Andrea Ruiz-Valdepenas Martin de Almagro

Cancer Research UK

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Anna Piskorz

Cancer Research UK Cambridge Center

James D. Brenton

University of Cambridge

Francesco Marass

ETH Zurich

Charlotte Hodgkin

Addenbrooke's Hospital

Christine Parkinson

Cambridge University Hospitals NHS Foundation Trust

James Morris

Nottingham University Hospitals NHS Trust

Linda Jones

Thomas Jefferson University

Dineika Chandrananda

Peter MacCallum Cancer Centre

Vincent Plagnol

Genomics (United Kingdom)

Sarah‐Jane Dawson

Peter MacCallum Cancer Centre

Cooperative Institutions

University of Cambridge

Cancer Research UK

Cancer Research UK Cambridge Center

Addenbrooke's Hospital

Cambridge University Hospitals NHS Foundation Trust

Barts Health NHS Trust

National Health Service

University College London

University of British Columbia

National Institute for Health Research

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Effects of Collection and Processing Procedures on Plasma Circulating Cell-Free DNA from Cancer Patients

Journal of Molecular Diagnostics (2018)

Bente Risberg Dana W.Y. Tsui Heather Biggs Andrea Ruiz-Valdepenas Martin de Almagro Sarah‐Jane Dawson

Circulating tumor DNA (ctDNA) offers new opportunities for noninvasive cancer management. Detecting ctDNA in plasma is challenging because it constitutes only a minor fraction of the total cell-free DNA (cfDNA). Pre-analytical factors affect cfDNA levels contributed from leukocyte lysis, hence the ability to detect low-frequency mutant alleles. This study investigates the effects of the delay in processing, storage temperatures, different blood collection tubes, centrifugation protocols, and sample shipment on cfDNA levels. Peripheral blood (n = 231) from cancer patients (n = 62) were collected into K

10.1016/j.jmoldx.2018.07.005

Cite

Citations (87)