Anu Rahal

Central Institute for Research on Goats

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Amit Kumar

Chaudhary Charan Singh Haryana Agricultural University

Rajesh Mandil

Sardar Vallabhbhai Patel University of Agriculture & Technology

Amit Kumar Verma

University of Pennsylvania

Atul Prakash

Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan

Kuldeep Dhama

Indian Veterinary Research Institute

Mahima Mahima

Dr. Shakuntala Misra National Rehabilitation University

Ruchi Tiwari

Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan

Jitendra K. Malik

Shobhit University

Satish K. Garg

University of Colorado Denver

Sandip Chakrabort

Tamil Nadu Veterinary and Animal Sciences University

Cooperative Institutions

Indian Veterinary Research Institute

Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan

Central Institute for Research on Goats

Indian Council of Agricultural Research

Sardar Vallabhbhai Patel University of Agriculture & Technology

Russian Academy of Sciences

University of Delhi

United States Food and Drug Administration

University of Hradec Králové

Institute of Evolutionary Physiology and Biochemistry

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Cimicifuga: A Revisiting Indigenous Herb with Multi-utility Benefits for Safeguarding Human Health - A Review

International Journal of Agronomy and Plant Production (2013)

Anu Rahal Amit Kumar Sandip Chakraborty Ruchi Tiwari Shyma K. Latheef

Since 18 th Century, in North American Indian medicine, black cohosh (Cimicifuga racemosa) has got a long history of use in traditional medicine. Species of Cimicifuga (about 15) exist in the northern temperate zones of the world. It’s use in the traditional medicine in Asian countries like China and Japan; India and Bhutan; and Myanmar points out popularity of this plant. Cimicifuga racemosa is widely used to relieve premenstrual symptoms, dysmenorrheal and signs/conditions of menopause and its effect are similar to like that of hormones. In homeopathy also, preparations of C. racemosa are used for treating discomfort in late pregnancy, headache, and depression as well as for labor pains. It is an effective ecofriendly drug for the treatment of abortion and prolapse as well as post-parturient care in large animals. Popularly known as Black cohosh, it has been shown to possess potent antiinflammatory, antineoplastic and antioxidant effects, which are altogether much helpful for a sound health. It has positive regulatory effects on gastrointestinal system, central nervous system and circulatory system of the body. Potent effects are observed on obstetric and gynaecological problems. It’s beneficial effects have also been observed on bone metabolism. It also shows endocrine activity. Besides these many other traditional / folk and modern uses of black cohosh have also been documented. Delaying the use of this plant until breast cancer treatment is over or avoidance of its concomitant use with drug like estone-3-sulphate will prove the judicious use of this plant for the purpose of human health care. With respect to liver disorder the harmful effect of the plant has raised safety issues as it may lead to fatal consequences. Discontinuing extract of the plant in any kind of hepatic dysfunction is the need of hour. Several other measures in addition include: post-marketing surveillance; labeling of the herbal product in a proper manner; conducting preclinical and clinical studies for short duration and spontaneous reporting programs and will further encourage its use. The present review discusses the beneficial usages and potent applications, photochemistry and pharmacodynamics of this novel herb and natural medicine to safeguard human health for betterment of the society as claimed in the gigantic traditional resources and well supported by scientific evidences along with precautionary measures for its use.

Black cohosh

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Multidrug Resistant Pathogenic Escherichia coli Status in Water Sources and Yamuna River in and Around Mathura, India

Pakistan Journal of Biological Sciences (2013)

