Lymphoma is considered as cancer of the lymphoid tissue that exists in two main categories, including Hodgkin's and non-Hodgkin's lymphoma. Primary extranodal non-Hodgkin's lymphoma of the mandibular condyle is extremely rarely reported. Comprehensive examination is required to establish more possible diagnosis for every patient. To learn more about this lesion, this case report of a patient with anaplastic large cell lymphoma occurring in the mandibular condyle has been presented. The pathological examination of this tumor included diffused atypical lymphocytic cells infiltrating, hyperchromatic nuclei and atypical mitosis. The patient has been treated chemotherapeutically by 6 cycles of EPOCH (Pirarubicin 20mg d1-2,10mg d3-4 and 151 Etoposide 50mg d1-4 and Vinorelbine 10mg d1-4 and Ifosfamide 1.5g d5 and 152 Prednisone 100mg d1-5) and has been followed up to 13 months. Considerable bone regeneration progressed through the follow up time. In conclusion, the primary extranodal non-hodgkin's lymphoma of the mandibular condyle should not be excluded from the differential diagnosis and this disease can be treated by chemical therapy.
Abstract Mitochondrial fission process 1 (MTFP1) is a novel nuclear‐encoded protein that promotes mitochondrial fission. Increasing lines of evidence indicate that increased mitochondrial fission is involved in carcinogenesis and tumor progression. However, the expression and biological effects of MTFP1 in cancer development is still unclear, especially in oral squamous cell carcinoma (OSCC). In this study, we first evaluated the expression of MTFP1 in 12‐paired OSCC tumor and peritumor tissues. We then explored the effects of MTFP1 knockdown or overexpression on cell growth by cell proliferation, colony formation, cell cycle, and cell apoptosis assays. Furthermore, the mechanisms by which MTFP1 promoted OSCC cell growth were explored. Our results showed that MTFP1 is frequently overexpressed in OSCC tissues. Functional experiments revealed that MTFP1 promoted the growth of OSCC cells by inducing the progression of cell cycle and suppressing cell apoptosis. Mechanistically, MTFP1 overexpression‐mediated mitochondrial fragmentation and subsequent ROS production was found to be involved in the promotion of OSCC cell growth. Collectively, our study demonstrates that MTFP1 plays a critical oncogenic role in OSCC carcinogenesis, which may serve as a potential therapeutic target in the treatment of this malignance.
Bacterial resistance to antibiotics can negatively affect the treatment of infected skin wounds. The combination of synergistic antibacterial therapies with photodynamic, photothermal, and chemodynamic therapies has been recognized as one of the most promising approaches. In this study, we have developed MSN@Ce6@MnO
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