ÁG

Álan Gomes Pöppl

Universidade Federal do Rio Grande do Sul

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Félix Hilário Díaz González

Universidade Federal do Rio Grande do Sul

Guilherme Luiz Carvalho de Carvalho

Universidade Federal do Rio Grande do Sul

Luiz Carlos Kucharski

Universidade Federal do Rio Grande do Sul

Priscila Viau Furtado

Universidade de São Paulo

Stella de Faria Valle

Universidade Federal do Rio Grande do Sul

Saulo Petinatti Pavarini

Universidade Federal do Rio Grande do Sul

Fabíola Peixoto da Silva Mello

Universidade Federal do Rio Grande do Sul

Milena Cleff de Oliveira

Universidade Federal do Rio Grande do Sul

Simone Tostes de Oliveira

Universidade Federal do Paraná

Luciana de Jesus

Universidade Federal do Rio Grande do Sul

Cooperative Institutions

Universidade Federal do Rio Grande do Sul

171

Universidade Federal de Santa Maria

Leipzig University

Universidade de São Paulo

Hospital de Clínicas de Porto Alegre

Hospital de Clínicas

Universidade Federal do Rio Grande

Universidade Estadual Paulista (Unesp)

Associação Brasileira de Oncologia Veterinária

University of Rio Grande and Rio Grande Community College

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Ovariohisterectomia em cadela e gatas : comparação entre os acessos laparoscópico e convencional

Mariana Lopes Pellizzari Fabiana Schiochet Antônio de Pádua Ferreira da Silva Filho Eduardo de Bastos Santos Emerson Antônio Contesini

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Oral metformin for type-2 diabetes mellitus treatment in a black-tufted marmoset (Callithrix penicillata)

Pesquisa Veterinária Brasileira (2024)

Janyni Duz Lívia Eichenberg Surita Letícia Machado Priscila Medina da Costa B.S. Machado

ABSTRACT: Type-2 diabetes mellitus (T2DM) is characterized by defects in insulin secretion and combined peripheral resistance to the hormone. Several non-human primates (NHP) species develop T2DM, mainly captive animals with reduced physical activity and incorrect feeding. This case report describes the T2DM treatment of a black-eared marmoset (Callithrix penicillata) by diet reformulation and metformin oral administration. An adult female was diagnosed with T2DM after hyperglycemia and high serum fructosamine associated with glycosuria and obesity. Metformin hydrochloride (125mg/animal, orally, q24h) associated with feeding intervention was started. After 26 days, a significant reduction in weight, glycemia, and serum fructosamine could be observed, showing satisfactory results for the adopted therapy. Metformin is considered a safe drug for T2DM treatment due to its low hypoglycemia risk. The new diet consisted of sweet potato, squash, and varied fruits offered twice daily. In addition, thawed-mice newborns, egg whites, and small portions of pelleted primate food. In the present report, metformin use, associated with a low glycemic index diet, was effective in treating this particular marmoset and may present a potential for T2DM treatment in other NHPs.

Glycosuria

Fructosamine

10.1590/1678-5150-pvb-7359

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Mixossarcoma esplênico em cão

ACTA SCIENTIAE VETERINARIAE (2017)

Taís Teixeira Zambarda Mariana de Jesus de Souza Jéssica Moreira Cannavon Clarisse Felten Saulo Petinatti Pavarini

