Luyang Zhang

Huazhong University of Science and Technology

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Yingsan Geng

Xi'an Jiaotong University

Zhiyuan Liu

University of Science and Technology Beijing

Xiaofei Yao

CCCC Highway Consultants (China)

Jianhua Wang

Jiangnan University

Xinggui Chen

Guangdong Medical College

Jiangjian Xie

Beijing Forestry University

Xiaofan Zhu

Institute of Hematology & Blood Diseases Hospital

Chen Guan

Qilu University of Technology

Yun Geng

Xi'an University of Technology

Björn W. Schuller

Technical University of Munich

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Institute of Hematology & Blood Diseases Hospital

Shanghai Jiao Tong University

Zhengzhou University

Xi'an Jiaotong University

Huazhong University of Science and Technology

Chinese Academy of Sciences

Ruijin Hospital

National Clinical Research

Academy of Medical Sciences

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[CD20 is not a poor prognostic factor for childhood B-lineage acute lymphoblastic leukemia with high white blood cell count].

PubMed (2020)

Luyang Zhang Xiaojuan Chen Shuchun Wang Ye Guo Wenyu Yang

To study the significance of CD20 combined with white blood cell (WBC) count at diagnosis in the prognosis assessment in children with B-lineage acute lymphoblastic leukemia (ALL).A retrospective analysis was performed on the medical data of 821 B-ALL children who were treated with CCLG-ALL2008 regimen from April 2008 to April 2015. Their survival status was followed up.Among the 821 children, 547 (66.6%) were negative, while 274 (33.4%) were positive for CD20 expression. Among 694 children with WBC<50×109/L (lower WBC count), the 5-year EFS rates were 65.9%±3.2% and 77.3%±2.0% for CD20 positive and negative patients respectively (P=0.001); the 5-year OS rates were 78.3%±2.9% and 87.5%±1.6% for CD20 positive and negative patients respectively (P=0.005); CD20 positive expression was an independent risk factor for EFS (HR=1.634, P=0.001) and OS (HR=1.761, P=0.005). Among 127 children with WBC>50×109/L (higher WBC count), the 5-year EFS rates was 64.3%±7.7% and 53.7%±5.5% for CD20 positive and negative patients respectively (P=0.135); the 5-year OS rate was 81.4%±6.4% and 58.6%±5.6% for CD20 positive and negative patients respectively (P=0.022); CD20 positive expression was an independent protective factor for OS (HR=0.367, P=0.016).In children with B-ALL who are treated with CCLG-ALL2008 regimen, those with CD20 positive expression in lower WBC count at diagnosis have a poor prognosis; however, those with CD20 positive expression in higher WBC count at diagnosis have a better long-time survival.

White blood cell

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A Novel Risk Defining System for Pediatric T-Cell Acute Lymphoblastic Leukemia From CCCG-ALL-2015 Group

Frontiers in Oncology (2022)

Xiaoming Liu Yao Zou Li Zhang Ye Guo Yumei Chen

T-cell acute lymphoblastic leukemia (T-ALL) is a rare hematological malignancy with a poor prognosis. The present study aims to identify the precise risk grouping of children with T-ALL.We analyzed the outcomes for 105 consecutive patients treated using the Chinese Children's Cancer Group ALL-2015 (CCCG-ALL-2015) protocol registered with the Chinese Clinical Trial Registry (ChiCTR-IPR-14005706) between 2015 and 2020 in our center. Nine out of 21 clinical and biological indicators were selected for the new scoring system based on the analysis in this study.The 5-year overall survival (OS), event-free survival (EFS), and disease-free survival (DFS) rates for the 105 patients were 83.1 ± 4.8%, 72.4 ± 5.6%, and 78.4 ± 3.6%, respectively. Based on the new scoring system, 90 evaluable children were regrouped into low-risk (n=22), intermediate-risk (n=50), and high-risk (n=18) groups. The 5-year survival (OS, EFS, and RFS) rates for all patients in the low-risk group were 100%, significantly higher than the rates for those in the intermediate-risk group (91.2 ± 5.2%, 74.4 ± 8.6%, and 82.5 ± 6.2%, respectively) and high-risk group (59.0 ± 13.2%, 51.9 ± 12.4%, and 51.9 ± 12.4%, respectively) (all P values < 0.01).The CCCG-ALL-2015 program significantly improved the treatment outcomes for childhood T-ALL as compared with the CCCG-ALL-2008 protocol. Our new refined risk grouping system showed better stratification among pediatric T-ALL patients and better potential in evaluating therapeutic efficacy.

Risk Stratification

10.3389/fonc.2022.841179

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Citations (8)

Prevention and management of hemorrhage during a laparoscopic colorectal surgery

Annals of Laparoscopic and Endoscopic Surgery (2016)

Luyang Zhang Junjun Ma Lu Zang Feng Dong Aiguo Lu

Laparoscopy is believed to play an important role in the treatment for colorectal cancer and is now extensively applied across the world. Although the safety and feasibility of laparoscopic colorectal surgery has been verified by several randomized controlled trials, intraoperative hemorrhage is still a challenge for clinicians, which could lead to conversion to laparotomy or increased mortality. In this article we discuss the strategy for prevention and management of hemorrhage in laparoscopic colorectal surgery in terms of anatomy and surgical skills.

