Enrica Verné

Polytechnic University of Turin

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i-10 index

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Document Type

Co-Authors

Marta Miola

Polytechnic University of Turin

164

Chiara Vitale‐Brovarone

Polytechnic University of Turin

161

Francesco Baino

Polytechnic University of Turin

129

Sara Ferraris

Polytechnic University of Turin

110

Silvia Spriano

Polytechnic University of Turin

Oana Bretcanu

Newcastle University

Monica Ferraris

Ospedale Policlinico San Martino

Andrea Cochis

Università degli Studi del Piemonte Orientale “Amedeo Avogadro”

Elisa Fiume

Polytechnic University of Turin

Lia Rimondini

Università degli Studi del Piemonte Orientale “Amedeo Avogadro”

Cooperative Institutions

Polytechnic University of Turin

134

University of Turin

Università degli Studi del Piemonte Orientale “Amedeo Avogadro”

National Interuniversity Consortium of Materials Science and Technology

Torino e-district

National Research Council

Friedrich-Alexander-Universität Erlangen-Nürnberg

Centre National de la Recherche Scientifique

Politecnico di Milano

University of Bologna

Author Statistics

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Antibiotics and cements for the prevention of biofilm-associated infections

Elsevier eBooks (2015)

Giuseppe Massazza Alessandro Bistolfi Enrica Verné Marta Miola L Ravera

Surgical Site Infection

10.1533/9780857097224.2.185

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Citations (2)

3-D high-strength glass–ceramic scaffolds containing fluoroapatite for load-bearing bone portions replacement

Materials Science and Engineering C (2009)

Francesco Baino Enrica Verné Chiara Vitale‐Brovarone

Fluorapatite

Simulated body fluid

Load bearing

Bioactive Glass

10.1016/j.msec.2009.04.002

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Citations (77)

Magnetite and silica-coated magnetite nanoparticles are highly biocompatible on endothelial cells in vitro

Biomedical Physics & Engineering Express (2017)

Enrico Catalano Marta Miola Sara Ferraris Saša Novak Francesca Oltolina

Superparamagnetic iron oxide nanoparticles (MNPs) have recently been investigated for biological applications with promising results, owing to their ability to be targeted and heated by magnetic fields. Silica is a very suitable coating material for MNPs, facilitating the loading of targeting moieties and drug delivery. However, the potential toxicity of SiO2-coated MNPs remains a major concern for clinical application. The synthesis, via wet-chemistry, and physico-chemical characterization of Fe3O4 and silica coated (Fe3O4-SiO2) MNPs are here described, examining in vitro cytocompatibility including viability, necrosis, intracellular reactive oxygen species (ROS) generation and apoptosis, in an endothelial cell model. The results showed that both types of SPION are spherical, 10–15 nm in diameter and can be dispersed in water-based media. In vitro characterization revealed both to be highly cytocompatible at 10 μg ml−1 concentration, suggesting their safe use in biomedical applications. Cytotoxicity, including ROS generation and expression of apoptosis activating enzymes (caspase 3), slightly increased at 80 μg ml−1, in a dose dependent manner. Fe3O4-SiO2 nanoparticles induced a higher level of ROS and expression of caspase 3. In conclusion data suggest that both SPION types may be differently aimed in biomedical application in relation to the dose, acting as biocompatible materials, as component of scaffolds, or as a device for theranostics.

Biocompatible material

Viability assay

Superparamagnetism

10.1088/2057-1976/aa62cc

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Citations (14)

Macroporous bioactive glass-ceramic scaffolds for tissue engineering

Journal of Materials Science Materials in Medicine (2006)

Chiara Vitale‐Brovarone Enrica Verné P. Appendino

Simulated body fluid

Bioactive Glass

Porosimetry

Biomaterial

10.1007/s10856-006-0533-8

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Citations (99)

Crystallization behavior of SiO2–P2O5–CaO–MgO–Na2O–K2O bioactive glass powder

Biomedical glasses (2019)

Elisa Fiume Enrica Verné Francesco Baino

Abstract The crystallization process of a bioactive silicate glass with 47.5SiO 2 -10Na 2 O-10K 2 O-10MgO-20CaO-2.5P 2 O 5 molar composition was investigated by using nonisothermal differential t hermal a nalysis (DTA). T he DTA plots recorded at different heating rates exhibited a single crystallization peak. The activation energy for crystallization was estimated by applying the equations proposed by Kissinger and Matusita-Sakka. The Johnson-Mehl-Avrami exponent (n) was assessed by using the Ozawa and Augis-Bennett methods. The analyses suggest that a surface crystallization mechanism with one-dimensional crystal growth is predominant. The activation energy for viscous flow was also assessed (176 kJ/mol) and was found lower than the activation energy for crystallization (271 kJ/mol). This confirms the stability of 47.5B against crystallization and its good sinterability, which is a highly attractive feature for producing glass products of biomedical interest, such as bioactive porous scaffolds for bone repair.