Background: Myxosarcomas (MXS) are malignant mesenchymal neoplasms originated from mainly mucin producing fibroblasts than collagen. Despite malignant neoplasms, MXS is believed to have low metastase generation ability. Myxosarcomas reports in dogs are widespread, usually involving trunk and limbs subcutaneous tissue. The aim of this report is to describe clinical, pathological, and immunohistochemistry aspects of a rare case of splenic myxosarcoma in a dog.Case: A 10-year-old, intact male Basset Hound, weiging 25 kg, showing signals such apathy, dark soft-stooled stools, progressive thinning, and increasing abdominal enlargement, perceived three months ago was brought to clinical consultation. Physical examination showed extremely pale oral and ocular mucosas, in addition to mild dehydration (6%), 35.4°C rectal temperature, and a very bulging abdomen, with no fluids or gases, evidence at abdominal percussion. A complete blood count (CBC) revealed neutrophilic leukocytosis and anemia. Patient´s abdominal cavity ultrasound examination showed an heterogeneous mass, occupying large part of cavity, and apparently from spleen origin. A spleenic multilobulated mass measuring 25 x 12 x 20 cm was obtained after exploratory laparotomy. The mass showed predominantly soft consistency with some firm areas, and no visible mesentery or other abdominal organs adhesions. Mass and spleen histopathological examination were routinely processed for histological analysis with haematoxylin and eosin and alcian blue staining. In addition, fragments of the neoplasm were submitted to immunohistochemistry (IHC) which confirmed myxosarcoma diagnosis. The owner returned to hospital two months after, complaining for apathy, prostration, anorexia, and abdominal pain. A new ultrasound examination were suggestive of liver and kidneys neoplasms. The tutor opted for patient´s euthanasia. However, dog´s necropsy was not authorized.Discussion: Myxosarcomas are malignant tumors considered rare in small animals, affecting mainly middle age or advanced age patients. Corroborating with the present case, the main clinical signs identified in cases of splenic neoplasias, in general, are abdominal distention and algia, emaciation, prostration, anemia, hypothermia, and inappetence. Regarding neutrophilic leukocytosis and anemia in CBC, those alterations are atributable to paraneoplastic syndromes commonly observed in small animals. The diagnosis of myxosarcoma was based on the pathological and IHC findings. The mesenchymal origin of the neoplastic cells was confirmed by the expression of vimentin and by the absence of cytokeratin labeling in the immunohistochemical examination. It was possible to confirm the diagnosis due to the presence of large amount of mucopolysaccharides between the neoplastic cells, demonstrated through Alcian Blue staining. Although rare, there have been reports of metastasis from cardiac myxosarcoma in humans and splenic myxosarcomas in dogs. The patient’s resubmission in two months with a new nonspecific clinical picture and documentation of hepatic and renal masses supports the possibility of agressive metastatic disease in the present case, despite the non-authorization of the autopsy examination. It was concluded by the present case report that MXS, although uncommon in small animals, should be included as a differential diagnosis in cases of abdominal neoplasias. The histopathological analysis and the immunohistochemical examination of neoplasms are important and should be considered in order to establish diagnosis and prognosis in dogs. Despite not confirmed by post-morten examination, agressive metastic disease seems likely in the present report, and emphasize MXS´malignat nature.

Abdominal cavity

Abdominal mass

Leukocytosis

10.22456/1679-9216.86239

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An overweight/obesity survey among dogs and cats attended at a veterinary teaching hospital during the second year of the COVID-19 pandemic

Arquivo Brasileiro de Medicina Veterinária e Zootecnia (2022)

B.S. Machado C.E. Bruno D.I. Silva J.C. Barth L.P. Santos

ABSTRACT Anecdotal reports suggest that the new coronavirus SARS-CoV-2 pandemic (COVID-19) has increased overweight and obesity prevalence in dogs and cats. The present report aimed to perform a retrospective overweight/obesity survey on 1,001 consecutive cases attended in the Veterinary Clinics Hospital from the Federal University of Rio Grande do Sul during its reopening to the public after months closed due to the pandemic. The overall overweight or obesity observed prevalence was 36.63%; being the frequency in cats slightly greater (38.37%) than compared to dogs (35.76%). No local increase in these frequencies was detected. Neutering (dogs and cats), age greater than 10 years (dogs), and male gender (cats) were factors associated with overweight/obesity. Bodyweight was not registered in about 30% of the medical records, while the body condition score was not registered in about 50% of the cases. These flaws were more often observed in feline medical records and efforts to improve these data records are warranted.

Neutering

Medical record

Pandemic

10.1590/1678-4162-12696

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Estrus cycle effect on muscle tyrosine kinase activity in bitches

Veterinary Research Communications (2011)

Álan Gomes Pöppl Sandra Costa Valle Félix Hilário Díaz González Carlos Afonso de Castro Beck Luiz Carlos Kucharski

Basal (medicine)

10.1007/s11259-011-9513-7

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Chronic liver disease associated to copper accumulation in an American pitbull terrier - case report.

Archives of Veterinary Science (2012)

Luciana Andreatta Torelly Pinto Tatiane da Silva Mottin Marcele Bettim Bandinelli David Driemeier Álan Gomes Pöppl

Chronic liver disease

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Hiperadrenocorticismo associado com linfossarcoma hepático em cão – relato de caso

Veterinária em Foco (2010)

Éverton Eilert Rodrigues Melina Garcia Guizzo Eduardo de Freitas Costa João Pereira Guahyba Bisneto Simone Tostes de Oliveira

