Hossein Ansari

Zahedan University of Medical Sciences

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Mansoureh Togha

Tehran University of Medical Sciences

Zeinab Ghorbani

Guilan University of Medical Sciences

Ali Totonchi

MetroHealth Medical Center

Soodeh Razeghi Jahromi

Sina Hospital

Pedram Shirani

National Nutrition and Food Technology Research Institute

Faezeh Khorsha

Tehran University of Medical Sciences

Azita Hekmatdoost

Shahid Beheshti University of Medical Sciences

Pegah Rafiee

Shahid Beheshti University of Medical Sciences

Bahman Guyuron

Case Western Reserve University

Morvarid Nourmohammadi

Tehran University of Medical Sciences

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Tehran University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Isfahan University of Medical Sciences

Zahedan University of Medical Sciences

Iran University of Medical Sciences

National Nutrition and Food Technology Research Institute

Shahid Beheshti University

Imam Hossein Hospital

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Jahrom University of Medical Sciences

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The effects of a multispecies probiotic supplement on inflammatory markers and episodic and chronic migraine characteristics: A randomized double-blind controlled trial

Cephalalgia (2019)

Fahimeh Martami Mansoureh Togha Maryam Seifishahpar Zeinab Ghorbani Hossein Ansari

Background The current study was designed to assess the effect of supplementation with a 14-strain probiotic mixture on episodic and chronic migraine characteristics. Methods Forty episodic and 39 chronic migraine patients who completed this randomized double-blind controlled trial received two capsules of multispecies probiotic or placebo. The migraine severity was assessed by visual analog scale (VAS). The number of abortive drugs consumed, migraine days, frequency and duration of attacks were recorded on paper-based headache diaries. Serum tumor necrosis factor alpha (TNF-α) and C- reactive protein (CRP) levels were measured at baseline and the end of the intervention. Results After a 10-week intervention, among episodic migraineurs the mean frequency of migraine attacks significantly reduced in the probiotic group compare to the placebo group (mean change: −2.64 vs. 0.06; respectively, p < 0.001). A significant reduction was also evident in the migraine severity (mean decrease: −2.14 in the probiotic group and 0.11 in the placebo group; p < 0.001). Episodic migraineurs who received the probiotic also showed significant reduction in abortive drug usage per week (mean change: −0.72; p < 0.001) compare to baseline, while there was no significant changes within the placebo group. In chronic migraine patients, after an 8-week intervention, the mean frequency of migraine attacks significantly reduced in the probiotic compared to the placebo group (mean change: −9.67 vs. −0.22; p ≤ 0.001). In contrast to the placebo, probiotic supplementation significantly decreased the severity (mean changes: −2.69; p ≤ 0.001), duration (mean changes: −0.59; p ≤ 0.034) of attacks and the number of abortive drugs taken per day (mean changes: −1.02; p < 0.001), in chronic migraine patients. We failed to detect any significant differences in the serum levels of inflammatory markers at the end of the study either in chronic or in episodic migraineurs. Discussion The results of this study showed that the 14-strain probiotic mixture could be an effective and beneficial supplement to improve migraine headache in both chronic and episodic migraineurs. Further research is required to confirm our observations.

Chronic Migraine

Placebo-controlled study

10.1177/0333102418820102

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Citations (78)

The association between dietary tryptophan intake and migraine

Neurological Sciences (2019)

Soodeh Razeghi Jahromi Mansoureh Togha Zeinab Ghorbani Azita Hekmatdoost Faezeh Khorsha

Quartile

10.1007/s10072-019-03984-3

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Citations (23)

The epidemiologic pattern of the accidents reported to the firefighting and safety services organization in Zahedan, 2012-2014

Quarterly Scientific Journal of Rescue and Relief (2016)

Mohsen Divband Hossein Ansari R Mirzaee

Source

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Demographic characteristics of patients with suicide attempt in Bojnurd 2014

Journal of North Khorasan University of Medical Sciences (2016)

SK Hojjat SE Hatami M Norozi Khalili Sakine Beygom Kazemi M Aghabalaii Danesh

10.29252/jnkums.7.3.537

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Drug–Drug Interactions in Headache Medicine

Headache The Journal of Head and Face Pain (2016)