Differential thermal analysis

10.1515/bglass-2019-0004

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Citations (17)

Composite bone cements loaded with a bioactive and ferrimagnetic glass-ceramic: Leaching, bioactivity and cytocompatibility

Materials Science and Engineering C (2015)

Enrica Verné Matteo Bruno Marta Miola Giovanni Maina Carlotta Bianco

Simulated body fluid

Bioactive Glass

10.1016/j.msec.2015.03.039

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Citations (48)

Processing of bone tissue engineering glass-ceramic scaffolds with adjustable strength and bioactive properties

Chiara Vitale‐Brovarone Enrica Verné Francesco Baino

Bioactive Glass

Mechanical strength

Source

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Citations (0)

Development of PMMA bone cement loaded with a ferrimagnetic bioactive glass ceramic for hypethermia treatment

Matteo Bruno Marta Miola Oana Bretcanu Andrea Cochis Lia Rimondini

INTRODUCTION The design of a composite material like Polymethylmethacrylate bone cement loaded with a bioactive and ferrimagnetic glass-ceramic is very useful against the development and proliferation of bone tumors. The biomaterial can be used in hyperthermia treatment that produces heat by hysteresis loss due to magnetic phase of the glass-ceramic[1]. The aim of the present work is the synthesis and characterization of a composite material in which the disperse phase is a glass ceramic (SC45) with magnetic property, embedded polymeric bone cement. EXPERIMENTAL METHODS The SC45 powders,(see [1] for the chemical composition) sieved below 20 micron, were mixed in different amounts (10, 15, 20% wt) with the polymeric solid phase of a commercial bone cement (Palamed®MV). The mixed powders and the liquid monomer of the bone cements were mixed manually for two minutes and after that put inside a mold, obtaining the composite cements. P10, P15, P20 and plain cement (as control) samples have been prepared. The characterizations were developed for all formulations proposed as described below. Mechanical testing of cement samples The compressive strength of the cement were evaluated according to standard ISO 5833 procedure. For each formulation 6 samples were tested. Calorimetric measurements The heat generation was measured with induction furnace at fixed frequency and alternate electromagnetic field. The samples were placed in a test tube with 10 ml of distilled water. The increase of temperature that occurred following the heat transfer from the magnetic phase of the composite to water, was measured with a thermocouple. SEM and EDS analysis before and after bioactivity test Scanning electron microscopy had been implemented to analyze the morphology and composition of the samples. RESULTS AND DISCUSSION The compression strength of the composites depends from the amount of glass-ceramic phase; nevertheless the reached values satisfy the ISO requirements ( >70 MPa). Calorimetric tests show an maximum increasing temperature of 40°C that respect the limit imposed by hyperthermia therapy. By soaking of the samples in SBF for 28 day the growth of hydroxyapatite was observed. CONCLUSION The preliminary experimental tests demonstrated a good mechanical properties and a good osteointegration. The calorimetric test evidenced a range of temperature adapted to biological environment. REFERENCES 1. O. Bretcanu et al. Journal of Magnetism and Magnetic Materials, 305 (2006) 529-533. ACKNOWLEDGMENTS The authors would like to thank to the MIUR Grant for Young researchers

Distilled water

Bone cement

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Composite Films of Gelatin and Hydroxyapatite/Bioactive Glass for Tissue-Engineering Applications

Journal of Biomaterials Science Polymer Edition (2010)

Piergiorgio Gentile Valeria Chiono Francesca Boccafoschi Francesco Baino Chiara Vitale‐Brovarone

Cross-linked gelatin/hydroxyapatite/bioactive glass (G/HA/CEL2) films with different compositions (100:0:0 (G1); 30:70:0 (G2); 30:0:70 (G3); 30:35:35 (G4) (%, w/w/w)) were prepared as scaffold materials for tissue-engineering applications, particularly in the field of bone repair. A bioactive glass with 45% SiO2, 3% P2O5, 26% CaO, 7% MgO, 15% Na2O and 4% K2O molar composition was selected (CEL2). Genipin was used as a cross-linker for the gelatin component. Samples were characterized in terms of their bioactivity, thermal properties, mechanical behaviour and cell compatibility. After only 3 days of incubation in simulated body fluid (SBF) at 37°C, calcium phosphate crystals precipitated on G3 and G4 surfaces, due to the high CEL2 bioactivity. Cross-linking increased the thermal stability of the gelatine component as indicated by thermal analysis (denaturation temperature was 92.3°C and 97.6°C for not cross-linked and cross-linked gelatin, respectively). Furthermore, tensile modulus of samples increased with increasing the inorganic phase amount (from 4.72 ± 0.23 MPa for G1 to 6.46 ± 0.05 MPa for G4). The adhesion and proliferation of human primary osteoblasts on composite films was evaluated. Cell viability was high with respect to the control for all samples and the presence of hydroxyapatite exerted an important role in the ability of mineralization.

Gelatin

Genipin

Simulated body fluid

Bioactive Glass

Thermal Stability

10.1163/092050609x12481751806213

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Citations (44)

Bioactive sol‐gel glasses: Processing, properties, and applications

International Journal of Applied Ceramic Technology (2018)

Francesco Baino Elisa Fiume Marta Miola Enrica Verné

Abstract Sol‐gel route has shown its enormous potential in tissue engineering applications as an advantageous method for the production of bioactive glasses aimed at regenerating both hard and soft tissues. This review discusses the chemical aspects of the method with emphasis on the morphological, chemical, mechanical, and biological properties of sol‐gel derived materials. The attention will be particularly focused on sol‐gel bioactive glasses and sol‐gel foam scaffolds for bone regeneration. The advantages deriving from the versatility of the sol‐gel method compared to the traditional melt‐quenching route will be underlined in terms of bioactivity, compositions, and processing parameters.

Bioactive Glass

10.1111/ijac.12873

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Citations (149)