Gaëlle Blond

Université de Strasbourg

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Jean Suffert

Centre National de la Recherche Scientifique

Mihaela Gulea

Université de Strasbourg

Aïcha Boudhar

Genomics (United Kingdom)

Bernard R. Langlois

Université Claude Bernard Lyon 1

Thierry Billard

Institut de Chimie et Biochimie Moléculaires et Supramoléculaires

Mélanie Charpenay

Université de Strasbourg

Catherine Hulot

Université de Strasbourg

Mickaël Choury

Université de Strasbourg

Sarah Blouin

Centre National de la Recherche Scientifique

Julia Leuger

Université Claude Bernard Lyon 1

Cooperative Institutions

Centre National de la Recherche Scientifique

Université de Strasbourg

Laboratoire d'Innovation Thérapeutique

Pharmac

Université Paris Cité

Université Paris-Saclay

Institut Polytechnique de Bordeaux

Laboratoire de Chémo-biologie synthétique et thérapeutique

Université Paris-Sud

Interfaces Traitements Organisation et Dynamique des Systèmes

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

CCDC 206171: Experimental Crystal Structure Determination

The Cambridge Structural Database (2004)

Dschun Song Gaëlle Blond Alois Fürstner

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Crystal (programming language)

10.5517/cc6xjp9

Cite

Citations (0)

Synthesis of original polycycles containing five-, six- and seven-membered rings through cyclocarbopalladations/C–H activation cascade reactions

Comptes Rendus Chimie (2017)

Jessie Joussot Angèle Schoenfelder Jean Suffert Gaëlle Blond

Different types of starting materials have been designed and their ability to undergo cascade reactions has been investigated. New polycycles containing five-, six-, and seven-membered rings are described via original cascade reactions. The process works via a twofold cyclocarbopalladation followed by C(sp2)-H or C(sp3)-H activation. During these cascades, the palladium is moving several times along the carbon structure forming three new CC bonds and three new cycles. Différents types de substrats de départ ont été conçus et leur capacité à subir des réactions en cascade a été étudiée. De nouveaux polycyles contenant des cycles à 5, 6 ou 7 atomes ont été synthétisés par des réactions en cascade originales. Le processus fonctionne via une double cyclocarbopalladation suivie d'une activation C(sp2)-H ou C(sp3)-H. Au cours de cette cascade, le palladium se déplace plusieurs fois sur la structure en formant trois nouvelles liaisons C–C et trois nouveaux cycles.

10.1016/j.crci.2017.01.005

Cite

Citations (7)

Gold(I)‐Catalyzed Carbothiolation via Rearrangement of S‐Propargyl Group: An Access to 3‐Allenyl or 3‐Indenyl Benzo[b]thiophenes

Advanced Synthesis & Catalysis (2022)

Camille Van Wesemael Nicolas Brach Mihaela Gulea Gaëlle Blond

Abstract A series of 3‐allenyl benzo[b]thiophenes were synthesized through a gold(I)‐catalyzed domino reaction. The process consists in a 5‐ endo ‐dig cyclization with C−S bond formation and consecutive S‐to‐C propargyl migration via [3,3]‐sigmatropic Claisen rearrangement. With aryl substituents on both triple bonds of the substrate, subsequent intramolecular hydroarylation on the formed allenyl system led to 3‐indenyl benzo[b]thiophenes. From a substrate bearing a 3‐butynol moiety diverse fused O ‐heterocycles have been obtained via intramolecular hydroalkoxylation. A gold‐mediated 1,3‐migration involving allenyl to propargyl rearrangement is also described. magnified image

Propargyl

Moiety

Cycloisomerization

Triple bond

Domino

10.1002/adsc.202201000

Cite

Citations (4)

New stable reagents for the nucleophilic trifluoromethylation. Part 4: Trifluoromethylation of disulfides and diselenides with hemiaminals of trifluoroacetaldehyde

Tetrahedron Letters (2001)

Gaëlle Blond Thierry Billard Bernard R. Langlois

Trifluoromethylation

Hemiaminal

10.1016/s0040-4039(01)00225-8

Cite

Citations (108)

Fenestranes in Synthesis: Unique and Highly Inspiring Scaffolds

Angewandte Chemie International Edition (2013)

Aïcha Boudhar Mélanie Charpenay Gaëlle Blond Jean Suffert

Abstract The scaffold of fenestranes is quite unique, as it contains four condensed cycles and a distorted tetracoordinated central carbon atom with bond angles greater than the regular 109°28“. In this Minireview, a detailed overview on the developments regarding this compound class, including their synthesis, is given for the time period since 2006. In the past years, natural products that belong to the class of heterofenestranes have been isolated and their syntheses will also be discussed.

