Johannes Baulmann

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H. Vetter

University Hospital Bonn

Rainer Düsing

Osnabrück University

Sakir Uen

University of Bonn

Stefan Richter

University of Applied Sciences Burgenland

Siegfried Eckert

Heart and Diabetes Center North Rhine-Westphalia

Marcus Dörr

Universitätsmedizin Greifswald

Kai Mortensen

University of Lübeck

Thomas Unger

Maastricht University

Marc‐Alexander Ohlow

SRH Wald-Klinikum Gera

Thomas Weber

Klinikum Wels-Grieskirchen

Cooperative Institutions

Charité - Universitätsmedizin Berlin

Universität Hamburg

University Medical Center Hamburg-Eppendorf

German Centre for Cardiovascular Research

Medical University of Graz

University Hospital Bonn

Universitätsmedizin Greifswald

University of Bonn

University of Lübeck

Humboldt-Universität zu Berlin

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C-FOS expression in the rat brain in response to substance P and neurokinin B

Brain Research (2001)

Heidi Spitznagel Johannes Baulmann Annegret Blume Thomas Unger Juraj Čulman

Forebrain

Neurokinin B

Neurokinin A

Tachykinin receptor

Tachykinin receptor 1

10.1016/s0006-8993(01)02858-x

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Citations (17)

Arterielle Gefäßsteifigkeit und Pulswellenanalyse

DMW - Deutsche Medizinische Wochenschrift (2010)

Johannes Baulmann Jens Nürnberger J Slaný R Schmieder Arno Schmidt‐Trucksäss

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study

10.1055/s-0030-1249183

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Citations (44)

Impact of Mental and Physical Stress on Blood Pressure and Pulse Pressure under Normobaric versus Hypoxic Conditions

PLoS ONE (2014)

Michael Trapp E Trapp J. Egger Wolfgang Domej Giuseppe Schillaci

Objective Hypobaric hypoxia, physical and psychosocial stress may influence key cardiovascular parameters including blood pressure (BP) and pulse pressure (PP). We investigated the effects of mild hypobaric hypoxia exposure on BP and PP reactivity to mental and physical stress and to passive elevation by cable car. Methods 36 healthy volunteers participated in a defined test procedure consisting of a period of rest 1, mental stress task (KLT-R), period of rest 2, combined mental (KLT-R) and physical task (bicycle ergometry) and a last period of rest both at Graz, Austria (353 m asl) and at the top station Dachstein (2700 m asl). Beat-to-beat heart rate and BP were analysed both during the test procedures at Graz and at Dachstein and during passive 1000 m elevation by cable car (from 1702 m to 2700 m). Results A significant interaction of kind of stress (mental vs. combined mental and physical) and study location (Graz vs. Dachstein) was found in the systolic BP (p = .007) and PP (p = .002) changes indicating that during the combined mental and physical stress task sBP was significantly higher under hypoxic conditions whereas sBP and PP were similar during mental stress both under normobaric normoxia (Graz) and under hypobaric hypoxia (Dachstein). During the passive ascent in cable car less trivialization (psychological coping strategy) was associated with an increase in PP (p = .004). Conclusion Our data show that combined mental and physical stress causes a significant higher raise in sBP and PP under hypoxic conditions whereas isolated mental stress did not affect sBP and PP under hypoxic conditions. PP-reaction to ascent in healthy subjects is not uniform. BP reactions to ascent that represents an accumulation of physical (mild hypobaric hypoxia) and psychological stressors depend on predetermined psychological traits (stress coping strategies). Thus divergent cardiovascular reactions can be explained by applying the multidimensional aspects of the biopsychosocial concept.

