I F Patrusheva

Institute of Experimental Cardiology

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ФТ

Ф. Т. Агеев

National Medical Research Center of Cardiology

Yа. A. Orlova

Lomonosov Moscow State University

БД

Б. Д. Кулев

Institute of Experimental Cardiology

ЗН

З. Н. Бланкова

National Medical Research Center of Cardiology

АК

А.Е. Кузьмина

Khakassian State University named after N.F. Katanov

Boris B. Salenko

Institute of Experimental Cardiology

Alexei P. Yurenev

Institute of Experimental Cardiology

E. M. Seredenina

Lomonosov Moscow State University

АП

А.Г. Плисюк

ВП

В П Зайцев

Research Centre for Medical Genetics

Cooperative Institutions

Institute of Experimental Cardiology

National Medical Research Center of Cardiology

Institute of Cardiology

Ministry of Health of the Russian Federation

Lomonosov Moscow State University

Moscow State University

University of Southern California

Russian Academy of Sciences

Kumamoto University

National Research Center for Preventive Medicine

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[Role of steroid hormones in the etiology and clinical course of hypertension].

PubMed (1979)

I K Shkhvatsabaia I F Patrusheva A. A. Nekrasova

Examination was conducted of 33 healthy persons and 85 individuals suffering from hypertensive disease (stage IB, 52 patients and stage IIB, 33 patients) from 18 to 45 years of age. The basal level of three steroid hormones (progesterone, aldosterone, hydrocortisone) was studied by the radio-immune method. It was established that stabilization of arterial pressure is attended by an increase in the aldosterone/progresterone and aldosterone/hydrocortisone ratios. During one stage of the disease the basal level of steroid hormones varied within different limits, particularly in labile hypertension. The interconnection of blood plasma steroid hormone level and the age, duration of the disease, aggravation by hereditary factors, level of arterial pressure and daily and basal natriuresis was revealed.

Basal (medicine)

Steroid hormone

Mineralocorticoid

Etiology

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The hypertensive heart: Pathogenesis, variants, and prognostic value.

Health Psychology (1988)

Alexei P. Yurenev Tkachuk Va А. В. Мазаев P B Dubov Elena G. Dyakonova

We examine the heart's involvement in arterial hypertension, reporting on several studies of hypertensive patients showing that left ventricular myocardial mass is a significant prognostic indicator of essential hypertension and that left ventricular hypertrophy (LVH) correlates with an induced increase in Ca2+ concentration in platelets. We also consider the LVH variant of asymmetric hypertrophy and the role of the hypertensive heart in coronary insufficiency, and we speculate on the significance of the degree of LVH and asymmetric hypertrophy as risk factors for predicting cardiac complications of essential hypertension.

Pathogenesis

Essential hypertension

Myocardial hypertrophy

10.1037/h0090274

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Citations (1)

Efficacy of relaxation techniques in hypertensive patients.

Health Psychology (1988)

Tatyana A. Aivazyan В П Зайцев Boris B. Salenko Alexei P. Yurenev I F Patrusheva

We examined 117 outpatients (20- to 45-year-old men) with mild essential hypertension before treatment, after the main treatment course (6 weeks), and at 12-month follow-up. The patients were randomized into two major groups: (a) a treatment group that received autogenic training (23 patients), biofeedback (24 patients), or breathing-relaxation training (23 patients) and (b) a control group that consisted of 24 patients who did not receive any intervention and 23 patients who were treated with a "psychological placebo." Clinical, psychological, and psychophysiological data from all patients who were offered relaxation therapy were analyzed. By the end of follow-up, and compared to the control group, the treatment group demonstrated a significant reduction in systolic and diastolic blood pressures, peripheral vascular resistance, and hypertensive response to emotional stress, and an improvement in psychological adaptation, quality of life, and capacity for work. Comparative analysis of the efficacy of different relaxation methods revealed that biofeedback and breathing-relaxation training resulted in the greatest reduction in blood pressure. The antihypertensive effect of relaxation therapy correlated positively with pretreatment blood pressure levels and negatively with the duration of illness and certain psychological features.

Autogenic training

Relaxation Therapy

Biofeedback

10.1037/0278-6133.7.suppl.193

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Citations (29)

[The effectiveness of psychorelaxation therapy in patients with hypertension].

