Ademir F. Morel

Universidade Federal de Santa Maria

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Ionara I. Dalcol

Universidade Federal de Santa Maria

Robert A. Burrow

University of Liverpool

Marco A. Mostardeiro

Universidade Federal de Santa Maria

Vinícius Ilha

Universidade Federal de Santa Maria

Eduardo Miranda Ethur

Univates

Alexandre T. Neto

Universidade Federal de Santa Maria

C.Z. Stuker

Universidade Federal de Santa Maria

Marcelo Pedroso

Universidade Federal de Santa Maria

Liziane Maria Barassuol Morandini

Universidade Federal de Santa Maria

Ubiratan F. da Silva

Universidade Federal de Santa Maria

Cooperative Institutions

Universidade Federal de Santa Maria

203

Universidade Federal de Santa Catarina

Universidade Federal do Rio Grande do Sul

Rede de Química e Tecnologia

Universidade Franciscana

Universidade de São Paulo

Universidade Estadual de Campinas (UNICAMP)

Departamento de Ciência e Tecnologia

University of Tübingen

Natura (Brazil)

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Oral treatment with methanolic extract of the root bark of Condalia buxifolia Reissek alleviates acute pain and inflammation in mice: Potential interactions with PGE2, TRPV1/ASIC and PKA signaling pathways

Journal of Ethnopharmacology (2016)

Róli Rodrigues Simões Igor dos Santos Coelho Caroline Cunha do Espírito Santo Ademir F. Morel Eliane Maria Zanchet

Capsaicin

Bisindolylmaleimide

TRPM8

10.1016/j.jep.2016.03.050

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Citations (16)

TheIn VitroGenotoxic Effect of Tucuma (Astrocaryum aculeatum), an Amazonian Fruit Rich in Carotenoids

Journal of Medicinal Food (2013)

Olmiro Cezimbra de Souza Filho Michele Rorato Sagrillo Luiz Filipe Machado Garcia Alencar Kolinski Machado Francine Carla Cadoná

Tucuma (Astrocaryum aculeatum) is an Amazonian fruit that presents high levels of carotenoids and other bioactive compounds such as quercetin. The extracts of tucuma peel and pulp present strong antioxidant activity which illustrate an elevated concentration that causes cytotoxic effects in human peripheral blood mononuclear cells (PBMCs). This study performed additional investigations to analyze the potential genotoxic effects of the tucuma extracts on PBMCs. The genotoxicity was evaluated by DNA fragmentation, Comet assay, and chromosomal instability G-band assays. The acute tucuma extract treatment showed genoprotective effects against DNA denaturation when compared with untreated PBMC cells. However, in the experiments with 24 and 72 h treatments to tucuma treatments, we observed low genotoxicity through a concentration of 100 μg/mL, some genotoxic effects related to intermediary concentrations (100–500 μg/mL), and more pronounced genotoxic effects on higher tucuma extract concentrations. After 24 h of treatment, the reactive oxygen species were similar among treatments and PBMC control groups. However, the caspase-1 activity related to the apoptosis and pyroptosis process increased significantly in higher tucuma concentrations. In summary, tucuma extracts, despite their higher antioxidant content and antioxidant activity, would present PBMCs genotoxic effects that are dependent on concentration and time exposition. These results need to be considered in future in vitro and in vivo studies of tucuma effects.

10.1089/jmf.2012.0287

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Citations (33)

Efficient Regiocontrolled Synthesis and Antimicrobial Activity of Pyrazoles

Synthesis (2007)

Mara Elisa Fortes Braibante Hugo T. S. Braibante Luciana de Carvalho Tavares S.F. Rohte Carla Costa

A series of 1,5-diphenyl-1H-pyrazol-3-amines, 3-ethoxy-5-phenyl-1H-pyrazole, 5-ethoxy-1,3-diphenyl-1H-pyrazole and 3-ethoxy-1,5-diphenyl-1H-pyrazole were efficiently prepared from the regiocontrolled cyclization of α-oxoketene O,N-acetals and/or β-oxo thioxoesters with hydrazine derivatives using montmorillonite K-10 as solid support with ultrasound. The antimicrobial activity of the heterocyclic compounds was evaluated by direct bioautography test.

Pyrazole

Azole

Hydrazine (antidepressant)

10.1055/s-2007-983771

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Citations (12)

CCDC 1850355: Experimental Crystal Structure Determination

The Cambridge Structural Database (2022)

J Dahmer Patrícia Marangon Luciana Adolpho Frederico Luiz Reis Graciela Maldaner

10.5517/ccdc.csd.cc203fwg

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Citations (0)

Synthesis of Tripeptide Fragments of 14-Membered Cyclopeptide Alkaloids

Journal für praktische Chemie (1997)

Marco A. Mostardeiro Eduardo Miranda Ethur Ademir F. Morel Ludger A. Wessjohann

10.1002/prac.19973390183

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Citations (3)

In vitro effects of Blepharocalyx salicifolius (H.B.K.) O. Berg on the viability of Echinococcus ortleppi protoscoleces

Revista do Instituto de Medicina Tropical de São Paulo (2017)

Charlise Bolson Noal Danieli Urach Monteiro Thiele Faccim de Brum Jéssica Emmanouilidis Régis Adriel Zanette

