences

Hooman Rahimipour

Firoozgar General Hospital

Mir Davood Omrani

Shahid Beheshti University of Medical Sciences

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Shahid Beheshti University of Medical Sciences

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Tehran University of Medical Sciences

Shahid Beheshti University

Tarbiat Modares University

University of Tehran

Tabriz University of Medical Sciences

Iran University of Medical Sciences

Research Institute for Endocrine Sciences

Baqiyatallah University of Medical Sciences

Islamic Azad University, Tehran

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Assessment of cardiovascular risk factors in patients with subclinical hypothyroidism

Acta Cardiologica (2016)

Narges Maleki Faranak Kazerouni Mehdi Hedayati Ali Rahimipour Hossein Maleki

Objective Overt hypothyroidism is associated with accelerated arteriosclerosis and cardiovascular disease (CVD). Whether subclinical hypothyroidism (SCH) is also associated with increased cardiovascular risk remains controversial. The present study aimed to evaluate risk factors for CVD in SCH patients in comparison to healthy controls.Methods We assessed common lipid variables, fasting glucose, insulin, malondialdehyde (MDA), total bilirubin (TB) and homeostasis model assessment (HOMA) index in 34 patients with SCH and 34 healthy controls.Results In SCH there was an elevated total cholesterol (TC) (P <0.01), low-density lipoprotein cholesterol (LDL-C) (P <0.01) and fasting glucose (P <0.001) concentration, a diminished TB value (P <0.001) and borderline elevated triglycerides (TG) (not reaching the limit of significance, P =0.063). LDL-C to HDL-C ratio was also elevated (P <0.05). MDA and HOMA index were higher in the SCH subjects but this difference was not statistically significant. Insulin, high-density lipoprotein cholesterol (HDL-C) remained unaltered. TSH was positively correlated with TC, LDL-C, fasting glucose (P <0.01) and MDA (P <0.001) and inversely correlated with TB (P <0.01). HOMA index was positively correlated with TG (P <0.001) and negatively correlated with HDL-C (P <0.01). In the SCH group, MDA was positively correlated with TC, LDL-C and TG (P <0.05). TB was negatively correlated with TG (P <0.05).Conclusion Our findings suggest that cardiovascular risk might be increased in patients with subclinical hypothyroidism which provides a possible explanation for the early detection and treatment of such individuals.

Subclinical infection

Malondialdehyde

Dyslipidemia

High-density lipoprotein

Lipid Profile

10.1080/ac.71.6.3178188

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Citations (8)

Comparative study of serum levels of Perforin in Prostate Cancer and Benign Prostatic Hyperplasia patients

Journal of paramedical sciences. (2013)

Jahangir Mohammadzade Houshang Amirrasouli Mohammad Esmaeil Akbari Babak Javanmard Faranak Kazerouni

Perforin(p) is the primary mediator of short term cytotoxicity, it is accumulated in response to proinflammatory cytokines and stored in T lymphocyte , NK cells and NKT cells are released upon activation. Perforin is a prototypical cytotoxic molecule involved in cell mediated immunity against various pathogens , alloantigens and particularly different tumors.The purpose of this study was to determine perforin level in prostate cancer (P.Ca) and Benign Prostatic Hyperplasia (BPH) This is study was performed on 59 patients consisting of 28 patients with P.Ca and 31 patients with BPH.Perforin and PSA levels were measured in cancer and BPH patients using ELISA method. Mean Perforin value was significantly lower in P.Ca patients than in BPH patients ( p < 0.01) where as mean serum PSA level was significantly higher in the cancer patients in comparison to the BPH group (P < 0.01 Our finding indicate probability of problem in expression of cytotoxic molecule ,perforin in and around the tumor.

Proinflammatory cytokine

10.22037/jps.v4i0.4029

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Assessment of Neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for detection of renal impairment in hypertensive patients

Journal of paramedical sciences. (2014)

Fatemeh Gharishvandi Faranak Kazerouni Esmat Ghanei Ali Rahimipour Houshang Amirrsouli

Chronic kidney disease (CKD) is probably the most important problem of public health in advanced countries. Kidneys are often damaged as a result of high blood pressure. One of our main concerns in patients with hypertension is early detection of kidney disorders. The routine biomarkers such as creatinine have some limitation for this purpose, however recent studies suggest plasma NGAL to be a better marker. Therefor in this study we assessed the diagnostic value of plasma NGAL and compared it with serum creatinine in hypertensive patients. This study was performed on 42 hypertensive patients and 30 healthy Volunteer, both with normal serum creatinine and urea concentration who referred to Shohada Tajrish Hospital, plasma NGAL were measured subsequently using ELISA method and eGFR was considered as the gold standard method(cut off value of 0.97 mg/dl). Our findings indicate that NGAL is a better indicator of kidney impairment in the early stages of CKD as compared with serum creatinine in hypertensive patients.

