Yanxian Zhang

Stanford University

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Jie Zheng

University of Akron

Yonglan Liu

National Cancer Institute

Baiping Ren

National Center for Toxicological Research

Dong Zhang

City University of Hong Kong

Yijing Tang

Massachusetts General Hospital

Yung Chang

Chung Yuan Christian University

Jintao Yang

Zhejiang University of Technology

Lijian Xu

Hunan University of Technology

Mingzhen Zhang

Frederick National Laboratory for Cancer Research

Qiang Chen

Yantai University

Cooperative Institutions

University of Akron

Chinese Academy of Sciences

University of Science and Technology Beijing

Hunan University of Technology

Wenzhou Medical University

Central South University

Zhejiang University of Technology

Zhejiang University

University of Chinese Academy of Sciences

Shanghai Jiao Tong University

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Gel protects therapeutic proteins from deactivation — even in the post

Nature (2024)

Yanxian Zhang Danny Hung‐Chieh Chou

10.1038/d41586-024-02233-8

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Citations (0)

Alkalescent nanotube films on a titanium-based implant: A novel approach to enhance biocompatibility

Materials Science and Engineering C (2016)

Yanxian Zhang Dong Chaofang Sefei Yang Junsheng Wu Kui Xiao

Biocompatibility

Passivation

10.1016/j.msec.2016.11.096

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Citations (12)

Highly stretchable, self-adhesive, biocompatible, conductive hydrogels as fully polymeric strain sensors

Journal of Materials Chemistry A (2020)

Dong Zhang Yijing Tang Yanxian Zhang Fengyu Yang Yonglan Liu

A new fully polymeric conductive hydrogel sensor with IPN structure was developed, which achieved ultra-high stretchability, strong surface adhesion, and high sensing stability in response to both large and subtle human movements.

Biocompatible material

Self adhesive

Electrically conductive

10.1039/d0ta07390c

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Citations (184)

Conformational-Specific Self-Assembled Peptides as Dual-Mode, Multi-Target Inhibitors and Detectors for Different Amyloid Proteins

SSRN Electronic Journal (2021)

Baiping Ren Yijing Tang Dong Zhang Yonglan Liu Yanxian Zhang

Prevention and detection of misfolded amyloid proteins and their β-structure-rich aggregates are the two promising but different (pre)clinical strategies to treat and diagnose neurodegenerative diseases including Alzheimer’s diseases (AD) and type II diabetes (T2D). Conventional strategies prevent the design of new pharmaceutical molecules with both amyloid inhibition and detection functions. Here, we proposed a “like-interacts-like” design principle to de novo design a series of new self-assembling peptides (SAPs), enabling to specifically and strongly interact with conformationally similar β-sheet motifs of Aβ (association with AD) and hIAPP (association with T2D). Considering that the β-sheet-rich conformations is the common structural feature for different amyloid proteins, SAPs have demonstrated the two integrated functions of (i) amyloid inhibition for preventing the aggregation and cytotoxicity of both Aβ and hIAPP and (ii) amyloid sensing for early detecting the toxic Aβ and hIAPP aggregates using in-house SAPs-based paper sensors and SPR sensors. The presence of both amyloid inhibition and detection in SAPs is stemmed from strong molecular interactions between amyloid proteins/aggregates and inhibitors/detectors, thus providing a new “kill two birds with one stone” multi-target model for expanding new therapeutic potentials of SAPs and others with built-in amyloid inhibition and detection functions.

Amyloid (mycology)

10.2139/ssrn.3984243

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The serious complication caused by ozone ablation employed for the treatment of lumbar intervertebral disc herniation:report of one case

Journal of interventional radiology (2011)

Yanxian Zhang

Lumbar disc herniation

Intervertebral Disc

Disc herniation

Source

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Thermo-Responsive and Shape-Adaptive Hydrogel Actuators from Fundamentals to Applications

Engineered Science (2019)

Yanxian Zhang Shaowen Xie Dong Zhang Baiping Ren Yonglan Liu

Shape adaptable hydrogel actuators, capable for changing their shapes in response to single or multiple thermo/other external stimulus, are considered as new emerging smart materials for a broad range of fundamental/industrial research and applications.This review mainly focuses on the recent progress (particularly over the past 5 years) on such thermo-responsive hydrogel actuators.Recent fundamental advances and engineering applications in materials design/synthesis/characterization, distinct actuation mechanisms, and intriguing examples of these hydrogel actuators of single or dual stimuli are selectively presented.Specific or general design principles for thermo-induced hydrogel actuators are also provided to better illustrate the structure-property relationship.In the end, we offer some personal perspectives on current major challenges and future research directions in this promising field.Overall, this review discusses current status, progress, and challenges of hydrogel actuators, and hopefully will motivate researchers from different fields to explore all the potentials of hydrogel actuators.

