Maristela Pereira

Instituto Federal do Espírito Santo

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Célia Maria de Almeida Soares

Universidade Federal de Goiás

Alexandre Melo Bailão

Universidade Federal de Goiás

Maria Sueli Soares Felipe

Universidade de Brasília

Clayton Luiz Borges

Universidade Federal de Goiás

Lívia do Carmo Silva

Universidade Federal de Goiás

Juliana Alves Parente

Marine Biological Laboratory

Kleber Santiago Freitas e Silva

Universidade Federal de Goiás

Rosália Santos Amorim Jesuíno

Universidade Federal de Goiás

Roosevelt Alves da Silva

Universidade Federal de Goiás

Silvia Maria Salem‐Izacc

Universidade Federal de Goiás

Cooperative Institutions

Universidade Federal de Goiás

233

Universidade de Brasília

117

Universidade de São Paulo

106

Universidade Federal de Minas Gerais

Universidade Federal do Rio Grande do Sul

Universidade Estadual de Campinas (UNICAMP)

Brazilian Agricultural Research Corporation

Fundação Oswaldo Cruz

Universidade Federal do Rio de Janeiro

National Council for Scientific and Technological Development

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Craneosinostosis sindrómica: Características craneodentofaciales, tratamiento ortodóntico-quirúrgico y factores asociados a tipos de síndrome

DOAJ (DOAJ: Directory of Open Access Journals) (2018)

Maristela Pereira Rafael Martins Afonso Pereira Márcia Pereira Guaita Fernanda Alessandra Silva Michels Cacio Moura Netto

Objetivos: Describir las caracteristicas craneodentofaciales, tratamientos ortodonticos-quirurgicos y establecer una asociacion entre los tipos de sindrome presentes en pacientes con craneosinostosis sindromica (CS). Material y metodos: Estudio retrospectivo de registros medicos y de ortodoncia de pacientes con CS. Los datos se recogieron en una forma especifica y se sometieron a un analisis estadistico descriptivo para observar la distribucion de frecuencias y se utilizo la prueba de Chi cuadrado con un nivel de significacion del 5% para asociar el sindrome y los tipos de variables. Resultados: El sindrome de Crouzon fue el tipo predominante (59.2%) y la braquicefalia fue el tipo mas frecuente de craneosinostosis (63.6%). Hubo una asociacion significativa entre las variables braquicefalia (p = 0,014), presencia de paladar hendido (p = 0,043), mordida cruzada posterior (p = 0,013), distraccion osteogenica realizada por elasticos intermaxilares (p = 0,030), barra de Erich (p = 0.007) y la extraccion (p = 0.041) y los sindromes estudiados. Conclusion: Los pacientes con CS a menudo tienen cambios craneodentofaciais y algunas variables tienen asociaciones significativas en relacion con los tipos de sindromes.

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PER-1 Extended-Spectrum β-Lactamase Production in anAlcaligenes faecalisClinical Isolate Resistant to Expanded-Spectrum Cephalosporins and Monobactams from a Hospital in Northern Italy

Microbial Drug Resistance (2000)

Maristela Pereira Mariagrazia Perilli Elisabetta Mantengoli Francesco Luzzaro Antonio Toniolo

An Alicaligenes faecalis (FL-424/98) resistant to expanded-spectrum cephalosporins and aztreonam was isolated from the urine of an inpatient at the Intensive Care Unit of the Varese Hospital (Northern Italy) after antimicrobial chemotherapy with cefazolin, vancomycin, and amikacin. Clavulanic acid restored the activity of expanded-spectrum cephalosporins, suggesting the production of an extended-spectrum β-lactamase (ESβL). A crude extract of FL-424/98 showed the presence of two β-lactamase activities focusing at pH 5.3 and 7.6, respectively. The ESβL activity, purified by means of three Chromatographic steps, was found to correspond to the pI 5.3 enzyme. Determination of kinetic parameters confirmed that the enzyme efficiently hydrolyzed expanded-spectrum cephalosporins and aztreonam. A colony-blot hybridization revealed the presence of blaPER-related sequences in FL-424/98, and sequencing confirmed the identity of this determinant with blaPER-1, previously detected in Pseudomonas aeruginosa, Acinetobacter, and Salmonella clinical isolates from Turkey. Finding of blaPER-1 in a species that can be part of the resident human microbiota raises the possibility that it could be an efficient shuttle for spreading of this resistance gene among other opportunistic pathogens that are normally members of the resident microbiota. Kinetic parameters determined for the PER-1 enzyme with some cephalosporin substrates were somewhat different from those previously reported.

