Salvatore Siciliano

Escola Nacional de Saúde Pública

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Document Type

Co-Authors

Jailson Fulgêncio de Moura

Leibniz Centre for Tropical Marine Research

Rachel Ann Hauser‐Davis

Fundação Oswaldo Cruz

Martin S. Springer

National Renewable Energy Laboratory

Ana Paula Madeira Di Beneditto

State University of Norte Fluminense

Davi Castro Tavares

Leibniz Centre for Tropical Marine Research

Paulo Henrique Ott

Universidade Estadual do Rio Grande do Sul

Renata Emin‐Lima

Instituto Sócioambiental

Julie A. DeMartino

Merck (Germany)

Lorraine Malkowitz

Montclair State University

Leila Soledade Lemos

Florida International University

Cooperative Institutions

Migration Institute of Australia

559

STMicroelectronics (France)

291

Universidade de São Paulo

167

Fundação Oswaldo Cruz

149

Universidade Federal do Rio de Janeiro

119

Universidade Estadual Paulista (Unesp)

Instituto Chico Mendes de Conservação da Biodiversidade

Merck & Co., Inc., Rahway, NJ, USA (United States)

Universidade Federal do Rio Grande do Sul

Universidade do Estado do Rio de Janeiro

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Papers

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An enteric microbiota assessment in sharks and rays from the Brazilian Amazon Coast

Environmental Biology of Fishes (2025)

Ivana Correia Costa Salvatore Siciliano Rachel Ann Hauser‐Davis Natascha Wosnick Getulio Rincón

10.1007/s10641-025-01666-y

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Citations (0)

Cloning, expression, and characterization of the human eosinophil eotaxin receptor.

The Journal of Experimental Medicine (1996)

Bruce L. Daugherty Salvatore Siciliano Julie A. DeMartino Lorraine Malkowitz Anna Sirotina

Although there is a mounting body of evidence that eosinophils are recruited to sites of allergic inflammation by a number of beta-chemokines, particularly eotaxin and RANTES, the receptor that mediates these actions has not been identified. We have now cloned a G protein-coupled receptor, CC CKR3, from human eosinophils which, when stably expressed in AML14.3D10 cells bound eotaxin, MCP-3 and RANTES with Kds of 0.1, 2.7 and 3.1 nM, respectively. CC CKR3 also bound MCP-1 with lower affinity, but did not bind MIP-1 alpha or MIP-1 beta. Eotaxin, RANTES, and to a lessor extent MCP-3, but not the other chemokines, activated CC CKR3 as determined by their ability to stimulate a Ca(2+) -flux. Competition binding studies on primary eosinophils gave binding affinities for the different chemokines which were indistinguishable from those measured with CC CKR3. Since CC CKR3 is prominently expressed in eosinophils we conclude that CC CKR3 is the eosinophil eotaxin receptor. Eosinophils also express a much lower level of a second chemokine receptor, CC CKR1, which appears to be responsible for the effects of MIP-1 alpha.

CC chemokine receptors

CCR3

Allergic Inflammation

CCL13

CCL5

10.1084/jem.183.5.2349

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Citations (563)

Staphylococcus spp. isolated from wild birds apprehended in the local illegal trade in Rio de Janeiro, Brazil, and relevance in public health

Letters in Applied Microbiology (2018)