10.30919/es8d788

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Citations (30)

Unraveling the immune system’s role in peripheral nerve regeneration: a pathway to enhanced healing

Frontiers in Immunology (2025)

Xu Zhang Yanxian Zhang Yuqing Chen Yuxiang Ji Yongmei Lyu

Peripheral nerve injury (PNI) represents a common challenge in clinical practice. In contrast to the central nervous system (CNS), the peripheral nervous system (PNS) in mature mammals possesses a limited regenerative capacity. Upon the occurrence of PNI, peripheral nerve regeneration (PNR) is initiated, facilitated by the activation of the immune microenvironment and the intrinsic growth potential of neurons. This regenerative process encompasses several key stages, including distal axon degeneration, myelin breakdown, clearance of myelin debris, inflammatory responses from non-neuronal cells, and subsequent axonal regeneration. The immune response, recognized for its role in clearing myelin debris and modulating the local inflammatory milieu, is crucial for initiating axonal regeneration at the proximal stump of nerves. Nevertheless, the precise mechanisms by which the immune response influences PNI and the strategies to harness this process to augment regeneration remain elusive. This article provides a comprehensive overview of the diverse roles and mechanisms of the immune system in PNR and presents insights into potential therapeutic strategies. Furthermore, the article examines immune-associated signaling pathways and their impact on PNR, underscoring the significance of immune modulation in enhancing patient outcomes with PNI. Ultimately, it encapsulates and forecasts the theoretical and practical directions of this field.

10.3389/fimmu.2025.1540199

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Sulfated zwitterionic poly(sulfobetaine methacrylate) hydrogels promote complete skin regeneration

Acta Biomaterialia (2018)

Jiang Wu Zecong Xiao Anqi Chen Huacheng He Chaochao He

10.1016/j.actbio.2018.02.034

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Citations (132)

Synthesis and Characterization of Ultralow Fouling Poly(N-acryloyl-glycinamide) Brushes

Langmuir (2017)

Fengyu Yang Yonglan Liu Yanxian Zhang Baiping Ren Jianxiong Xu

The rational design of biomaterials with antifouling properties still remains a challenge, although this is important for many bench-to-bedside applications for biomedical implants, drug delivery carriers, and marine coatings. Herein, we synthesized and characterized poly(N-acryloylglycinamide) (polyNAGA) and then grafted poly(NAGA) onto Au substrate to form polymer brushes with well-controlled film stability, wettability, and thickness using surface-initiated atom transfer radical polymerization (SI-ATRP). The NAGA monomer integrates two hydrophilic amides on the side chain to enhance surface hydration, which is thought as a critical contributor to its antifouling property. The antifouling performances of poly(NAGA) brushes of different film thicknesses were then rigorously assessed and compared using protein adsorption assay from undiluted blood serum and plasma, cell-adhesive assay, and bacterial assay. The resulting poly(NAGA) brushes with a film thickness of 25-35 nm exhibited excellent in vitro antifouling ability to prevent unwanted protein adsorption (<0.3 ng/cm2) and bacterial and cell attachments up to 3 days. Molecular dynamics (MD) simulations further showed that two hydrophilic amide groups can interact with water molecules strongly to form a strong hydration layer via coordinated hydrogen bonds. This confirms a positive correlation between antifouling property and surface hydration. In line with a series of polyacrylamides and polyacrylates as antifouling materials synthesized in our lab, we propose that small structural changes in the pendent groups of polymers could largely improve the antifouling capacity, which may be used as a general design rule for developing next-generation antifouling materials.

Characterization

Biofouling

10.1021/acs.langmuir.7b03435

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Citations (32)

Amyloid cross-seeding between Aβ and hIAPP in relation to the pathogenesis of Alzheimer and type 2 diabetes

Chinese Journal of Chemical Engineering (2020)

Yanxian Zhang Yijing Tang Dong Zhang Yonglan Liu Jian He

Pathogenesis

Amyloid (mycology)

Amyloid disease

10.1016/j.cjche.2020.09.033

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Citations (18)