Gu Sun

Chungbuk National University

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Jianfeng Bai

Shanghai Polytechnic University

Jiyeon Kim

Asan Medical Center

Ho Jun Song

Korea Institute of Industrial Technology

Zhao Zhi-quan

Liuzhou Maternal and Child Health Hospital

Sang‐Bae Han

Chungbuk National University

Min Jong Song

Samsung Medical Center

Chul Ju Hwang

Chungbuk National University

Joo Yeon Park

Murdoch University

Lianzhen Yu

Nanjing Medical University

Liang Qian

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Jiangsu Province Hospital

Nanjing Medical University

Chungbuk National University

Sungkyunkwan University

Yale University

Hanyang University

Government of the Republic of Korea

Catholic University of Korea

Yonsei University

Chinese Academy of Medical Sciences & Peking Union Medical College

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Clinical research of laparoscopic common bile duct exploration with primary suture and T tube drainage in the management of choledocholithiasis

International Journal of Surgery (2019)

LU Wen-xiong Gu Sun Jianfeng Bai Yi Shi Dongsheng Zhang

Univariate analysis

10.3760/cma.j.issn.1673-4203.2019.10.006

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Cholangiojejunostomic endo-drainage in the treatment of intrahepatic gallstones

中华肝胆外科杂志 (1998)

Gu Sun

目的比较肝内胆管结石治疗中胆肠Roux-en-Y内引流及单纯外引流的治疗效果.方法对我院近五年中收治的181例肝内胆管结石患者的治疗结果进行对比总结.结果内引流手术存在排石不净,引流局限,返流及吻合口狭窄等问题,再手术率相对较高,而单纯外引流不仅创伤小,术后并发症少,再手术率低,且维护了胆汁的正常生理排泄通道.术后辅以胆道镜取石及冲洗,结石取尽率可达98%.结论应严格掌握内引流适应证,在无肝内大肝管狭窄的情况下,采用胆管切开取石及单纯外引流,术后辅以胆道镜取石,治疗效果较内引流为佳.

10.3760/cma.j.issn.1007-8118.1998.02.012

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Expression of COX-2 proteins in gastric mucosal lesions

World Journal of Gastroenterology (2004)

Lianzhen Yu Hengjun Gao Jianfeng Bai Gu Sun Han-Lin Zhao

AIM:To investigate the expression of COX-2 proteins in gastric mucosal lesions and to assess the relationship between COX-2 expression and type, pathologic stage, differentiation, or lymph node metastasis in gastric cancer and the relationship between COX-2 expression and H pylori infection in gastric mucosal lesions. METHODS:Thirty patients with gastric carcinoma underwent surgical resection.Samples were taken from tu mor si te and pa rac anc er ous ti ssu es, an d A BC immunohistochemical staining was used to detect the expression of COX-2 proteins.H pylori was determined by rapid urea test combined with pathological stating/ 14 C urea breath test. RESULTS:The positive rate and staining intensity of mutant COX-2 gene expression in gastric cancer were significantly higher than those in paracancerous tissues (66.7% vs 26.7%) (P<0.01,P<0.001).There was a significant correlation between COX-2 and pathologic stage or lymph node metastasis type of gastric carcinoma (76.0%vs 20.0%, 79.2% vs 16.7%) (P<0.05).No correlation was found between COX-2 expression and type or grade of differentiation (P>0.05).COX-2 expression of intestinal metaplasia (IM) or dysplasia (DYS) with positive H pylori was significantly higher than that with negative H pylori (50.6% vs 18.1%, 60.0% vs 33.3%) (P<0.05).CONCLUSION: COX-2 overexpression was found in a large proportion of gastric cancer tissues compared with matched non-cancerous tissues and was significantly associated with advanced tumor stage and lymph node metastasis.Overexpression of COX-2 plays an important role in tumor progression of gastric cancer.COX-2 may also play a role in the early development/promotion of gastric carcinoma and is associated with H pylori infection.

