[Objective] To study the relationship between the dosage and the efficacy,the side effects and the quality of life of transdermal Fentanyl-Duragestic in the treatment of gastrointestinal cancer-related pain.[Methods] Twenty-eight patients suffered from grade Ⅲ-Ⅳ continuous chronic pain were administered the drug.The dosage was 25 μg/h and the Duragesic was changed ever 72 hours.Each patient was at least treated for 7 days.The severity of pain,side effects and the quality of life were observed after and before the treatment.[Results] Duragesic had satisfactory effect on severe pain of all advanced cancer patients.There were twenty-six CR and PR patients with an effective rate of 92.9 %,and there were significant differences between before and after the use of Durageics(P0.05).The side effects included nausea, vomitting,dizziness,sleepy and constipation.The incidence of side effects was very low.[Conclusion]Duragesic has a continuous,stable and safe effect on pain relief.The administration is simple and convenient and side effects are mild.The quality of life is improved after treatment.
To investigate the effect of Omeprazole and Chinese herbs on reflux esophagitis(RE). Methods:Thirty patients diagnosed as RE by endoscopy were given Omeprazole 20mg once a day and oral prescription of Chinese herbs. Control group of 28 cases were treated only with Omeprazole 20mg once a day. After treated for 4 weeks, the two groups were checked with endoscopy. Results: Healing rate (by endoscopy) and total effective rate of the group treated with Omeprazole together with Chinese herbs were 60.0% and 96.7%, and those of control group were 50.0% and 78.6% respectively. The difference between the two groups was significant (P0.01), Conclusion: The effect of Omeprazole and Chinese herbs on RE was better than that of simple Omeprazole.
Objective To investigate the effect of Bushen Yiqi Huoxue(Reinforcing Kidney Replenishing qi and Promoting Blood Circulation) Decoction on the expression of IGF-1,IGFBP-1 and IGFBP-3 proteins in fetal liver of Fetal growth restriction(FGR) rat.Methods The smoke inhalation rat model was created.Thirty two pregnant Sprague-Dawley rats were randomly dividedly into four groups: control group,FGR group,group of FGR treated with Bushen Yiqi Huoxue Decoction(Chinese medicine group),group of FGR treated with arginine(arginine group).The expression of IGF-1,IGFBP-1 and IGFBP-3 proteins in fetal liver were analyzed by immunohistochemistry.Result Compared with FGR group,the expression of IGF-1 and IGFBP-3 in fetal liver of Chinese medicine group increased significantly(P0.05),whereas the expression of IGFBP-1 decreased significantly(P0.05);in addition,the expression of IGF-1 was higher than that of arginine group(P0.05).The difference among Chinese medicine group and control group was insignificant(P0.05).Conclusion The effect of Bushen Yiqi Huoxue Decoction on preventing and treating FGR may be attributed to regulating the expression of IGF-1,IGFBP-1 and IGFBP-3.
[Objective]To study the effect of berberine on cell proliferation and the expression of vascular endothelial growth factor(VEGF)in HepG2 cells.[Methods]After being treated with different concentrations of berberine for 24h,HepG2 cells growth inhibition was assessed by MTT assay.VEGF levels of mRNA and protein in HepG2 were detected by Real-time PCR and Western blot respectively.[Results]In certain concentration range,berberine inhibited cellular proliferation and down-regulated the mRNA and protein expression of VEGF in dose-dependant manner.[Conclusion]Berberine can inhibit the proliferation of HepG2 cells and expression of VEGF,and anti-angiogenesis may be one of the mechanisms of its antitumor action.
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