Colorectal Surgery

10.21037/ales.2016.11.22

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Prevention and management of hemorrhage during a laparoscopic colorectal surgery

Annals of Laparoscopic and Endoscopic Surgery (2016)

Luyang Zhang Junjun Ma Lu Zang Feng Dong Aiguo Lu

Colorectal Surgery

10.21037/3615

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Citations (4)

Novel Gene Variants in SRY-negative 46, XX male syndrome with Bone Marrow Failure by Whole Exome Sequencing

Authorea (Authorea) (2020)

Ao‐Li Zhang Li Xian Chang Li Zhang Chao Liu Li Peng Liu

46, XX male syndrome is a rare disorder of sex development. One-tenth of 46, XX male syndrome is sex-determining region Y (SRY)-negative. We used whole-exome sequencing (WES) analysis associated genes to investigate the underlying genetic etiology of 46, XX male syndrome patients with bone marrow failure with a typical male phenotype. WES reveals SRY and SRY-box family genes were negative. Simultaneously, gene variants were detected in female pathway, testis development, and steroid receptor genes. There are undefined gene variants associated with congenital bone marrow failure. WES proved an efficient diagnostic method toward 46, XX male syndrome patients with hematological disorder.

Testis determining factor

10.22541/au.159200608.88705488

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Research and Verification of Opening Characteristics of a Modular 72.5 kV Fast Vacuum Circuit Breaker

Chen Guan Xiaofei Yao Luyang Zhang Qing Zhao Jianhua Wang

It is significant for clearing a short circuit fault in a very short time, by a fast vacuum circuit breaker (FVCB), since it can effectively improve the transient stability of the power system. In this paper, a modular single-break 72.5 kV FVCB with a novel oil damper is proposed, which use electromagnetic repulsion actuator (EMA) as an operating mechanism and is used to be constituted a 550 kV FVCB by six modules series connected. A multi-physics coupling simulation model was built, by taking into consideration of the motion characteristics including: the opening speed, the displacement of the movable contact, the electromagnetic repulsion force, and the buffering force. According to the simulation result, the prototype of 72.5kV FVCB was designed and developed. In this case, the opening velocity of 72.5kV FVCB was measured, and the average opening velocity can reach 2m/s to 6m/s.

Transient (computer programming)

10.1109/asemd49065.2020.9276177

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DB3V: A Dialect Dominated Dataset of Bird Vocalisation for Cross-corpus Bird Species Recognition

Interspeech 2022 (2024)

Xin Jing Luyang Zhang Jiangjian Xie Alexander Gebhard Alice Baird

In ornithology, bird species are known to have variedit's widely acknowledged that bird species display diverse dialects in their calls across different regions. Consequently, computational methods to identify bird species onsolely through their calls face critsignificalnt challenges. There is growing interest in understanding the impact of species-specific dialects on the effectiveness of bird species recognition methods. Despite potential mitigation through the expansion of dialect datasets, the absence of publicly available testing data currently impedes robust benchmarking efforts. This paper presents the Dialect Dominated Dataset of Bird Vocalisation (D3BV), the first cross-corpus dataset that focuses on dialects in bird vocalisations. The D3BV comprises more than 25 hours of audio recordings from 10 bird species distributed across three distinct regions in the contiguous United States (CONUS). In addition to presenting the dataset, we conduct analyses and establish baseline models for cross-corpus bird recognition. The data and code are publicly available online: https://zenodo.org/records/11544734

10.21437/interspeech.2024-143

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Iron metabolism regulation and its related diseases

Guoji shuxue ji xueyexue zazhi (2017)

Luyang Zhang Danfeng Zhang

Iron is a kind of essential metal for many organisms due to its ability to transfer electrons in reduction/oxidation reaction. Over the last 2 decades, the discovery of mutations in genes leading to hereditary disorders of iron overload, iron deficiency, and iron maldistribution have accelerated our understanding of human iron homeostasis. This article will review the iron metabolism, the regulatory mechanism of iron homeostasis, and its related diseases according to pertinent literatures. Key words: Iron metabolism disorders; Iron overload; Anemia, iron-deficiency; Iron metabolism; Iron metabolism disorders; Hepcidins

Homeostasis

10.3760/cma.j.issn.1673-419x.2017.01.013

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A simple and reliable credit-balanced incentive scheme for wireless ad-hoc networks

Luyang Zhang Mahesh Sooriyabandara Zhong Fan

One of the fundamental challenges in wireless ad-hoc networking is promotion of cooperation among rational and selfish nodes. Various schemes have been proposed in the literature to stimulate nodes collaboration by improving data forwarding function or route discovery function. The novel algorithm proposed in this paper enhances these two ad-hoc networking functions by utilizing a unique credit-reputation hybrid approach. In the data forwarding phase, a reputation and credit combined mechanism offers incentives with simpler and less overhead process; in the route discovery phase, a new routing metric considering the remaining energy as well as balance between credits and energy has been introduced. Simulations results show that the scheme could successfully stimulate node cooperation by manipulating credits and reputation restrictions and more importantly actively discouraging three types of selfish behaviors.

10.1109/iwcmc.2011.5982711

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Application of NLP Technology in the Information Extraction of Bridge Management and Maintenance Documents

Report (2022)

Luyang Zhang Ye Xia Limin Sun

<p>Bridge management and maintenance document is the accumulation of authoritative technical data to record the history of bridge operation, current technical status and management and maintenance process, which contains substantial information to support bridge maintenance decision. With more and more extensive application of bridge health monitoring in civil engineering industry, bridge management and maintenance documents become more common and quantitative. Therefore, a large number of these reports need to be manually read and analyzed to obtain effective information, which will waste a lot of effort. In order to improve this situation, this paper develops a frequency state analyzer using LSTM neural network to classify these documents automatically, and improve the efficiency of bridge management and maintenance work.</p>

Bridge (graph theory)

Bridge maintenance

Maintenance engineering

10.2749/nanjing.2022.1224

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