Abdel-Aziz A. El-Refaeey

Mansoura University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Visfatin gene expression and oxidative stress in pregnancy induced hypertension

Egyptian Journal of Basic and Applied Sciences (2017)

Hanan M.A. El-Taweel Nevein A. Salah Amal Selem Abdel-Aziz A. El-Refaeey A. F. Abdel-Aziz

Preeclampsia, a hypertensive disorder of pregnancy, was related to hypertension, diabetes, oxidative stress, obesity, in addition to polycystic ovarian diseases. Visfatin, potentially a new adipokine has emerged having high contribution in pathogenesis of preeclampsia. Oxidative stress was increased lipid peroxidation and caused vascular endothelial damage. This study was conducted with the aim of evaluating the level of visfatin gene expression in placenta and measuring some oxidative stress parameters. Eighty Egyptian patients of newly diagnosed pregnant hypertensive disorder were selected for the study which was recruited from Mansoura University Hospital, Department of Obstetrics and Gynecology and also normotensive pregnant women were collected. The pregnant women groups were classified into four groups: gestational hypertension (n = 20), mild preeclampsia (n = 16), severe preeclampsia (n = 25), chronic hypertension with superimposed preeclampsia (n = 19) and compared with normotensive pregnant women (n = 10) as control group. Visfatin gene expression level was decreased in placenta of pregnant hypertensive disorder women groups with mean 1.28 ± 0.42, 1.01 ± 0.24, 0.40 ± 0.14 and 0.32 ± 0.11 respectively when compared to normotensive pregnant women with mean 1.56 ± 0.69. Additionally, catalase activity, total antioxidant capacity and reduced glutathione levels were decreased in hypertensive pregnant women groups compared with normotensive ones. On the other hand malondialdhyde level was increased in preeclampsia groups when compared with normalized pregnant women. Decreased visfatin level has an important pathophysiology of preeclampsia and suggests the complication in pregnancy. Also the imbalance between oxidant and antioxidant has an important causative factor in the pathogenesis of preeclampsia.

Pathogenesis

Gestational hypertension

Endothelial Dysfunction

10.1016/j.ejbas.2017.12.002

Cite

Citations (6)

Relationship of paternal age with outcome of percutaneous epididymal sperm aspiration–intracytoplasmic sperm injection, in cases of congenital bilateral absence of the vas deferens

Fertility and Sterility (2015)

Samir Elhanbly Moustafa A. Elsaied Mohamed Fawzy Abdel-Aziz A. El-Refaeey Taymour Mostafa

Vas deferens

Testicular sperm extraction

Sperm Retrieval

10.1016/j.fertnstert.2015.06.020

Cite

Citations (15)

Association between Follicle Stimulating Hormone Receptor (FSHR) Polymorphism and Polycystic Ovary Syndrome among Egyptian Women

International Journal of Biochemistry Research & Review (2015)

Ahmed Abdelaziz Ahmed M.A. El-Sokkary Abdel-Aziz A. El-Refaeey Mohamed Mohamed Adel El‐Sokkary H. Osman

Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder and the criteria are specified by common complex genetic hyperandrogenism, oligomenorrhea or amenorrhea and polycystic ovary morphology.It is a leading cause of female infertility.The prevelance of PCOS among reproductive age women has been estimated to be 4-12%.The association between PCOS and FSH receptor (FSHR) polymorphism attracts wide attention.The aim of the present study was to evaluate whether polymorphism of FSHR at Ala307Thr codon is associated with PCOS and with

Hyperandrogenism

Follicle-stimulating hormone receptor

10.9734/ijbcrr/2015/13896

Cite

Citations (5)

Novel modification ofB‐Lynch uterine compression sutures for management of atonic postpartum hemorrhage:VVuterine compression sutures

Journal of Obstetrics and Gynaecology Research (2013)

Abdel-Aziz A. El-Refaeey Ahmed Gibreel Muhammad Fawzy

Abstract Aim The aim of this study was to demonstrate a novel modification of uterine compression sutures for use in women with primary postpartum hemorrhage and to evaluate its effectiveness. Material and Methods This was a prospective observational study. Nineteen patients with atonic postpartum hemorrhage were subjected to the novel VV uterine compression sutures at the time of cesarean delivery. Results The procedure was successful in 18 out of 19 women (94.7%) in controlling the bleeding and preserving the patient's uterus. Only one patient required supravaginal hysterectomy. Conclusions VV compression sutures comprise an easy, safe and effective procedure that can be applied in cases of atonic postpartum hemorrhage.

Cesarean delivery

Uterotonic

10.1111/jog.12166

Cite

Citations (7)

#977 Role of intraoperative sentinel lymph nodes sampling in the management of women with early ovarian cancers

Hanan Nabil Dina Samy Elsaied Abdel-Aziz A. El-Refaeey

Introduction/Background

Systematic paraaortic and pelvic lymphadenectomy is the standard of surgical staging in suspected early epithelial ovarian cancer, However, this procedure is associated with high morbidity. The concept of sentinel lymph node is to determine whether the cancer has spread to the first lymph node, If the sentinel node is negative for malignancy, then there is a high likelihood that the cancer has not spread to other lymph nodes, so if we can prove its accuracy, we can skip complete lymphadenectomy and its co morbidities.

Objectives

To assess the feasibility and the accuracy of the sentinel node procedure in early ovarian cancer. Methodology this is a prospective single-arm study included patients with presumed early stages epithelial ovarian cancer planned for staging laparotomy. After abdominal exploration and before removal of the ovary, 0.5 ml of methylene blue dye was injected on the dorsal and ventral side of the ovarian ligament and the infundiblo-pelvic ligament. The pelvic and lumboaortic retroperitoneum is then accessed and inspected to identify and remove the sentinel nodes, then staging is completed as usual including systematic pelvic and paraaortic lymphadenectomy.

Results

37 patients were included. Sentinel nodes were identified in 20 patients (detection rate, 54%). 3 patients had positive nodes out of 4 patients with lymphatic dissemination, (sensitivity, 75%) false-negative rate, 5%; negative predictive value, 93.7%, 3 (8%) intra- and 1 postoperative complication occurred.

Conclusion

The detection of sentinel node in early epithelial ovarian cancer is low using blue dye alone. However, the sentinel node procedure is feasible and has the potential to provide reliable and useful information on nodal status and may allow the avoidance of systematic lymphadenectomy in the future.

Disclosures

Nothing to disclose

Lymphadenectomy

Paraaortic lymph nodes

10.1136/ijgc-2023-esgo.679

Cite

Citations (0)

Does combined prednisolone and low molecular weight heparin have a role in unexplained implantation failure?

Archives of Gynecology and Obstetrics (2013)

Muhammad Fawzy Abdel-Aziz A. El-Refaeey

Prednisolone

Implantation failure

Basal (medicine)

10.1007/s00404-013-3020-8

Cite

Citations (37)