Damião Pergentino de Sousa

Universidade Federal da Paraíba

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Reinaldo Nóbrega de Almeida

Universidade Federal da Paraíba

Rivelilson Mendes de Freitas

Universidade Federal do Piauí

Tamires Cardoso Lima

Universidade Federal de Sergipe

Yunierkis Pérez‐Castillo

Universidad de Las Américas

Lucindo José Quintans‐Júnior

Universidade Federal de Sergipe

Luciana Nalone Andrade

Universidade Federal de Sergipe

Antônia Amanda Cardoso de Almeida

Universidade Federal do Piauí

Carlos da Silva Maia Bezerra Filho

Universidade Federal da Paraíba

Ricardo Dias de Castro

Universidade Federal da Paraíba

Francisco de Assis Oliveira

Universidade Federal do Piauí

Cooperative Institutions

Universidade Federal da Paraíba

244

Universidade Federal do Piauí

239

Universidade Federal de Sergipe

142

Universidade Federal do Ceará

139

Universidade de São Paulo

101

Ordem dos Médicos

Centro Universitário Cesmac

Universidade Federal do Rio Grande do Norte

Universidade Federal de Pernambuco

Universidade Federal de Minas Gerais

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Avaliação do potencial antioxidante in vitro do composto ciano-carvona

DOAJ (DOAJ: Directory of Open Access Journals) (2012)

Dayane Alves Costa Guilherme Antônio Lopes de Oliveira Damião Pergentino de Sousa Rivelilson Mendes de Freitas

O presente estudo avaliou o potencial antioxidante in vitro da ciano-carvona contra a formacao de substâncias reativas com o acido tiobarbiturico (TBARS), radical hidroxila e producao de oxido nitrico. Observou-se que a ciano-carvona (0,9, 1,8, 3,6, 5,4 e 7,2 µg/mL), foi capaz de prevenir a peroxidacao lipidica induzida por 2,2’-azobis-2-amidinopropano (AAPH), inibindo a quantidade de TBARS formada. Resultado semelhante foi obtido com o Trolox (140 µg/mL), um analogo sintetico hidrofilico do α-tocoferol, que e largamente usado como padrao antioxidante. Este resultado sugere que a ciano-carvona pode exercer um efeito antioxidante contra a peroxidacao lipidica in vivo. A ciano-carvona tambem produziu uma remocao do radical hidroxila, sugerindo uma possivel capacidade de protecao contra danos celulares in vitro produzidos por este radical. O Trolox tambem reduziu significativamente a quantidade deste radical. Em relacao a producao de oxido nitrico, foi detectado uma diminuicao significativa na producao deste composto pela ciano-carvona, demonstrando uma propriedade antioxidante in vitro, um achado que pode ser explorado para a protecao in vivo das biomoleculas, como lipidios da membrana celular. A ciano-carvona revelou potencial antioxidante in vitro, por meio da capacidade de remocao contra radicais hidroxilas e do oxido nitrico, bem como preveniu a formacao de TBARS.

Trolox

TBARS

Source

Cite

Citations (7)

Larvicidal activity of para-Benzoquinones

Parasitology Research (2010)

Damião Pergentino de Sousa Ygor W. Vieira Marciana P. Uliana Manuela A. Melo Timothy J. Brocksom

Benzoquinone

Isopropyl

10.1007/s00436-010-1942-7

Cite

Citations (16)

Comparison of behavioral, neuroprotective, and proinflammatory cytokine modulating effects exercised by (+)‐cis‐EC and (−)‐cis‐EC stereoisomers in a PTZ‐induced kindling test in mice

Fundamental and Clinical Pharmacology (2018)

Paula Regina Rodrigues Salgado Diogo Vilar da Fonsêca Cynthia Germoglio Farias de Melo Fagner Carvalho Leite Adriano Francisco Alves

