The purpose of this study was to determine whether quantitative pulmonary perfusion parameters obtained from 3D dynamic contrast-enhanced MR perfusion data can be used to assess the severity of primary pulmonary hypertension (PPH) as indicated by pulmonary vascular resistance (PVR) and mean pulmonary artery pressure (MPAP).Three-dimensional dynamic contrast-enhanced MRI has potential for assessment of disease severity as indicated by PVR and MPAP in patients with PPH.

Dynamic contrast

10.2214/ajr.05.0135

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Citations (117)

Dynamic MR imaging: value of differentiating subtypes of peripheral small adenocarcinoma of the lung

European Journal of Radiology (2004)

Yoshiharu Ohno Hiroto Hatabu Daisuke Takenaka Hidemasa Uematsu Chiho Ohbayashi

Pulmonary adenocarcinoma

Dynamic Contrast-Enhanced MRI

Dynamic contrast

10.1016/j.ejrad.2004.01.015

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Citations (37)

Respiratory gated lung CT using 320-row Area Detector CT

Rinshō hōshasen (2010)

Ryo Sakamoto S Noma Takanori Higashino Takanori Taniguchi Yuko Nishimoto

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Machine learning-based computer-aided simple triage (CAST) for COVID-19 pneumonia as compared with triage by board-certified chest radiologists

Japanese Journal of Radiology (2023)

Yoshiharu Ohno Takatoshi Aoki Masahiro Endo Hisanobu Koyama Hiroshi Moriya

Abstract Purpose Several reporting systems have been proposed for providing standardized language and diagnostic categories aiming for expressing the likelihood that lung abnormalities on CT images represent COVID-19. We developed a machine learning (ML)-based CT texture analysis software for simple triage based on the RSNA Expert Consensus Statement system. The purpose of this study was to conduct a multi-center and multi-reader study to determine the capability of ML-based computer-aided simple triage (CAST) software based on RSNA expert consensus statements for diagnosis of COVID-19 pneumonia. Methods For this multi-center study, 174 cases who had undergone CT and polymerase chain reaction (PCR) tests for COVID-19 were retrospectively included. Their CT data were then assessed by CAST and consensus from three board-certified chest radiologists, after which all cases were classified as either positive or negative. Diagnostic performance was then compared by McNemar’s test. To determine radiological finding evaluation capability of CAST, three other board-certified chest radiologists assessed CAST results for radiological findings into five criteria. Finally, accuracies of all radiological evaluations were compared by McNemar’s test. Results A comparison of diagnosis for COVID-19 pneumonia based on RT-PCR results for cases with COVID-19 pneumonia findings on CT showed no significant difference of diagnostic performance between ML-based CAST software and consensus evaluation ( p > 0.05). Comparison of agreement on accuracy for all radiological finding evaluations showed that emphysema evaluation accuracy for investigator A (AC = 91.7%) was significantly lower than that for investigators B (100%, p = 0.0009) and C (100%, p = 0.0009). Conclusion This multi-center study shows COVID-19 pneumonia triage by CAST can be considered at least as valid as that by chest expert radiologists and may be capable for playing as useful a complementary role for management of suspected COVID-19 pneumonia patients as well as the RT-PCR test in routine clinical practice.

McNemar's test

Triage

Institutional review board

10.1007/s11604-023-01495-y

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Assessment of bolus injection protocol with appropriate concentration for quantitative assessment of pulmonary perfusion by dynamic contrast‐enhanced MR imaging

Journal of Magnetic Resonance Imaging (2006)

