Jean‐François Dierick

GlaxoSmithKline (Belgium)

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Olivier Toussaint

University of Namur

Florence Debacq‐Chainiaux

University of Namur

Thierry Pascal

GlaxoSmithKline (Belgium)

José Remacle

University of Namur

Christophe Frippiat

University of Basrah

Marie‐Laure Fauconnier

University of Liège

Pierre Delaplace

University of Liège

João Pedro de Magalhães

University of Birmingham

José Remacle

St. John's National Academy of Health Sciences

François Eliaers

University of Namur

Cooperative Institutions

University of Namur

Centre National de la Recherche Scientifique

Université Libre de Bruxelles

Ghent University

Inserm

Ghent University Hospital

Universidad Autónoma de Madrid

Chinese PLA General Hospital

National Institute of Advanced Industrial Science and Technology

University of Florence

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The Glossina morsitans tsetse fly saliva: General characteristics and identification of novel salivary proteins

Insect Biochemistry and Molecular Biology (2007)

Jan Van Den Abbeele Guy Caljon Jean‐François Dierick L. Moens Karin De Ridder

Glossina morsitans

Tsetse fly

Salivary Proteins

Identification

10.1016/j.ibmb.2007.06.006

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Citations (32)

Approach of evolutionary theories of ageing, stress, senescence-like phenotypes, calorie restriction and hormesis from the view point of far-from-equilibrium thermodynamics

Mechanisms of Ageing and Development (2002)

Olivier Toussaint José Remacle Jean‐François Dierick Thierry Pascal Christophe Frippiat

Calorie Restriction

Senescence

Hormesis

Calorie

Autocatalytic reaction

10.1016/s0047-6374(02)00031-3

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Citations (43)

Role of subcytotoxic stress in tissue ageing

Topics in current genetics (2003)

Olivier Toussaint Michel Salmon Véronique Royer Jean‐François Dierick João Pedro de Magalhães

Source

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Citations (2)

Regulation of the alpha-fetoprotein promoter: Ku binding and DNA spatial conformation

Biochimie (2006)

P. Liénard Christelle De Mees Pierre Luc Dreze Marc Dieu Jean‐François Dierick

Footprinting

Transcription

DNA footprinting

DNA binding site

Hypersensitive site

10.1016/j.biochi.2006.05.006

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Citations (6)

Characterization of RNA polymerase II subunits of Trypanosoma brucei

Molecular and Biochemical Parasitology (2006)

Sara Devaux Laurence Lecordier Pierrick Uzureau David Walgraffe Jean‐François Dierick

RNA polymerase II

RNA polymerase I

RNA polymerase III

Transcription

Small nuclear RNA

10.1016/j.molbiopara.2006.02.020

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Citations (33)

Potato (Solanum tuberosum L.) tuber ageing induces changes in the proteome and antioxidants associated with the sprouting pattern

Journal of Experimental Botany (2009)

Pierre Delaplace Marie‐Laure Fauconnier Kjell Sergeant Jean‐François Dierick Mouhssin Oufir

During post-harvest storage, potato tubers age as they undergo an evolution of their physiological state influencing their sprouting pattern. In the present study, physiological and biochemical approaches were combined to provide new insights on potato (Solanum tuberosum L. cv. Désirée) tuber ageing. An increase in the physiological age index (PAI) value from 0.14 to 0.83 occurred during storage at 4 °C over 270 d. Using this reference frame, a proteomic approach was followed based on two-dimensional electrophoresis. In the experimental conditions of this study, a marked proteolysis of patatin occurred after the PAI reached a value of 0.6. In parallel, several glycolytic enzymes were up-regulated and cellular components influencing protein conformation and the response to stress were altered. The equilibrium between the 20S and 26S forms of the proteasome was modified, the 20S form that recycles oxidized proteins being up-regulated. Two proteins belonging to the cytoskeleton were also differentially expressed during ageing. As most of these changes are also observed in an oxidative stress context, an approach focused on antioxidant compounds and enzymes as well as oxidative damage on polyunsaturated fatty acids and proteins was conducted. All the changes observed during ageing seemed to allow the potato tubers to maintain their radical scavenging activity until the end of the storage period as no accumulation of oxidative damage was observed. These data are interpreted considering the impact of reactive oxygen species on the development and the behaviour of other plant systems undergoing ageing or senescence processes.

Sprouting

Solanum tuberosum

Proteome

Senescence

Proteolysis

10.1093/jxb/erp008

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Citations (58)

Haemorrhagic Diathesis in Neonatal Calves: An Emerging Syndrome in Europe

Transboundary and Emerging Diseases (2010)

Bart Pardon Lennert Steukers Jean‐François Dierick Richard Ducatelle V. Saey

In 2008 and 2009 a large number of cases of haemorrhagic diathesis (HD) in neonatal calves were reported in different European countries. In Flanders, 84 cases of neonatal HD in 30 herds were reported in this period. The disease typically affects calves younger than 1 month old from different breed and gender. Prominent clinical signs are cutaneous bleeding, petechiae on all mucosae, melena and often high fever. Early in the disease, the mental state of the animals is uncompromised. The typical haematological finding is pancytopenia, with severe to complete thrombocytopenia being the cause of the increased susceptibility to bleeding. In seven of the affected herds blood samples of calves of the same age group as the clinical case were collected and on six of those farms at least one subclinical case could be identified. Necropsy findings were generalized petechiae, ecchymoses or haemorrhages and variable lymphadenopathy. Histopathology of haemorrhagic lesions revealed multifocal extravasation of red blood cells (haemorrhage) with preservation of tissue architecture and absence of other abnormalities. Total bone marrow aplasia and depletion of all lymphoid tissue was the most prominent finding on histology. Activated macrophages and haemophagocytosis were seen on bone marrow cytology from two live calves. Polymerase chain reaction for bovine viral diarrhoea virus, bluetongue and epizootic haemorrhagic disease virus was negative. Several attempts to isolate a viral agent were unsuccessful.

Histopathology

Lymphocytopenia

Subclinical infection

10.1111/j.1865-1682.2010.01098.x

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Citations (50)

Recommendations of the VAC2VAC workshop on the design of multi-centre validation studies

Biologicals (2018)

Marlies Halder Hilde Depraetere Frédérique Delannois Arnoud M. Akkermans Marie‐Emmanuelle Behr‐Gross

Within the Innovative Medicines Initiative 2 (IMI 2) project VAC2VAC (Vaccine batch to vaccine batch comparison by consistency testing), a workshop has been organised to discuss ways of improving the design of multi-centre validation studies and use the data generated for product-specific validation purposes. Moreover, aspects of validation within the consistency approach context were addressed. This report summarises the discussions and outlines the conclusions and recommendations agreed on by the workshop participants.

Model Validation

10.1016/j.biologicals.2018.01.003

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Citations (6)

A Case of Imported Melioidosis Presenting as Prostatitis

Infection (2003)

A. M. Heyse Jean‐François Dierick H. Vanhouteghem Filip Ameye D Baert

Melioidosis

Burkholderia pseudomallei

Sulfamethoxazole

Trimethoprim

10.1007/s15010-002-2112-3