Epoxy-carvone (EC) has chiral centers that allow generation of stereoisomers, including (+)-cis-EC and (-)-cis-EC, whose effects in the kindling tests have never been studied. Accordingly, this study aims to comparatively investigate the effect of stereoisomers (+)-cis-epoxy-carvone and (-)-cis-epoxy-carvone on behavioral changes measured in scores, in the levels of cytokines (IL-1β, IL-6, and TNFα) and neuronal protection in the face of continuous treatment with pentylenetetrazol. Swiss mice were divided into five groups (n = 10), receiving vehicle, (+) - cis-EC, (-) - cis-EC (both at the dose of 30 mg/kg), and diazepam (4 mg/kg). Thirty minutes after the respective treatment was administered to the animals one subconvulsive dose of PTZ (35 mg/kg). Seven subconvulsives treatments were made on alternate days, in which each treatment several parameters were recorded. In the eighth treatment, the animals receiving the highest dose of PTZ (75 mg/kg) and were sacrificed for quantification of cytokines and histopathologic analysis. All drugs were administered by intraperitoneal route. In the kindling test, (+)-cis-EC and (-)-cis-EC reduced the average scores. The stereoisomer (+)-cis-EC decreased levels of proinflammatory cytokines IL-1β, IL-6, and TNFα, whereas comparatively (-)-cis-EC did not reduce IL-1β levels. Histopathological analysis of the mice hippocampi undergoing this methodology showed neural protection for treated with (+)-cis-EC. The results suggest that the anticonvulsant effect of (+)-cis-EC possibly takes place due to reduction of proinflammatory cytokines involved in the epileptogenic process, besides neuronal protection, yet further investigation of the mechanisms involved is required.

Proinflammatory cytokine

Pentylenetetrazol

10.1111/fcp.12366

Cite

Citations (7)

Microencapsulação do óleo essencial de Citrus sinensis (L) Osbeck pelo método da coacervação simples

J. K. M. C. Gonsalves A. M. Costa Damião Pergentino de Sousa Sócrates C.H. Cavalcanti Rogéria de Souza Nunes

Dengue, a major public health problem in the world, is transmitted by Aedes aegypti. The chemical control, mainly organophosphates, is one of the most effective. However, the resistance shows up as a major problem. A viable alternative vector control would be the use of monoterpenes or their complex mixtures (essential oils). Limonene, the main constituent of essential oil of Citrus sinensis, has strong larvicidal activity against larvae of Aedes aegypti. Therefore, the use of oil in the larvicidal control of Aedes aegypti proved to be adequate. However, the low stability of essential oil (volatility, oxidation of the constituents, among others), use direct disadvantage and needs to be microencapsulation. In this sense microcapsules were prepared by simple coacervation and characterized by FTIR. Chitosan was used as a polymer forming wall showed a degree of deacetylation of 87.31%, the yield of the process of formation of microcapsules was 82.81% and the encapsulation efficiency of the essential oil was 31.16%. With the spectroscopic characterization was possible to observe the cross-linking of chitosan by glutaraldehyde (formation of imine grouping - 1656 cm-1).

Citrus × sinensis

Cite

Citations (7)

Anticonvulsant effect of a natural compound α,β-epoxy-carvone and its action on the nerve excitability

Neuroscience Letters (2008)

Reinaldo Nóbrega de Almeida Damião Pergentino de Sousa Franklin Ferreira de Farias Nóbrega Fladmir de Sousa Claudino Demétrius A. M. Araújo

Flumazenil

Picrotoxin

Convulsion

10.1016/j.neulet.2008.07.037

Cite

Citations (54)

Molecular Modeling and In Vitro Evaluation of Piplartine Analogs against Oral Squamous Cell Carcinoma

Molecules (2023)

Rayanne H. N. Silva Thaíssa Queiróz Machado Anna Carolina Carvalho da Fonseca Eduardo Tejera Yunierkis Pérez‐Castillo