Anita Anita Amit Kumar Amit Kumar Verma Manoj Gupta Anu Rahal

The present study was taken to understand the status of water resources in the holy city of Mathura, India. As it is a tourist place and pilgrims come from all around the world, there are more chances of spread of pathogens through them. The pathogens which are particularly excreted through urine and feces are most commonly excreted out. E. coli is one of them which causes many severe diseases particularly in neonatal calves or neonates of human. As the city has its limitation of accommodation and river Yamuna is also shrinking, the pressure of millions of pilgrims has enormous, drastic and stipulated effect on water resources particularly river Yamuna. The samples collected showed the presence of pathogenic E. coli. Out of total 100 samples 40 were found positive for E. coli. The 60 samples of different water resources showed the presence of E. coli in 26 samples while 14 were found positive out of 40 samples of Yamuna water. The total coliforms count ranged between 1.08 log10 CFU m L(-1) to 6.34 log10 CFU m L(-1) in drinking water sources and waste water, respectively. The high percentage of positive samples and coliforms count may be because of the method and place of sample collection. When these isolates were analyzed for antibiotic sensitivity pattern against some commonly used antibiotics. They showed a variable effectiveness against them. The number of resistant isolate is significant enough to make an alert at the earliest to protect the water resources and also to secure better and brighter future of human population.

10.3923/pjbs.2014.540.544

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Inorganic Versus Organic Selenium Supplementation: A Review

Pakistan Journal of Biological Sciences (2012)

Mahima Mahima Amit Kumar Verma Amit Kumar Anu Rahal Vinod Kumar

Selenium is an essential trace element in the diets which is required for maintenance of health, growth and biochemical-physiological functions. The area covered in this review has been rapidly unfolding in recent years and has already acquired a vast spread. This study presents a concise introductory overview of the effect of organic and inorganic selenium on growth performance, carcass traits, daily egg production, egg quality, Se uptake in various tissues and plasma and plasma glutathione peroxidase activity in animals.

Trace element

10.3923/pjbs.2012.418.425

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Citations (66)

Curcumin attenuates oxidative stress-induced altered histoarchitecture of testes in experimentally exposed rats to metal mixture (lead, arsenic, cadmium, mercury, iron, and copper) for 28 days

Toxicological & Environmental Chemistry Reviews (2014)

Shaikh Mohd. Zoheb Atul Prakash Anu Rahal Rajesh Mandil Neeraj Kumar Gangwar

This study was undertaken to assess the toxicity of mixture of six metals including lead (Pb), arsenic (As), cadmium (Cd), mercury (Hg), iron (Fe), and copper (Cu) at environmentally realistic concentrations and to determine whether curcumin was able to prevent testicular injury in rats. Forty-two rats were divided into seven groups, six animals/group: control (water), vehicle control (groundnut oil), curcumin (100 mg/kg body wt.), 10x mixture, 100x mixture, 10x plus curcumin, and 100x plus curcumin. At the end of exposure period of 28 days, rats were sacrificed and testes were collected for the analysis of oxidative stress markers, testicular enzymes, and histopathology. At 10x and 100x dose, % weight gain was significantly reduced compared to control, accompanied by decreased absolute testicular weight in 100x mixture group; however, relative weight among groups did not show any significant difference. Exposure of 10x and 100x mixture elevated the levels of lipid peroxidation products; whereas, catalase activity was significantly lowered. Glutathione content and superoxide dismutase activity were almost comparable among groups. Significant decrease in 17-β-hydroxysteroid hydrogenase and acid phosphatase, increase in γ-glutamyl transferase activity at 100x exposure level was observed. Lactate dehydrogenase and sorbitol dehydrogenase activity was comparable amongst all groups. Histopathological examination revealed degenerative changes in seminiferous tubules and spermatogonial cells. Co-administration of curcumin with metallic mixture effectively countered 10x and 100x metal mixtures-induced oxidative stress and improved antioxidant status of the tissue and restored activities of testicular enzymes. In conclusion, evidence indicates that major action of metals in testicular degeneration may be oxidative stress.