Neutrophil gelatinase-associated lipocalin

10.22037/jps.v5i1.5466

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Citations (5)

The influence of SLC22A3 rs543159 and rs1317652 genetic variants on metformin therapeutic efficacy in newly diagnosed patients with type 2 diabetes mellitus: 25 weeks follow-up study

Gene (2022)

Rana Taheri Faranak Kazerouni Reza Mirfakhraei Saeid Kalbasi Seyedeh Zahra Shahrokhi

Pharmacodynamics

10.1016/j.gene.2022.146382

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Citations (7)

The Effect of Altered Mucin1, FGF2, and HBEGF Gene Expression at The Ectopic Implantation Site and Endometrial Tissues in The Tubal Pregnancy Pathogenesis: A Case-Control Study.

PubMed (2023)

Nadia Noghrehalipour Reza Aflatoonian Ali Rahimipour Samaneh Aghajanpour Aida Najafian

Ectopic pregnancy (EP) is defined as implantation and development of an embryo outside of the uterine tissue. Women undergoing assisted reproductive technologies (ART), particularly frozen embryo transfer (FET), are in high-risk populations for EP. Mucin1 (MUC1), fibroblast growth factor-2 (FGF2), and Heparin-binding epidermal growth factor (HBEGF) genes are involved in the endometrial receptivity pathway, leading to normal eutopic implantation; Although, their relevance in the tubal pregnancy after FET is unknown. We aimed evaluation of Mucin1, FGF2, and HBEGF expression fold as endometrial receptive markers in the EP patients following the FET cycle.A case-control study was conducted on ten patients (five EP patients and five women in the pseudo-pregnancy group, as the control samples). Pseudo-pregnancy group was established in women who were candidates for hysterectomy for benign diseases. Fallopian tube biopsies and corresponding endometrial tissues from these patients were taken during the hysterectomy. However, the fallopian tube and endometrial tissues of EP patients were obtained during salpingectomy. The mRNA expressions of Mucin1, FGF2, and HBEGF genes in the fallopian tube and endometrial tissues were measured by real-time polymerase chain reaction (PCR) assay.MUC1 mRNA expression level in the endometrium of the case group was higher than in the control group (P=0.04); however, its mRNA expression in the fallopian samples of the case group in comparison with the control group was significantly decreased (P=0.001). The HBEGF mRNA expression level was not significantly different between the case and control endometrium, whereas its expression was significantly increased in the case fallopian samples compared with the control ones (P=0.001). The same pattern was observed for FGF2 mRNA expression level in the fallopian samples of the case group but was significantly reduced in the endometrial samples in comparison with the control samples (P=0.03).Mucin1, FGF2, and HBEGF gene mRNA expression changes may explain the embryo rejection from the uterus and the establishment of a receptive phenotype in fallopian cells.

Fallopian tube

10.22074/ijfs.2023.1972252.1390

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Citations (1)

Can miR-145-5p be used as a marker in diabetic patients?

Archives of Physiology and Biochemistry (2020)

Seyedeh Zahra Shahrokhi Leyla Saeidi Mirsaber Sadatamini Meisam Jafarzadeh Ali Rahimipour

In the light of emerging global epidemics of type 2 diabetes mellitus significant efforts are continuing to discover novel biomarkers for early detection of the disease. Since miRNAs play an important role in both the initiation and progress of many pathologic processes such as diabetes, in this study we aimed to evaluate expression level of plasma miR-145-5p in diabetics and pre-diabetics in comparison to the control group and assess its use as a biomarker in diagnosis of T2D. The plasma level of miR-145-5p was assessed in three groups including 20 prediabetic patients, 20 T2D patients and 20 healthy controls using RT-qPCR. Biochemical parameters were also measured by the auto-analyzer. Expression level of miR-145-5p was down-regulated in the prediabetics and the T2D patients compared to the controls. In the control group miR-145-5p showed a borderline correlation with FBS (p = .06), while in the prediabetic group miR-145 showed a significant negative correlation with FBS and finally in the T2D patients miR-145 was negatively correlated with HbA1c and TC and showed a negative borderline correlation with FBS. The ROC analysis indicated a significant ability for miR-145-5p in discriminating between the diabetics and pre-diabetics from the healthy subjects. Our results demonstrated that the miR-145-5p expression level is deregulated in the diabetics and the prediabetics. Furthermore miR-145-5p displayed a significant ability to discriminate the diabetics from the healthy subjects. These results suggest that miR-145-5p may be a useful biomarker for the diagnosis of T2DM.

10.1080/13813455.2020.1762657

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Citations (29)

Evaluation of some factors affecting the risk of kidney damage in patients with hypertension

Journal of paramedical sciences. (2014)