Cancer is a principal cause of death in the world, and providing a better quality of life and reducing mortality through effective pharmacological treatment remains a challenge. Among malignant tumor types, squamous cell carcinoma-esophageal cancer (EC) is usually located in the mouth, with approximately 90% located mainly on the tongue and floor of the mouth. Piplartine is an alkamide found in certain species of the genus Piper and presents many pharmacological properties including antitumor activity. In the present study, the cytotoxic potential of a collection of piplartine analogs against human oral SCC9 carcinoma cells was evaluated. The analogs were prepared via Fischer esterification reactions, alkyl and aryl halide esterification, and a coupling reaction with PyBOP using the natural compound 3,4,5-trimethoxybenzoic acid as a starting material. The products were structurally characterized using 1H and 13C nuclear magnetic resonance, infrared spectroscopy, and high-resolution mass spectrometry for the unpublished compounds. The compound 4-methoxy-benzyl 3,4,5-trimethoxybenzoate (9) presented an IC50 of 46.21 µM, high selectively (SI > 16), and caused apoptosis in SCC9 cancer cells. The molecular modeling study suggested a multi-target mechanism of action for the antitumor activity of compound 9 with CRM1 as the main target receptor.

10.3390/molecules28041675

Cite

Citations (3)

Evaluation of the Anticonvulsant Activity of Terpinen-4-ol

Zeitschrift für Naturforschung C (2009)

Damião Pergentino de Sousa Franklin F. F. Nóbrega Liana Clébia Soares Lima de Morais Reinaldo Nóbrega de Almeida

Terpinen-4-ol is a monoterpenoid alcohol and component of the essential oils of several aromatic plants. Similarly to terpinen-4-ol, other monoterpenoid alcohols have shown anticonvulsant activity in convulsion animal models. The present study aimed to investigate the anticonvulsant activity of terpinen-4-ol. Treatment of mice with terpinen-4-ol ( 200 mg/kg) caused a signifi cant decrease in the spontaneous motor activity at 30, 60 and 120 min after administration. Terpinen-4-ol (100 and 200 mg/kg) produced a significant dosedependent increase in the duration of sleeping in mice. Pretreatment of mice with terpinen-4- ol at doses of 100, 200 and 300 mg/kg significantly increased the latency of pentylenetetrazole -induced convulsions. Terpinen-4-ol (200 and 300 mg/kg) also inhibited the induced seizures of picrotoxin. In another model, maximal electroshock seizure, terpinen-4-ol decreased the tonic hind convulsions percentage at the dose of 300 mg/kg. From the overall results we can conclude that terpinen-4-ol showed a depressant effect on the central nervous system and significant anticonvulsant activity.

Picrotoxin

Convulsion

10.1515/znc-2009-1-201

Cite

Citations (38)

Evaluation of antimicrobial, cytotoxic and chemopreventive activities of carvone and its derivatives

Brazilian Journal of Pharmaceutical Sciences (2018)

Isabela Jacob Moro Gabrielle Demmany Gualberto Alexandre Gondo Elaíse Gonçalves Pierri Rosemeire Cristina Linhari Rodrigues Pietro Christiane Pienna Soares

Considering the reported activity of carvone in the literature, this study aimed to evaluate the antimicrobial, cytotoxic and chemopreventive activities of (+)- and (-)-carvone, (+)- and (-)- hydroxydihydrocarvone and α,β-epoxycarvone. (+)-Hydroxydihydrocarvone (HC+), (-)-hydroxydihydrocarvone (HC-) and α,β-epoxycarvone (EP) were obtained by synthesis using (+)-carvone (C+) or (-)-carvone (C-) as precursors. The antifungal activity (MIC and MFC) were evaluated against Candida parapsilosis, C. tropicalis, C. krusei and C. albicans and the antibacterial activity (MIC and MBC) against Escherichia coli and Staphylococcus aureus. The cytotoxicity assays were performed with human cancer cell lines HepG-2 and SiHa and the normal strain MRC-5 through sulphorrodamine B assay. Chemoprevention was evaluated through quinone reductase assay. Our results showed no cytotoxicity on tumor and normal cell lines and no induction of the quinone reductase enzyme. C- and HC- presented activity against E. coli. All compounds presented weak antifungal activity against C. tropicalis and C. parapsilosis. EP and C+ showed moderate activity against C. krusei. Results suggest the potential use of carvones and its derivatives as antifungal agents against Candida yeasts. The absence of cytotoxicity in cell lines indicates safety in the use of these compounds.