Mental stress

Hypoxia

10.1371/journal.pone.0089005

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Citations (44)

Cannabinoid receptor 1 inhibition improves cardiac function and remodelling after myocardial infarction and in experimental metabolic syndrome

Journal of Molecular Medicine (2013)

Svetlana Slavić Dilyara Lauer Manuela Sommerfeld Ulrich Rudolf Kemnitz Aleksandra Grzesiak

Rimonabant

10.1007/s00109-013-1034-0

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Citations (78)

Arterielle Gefäßsteifigkeit - Biomarker des kardiovaskulären Risikos und ihr Zusammenhang zu kardiovaskulären Erkrankungen

Journal für Hypertonie (2010)

Klaus Leth Mortensen Thomas Weber Johannes Baulmann

Abstract: Arterial Stiffness: Biomarker ofCardiovascular Risk and Association withCardiovascular Diseases. Today, the assess-ment of arterial stiffness experiences more andmore clinical valuation. The measured parame-ters (pulse wave velocity, augmentation indexand central pulse pressure) are very important inpathophysiological terms and share indepen-dent prognostic value. The assessment of theseparameters helps to identify and stratify pa-tients with a high risk for future cardiovascularevents. The impact of the modification of ar-terial stiffness requires further research todayas well as in the future. J Hyperton 2010; 14(2): 31–5. Aus der 1 Medizinischen Klinik II, Kardiologie und Angiologie, Campus Lubeck,Universitatsklinikum Schleswig-Holstein, Deutschland, 2 II. Internen Abteilung/Kardio-logie und Internistische Intensivmedizin, Klinikum Wels-Grieskirchen, und 3 Medizi-nischen Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Deutschland Korrespondenzadresse: Dr. med. Kai Mortensen, Medizinische Klinik II, CampusLubeck, Universitatsklinikum Schleswig-Holstein, D-23538 Lubeck, Ratzeburger Allee 160;E-Mail: kai.mortensen@uk-sh.de

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PM258 The effects of compound 21 on L-NAME-induced hypertension in rats

Global Heart (2014)

Ludovít Paulis Sophie T.R. Becker Patrick Schmerler Svetlana Slavić Elena Kaschina

10.1016/j.gheart.2014.03.1628

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ST-segment depression in hypertensive patients is linked to elevations in blood pressure, pulse pressure and double product by 24-h Cardiotens monitoring

Journal of Hypertension (2003)

Sakir Uen Johannes Baulmann Rainer Düsing K Glänzer H. Vetter

Various statements are made concerning peaks of heart rate (HR), blood pressure (BP) and double product (product of HR and systolic BP) as triggers for ST-segment depression. The aim of the present study was to identify determinants of ST-segment depression with a new ambulatory device for simultaneous 24-h electrocardiogram (ECG) and BP monitoring.A total of 63 treated patients (63 +/- 9 years, 33 women and 30 men) with arterial hypertension and ischemic heart disease were studied with a new ambulatory 24-h BP measurement (ABPM) device evaluated according to the BHS protocol (Cardiotens, Meditech, Hungary). This device allows simultaneous ST-segment analysis with extra BP recordings triggered by episodes of ST-segment depression.ST-segment (Holter ECG) depression (> 1 mm and > 60 s) was demonstrated in 26 patients with a mean duration of 4.95 +/- 2.6 min and a peak in the early morning hours. All ST-segment depressions were silent and occurred during a significant increase of BP (15 +/- 11 mmHg systolic and 10 +/- 5 mmHg diastolic, compared with the mean ABPM values) and a significant increase of the double product from 10 921 +/- 2 395 (24-h mean) to 14 515 +/- 2329 (during ST-depression). The recorded systolic and diastolic BP (SBP, DBP) values from the pre ST-event were significant higher compared with 24-h values (153 +/- 19 versus 145 +/- 22 mmHg systolic, 83 +/- 12 versus 78 +/- 14 diastolic). The mean pulse pressure (PP) value in the group with ST-depression was significantly higher than in the group without ST changes (69 +/- 16 versus 58 +/- 10 mmHg; P < 0.005). A total of 73% of patients with ST-events compared with 35% without ST-events showed a PP >or= 60 mmHg (P = 0.025).Simultaneous ABPM and ST-segment analysis identifies episodes of silent myocardial ischemia during increases of BP and HR. Hypertensive patients with ischemic heart disease and ST events show higher mean pulse pressure values than are observed in patients without events. A PP of >or= 60 mmHg is linked to an increased risk of silent myocardial ischemias.

