The purpose of this study was to contrast histologically the pulp response to formocresol with the response to electrosurgical pulpotomy in a primate model. Both the primary and permanent incisors and molars were treated. Coronal pulp amputation was accomplished mechanically. The remaining pulp stumps were treated by either formocresol or momentary electrosurgery exposure. Results were evaluated at one hour, one week, and two months postoperatively. Results with the conventional formocresol treatment were consistent with other studies showing favorable pulp response. The electrosurgical approach produced no furcation or periapical involvement and exhibited no evidence of necrosis in the apical two-thirds of the root. Histologically, in this study electrosurgery pulpotomy had as favorable a tissue response as the conventional formocresol treatment for the time studied.

Pulpotomy

Electrosurgery

Pulpectomy

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Citations (39)

Protooncogene activation in spontaneously occurring and chemically induced rodent and human lung tumors.

PubMed (1992)

Reynolds Sh Wiest Js Devereux Tr Anderson Mw You M

Human lung

Rodent model

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Citations (16)

Role of oncogenes in chemical carcinogenesis: extrapolation from rodents to humans.

PubMed (1988)

Anderson Mw Maronpot Rr Reynolds Sh

Proto-oncogenes are cellular genes that are expressed during normal growth and development processes. These genes can be activated to cancer-causing oncogenes by point mutations or by gross DNA rearrangement, such as chromosomal translocation or gene amplification. Activated versions of proto-oncogenes have been observed in various human and rodent tumours. Examples will be discussed, as will the activation of proto-oncogenes by chemical carcinogens. Most chemicals are classified as potentially hazardous to humans on the basis of long-term carcinogenesis studies in rodents. Oncogene analysis of tumours of spontaneous origin and from carcinogenesis studies may aid in risk analyses on the basis of rodent carcinogenesis studies.

Proto-Oncogenes

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Citations (7)

A novel mechanism of in vivo ras gene activation involving tandem duplication of coding sequences.

PubMed (1994)

Wiest Js Burnett Vl Anderson Mw Reynolds Sh

Coding region

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Citations (5)

The clinical course of patients with calcific aortic stenosis.