Intestinal metaplasia

10.3748/wjg.v10.i2.292

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Several strategies of treating choledocholithiasis in laparoscopic operation

Journal of laparoscopic surgery (2005)

Gu Sun

Objective:To summarize the clinical experiences of treating choledocholithiasis in laparoscopic operation,discuss the choice of operating methods and announcements in practice.Methods:Analyze the clinical data of 84 patients,performing laparoscopic common bile duct exploration(LCBDE)with transcystic approach,LCBDE with primary suture,LCBDE with T tube drainage and laparoscopic cholecystectomy associating with preoperative or postoperative endoscopic sphincterotomy(ES)respectively.Results:All the four operation methods got satisfied results,neverthless the rate of bile leakage was higher in LCBDE with primary suture.Conclusions:There are no fixed rules can be complied when treating choledochoithiasis with laparoscopic operation.The optimal judgment made by the perator depened on the situation of the patient,the experiences of the operator and the equipments related.

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Cancer Cell Growth Inhibitory Effect of Bee Venom via Increase of Death Receptor 3 Expression and Inactivation of NF-kappa B in NSCLC Cells

Toxins (2014)

Kyung Un Choi Chul Ju Hwang Gu Sun Mi Park Joo Kim

Our previous findings have demonstrated that bee venom (BV) has anti-cancer activity in several cancer cells. However, the effects of BV on lung cancer cell growth have not been reported. Cell viability was determined with trypan blue uptake, soft agar formation as well as DAPI and TUNEL assay. Cell death related protein expression was determined with Western blotting. An EMSA was used for nuclear factor kappaB (NF-κB) activity assay. BV (1–5 μg/mL) inhibited growth of lung cancer cells by induction of apoptosis in a dose dependent manner in lung cancer cell lines A549 and NCI-H460. Consistent with apoptotic cell death, expression of DR3 and DR6 was significantly increased. However, deletion of DRs by small interfering RNA significantly reversed BV induced cell growth inhibitory effects. Expression of pro-apoptotic proteins (caspase-3 and Bax) was concomitantly increased, but the NF-κB activity and expression of Bcl-2 were inhibited. A combination treatment of tumor necrosis factor (TNF)-like weak inducer of apoptosis, TNF-related apoptosis-inducing ligand, docetaxel and cisplatin, with BV synergistically inhibited both A549 and NCI-H460 lung cancer cell growth with further down regulation of NF-κB activity. These results show that BV induces apoptotic cell death in lung cancer cells through the enhancement of DR3 expression and inhibition of NF-κB pathway.

DAPI

Viability assay

Trypan blue

10.3390/toxins6082210

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A Real-Time Multi-Channel Signal Acquisition Card Based on PCI Express Interface

International Conference on Communication Software and Networks (2009)

Gu Sun Zishu He

In this paper, we introduce a real-time multi-channel signal acquisition card based on PCI express interface and describe the design of direct memory access (DMA) data transfer system based on PCI-express windows driver model (WDM). The signal acquisition card contains a programmable FPGA logic and a PLX PCI express-to-PCI bridge. The solution to use a PLX PEX 8114 bridge external to the programmable FPGA logic allows to greatly simplifying projects at the level of the on-board local bus. We also compare the performance with another card which is based on PCI interface. Our result shows that PCI express interface can achieve significant performance benefit. The high performance, low cost, and easy connectivity of PCI express interface are ideal for many applications - especially those currently limited by the lack of high-speed interconnect.

PCI configuration space

Interface (matter)

SIGNAL (programming language)

10.1109/iccsn.2009.73

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猪基源のヘパリンおよび粗のAS-PCRおよびARMS分子検出【JST・京大機械翻訳】

Yaoxue Xuebao (2008)

YU Zhiyong Ding Ge Ding Xiaoyu Chu Bihai Liang Qian

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