Yoshiharu Ohno Kenya Murase Takanori Higashino Munenobu Nogami Hisanobu Koyama

Abstract Purpose To determine the appropriate concentration for quantitative assessment of dynamic contrast‐enhanced pulmonary MR imaging. Materials and Methods A total of 40 consecutive patients with small bronchioalveolar carcinoma underwent perfusion single‐photon emission tomography (SPECT) and three‐dimensional (3D) dynamic MR imaging with a 3D radiofrequency spoiled gradient‐echo sequence. In each patient, 5 mL of contrast media with 0.1, 0.3, and 0.5 mmol/mL were administered at a rate of 5 mL/second. All patients were divided into two groups (<70 kg and ≥70 kg) for assessment of appropriate concentration to quantitatively assess regional perfusion parameter in routine clinical practice. Pulmonary blood flow (PBF) in each protocol was calculated from a signal intensity (SI)–time course curve. Differences and limits of agreement of PBF between dynamic MR imaging (PBF MR ) using three different concentrations and perfusion SPECT (PBF SPECT ) were statistically compared in both patient groups. Results PBF MR using 0.3 mmol/mL in the <70‐kg group and 0.5 mmol/mL in the ≥70‐kg group showed no significant difference compared with PBF SPECT ( P > 0.05). Limits of agreements in 0.3 mmol/mL in the <70‐kg group and 0.5 mmol/mL in the ≥70‐kg group were smaller than those of the other concentrations and small enough for clinical purposes. Conclusion Appropriate concentrations provide accurate and reproducible assessments of regional pulmonary perfusion parameters on 3D dynamic MR perfusion imaging. We suggest using 5 mL of contrast media with 0.3 mmol/mL for patients weighing less than 70 kg and 0.5 mmol/mL for patients weighing 70 kg or more. J. Magn. Reson. Imaging 2007. © 2006 Wiley‐Liss, Inc.

Dynamic contrast

Bolus (digestion)

Dynamic imaging

Dynamic Contrast-Enhanced MRI

10.1002/jmri.20790

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Citations (48)

Dynamic Perfusion MRI Versus Perfusion Scintigraphy: Prediction of Postoperative Lung Function in Patients with Lung Cancer

American Journal of Roentgenology (2004)

Yoshiharu Ohno Hiroto Hatabu Takanori Higashino Daisuke Takenaka Hirokazu Watanabe

OBJECTIVE. The purpose of this study was to determine the capability of dynamic perfusion MRI as an alternative to pulmonary perfusion scintigraphy for prediction of postoperative lung function in patients with lung cancer.

Dynamic Contrast-Enhanced MRI

10.2214/ajr.182.1.1820073

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Citations (87)

New MR Imaging of Lung Cancer

Haigan (2003)

Yoshiharu Ohno Munenobu Nogami Takanori Higashino Hirokazu Watanabe Daisuke Takenaka

1991年のRadiologic Diagnostic Oncology Group (RDOG) の報告以来, 肺癌患者におけるMRIの臨床応用は限定された状況においてのみCTに対して相補的に用いられるにとどまってきた. 一方, 換気・血流シンチに代表される肺機i能診断法や, 2-[fluorine-18]-fluoro-2-deoxy-D-glucoseによるポジトロンエミッショントモグラフィー (FDGPET) に代表されるPET検査においては腫瘍の代謝を画像化する新たな画像診断法として脚光を浴びている. しかし, 近年のMR装置や撮像法の進歩及び各種造影剤の併用により肺癌患者のMRI診断における形態的, 機i能的評価能は飛躍的に進歩し, より正確且つ定量的評価を可能とし, 各種画像診断法の代替として潜在的に応用されうるものになりつつある.本稿においては肺癌のMRI診断について,(1) 肺腫瘤の質的診断,(2) 肺癌と二次変化の鑑別診断,(3) 縦隔浸潤診断,(4) 胸壁浸潤診断,(5) リンパ節転移診断,(6) 遠隔転移診断, 及び (7) 肺癌におけるMRIを用いた肺機能診断に関して最新の知見を踏まえて述べる. 肺癌におけるMRIの臨床応用及び研究に関しては, 様々な技術的問題点があるものの, 様々な分野での研究が進むことにより急速に進歩する可能性を秘めており, 近い将来MRIは肺癌診断の重要な一翼を担うものになると信ずる.

10.2482/haigan.43.818

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CT-Guided Transthoracic Needle Aspiration Biopsy of Small (≤ 20 mm) Solitary Pulmonary Nodules

American Journal of Roentgenology (2003)

Yoshiharu Ohno Hiroto Hatabu Daisuke Takenaka Takanori Higashino Hirokazu Watanabe

CT-Guided Transthoracic Needle Aspiration Biopsy of Small (≤ 20 mm) Solitary Pulmonary NodulesYoshiharu Ohno1, Hiroto Hatabu2, Daisuke Takenaka1, Takanori Higashino1, Hirokazu Watanabe1, Chiho Ohbayashi3 and Kazuro Sugimura1Audio Available | Share

Chest tube

10.2214/ajr.180.6.1801665

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Citations (266)

Pulmonary sarcoidosis: various HRCT patterns and differential diagnosis

臨床放射線 (2014)

Yuko Nishimoto Noma Shigeyuki Takanori Higashino Kusunoki Naoaki Akiko Terada

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