Hossein Ansari Sanaz Ziad

The main treatments in a majority of headache patients are pharmacologic therapies. As a result, it is imperative to have strong background in pharmacotherapy used to treat headaches in order to provide optimal therapy and avoid drug interactions. One of the main reasons for failure of pharmacologic treatment of headaches is drug-drug interactions (DDIs). While there are many distinct pathways and mechanisms in which DDIs can occur, most occur through alterations within the cytochrome P450 pathways (CYP). Drugs that cause induction, inhibition, or are simply substrates for these pathways are responsible for many of the DDIs.We review and discuss the important and potential DDIs of commonly used headache medication often encountered in clinical practice. We divide the drugs into two classes, abortive and preventive. Within each group we select the most commonly used drugs and provide a detailed discussion of the mechanisms of interaction for each. Also included are commonly used herbal supplements, which can interact with headache medications.Drug-drug-interactions are a major concern when developing a treatment regimen for patients suffering from headaches. There is a growing need for physician attention to the pharmacokinetics of drugs to improve the quality of patient care. It is vital that prescribing physicians be aware of the DDIs associated with the commonly prescribed headache medications to optimize patient care and therapy results.

Pharmacotherapy

Regimen

10.1111/head.12864

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Citations (29)

Cluster-Tic or Tic-Cluster? Trigeminal Neuralgia (Tic) Turning to Trigeminal Autonomic Cephalalgia (TAC) Following Venous Decompression of the Trigeminal Nerve: A Case Report and Review of the Literature

Patrick Chen Sharona Ben‐Haim Jason Handwerker Hossein Ansari

Abstract Objective: We present a rare case of Tic-cluster in the context of venous compression of the trigeminal nerve. Background: Cluster-Tic syndrome is a rare headache condition with features of both trigeminal neuralgia (Tic) and trigeminal autonomic cephalalgia symptom (TAC). Methods: Case report and review of literature. Results: A 75-year old man presents with left sided paroxysmal pain consistent with trigeminal neuralgia (Tic). Magnetic resonance demonstrated a venous compression of the posterior-medial aspect of the left trigeminal ganglion. He underwent microvascular decompression which confirmed petrosal vein compression with subsequent symptomatic resolution. After two years of remission, he had a new left unilateral throbbing headache consistent with International Classification of Headache Disorders (ICHD)- 3 cluster headache definition, which improved with steroids. Conclusion: Cluster-Tic syndrome has variable clinical presentations. Tic can precede cluster and the possible role of venous trigeminal compression in this headache remains unclear.

Cluster headache

Cephalalgia

Trigeminal Nerve

Microvascular Decompression

Nerve compression syndrome

10.30756/ahmj.2020.01.02

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Bariatric Surgery in Migraine patients: CGRP Level and Weight Loss

Obesity Surgery (2022)

Helia Hemasian Etefagh Shahab Shahabi Shahmiri Hamid Melali Masoud Sayadi Hossein Ansari

10.1007/s11695-022-06218-2

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Citations (5)

Primary Headache Disorders

Oxford University Press eBooks (2015)

Hossein Ansari F. Michael Cutrer

Primary (astronomy)

Primary headache

10.1093/med/9780190244927.003.0059

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Migraine Surgery

Bahman Guyuron Hossein Ansari Jeffrey E. Janis Ibrahim Khansa Ali Totonchi

10.1055/b-005-143643

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Citations (1)

The association between dietary acid load and the migraine odds

Research Square (Research Square) (2020)

Maryam Mousavi Soodeh Razeghi Jahromi Mansoureh Togha Zeinab Ghorbani Azita Hekmatdoost

Abstract Background : According to previous evidence, it has been shown that high acidic load in human body could affect inflammatory factors and the nitric oxide pathway. On the other hand, these factors are thought to play a role in initiation of migraine attacks. Therefore, we aimed to explore the association between dietary acid load and the odds of migraine in a case-control study. Methods: The migraine group (n=514, diagnosed according to the ICHDIII criteria) was recruited from a tertiary headache clinic. The controls consisted of 582 sex-matched healthy volunteers who were randomly selected from the general population. For dietary intake assessments, we used a validated 168-item semiquantitative food frequency questionnaire (FFQ). Using three different measures, such as potential renal acid load (PRAL), net endogenous acid production (NEAP), and protein /potassium ratio for estimation of the dietary acid load. Results: According to multivariable logistic regression analysis, in comparison with the lowest tertile, highest tertile of dietary acid load measures including PRAL (OR=7.208, 95% CI 3.33– 15.55), NEAP (OR=4.108, 95% CI 1.924– 8.774), protein/potassium ratio (OR=4.127, 95% CI 1.933– 8.814) were shown to significantly increase odds of migraine (P for trend= <0.001). Conclusions: In this study, it was found that high dietary acid load may be associated with higher odds of migraine. Consequently, restricting dietary acid load could be beneficial in reducing the odds of developing migraine in susceptible subjects.

Odds

10.21203/rs.3.rs-56657/v1

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