Alcaligenes faecalis

Alcaligenes

Beta-lactamase

Broad spectrum

Cephalosporin C

10.1089/mdr.2000.6.85

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Citations (53)

Development, characterization, andin vitro–in vivoevaluation of polymeric nanoparticles containing miconazole and farnesol for treatment of vulvovaginal candidiasis

Medical Mycology (2017)

Adelaide Fernandes Costa Deize Evangelista Araújo Mirlane Santos Cabral Isabella Teles Brito Liliana Borges de Menezes Leite

Vulvovaginal candidiasis (VVC) is caused mainly by the opportunistic fungus Candida albicans, and its yeast to hyphae transition is considered a major virulence factor. Farnesol is a molecule that inhibits yeast to hyphae transition. The increased incidence of VVC has influenced a need for developing new therapeutic strategies. The objective was to develop a mucoadhesive nanostructured system composed of miconazole and farnesol co-encapsulated within chitosan nanoparticles. The miconazole presented a minimal inhibitory concentration (MIC) of 1 μg/ml against C. albicans. The farnesol was capable of inhibiting yeast to hyphae transition at levels greater or equal to 300 μM. The combination of miconazole and farnesol showed no change in miconazole MIC. Chitosan nanoparticles containing miconazole and farnesol were prepared by ionic gelation and showed favorable characteristics for use on mucous membranes. They showed size variation and polydispersion index (PDI) after 30 days, but the efficiency of drug encapsulation was maintained. Regarding toxicity in cultured fibroblasts (BALB/c 3T3) the nanoparticles were considered nontoxic. The nanoparticles showed antifungal activity against the C. albicans strain used with MICs of 2.5 μg/ml and 2 μg/ml for nanoparticles containing miconazole or miconazole/farnesol, respectively. Nanoparticles containing farnesol inhibited yeast to hyphae transition at concentrations greater than or equal to 240 μM. The in vivo antifungal activity was assessed in the murine model for VVC. The results suggested that chitosan nanoparticles containing miconazole and farnesol were effective at inhibiting fungal proliferation. Additionally, chitosan nanoparticles containing farnesol were capable of decreasing the pathogenicity of infection, demonstrated through the absence of inflammation.

Antifungal drugs

10.1093/mmy/myx155

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Citations (70)

Genes Potentially Relevant in the Parasitic Phase of the Fungal Pathogen Paracoccidioides brasiliensis

Mycopathologia (2010)

Clayton Luiz Borges Alexandre Melo Bailão Sônia Nair Báo Maristela Pereira Juliana Alves Parente

Paracoccidioides

Dimorphic fungus

Pathogenic fungus

10.1007/s11046-010-9349-7

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Citations (15)

Dynamic behavior of Dengue and Zika viruses NS1 protein reveals monomer–monomer interaction mechanisms and insights to rational drug design

Figshare (2019)

Ricardo Lemes Gonçalves Gabriela de Lima Menezes Luciane Sussuchi da Silva Marcos Lázaro Moreli Melina Mottin

Communicated by Ramaswamy H. Sarma

Zika Virus

Rational design

10.6084/m9.figshare.9958241

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Characterization of a chaperone ClpB homologue of Paracoccidioides brasiliensis

Yeast (2002)

Rosália Santos Amorim Jesuíno Maristela O. Azevedo Maria Sueli Soares Felipe Maristela Pereira Célia Maria de Almeida Soares

Abstract We report the cloning and sequence analysis of a genomic clone encoding a Paracoccidioides brasiliensis ClpB chaperone homologue ( Pb ClpB). The clpb gene was identified in a λ Dash II library. Sequencing of Pbclpb revealed a long open reading frame capable of encoding a 792 amino acid, 87.9 kDa protein, pI of 5.34. The predicted polypeptide contains several consensus motifs of the ClpB proteins. Canonical sequences such as two putative nucleotide‐binding sites, chaperonins ClpA/B signatures and highly conserved casein kinase phosphorylation domains are present. ClpB is 69% to 49% identical to members of the ClpB family from several organisms from prokaryotes to eukaryotes. The transcript of Pb clpB was detected as a mRNA species of 3.0 kb, preferentially expressed in the yeast parasitic phase of the fungus. A 89 kDa protein was also detected in yeast cells of P. brasiliensis . The sequence of the clpb gene and the deduced ClpB protein have been submitted to GenBank under Accession No. AF449501. Copyright © 2002 John Wiley & Sons, Ltd.

CLPB

Chaperone (clinical)

10.1002/yea.888

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Citations (19)

The complete genome sequence ofChromobacterium violaceumreveals remarkable and exploitable bacterial adaptability

Proceedings of the National Academy of Sciences (2003)

Ana Tereza Ribeiro de Vasconcelos Darcy F. de Almeida Mariangela Hungría C. T. Guimarães Regina Vasconcellos Antônio

Chromobacterium violaceum is one of millions of species of free-living microorganisms that populate the soil and water in the extant areas of tropical biodiversity around the world. Its complete genome sequence reveals ( i ) extensive alternative pathways for energy generation, ( ii ) ≈500 ORFs for transport-related proteins, ( iii ) complex and extensive systems for stress adaptation and motility, and ( iv ) widespread utilization of quorum sensing for control of inducible systems, all of which underpin the versatility and adaptability of the organism. The genome also contains extensive but incomplete arrays of ORFs coding for proteins associated with mammalian pathogenicity, possibly involved in the occasional but often fatal cases of human C. violaceum infection. There is, in addition, a series of previously unknown but important enzymes and secondary metabolites including paraquat-inducible proteins, drug and heavy-metal-resistance proteins, multiple chitinases, and proteins for the detoxification of xenobiotics that may have biotechnological applications.

