Minsoon Kim

Sylvester Comprehensive Cancer Center

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Kibeom Jang

Sylvester Comprehensive Cancer Center

Joyce M. Slingerland

University of Miami

Dekuang Zhao

Shanghai Tenth People's Hospital

Tan A. Ince

NewYork–Presbyterian Brooklyn Methodist Hospital

Diana J. Azzam

Florida International University

Seth A. Wander

Harvard University

Alexandra H. Besser

University of California, San Diego

Hyunho Yoon

Sylvester Comprehensive Cancer Center

Burcu Ergonul

Sylvester Comprehensive Cancer Center

Pablo Torné‐Poyatos

Instituto de Investigación Biosanitaria de Granada

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University of Miami

Sylvester Comprehensive Cancer Center

Georgetown University

Georgetown University Medical Center

Universidad de Granada

Central South University

The University of Texas MD Anderson Cancer Center

Instituto de Investigación Biosanitaria de Granada

Complejo Hospitalario Universitario de Granada

Jackson Memorial Hospital

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p27 transcriptionally coregulates cJun to drive programs of tumor progression

Proceedings of the National Academy of Sciences (2019)

Hyunho Yoon Minsoon Kim Kibeom Jang Miyoung Shin Alexandra H. Besser

p27 shifts from CDK inhibitor to oncogene when phosphorylated by PI3K effector kinases. Here, we show that p27 is a cJun coregulator, whose assembly and chromatin association is governed by p27 phosphorylation. In breast and bladder cancer cells with high p27pT157pT198 or expressing a CDK-binding defective p27pT157pT198 phosphomimetic (p27CK−DD), cJun is activated and interacts with p27, and p27/cJun complexes localize to the nucleus. p27/cJun up-regulates TGFB2 to drive metastasis in vivo. Global analysis of p27 and cJun chromatin binding and gene expression shows that cJun recruitment to many target genes is p27 dependent, increased by p27 phosphorylation, and activates programs of epithelial–mesenchymal transformation and metastasis. Finally, human breast cancers with high p27pT157 differentially express p27/cJun-regulated genes of prognostic relevance, supporting the biological significance of the work.

10.1073/pnas.1817415116

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Supplementary Table S1 from Interactions between Adipocytes and Breast Cancer Cells Stimulate Cytokine Production and Drive Src/Sox2/miR-302b–Mediated Malignant Progression

Manuel Picon‐Ruiz Chendong Pan Katherine Drews‐Elger Kibeom Jang Alexandra H. Besser

<p>Primer Sequences.</p>

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10.1158/0008-5472.22408614.v1

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