Candida parapsilosis

Carvone

Candida krusei

10.1590/s2175-97902017000400076

Cite

Citations (37)

Gastroprotection of (‐)‐α‐bisabolol on acute gastric mucosal lesions in mice: the possible involved pharmacological mechanisms

Fundamental and Clinical Pharmacology (2009)

Nayrton Flávio Moura Rocha Edith Teles Venâncio Brinell Arcanjo Moura Maria Izabel Gomès Silva Manoel Rufino Aquino Neto

Abstract (‐)‐α‐Bisabolol is an unsaturated, optically active sesquiterpene alcohol obtained by the direct distillation essential oil from plants such as Vanillosmopsis erythropappa and Matricaria chamomilla . (‐)‐α‐Bisabolol has generated considerable economic interest, since it possesses a delicate floral odor and has been shown to have anti‐septic and anti‐inflammatory activity . The aim of this work was to evaluate the gastroprotective action of (‐)‐α‐bisabolol on ethanol and indomethacin‐induced ulcer models in mice, and further investigate the pharmacological mechanisms involved in this action. The oral administration of (‐)‐α‐bisabolol 100 and 200 mg/kg was able to protect the gastric mucosa from ethanol (0.2 mL/animal p.o.) and indomethacin‐induced ulcer (20 mg/kg p.o.). Administration of l ‐NAME (10 mg/kg i.p.), glibenclamide (10 mg/kg i.p.) or indomethacin (10 mg/kg p.o.) was not able to revert the gastroprotection promoted by (‐)‐α‐bisabolol 200 mg/kg on the ethanol‐induced ulcer. Dosage of gastric reduced glutathione (GSH) levels showed that ethanol and indomethacin reduced the content of non‐protein sulfhydryl (NP‐SH) groups, while (‐)‐α‐bisabolol significantly decreased the reduction of these levels on ulcer‐induced mice, but not in mice without ulcer. In conclusion, gastroprotective effect on ethanol and indomethacin‐induced ulcer promoted by (‐)‐α‐bisabolol may be associated with an increase of gastric sulfydryl groups bioavailability leading to a reduction of gastric oxidative injury induced by ethanol and indomethacin.

Capsaicin

Mechanism of Action

10.1111/j.1472-8206.2009.00726.x

Cite

Citations (51)

Larvicidal Activity of Cinnamic Acid Derivatives: Investigating Alternative Products for Aedes aegypti L. Control

Molecules (2020)

Marianna Oliveira de Araújo Yunierkis Pérez‐Castillo Louise Helena Guimarães de Oliveira Fabíola da Cruz Nunes Damião Pergentino de Sousa

The mosquito Aedes aegypti transmits the virus that causes dengue, yellow fever, Zika and Chikungunya viruses, and in several regions of the planet represents a vector of great clinical importance. In terms of mortality and morbidity, infections caused by Ae. aegypti are among the most serious arthropod transmitted viral diseases. The present study investigated the larvicidal potential of seventeen cinnamic acid derivatives against fourth stage Ae. aegypti larvae. The larvicide assays were performed using larval mortality rates to determine lethal concentration (LC50). Compounds containing the medium alkyl chains butyl cinnamate (7) and pentyl cinnamate (8) presented excellent larvicidal activity with LC50 values of around 0.21–0.17 mM, respectively. While among the derivatives with aryl substituents, the best LC50 result was 0.55 mM for benzyl cinnamate (13). The tested derivatives were natural compounds and in pharmacology and antiparasitic studies, many have been evaluated using biological models for environmental and toxicological safety. Molecular modeling analyses suggest that the larvicidal activity of these compounds might be due to a multi-target mechanism of action involving inhibition of a carbonic anhydrase (CA), a histone deacetylase (HDAC2), and two sodium-dependent cation-chloride co-transporters (CCC2 e CCC3).

Larvicide

Cinnamic acid

Antiparasitic

Zika Virus

10.3390/molecules26010061

Cite

Citations (32)