Carbon atom

10.1002/anie.201304555

Cite

Citations (45)

2.1.3 Domino Transformations Involving an Electrocyclization Reaction

Georg Thieme Verlag eBooks (2016)

Morgan Donnard Jean Suffert Mihaela Gulea Gaëlle Blond Sarah Blouin

Electrocyclization processes represent a powerful and efficient way to produce carbo- or heterocycles stereoselectively. Moreover, when electrocyclizations are involved in domino processes, the overall transformation becomes highly atom and step economic, enabling access to structurally complex molecules. This chapter is devoted to significant contributions published in the last 15 years, focusing on synthetic methodologies using electrocyclization as a key step in a domino process.

Domino

Domino Effect

Electrocyclic reaction

10.1055/sos-sd-220-00070

Cite

Citations (0)

Generation and Use of an Equivalent of Difluoroacetamide or Difluoroacetate Anions Part 3 of the Series: Reactivity of Stable Trifluoroacetaldehyde hemiaminals. Part 2: T. Billard, B. R Langlois, J. Org. Chem. 2002, 67, 997–1000.

Chemistry - A European Journal (2002)

Gaëlle Blond Thierry Billard Bernard R. Langlois

A new difluoromethylcarboxyl building block has been generated. Its reactivity towards various electrophiles allows the synthesis of various difluoromethylated compounds. Ethers of trifluoroacetaldehyde hemiaminals can undergo dehydrofluorination under basic conditions to provide ethers of difluoroketene hemiaminals. The latter behave as equivalents of difluoroacetamide or difluoroacetate anions towards various electrophiles, yielding a range of difluoromethylcarbonyl products. Les éthers d'hémiaminals du trifluoroacétaldéhyde subissent, en milieu basique, une déshydrofluoration pour conduire à des éthers d'hémiaminals de difluorocétènes. Ces derniers peuvent alors réagir comme des équivalents d'anions de dérivés de l'acide difluoroacétique envers divers électrophiles pour fournir des composés difluorométhylés variés.

Reactivity

10.1002/1521-3765(20020703)8:13<2917::aid-chem2917>3.0.co;2-m

Cite

Citations (15)

Fenestrane in der Synthese: einzigartige und inspirierende Grundgerüste

Angewandte Chemie (2013)

Aïcha Boudhar Mélanie Charpenay Gaëlle Blond Jean Suffert

Abstract Das Gerüst von Fenestranen ist einzigartig, da es vier kondensierte Ringe und ein verzerrtes vierfach koordiniertes zentrales Kohlenstoffatom aufweist, dessen Bindungswinkel größer als die regulären 109°28′′ sind. In diesem Kurzaufsatz wird eine detaillierte Übersicht über die Entwicklungen bezüglich dieser Verbindungsklasse, einschließlich ihrer Synthese, für den Zeitraum seit 2006 gegeben. In den vergangenen Jahren wurden Naturstoffe, die als Heterofenestrane klassifiziert werden können, isoliert, und deren Synthesen werden ebenfalls diskutiert.

10.1002/ange.201304555

Cite

Citations (22)

CCDC 783560: Experimental Crystal Structure Determination

The Cambridge Structural Database (2011)

Julien Pétrignet Aïcha Boudhar Gaëlle Blond Jean Suffert

10.5517/ccv9c4m

Cite

Citations (0)

Solvent Effect in Gold(I)-Catalyzed Domino Reaction: Access to Furopyrans

Organic Letters (2020)

Patrick Wagner Nayan Ghosh Vincent Gandon Gaëlle Blond

We report an efficient synthesis of furopyrans through a gold(I)-catalyzed domino reaction. By starting from the same source and changing the solvent of the reaction, two classes of furopyrans are accessible. During this one-step process, which takes place in DMF, two bonds and two heterocycles are formed. DFT calculations furnish the mechanistic understanding of this transformation. The sequence includes a 5-endo-dig cyclization, a regioselective 8-endo-dig cyclization, and a retro 8π and a 6π electrocyclization.

Domino

Cascade reaction

Dig

Sequence (biology)

Reaction conditions

10.1021/acs.orglett.0c02663

Cite

Citations (11)