Fatemeh Gharishvandi Faranak Kazerouni Ali Rahimipour Malihe Nasiri

Chronic kidney disease (CKD) is an increasing cause of morbidity and mortality worldwide. Prospective data on risk factors for CKD are few. Hypertension is one of the risk factors for CKD. In the past serum creatinine concentration was used as marker of kidney function but it proffers a late reflection of reduced glomerular filtration rate(GFR), which limits its ability to detect impaired kidney function. Cystatin C and NGAL have recently been proven useful to quantitate CKD. Therefore in this study, we assessed the effect of some risk factors on reduction of estimated glomerular filtration rate (eGFR) in patients with high blood pressure. This study was performed on 42 hypertensive patients and 30 healthy volunteers, both with normal serum creatinine and urea concentration. In this study, we measured serum cystatin C and Plasma NGAL. Serum creatinine and urea levels of the patients were measured after an overnight fasting. . Estimated glomerular filtration rate (eGFR) was considered as the gold standard method .Serum cystatin C and plasma NGAL were measured using commercially available human ELISA kits. Logistic regression and T-test were used for statistical analysis. The results of logistic regression showed that among the variables studied, plasma levels of NGAL, age and duration of hypertension were significantly associated with the eGFR<78(P<0.05). Our findings suggest that, increased levels of NGAL, age and duration of hypertension predicts a higher odds of impaired renal function

10.22037/jps.v5i4.7786

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Citations (1)

Pyrazole Derivatives Induce Apoptosis via ROS Generation in the Triple Negative Breast Cancer Cells, MDA-MB-468

Asian Pacific Journal of Cancer Prevention (2021)

Maryam Ashourpour Fatemeh Mostafavi Hosseini Mohsen Amini Ebrahim Saeedian Moghadam Faranak Kazerouni

Triple-negative breast cancer accounts for approximately 15-20% of all breast carcinomas and is associated with earlier age of onset, aggressive clinical course, and dismal prognosis. A series of 1,3-diaryl-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1 H-Pyrazole and 1,3-diaryl-5- (3,4,5-trimethoxyphenyl)- 1 H-Pyrazole were evaluated for their anticancer activity against MDA-MB-468, human triple negative breast cancer cell line.The cytotoxic effects of Pyrazole derivatives on the growth of MDA-MB-468 and AGO1522 were determined using MTT assay. Annexin-V-FITC and PI staining were performed to detect apoptosis and cell cycle distribution using Flow cytometry. The level of Reactive oxygen species (ROS) formation and caspase 3 activity were determined accordingly.Pyrazole derivatives induced a dose and time-dependent cell toxicity in MDA-MB-468 compared with untreated cells. The results showed that 3-(4-methoxyphenyl)-1-(p-tolyl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-Pyrazole (3f) was the most active compound with IC50 values 14.97 μM and 6.45 μM compared with Paclitaxel with IC50 values 49.90 μM and 25.19 μM, after 24 and 48 hours, respectively. Upon treatment with 14.97 μM of 3f after 24 h, the compound induced cell cycle arrest in S phase. 3f provoked apoptosis was accompanied by the elevated level of ROS and increased caspase 3 activity in MDA-MB-468 cells compared with untreated cells.The overall results of the present study provided evidence for the cytotoxicity of compound 3f against MDA-MB-468 cells in comparison to reference standard, Paclitaxel. It proves that compound 3f can trigger apoptosis through ROS production and caspase 3 activation. These bring supportive data for future investigations that will lead to their use in cancer therapy.
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Pyrazole

MTT assay

Triple-negative breast cancer

MCF-7

10.31557/apjcp.2021.22.7.2079

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Citations (12)

Deregulation of long noncoding RNA SNHG17 and TTC28-AS1 is associated with type 2 diabetes mellitus

Scandinavian Journal of Clinical and Laboratory Investigation (2019)

Mahroo Mohamadi Hamid Ghaedi Faranak Kazerouni Maryam Omidvar Saeid Kalbasi

Long noncoding RNAs (lncRNAs) have emerged as key players in several biological processes and complex diseases including type 2 diabetes mellitus (T2DM). The purpose of this study was to investigate the expression levels of SNHG17 and TTC28-AS1 in T2DM patients. Quantitative real-time RT-PCR analysis was performed using peripheral blood mononuclear cells (PBMCs) samples from patients diagnosed with T2DM and healthy controls. Binary logistic regression analysis was carried out to determine the odds of development of T2DM based on expression levels of lncRNAs and clinical characteristic of the subjects. Spearman's correlation analysis was used to clarify the correlation between SNHG17 and TTC28-AS1 expressions to metabolic features. We found that SNHG17 and TTC28-AS1were down-regulated in the T2DM group compared to the healthy control group. The logistic regression revealed that body mass index (BMI), systolic blood pressure (SBP), fasting blood glucose (FBG) and TTC28-AS1 expression substantially affect T2DM susceptibility. Furthermore, expression of SNHG17 was negatively correlated with high-density lipoprotein cholesterol (HDL-C) and expression of TTC28-AS1 was positively correlated with low-density lipoprotein cholesterol (LDL-C). Decreased expressions of lncRNAs TTC28-AS1 and SNHG17 in T2DM are possibly associated with the development of T2DM.

High-density lipoprotein

10.1080/00365513.2019.1664760

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Citations (24)

Anti-Müllerian Hormone: genetic and environmental effects

Clinica Chimica Acta (2017)

Seyedeh Zahra Shahrokhi Faranak Kazerouni Firouzeh Ghaffari

Anti-Müllerian hormone

Ovarian Reserve

10.1016/j.cca.2017.11.027

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Citations (35)