James H. Paton

Burton Hospitals NHS Foundation Trust

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D. S. Reeves

Southmead Hospital

C.A. Bartzokas

Clatterbridge Cancer Centre NHS Foundation Trust

David S. Reeves

British Society for Antimicrobial Chemotherapy

M.F. Gibson

University of Liverpool

R S Croton

Royal Liverpool University Hospital

Nicholas Barber

Washington and Lee University

Dimitra Petrakaki

University of Sussex

Maryam Ali

London School of Economics and Political Science

G A McLoughlin

Amirhossein Takian

Tehran University of Medical Sciences

Cooperative Institutions

University College London

University of Edinburgh

London School of Economics and Political Science

Royal Liverpool University Hospital

University of Liverpool

Liverpool Hospital

University of Cambridge

University of Nottingham

University of Manchester

University of London

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Prevention of meningitis in head injury.

BMJ (1985)

Michael Kelly James H. Paton

trimethoprim has remained the same (260" ) in the six months before the change and in the six months afterwards.Resistance to sulphon- amides has dropped from 40°' to 37°0.Between 1983 and 1984 the total amount of trimethoprim prescribed in the hospital in- creased by 3100.These findings are in accord with our previous data that there is no evidence that adding a sulphonamide to trimethoprim discourages resistance.We would like to invite Dr Maskell to per- form the following experiments: select cul- tures of either fully sensitive or sulphonamide resistant (trimethoprim sensitive) entero- bacteriaceae, expose them to trimethoprim of the sort of concentration-for example, 256 ,ug/ml-to which strains are highly resis- tant, and see if any resistant variants can be selected.She will find few such variants from either type of culture, and the few bacteria that may struggle through will be grossly defective and probably not pathogenic.Surely the time has come to withdraw co- trimoxazole for urinary and many other infections, such as typhoid.The major active component of co-trimoxazole is trimethoprim.It is effective and safe.It should be used alone unless reliable evidence is presented that sulphonamides have a contribution.

10.1136/bmj.290.6466.470-b

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Control and Eradication of Methicillin-Resistant Staphylococcus Aureus on a Surgical Unit

Staphylococcus aureus: Resources (1984)

C.A. Bartzokas James H. Paton M.F. Gibson Rikki Graham G A McLoughlin

AFTER the appearance of sporadic cases in 1961,1 the incidence of methicillin-resistant Staphylococcus aureus infections in the United Kingdom,2 Scandinavia,3 and Europe4 increased gradually throughout the 1960s, reaching a peak at the end of the decade before waning in the Old World. Because conventional procedures for source isolation and disinfection failed to contain their spread in most hospitals, strains of methicillin-resistant S. aureus are now endemic throughout the United States5 , 6 and eastern Australia.7 In the autumn of 1982 a methicillin-resistant S. aureus, phage type 29, introduced to our district general hospital from the community in the spring, caused a . . .

Phage typing

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The Long and Winding Road: An Independent Evaluation of the Implementation and Adoption of the National Health Service Care Records Service (NHS CRS) in Secondary Care in England

Kathrin Cresswell Maryam Ali Anthony Avery Nicholas Barber Tony Cornford

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Preaching Christian doctrine in a post-Christian society

James H. Paton

Public Theology

Church in Global Cities

Global Christianity

African Christianity

Religious Experience

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Fluoroquinolone Antibiotics

Drugs (1988)

James H. Paton D. S. Reeves

10.2165/00003495-198836020-00004

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Citations (161)

An Address ON THE GENERAL PRACTITIONER AS A RESEARCH WORKER.

The Lancet (1924)

James H. Paton

10.1016/s0140-6736(01)04538-x

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Citations (1)

Control and Eradication of Methicillin-ResistantStaphylococcus aureuson a Surgical Unit

New England Journal of Medicine (1984)

C.A. Bartzokas James H. Paton M.F. Gibson Robert H. Graham Gráinne McLoughlin

Isolation

Phage typing

10.1056/nejm198411293112207

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Citations (155)

Interaction between ciprofloxacin and vancomycin against staphylococci

Journal of Antimicrobial Chemotherapy (1987)

James H. Paton Elizabeth W. Williams

The interaction between ciprofloxacin and vancomycin against nine isolates of Staphylococcus epidermidis from cases of infective endocarditis and three strains of S. aureus was studied. Killing curves indicated the presence of antagonism in the early stages, the clinical significance of which is uncertain. No synergy was found and the combination therefore does not appear to offer any advantages over vancomycin alone for the treatment of staphylococcal infections.

10.1093/jac/20.2.251

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Citations (5)

Clinical Features and Management of Adverse Effects of Quinolone Antibacterials

Drug Safety (1991)

James H. Paton David S. Reeves

Quinolone

10.2165/00002018-199106010-00002

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Citations (53)

First multiresistant pneumococcus in Britain.

BMJ (1987)

James H. Paton D. S. Reeves

10.1136/bmj.295.6602.810

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Citations (11)