Pulse pressure

Depression

ST depression

10.1097/00004872-200305000-00023

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Citations (41)

Validation of non-invasive central blood pressure devices: ARTERY Society task force consensus statement on protocol standardization

European Heart Journal (2016)

James E. Sharman Alberto Avolio Johannes Baulmann Athanase Bénétos Jacques Blacher

Brachial cuff blood pressure (BP) is clinically important, but may be an inaccurate substitute for central BP. Many non-invasive devices have been developed that purport to estimate central BP from peripheral artery sites, yet with no standardized guidelines; the accuracy testing of these new devices has not been undertaken in a uniform fashion with comparable protocols. This is an abridged paper describing the recommendations reached by an international task force convened to identify issues that need to be addressed and reach consensus relating to methods for assessing and reporting the accuracy (validation) of central BP devices. The recommendations are endorsed by the Association for Research into Arterial Structure and Physiology (ARTERY) Society, as well as the European Society of Hypertension (ESH) Working Group on Arterial Structure and Function, and the ESH Working Group on Blood Pressure Monitoring and Cardiovascular Variability. Researchers interested in validating central BP monitors should read the full version of the statement.

Task force

Statement (logic)

Brachial artery

Consensus conference

10.1093/eurheartj/ehw632

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Citations (209)

PREDICTORS OF SILENT MYOCARDIAL ISCHEMIA DETECTED IN DAILY LIFE

Journal of Hypertension (2004)

Sakir Uen Johannes Baulmann B Weisser Rainer Düsing H. Vetter

Uen, S.; Baulmann, J.; Weisser, B.; Düsing, R.; Vetter, H.; Mengden, T. Author Information

10.1097/00004872-200406002-00330

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Impact of anti‐infective periodontal therapy on parameters of vascular health

Journal Of Clinical Periodontology (2017)

Yvonne Jockel‐Schneider Markus Bechtold Imme Haubitz Stefan Störk Stefan Fickl

Abstract Aim This study assessed the impact of anti‐infective periodontal therapy on the status of vascular health. Materials and Methods Periodontal and vascular health of 55 patients with severe untreated chronic periodontitis was evaluated before and 12 months after anti‐infective periodontal therapy. Observed parameters were bleeding on probing (BoP), pocket probing depth ( PPD ), periodontal inflamed surface area index ( PISA ), pulse wave velocity ( PWV ), augmentation index ( AI x), central pulse pressure ( PP ao) and peripheral systolic pressure ( RR sys). Results Δ PISA (baseline‐12 months) correlated with Δ PWV (τ 0.21; p < .03), Δ AI x (τ 0.29; p < .002) and Δ PP ao (τ 0.23; p < .02). ΔBoP% (baseline‐12 months) correlated with Δ PWV (τ 0.18; p < .05) and Δ AI x (τ 0.25; p < .01), while mean Δ PPD (baseline‐12 months) correlated with Δ PWV (τ 0.24; p < .01) and Δ AI x (τ 0.21; p < .03). Grouping patients evenly into three groups based on tertiles of BoP resolution after 12 months revealed a significant decrease in the observed PWV median value by −0.6 m/s ( p < .04) in the best response tertile (ΔBoP ≥ 88%). In the worst response tertile (ΔBoP ≤ 66%), by contrast, significant increase in PP ao (+10.5 mmHg; p < .02) and AI x (+5.5; p < .02) was observed. Conclusion Efficacious resolution of periodontal inflammation may beneficially impact on vascular health.

Bleeding on probing

10.1111/jcpe.12849

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Citations (17)