Scolicidal agents are important in the treatment of cystic echinococcosis. This study evaluated the scolicidal activity of the plant Blepharocalyx salicifolius (H.B.K.) Berg against Echinococcus ortleppi protoscoleces. The parasite species was identified by amplifying a fragment of the gene cytochrome c oxidase subunit 1 (COX 1). B. salicifolius crude extract at concentrations of 100, 200, 300 and 400 mg/mL was analyzed at different times (5, 10, 15, 30, 45 and 60 min). N-butanol and ethyl acetate fractions (100 and 200 mg/ mL) were also analyzed at 5, 10, 15 and 30 min. Both fractions showed 100% scolicidal activity at the concentration of 200 mg/mL at 5 min. Gallic acid, identified as the major compound of the ethyl acetate fraction- was responsible for the observed scolicidal activity. The results showed that crude extract and fractions of B. salicifolius have scolicidal effect against E. ortleppi protoscoleces.

10.1590/s1678-9946201759042

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Citations (5)

Chemical Composition and Inhibitory Effects of Hypericum brasiliense and H. connatum on Prolyl Oligopeptidase and Acetylcholinesterase Activities

Medicinal Chemistry (2016)

Maura Z. Santos Ionara I. Dalcol Luciana Adolpho Meritxell Teixidò Teresa Tarragó

The genus Hypericum (family Clusiaceae) comprises various species that are used in traditional medicine, such as wound healing, antidepressant, and anticancer agents.The aim of this study was to evaluate the inhibitory capacity of extracts and fractions from two Hypericum species used in the Brazilian folk medicine (H. brasiliense and H. connatum) against the enzymes prolyl oligopeptidase (POP), dipeptidyl peptidase-IV (DPP-IV), and acetylcholinesterase (AChE), as well as to identify their main active constituents.Dried aerial parts of H. connatum and H. brasiliense were subjected to extraction with 8:2 methanol-H2O. Each hydroalcoholic extract was fractioned resulting in ethyl acetate and aqueous fractions. The activity of POP, DPP-IV and AChE was determined in vitro in 96-well microplates.The main components identified in the plant extracts were chlorogenic acid (1), quercitrin (2), rutin (3), quercetin (4), and isoquercitrin (5). Hydroalcoholic extracts, ethyl acetate and aqueous fractions showed high POP inhibitory activity with IC50 values of 2.6 to 3.7 µg/mL. AChE and DPP-IV inhibitory effects were very low for all extracts and substances.Chlorogenic acid (1) and quercetin (4) were the main constituent responsible for the activity observed against POP. Parallel artificial membrane permeability assay of ethyl acetate fractions of both species showed that the metabolite that can effectively pass through the lipid membrane is 4, the aglycone form of 2, 3 and 5.

Quercitrin

Stigmasterol

Chlorogenic Acid

Oligopeptidase

Ursolic acid

Hyperforin

Aglycone

Hypericum

Hyperoside

IC50

10.2174/1573406411666151026121845

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Citations (4)

Limonin Derivatives: Synthesis Using Methodology in Solution and Heterogeneous Medium and Evaluation of the Antimicrobial Activity

Journal of the Brazilian Chemical Society (2015)

L. Carvalho de Tavares Tanize S. Fernandes Vinícius Ilha Alexandre Tiburski Neto Eveline W. dos Santos

We herein described the preparation of a novel series of limonin derivatives (modification in A-ring), which was synthesized efficiently using methodology in solution as well as in heterogeneous medium (K-10).In addition, we obtained derivatives by inserting the 1,2,3-triazole nucleus via click reaction and also prepared derivatives from reactions with limonin-7-oxime.All compounds were submitted to investigation of the antimicrobial activity against a collection of microorganisms.The results of the antimicrobial activity, in general, demonstrated that a relevant number of synthetic derivatives presented higher activity than the natural product.

Limonin

10.5935/0103-5053.20150266

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Citations (10)

Antinociceptive Effects of 14-Membered Cyclopeptide Alkaloids

Journal of Natural Products (2009)

Gabriela Trevisan Graciela Maldaner Nádia Aléssio Velloso Gabriela da Silva Sant’Anna Vinícius Ilha

The analgesic potential of six 14-membered-ring cyclopeptide alkaloids, namely, franganine (1), discarine B (2), scutianines B (3), C (4), and D (5), and adouetine X (6), have been investigated. Among the compounds tested, only franganine (1) and adouetine X (6) produced antinociceptive effects in a mouse model of acute pain, without inducing undesirable side effects. Furthermore, compound 6 also exhibited a pronounced analgesic effect in a chronic neuropathic pain model in mice. It has been found that adouetine X (6) can decrease the activities of Ca2+-ATPase and Na+/K+-ATPase in vitro. Thus, the present findings have demonstrated that adouetine X (6) is a promising analgesic agent.

10.1021/np800377y

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Citations (53)

Chapter 2 Cyclopeptide Alkaloids from Higher Plants

The Alkaloids. Chemistry and biology/The alkaloids. Chemistry and biology (2009)

Ademir F. Morel Graciela Maldaner Vinícius Ilha

Sensu stricto

10.1016/s1099-4831(09)06702-9

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Citations (15)