C. Matías Ingrid Annes Pereira Dália P. Rodrigues Salvatore Siciliano

This work aimed to investigate the prevalence of Staphylococcus in wild birds seized in illegal trade and their antimicrobial resistance patterns. Cloacal samples were obtained from 109 wild birds apprehended in the street markets in Rio de Janeiro, Brazil. Staphylococcus spp. were phenotypically and genotypically identified, and resistance profile was evaluated according to Clinical and Laboratory Standards Institute guidelines and by polymerase chain reaction of mecA and blaZ genes. Staphylococcus was detected in 45·9% (50/109) of the cloacal swab samples, and 39 (78·0%) isolates were resistant to one or more of the nine antimicrobials tested and were also positive to mecA (12/39) or blaZ genes (14/39). High percentage of resistance was detected to ampicillin, oxacillin, cefoxitin, clindamycin and tetracycline, with the absence of resistance to vancomycin. Wild birds captured and submitted to captive stress conditions of illegal trade market of Brazil may have an important role as reservoirs of Staphylococcus spp. and its antimicrobial resistance mechanisms. The significance of this study is revealed by the zoonotic and pathogenic potential of staphylococci and that impact to public health and requires monitoring polices of wild birds health in tropical areas.The isolation of Staphylococcus species that are not commonly isolated from wild bird faeces, the relatively high proportion of strains showing degrees of resistance to β-lactamics, lincosamides and tetracycline, and also the presence of mecA and blaZ genes that has been associated with multidrug phenotype reveal its public health relevance and zoonotic potential. Consequently, this represents an important route to transmission of this pathogen and its antimicrobial resistance mechanisms throughout national and international frontiers fostered by the illegal trade of wild animals and close contact with humans.

10.1111/lam.13035

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Citations (12)

Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains

Bioorganic & Medicinal Chemistry Letters (2004)

Dong‐Ming Shen Min Shu Sander G. Mills Kevin T. Chapman Lorraine Malkowitz

Piperidine

Moiety

CCR5 receptor antagonist

Pyrazole

Isoxazole

Side chain

Nitrogen atom

10.1016/j.bmcl.2003.12.004

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Citations (37)

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity

Bioorganic & Medicinal Chemistry Letters (2002)

Jeffrey J. Hale Richard J. Budhu Sander G. Mills Malcolm MacCoss Sandra L. Gould

CCR5 receptor antagonist

Pyrrolidine

10.1016/s0960-894x(02)00605-4

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Citations (19)

A toninha, Pontoporia blainvillei (Gervais & d'Orbigny, 1844) (Mammalia, Cetacea, Pontoporiidae), nos estados do Rio de Janeiro e Espirito Santo, costa sudeste do Brasil: caracterizacao dos habitats e fatores de isolamento das populacoes

Salvatore Siciliano Ana Paula Madeira Di Beneditto Renata Maria Arruda Ramos

Cetacea

Source

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Citations (35)

Interspecific variation of essential and non-essential trace elements in sympatric seabirds

Environmental Pollution (2018)

Jailson Fulgêncio de Moura Davi Castro Tavares Leila Soledade Lemos Esteban Acevedo‐Trejos Tatiana Dillenburg Saint’Pierre

10.1016/j.envpol.2018.06.092

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Citations (19)

Magellanic penguins: stomach contents and isotopic profiles to assess the feeding demands of juveniles in a wintering area off Brazil

Journal of the Marine Biological Association of the United Kingdom (2014)

Ana Paula Madeira Di Beneditto Roberta Aguiar dos Santos Karen Russel Rosa Salvatore Siciliano

The stomach contents of juvenile Magellanic penguins, Spheniscus magellanicus , stranded along the Atlantic coast (21–23°S) during the extreme mortality event of 2008 were analysed. The isotopic profiles of this species and their prey in a wintering area are presented to identify trophic relationships and to evaluate whether the prey species recovered in the stomach contents were assimilated. The prey groups recorded were molluscs (cephalopods and gastropods), teleost fish, and, to a lesser extent, crustaceans (decapods and isopods). Cephalopods were the most representative prey, and Argonauta nodosa was the most abundant species. Plant remains and solid waste were atypical items found in the stomach contents. The nitrogen isotope (δ 15 N) values found in this study confirm the higher trophic position of the penguins (14.5‰) relative to their prey (11.7–12.3‰). The carbon isotope (δ 13 C) measurements of all species are characteristic of marine coastal environments (−18.7 to −16.8‰). A Bayesian approach applied to stable isotope mixing models showed that cephalopods are assimilated to a greater extent than fish. However, the poor nutritional condition of specimens that reach the Brazilian coast, especially at the northern limit of migration (~21°S), indicates that prey ingestion is not sufficient for the maintenance of body weight.

Isotope Analysis

δ15N

10.1017/s0025315414001532

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Citations (18)

Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds

Bioorganic & Medicinal Chemistry Letters (2004)

Dong‐Ming Shen Min Shu Christopher A. Willoughby Shrenik Shah Christopher L. Lynch

Pyrrolidine

Piperidine

Pyrazole

Isopropyl