10.1080/02772248.2014.975425

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Citations (13)

Neem Extract

Elsevier eBooks (2016)

Dinesh Kumar Anu Rahal Jitendra K. Malik

Nutraceutical

Neem Oil

10.1016/b978-0-12-802147-7.00043-7

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Citations (17)

Strategies to combat antimicrobial resistance in Indian scenario

The Indian Journal of Animal Sciences (2021)

Anu Rahal Amit Kumar

Antimicrobial resistance (AMR) is one of the major public health crisis recognised globally. Microbial infections cause significant productivity losses in animals and humans. In livestock, these microbial infections reduce the growth rates and fertility, diminish production of meat and milk, and occasionally lead to mortality, and are therefore, a major concern for animal welfare. In the dearth of alternative prophylactic measures, antibiotics remain the principal tool for their management. Once an antibiotic is used rampantly, resistance against it is inevidently seen in the microbe population and the hunt for a new drug grows. Discovery and development of a new antimicrobial drug is a time taking and expensive procedure with limited assurance of success. As a result, the past few decades have witnessed only a very few new classes of antibiotics. If the AMR can be restricted or reverted, the success rate of antimicrobial therapy can be boosted and many public health issues be avoided. All these ask for a comprehensive plan to prevent or reduce the antimicrobial resistance and economic losses to the animal husbandry sector. The present review provides an overview of AMR in India, mechanism of its occurrence and the possible roadmap to combat the emerging threat of AMR in Indian scenario.

Animal Husbandry

10.56093/ijans.v91i2.113812

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Citations (1)

List of Contributors

Elsevier eBooks (2016)

Abul H. Ahmad Arturo Anadón Rashmi Anand Vellareddy Anantharam Csaba András

10.1016/b978-0-12-802147-7.00080-2

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Citations (0)

Distribution and mtabolism of DDT, carbaryl and methyl parathion in S- and R-strains of Spodoptera littoralis (Boisd.)

Toxicology (1973)

M. Hamdy. Balba M. D. Abdallah M.H. Zazou Anu Rahal

Hindgut

Carbaryl

Hemolymph

Parathion methyl

Spodoptera littoralis

Parathion

Cuticle (hair)

Foregut

10.1016/0300-483x(73)90002-4

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Citations (1)

Pharmacokinetics of Florfenicol Following Single Dose Intravenous and Intramuscular Administration in Goats

Journal of Applied Animal Research (2009)

Sheetal Verma Abdul Hamid Ahmad Anu Rahal Krishna P. Singh

Abstract Verma, S., Ahmad, A.H., Rahal, A. and Singh, K.P. 2009. Pharmacokinetics of florfenicol following single dose intravenous and intramuscular administration in goats. J. Appl. Anim. Res., 36: 93–96. Pharmacokinetics of florfenicol following intravenous (i.v.) and intramuscular (i.m.) administration (20 mg.kg−1) was studied in healthy goats. Based on pharmacokinetic data, an i.v. and i.m. dosage regimen of florfenicol in goats was calculated to be 14.38 and 15.08 mg.kg−1, respectively, at 12 h interval. Keywords: Pharmacokineticsflorfenicolgoat

Florfenicol

Intramuscular injection

Regimen

10.1080/09712119.2009.9707039

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Citations (7)

Prophylactic Efficacy of Podophyllum hexandrum in alleviation of immobilization stress-induced oxidative damage in rat

Anu Rahal Deepak Mehra Subbanna Rajesh Vivek Singh Ausaf Ahmad

Free radicals are generated in the body by means of various conditions such as exercise, pollution, stress, poor diet, and smoking. They are known to attack the cell components and increase the risk of heart disease, ulcer, stroke, or cancer. In this study, we evaluated whether podophyllum treatment has a prophylactic effect on the prooxidant–antioxidant state following immobilization stress treatment in rats. Immobilization stress caused an increase in free radical production as evidenced by an increase in the levels of malondialdehyde (MDA) and a decrease in the levels of glutathione (GSH) and superoxide dismutase (SOD) in erythrocytes, liver and kidney. Both AL and AQ restored the increased LPO and decreased GSH and SOD significantly in immobilized rats and non-significantly in normal rats. Alcoholic extract was more efficacious in preventing excess free radical production as compared to aqueous extract. The potentiated antioxidant potential of erythrocytes due to Podophyllum administration can play an important role in the protective mechanism against immobilization induced oxidative damage.

Malondialdehyde

Podophyllum

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Citations (8)