J. W. Hirman

GlaxoSmithKline (United States)

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Co-Authors

G. Heckman

Oregon National Primate Research Center

D. F. Neidig

United States Air Force Research Laboratory

D. M. Speich

Goddard Space Flight Center

W.E. Flowers

P. Seagraves

High Altitude Observatory

P. Wiborg

United States Air Force Research Laboratory

Joseph M. Kunches

National Oceanic and Atmospheric Administration

C. C. Balch

National Oceanic and Atmospheric Administration

R. N. Grubb

University of Colorado Boulder

P. L. Bornmann

National Oceanic and Atmospheric Administration

Cooperative Institutions

National Oceanic and Atmospheric Administration

NOAA Earth System Research Laboratory

Goddard Space Flight Center

University of Colorado Boulder

Sterling Research Group

NOAA Space Weather Prediction Center

Pinnacle Clinical Research

GlaxoSmithKline (United States)

United States Air Force Research Laboratory

NOAA Weather Prediction Center

Author Statistics

Papers

Citation

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Research Field

Objective method for forecasting solar flares. Environmental research papers

D. F. Neidig P. Wiborg P. Seagraves J. W. Hirman W.E. Flowers

Solar parameters derived from the region analysis program at the NOAA Space Environment Services Center (SESC) are submitted to a multivariate discriminant analysis (MVDA) in which the parameters relevant to flare prediction are identified and incorporated in a classification procedure to produce a flare forecast. The analysis uses two years of data (6095 solar active region-days). The MVDA forecast is compared with a subjective forecast derived from the SESC forecast during the same period, and is found to have greater accuracy overall. Specific recommendations are made concerning the application of the technique in a forecasting operation, and in the types of data required for future improvement.

Solar flare

Flare

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Citations (0)

The World Space Weather Service

Richard J. Thompson G. Heckman J. W. Hirman

Space Weather

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Citations (2)

Retapamulin Ointment Twice Daily for 5 Days vs Oral Cephalexin Twice Daily for 10 Days for Empiric Treatment of Secondarily Infected Traumatic Lesions of the Skin

SKINmed Dermatology for the Clinician (2006)

Almena Free Eli M. Roth Marybeth Dalessandro J. W. Hirman Nicole Scangarella

Introduction : Retapamulin is a novel, topical antibacterial of the pleuromutilin class in development for the treatment of secondarily infected traumatic lesions of the skin. Methods : The efficacy, safety, and tolerability of topical retapamulin ointment, 1% for 5 days twice daily was evaluated in 2 identical, randomized, double‐blind, double‐dummy, multicenter studies vs oral cephalexin, 500 mg twice daily for 10 days, in 1904 patients with secondarily infected traumatic lesions. Results : Clinical success rates were 89.5% in protocol‐adherent patients receiving retapamulin compared with 91.9% for cephalexin (treatment difference, −2.5% [95% confidence interval, −5.4% to 0.5%]). In patients with Staphylococcus aureus or Streptococcus pyogenes at baseline, clinical success was 89.2% (365/409) for retapamulin and 92.6% (63/68) for cephalexin. Safety and tolerability were similar between treatments. Noncompliance (defined as using or taking <80% of doses) was recorded in 8.0% (51/636) of patients taking cephalexin compared with 0.39% (5/1268) of patients receiving retapamulin. Conclusions : Retapamulin offers a novel, effective, and convenient topical treatment for secondarily infected traumatic lesions.

Tolerability

10.1111/j.1540-9740.2006.05774.x

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Citations (44)

A radio frequency user's guide to the Space Environment Services Center geophysical alert broadcasts

David A. Rosenthal J. W. Hirman

Center (category theory)

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Citations (3)

A compilation of solar flares reported during the SKYLAB mission

NASA STI/Recon Technical Report N (1977)

J. W. Hirman R. Losey G. Heckman

Solar flare

Solar prominence

Flare

Source

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Citations (2)

Space Environment Laboratory Data Acquisition and Display System II

Cheryl M. Cruickshank James R. Abeyta C. C. Balch William P. Barrett F. C. Cowley

Source

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Missing Data in Confirmatory Clinical Trials

Journal of Biopharmaceutical Statistics (2009)

Paul A. Flyer J. W. Hirman

Missing data for key efficacy and safety endpoints in clinical trials have the potential to undermine the scientific integrity of the study and prevent definitive conclusions regarding the safety and efficacy of an experimental product. Much of the missing data is the result of poor protocol design and a lack of agreement in the scientific community regarding the collection of study data after treatment discontinuation instead of an inability to collect the data. Rather than dealing with the fundamental causes of missing data, the statistical community has traditionally attempted to explicitly impute the missing data based upon observed data or more recently through the use of statistical models that implicitly impute the missing data. In this article, the causes for missing data are described and a number of approaches to maintain the integrity of the studies are described.

Imputation (statistics)

Discontinuation

10.1080/10543400903242746

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Citations (21)

Compilation of solar flares reported during the Skylab mission. Technical memo. [May 1, 1973 to Feb. 28, 1974]

J. W. Hirman R. Losey G. Heckman

Solar flares reported from visual observations in real-time and from film reviews for the Skylab period are listed in conjunction with their x-ray activity. Summaries of activity are listed by both Boulder and McMath region numbers, and also a cross-reference of the Boulder, McMath, and Mt. Wilson region numbers is given. This compilation consists of all the observations of flare activity reported for the period 1 May 1973 - 28 Feb 1974 both from visual observations reported in real time and from film reviews.

Solar flare

Flare

Conjunction (astronomy)

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Solar environment support for Skylab

Annual Meeting (1974)

J. W. Hirman

Solar support for the ATM PIs (Apollo Telescope Mount Principle Investigators) and NASA was provided by NOAA's real-time data network through the NOAA-SOLAR facility in the ATM Science Support Room at Mission Control in Houston, Tex. Support was in the form of solar data - e.g., ground-based photographs of H-alpha (hydrogen-alpha), calcium, and magnetograms; voice/teletype reports of activity; analysis and forecasts; and assistance to the PIs and NASA as needed. This required establishing a communication system to a worldwide network of observatories, acquiring data transmission and dissemination equipment, and developing techniques to improve ATM related forecasts. This support began about one month before the first launch of the Skylab series and continued until splashdown of the last mission.

Solar telescope

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SESC Methods for Short-Term (3-Day) Flare Forecasts

J. W. Hirman

Flare

Source

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Citations (1)