Chromobacterium violaceum

ORFS

Bacterial genome size

Chitinase

Comparative Genomics

10.1073/pnas.1832124100

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Citations (275)

1-(4-Methoxyphenyl)-2-(6-methyl-2-nitro-3-pyridyloxy)propan-1-one

Acta Crystallographica Section E Structure Reports Online (2005)

Ivo Vencato Pedro Henrique Ferri Suzana C. Santos Maristela Pereira C. Lariucci

The title compound, C16H16N2O5, is a β-ketoether derivative closely related to natural 8,4′-oxyneolignans, which are of interest because of their moderate antifungal activity against systemic mycosis. The nitro group is not coplanar with the aromatic ring, as shown by a torsion angle of 47.2 (4)°. The molecules are linked by two non-classical intermolecular C—H⋯O hydrogen bonds with distances between donors and acceptors of 3.441 (5) and 3.539 (5) Å, leading to the formation of molecular stacking perpendicular to the bc plane.

Derivative (finance)

10.1107/s1600536804032301

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Phylogenetic characterization of Babesia canis vogeli in dogs in the state of Goiás, Brazil

Revista Brasileira de Parasitologia Veterinária/Brazilian Journal of Veterinary Parasitology (2011)

Sabrina Castilho Duarte Juliana Alves Parente Maristela Pereira Célia Maria de Almeida Soares Guido Fontgalland Coelho Linhares

The genus Babesia comprises protozoa that cause diseases known as babesiosis. Dogs are commonly affected by Babesia canis or Babesia gibsoni. Babesia canis is divided into the subspecies Babesia canis canis, Babesia canis vogeli and Babesia canis rossi. Among these, Babesia canis vogeli predominates in Brazil. The objective of this study was to conduct a phylogenetic analysis on Babesia isolates from dogs in Goiânia, Goiás. Blood samples were obtained from 890 dogs presenting clinical signs suggestive of canine babesiosis that were attended at a veterinary hospital of Goiás. Only samples presenting typical intraerythrocytic parasites were used in the study. These were subjected to DNA extraction and amplification of a fragment of the 18S rRNA, by means of PCR. The PCR products were purified and sequenced. Sequences were obtained from 35 samples but only 17 of these were kept after quality assessment. Similarity analysis using BLASTn demonstrated that all 17 sequences corresponded to B. canis vogeli. Analysis using the Mega4 software showed that the isolates of B. canis vogeli from dogs in Goiânia present a high degree of molecular similarity (99.2 to 100%) in comparison with other reference isolates from other regions of Brazil and worldwide, deposited in GenBank.

Babesia canis

10.1590/s1984-29612011000400004

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Citations (22)

Iron Deprivation Modulates the Exoproteome in Paracoccidioides brasiliensis

Frontiers in Cellular and Infection Microbiology (2022)

Aparecido Ferreira de Souza Laurine Lacerda Pigosso Lana O’Hara Souza Silva Italo Dany Cavalcante Galo Juliano D. Paccez

Fungi of the Paracoccidioides genus are the etiological agents of the systemic mycosis paracoccidioidomycosis and, when in the host, they find a challenging environment that is scarce in nutrients and micronutrients, such as Fe, which is indispensable for the survival of the pathogen. Previous studies have shown that fungi of this genus, in response to Fe deprivation, are able to synthesize and capture siderophores (Fe3+ chelators), use Fe-containing host proteins as a source of the metal, and use a non-canonical reductive pathway for Fe3+ assimilation. Despite all of these findings, there are still gaps that need to be filled in the pathogen response to metal deprivation. To contribute to the knowledge related to this subject, we obtained the exoproteome of Paracoccidioides brasiliensis (Pb18) undergoing Fe deprivation and by nanoUPLC-MSE. One hundred forty-one proteins were identified, and out of these, 64 proteins were predicted to be secreted. We also identified the regulation of several virulence factors. Among the results, we highlight Cyb5 as a secreted molecule of Paracoccidioides in the exoproteome obtained during Fe deprivation. Cyb5 is described as necessary for the Fe deprivation response of Saccharomyces cerevisiae and Aspergillus fumigatus. Experimental data and molecular modeling indicated that Cyb5 can bind to Fe ions in vitro, suggesting that it can be relevant in the arsenal of molecules related to iron homeostasis in P. brasiliensis.

Paracoccidioides

Fungal protein

10.3389/fcimb.2022.903070

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Citations (2)