Hyperadrenocorticism or canine Cushing´s syndrome is a hormonal disturbance due to excessive endogenous glucocorticoid production or glucocorticoid excessive administration, resulting in high cortisol plasma levels. In Brazil, criterious mitotane administration is the most available efficient treatment. ACTH stimulation tests must be performed periodically with the aim of avoid hypocortisolism crisis in these patients. The purpose of this work was to report a pituitary-dependent hyperadrenocorticism (PDH) associated to hepatic lymphosarcoma in a 10 years old female Poodle that was being treated for PDH during one year. In a clinical revision owners report sickness, inappetence and prostration. Clinical examination evidenced icterus and abdominal pain. Leptospirosis was excluded by sorologic trial and by urinary PCR, as well as hypoadrenocorticism from ACTH stimulation test. Ultrassonography evidenced hepatomegalia with many heterogenic mass with irregular boards. Fine needle aspirative biopsia ultrassom guided evidenced lymphosarcoma. The patient died few days after biopsia.

Mitotane

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Influência do ciclo estral sobre a sensibilidade à insulina em fêmeas caninas.

Camila Lüdke Rossetti Álan Gomes Pöppl Sandra Costa Valle

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Applying Children's Enuresis Treatment with Amitriptyline for Canine Post-Spaying Urinary Incontinence: A Pilot Estriol-Controlled Randomized Clinical Trial

SSRN Electronic Journal (2022)

Luciana de Jesus Milena Cleff de Oliveira Daniela Jardim Lopes Fabíola Peixoto da Silva Mello Stella de Faria Valle

Urinary incontinence due to urethral sphincter mechanism incompetence (USMI) affects up to 20% of bitches that undergo spaying surgery. Amitriptyline is a tricyclic antidepressant whose urinary retention is a reported side effect. This study aimed to assess the efficacy and safety of amitriptyline when compared to estriol orally. Fifteen bitches with a clinical diagnosis of post-spaying UI were evaluated during 60 days in a non-blinded randomized clinical trial. All patients were enrolled after clinical evaluation consisting of anamnesis, physical examination, and complementary exams (hemogram, biochemical parameters, urinalysis, and abdominal ultrasound). The amitriptyline (AMT) group consisted of 8 bitches, which received the initial dose of 1mg/kg every 12 hours, whereas the estriol (EST) group consisted of 7 bitches which were initially treated with 1mg/animal every 24 hours. Patients underwent clinical evaluation at 7 days, and then at 21 and 60 days of treatment to assess safety and efficacy, as well as adjustments of dose when necessary. A urinary incontinence scale was used to assess the level of incontinence and therapeutic response to treatment. During the period of the study, estriol was fully effective in 71% of cases and amitriptyline in 62%. Both drugs proved safe in the medical treatment of USMI, with adverse effects such as somnolence (AMT, n=5/8) and male attraction (EST, n=1/7). The results support the amitriptyline recommendation as a substitute for estriol in USMI treatment.

Estriol

10.2139/ssrn.4290965

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Congresso Internacional da Associação Brasileira de Endocrinologia Veterinária

ACTA SCIENTIAE VETERINARIAE (2024)

Álan Gomes Pöppl

MENSAGEM DO DIRETOR CIENTÍFICO Chegamos a quinta edição do Congresso Internacional da Associação Brasileira de Endocrinologia Veterinária (CIABEV). Ao longo dos 14 anos de existência da ABEV, diversos eventos científicos foram promovidos pelas Comissões Científicas a cada gestão trazendo tópicos de atualização e oportunidades de reencontros e networking entre seus associados. Entretanto, nossos Congressos sempre foram o ápice da programação científica de cada gestão, e nesta quinta edição não será diferente. Além de uma grade de palestras elaborada com todo carinho pela Comissão Científica, buscando trazer tópicos atuais e relevantes para a endocrinologia, com palestrantes nacionais e internacionais renomados, 71 trabalhos científicos aprovados para apresentação enriquecerão a programação do evento com as novidades acadêmicas desenvolvidas por nossos congressistas. Desejamos que sua presença e convívio entre nossos pares endocrinólogos nacionais e internacionais durante o CIABEV traga além de atualização, conhecimento e novas perspectivas sobre velhos temas, muitos bons momentos de interações, conexões e parcerias para novos projetos. Que os tópicos cobertos na grade científica possam colaborar na rotina diária de cada congressista e refletir em melhores práticas para benefício de nossos pacientes. Obviamente, esperamos que a escolha de Foz do Iguaçu como nossa casa entre os dias 16 e 18 de outubro de 2024 favoreça momentos agradáveis de turismo e confraternização que façam com que o CIABEV 2024 seja motivo de agradáveis lembranças por muitos e muitos anos. Que tenhamos todos um excelente congresso!Prof. Dr. Álan Gomes Pöppl

10.22456/1679-9216.143095

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