PubMed (1988)

T A Aĭvazian В П Зайцев Boris B. Salenko А П Юренев I F Patrusheva

A study of 117 patients with labile essential hypertension before as well as 6 weeks and 12 months after psychorelaxation treatment (PRT), making use of autogenous training, biological feedback or respiratory relaxation training techniques (the main group), and the control patients, exposed to no psychological effects and those on the so-called psychological placebo, demonstrated a significantly greater fall of systolic and diastolic arterial blood pressure, total peripheral resistance and hypertensive response to emotional stress, as well as better psychological adaptation, quality of life and working capacity in the main-group patients, as compared to the controls, by the end of the study.

Placebo group

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[Treatment of patients with arterial hypertension in Moscow].

PubMed (2001)

А П Юренев I F Patrusheva М. Д. Смирнова L M Kunnova

To analyze treatment for arterial hypertension in Moscow.1056 case histories of hypertensive patients referred to Moscow city cardiological hospital in 1999 were analysed. The analysis covered the following issues: frequency of use of antihypertensive drugs depending on the disease stage; adequacy of the doses; changes in the treatment due to the presence of hypertrophy of the left ventricular myocardium, cardiac failure, vascular complications, diabetes mellitus.Treatment of hypertension was not adequate in many patients. Often, inadequate decisions were made on the drugs doses, course regimens, monotherapy.Insufficiently effective treatment of arterial hypertension can result in aggravation of the disease and frequent complications.

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Long-term reduction in aortic stiffness in routine clinical practice

Yа. A. Orlova I F Patrusheva З. Н. Бланкова I.V. Barinova Ф. Т. Агеев

Clinical Practice

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Фелодипин в амбулаторной практике: что может влиять на эффективность лечения и приверженность к терапии больных артериальной гипертонией

Т В Фофанова Yа. A. Orlova I F Patrusheva М. Д. Смирнова А.Е. Кузьмина

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LONG-TERM REDUCTION IN AORTIC STIFFNESS IN ROUTINE CLINICAL PRACTICE.

Journal of Hypertension (2011)

Yа. A. Orlova I F Patrusheva I.V. Barinova З. Н. Бланкова Ф. Т. Агеев

10.1097/00004872-201106001-01007

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Zofenopril in the treatment of patients with arterial hypertension and stable coronary heart disease: effects on oxidative stress and flowdependent vasodilatation

CARDIOVASCULAR THERAPY AND PREVENTION (2011)

Ф. Т. Агеев А. Г. Овчинников A. G. Plisyuk N. E. Arzamastseva Б. Д. Кулев

Aim. To compare the effects of ACE inhibitors zofenopril and perindopril on endothelial function and oxidative stress (OS) in patients with stable CHD and AH. Material and methods. In total, 40 patients with stable CHD (Functional Class II-III effort angina) and Stage 1-2 AH received zofenopril (7,5-30 mg/d; mean dose 18,6±8,8 mg/d; n=17) or perindopril (2-8 mg/d; mean dose 4,1±2,1 mg/d; n=23) for 12 weeks. At baseline and in the end of the study, all patients underwent reactive hyperemia test (RHT), to assess flow-dependent vasodilatation of brachial artery, and the measurement of OS parameters (malone dialdehyde, MDA, in low-density lipoproteins, MDALDL) and antioxidant parameters (superoxide dismutase (SOD) and glutathione peroxidase (GPO) activity in erythrocytes). Results. In both groups, a similar reduction in systolic and diastolic blood pressure levels was observed. In the zofenopril group, a significant elevation in brachial artery diameter increase during RHT, a significant increase in GPO activity, and some reduction in MDALDL levels were observed, which points to antioxidant system (AOS) activation and OS reduction. No similar changes of these parameters were observed in the perindopril group. Conclusion. In patients with stable CHD and AH, zofenopril, but not perindopril, reduced OS severity and increased AOS system activity, which was associated with improved endothelial-dependent vasodilatation.

Perindopril

Brachial artery

Reactive hyperemia

Endothelial Dysfunction

10.15829/1728-8800-2011-3-15-21

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Оценка влияния ингибитора ангиотензинпревращающего фермента моэксиприла на функциональное состояние сосудистой стенки у больных с артериальной гипертонией II-III степени

Кардиология (2007)

Ф. Т. Агеев Е.М. Середенина Yа. A. Orlova Б. Д. Кулев А.Г. Плисюк

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