Jin Sun

Shenyang Pharmaceutical University

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i-10 index

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Co-Authors

Zhonggui He

Shenyang Pharmaceutical University

242

Bingjun Sun

Shenyang Pharmaceutical University

Cong Luo

Shenyang Pharmaceutical University

Zhonggui He

Shenyang Pharmaceutical University

Yongjun Wang

Shenyang Pharmaceutical University

Mengchi Sun

Shenyang Pharmaceutical University

Yinghua Sun

Shenyang Pharmaceutical University

Qiming Kan

Shenyang Pharmaceutical University

Xuanbo Zhang

National University of Singapore

Shenwu Zhang

Shenyang Pharmaceutical University

Cooperative Institutions

Shenyang Pharmaceutical University

493

Chinese Academy of Sciences

197

Chinese Academy of Medical Sciences & Peking Union Medical College

108

Shanghai Jiao Tong University

103

Sun Yat-sen University

Zhejiang University

Nanjing Medical University

Sichuan University

University of Chinese Academy of Sciences

Huazhong University of Science and Technology

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Determination of Doxorubicin in Stealth Hyalurionic Acid-Based Nanoparticles in Rat Plasma by the Liquid–Liquid Nanoparticles-Breaking Extraction Method: Application to a Pharmacokinetic Study

Journal of Chromatographic Science (2016)

Xiaopeng Han Wei Wei Lu Zhong Cong Luo Chunnuan Wu

An efficient extraction of doxorubicin (Dox) from homemade stealth hyalurionic acid (HA)-based nanoparticles (NPs) in rat plasma could not be performed by previously published methods. Therefore, we attempted to establish the novel NPs-breaking and UPLC-MS-MS method for evaluating the pharmacokinetic profiles of the homemade stealth HA NPs in rats. The pretreatment method of plasma samples used the liquid-liquid extraction method with isopropyl alcohol as NPs-breaking and protein-precipitating solvents, and the NPs-breaking efficiency of isopropyl alcohol was as high as 97.2%. The analyte and gliclazide (internal standard) were extracted from plasma samples with isopropyl alcohol and were separated on UPLC BEH C18 with a mobile phase consisting of methanol and water (containing 0.1% formic acid). The method demonstrated good linearity at the concentrations ranging from 5 to 5,000 ng/mL. The intra- and interday relative standard deviations were >10%. Finally, the method was successfully applied to a pharmacokinetic study of homemade stealth HA-based NPs in rats following intravenous administration.

Isopropyl alcohol

Liquid–liquid extraction

Isopropyl myristate

10.1093/chromsci/bmw074

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Citations (4)

Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Advanced Healthcare Materials (2024)

Dongqi Sun Xinxin Sun Xuan Zhang Jiaping Wu Xianbao Shi

Abstract Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species ‐mediated cancer therapies, exhibiting its potential as a sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions and hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals. Its notable advantages in cancer treatment are demonstrated, including tumor specificity, autonomy from external triggers, and a favorable side‐effect profile. Recent advancements in nanomedicine are devoted to enhancing CDT, promising a comprehensive optimization of CDT efficacy. This review systematically elucidates cutting‐edge achievements in chemodynamic nanotherapeutics, exploring strategies for enhanced Fenton or Fenton‐like reactions, improved tumor microenvironment modulation, and precise regulation in energy metabolism. Moreover, a detailed analysis of diverse CDT‐mediated combination therapies is provided. Finally, the review concludes with a comprehensive discussion of the prospects and intrinsic challenges to the application of chemodynamic nanotherapeutics in the domain of cancer treatment.

Cancer Treatment

10.1002/adhm.202400809

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Citations (12)

Construction and identification of small hairpin RNA plasmids targeting neuropilin-1 gene and their inhibitory effect on human nasopharyngeal carcinoma CNE-2Z cell proliferation in vitro and in vivo

European Archives of Oto-Rhino-Laryngology (2016)

Jin Sun Liang Wang Weihua Lou Hua Cao Xiufen Tian

10.1007/s00405-015-3873-5

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Citations (3)

Enhanced paracellular and transcellular paclitaxel permeation by chitosan–vitamin E succinate–N-acetyl-l-cysteine copolymer on Caco-2 cell monolayer

Journal of Nanoparticle Research (2014)

He Lian Tianhong Zhang Jin Sun Xiaohui Pu Yilin Tang

Paracellular transport

Nanocarriers

Transcellular

10.1007/s11051-014-2355-9

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Citations (9)

In situ self-assembled nanomedicines for cancer treatment

Chemical Engineering Journal (2023)

Xinxin Sun Xiaohong Yang Yao Chen Jin Sun Zhonggui He

Nanocarriers

Cancer Therapy

Cancer Treatment

10.1016/j.cej.2023.143365

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Citations (16)

Nanotherapeutics for Antimetastatic Treatment

Trends in cancer (2020)

Fujun Yang Zhiqiang Zhao Bingjun Sun Qin Chen Jin Sun

10.1016/j.trecan.2020.05.001

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Citations (61)

Long-acting bioengineered platelets with internal doxorubicin loaded and external quercetin liposomes anchored for post-surgical tumor therapy.

PubMed (2025)

Qi Lu Zeyu Han Xia Wang Lili Du Xiaoyuan Fan

10.1016/j.jconrel.2025.02.042

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Citations (0)

Contributors

Elsevier eBooks (2019)

Eva Bauer Alison R. Bentley Hans‐Joachim Braun Susanne Dreisigacker Tzion Fahima

10.1016/b978-0-08-102163-7.09990-7

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Data from Wwox Suppresses Prostate Cancer Cell Growth through Modulation of ErbB2-Mediated Androgen Receptor Signaling

Haiyan Qin Dimitrios Iliopoulos Tatsuya Nakamura Stefan Costinean Stefano Volinia

<div>AbstractThe expression of the WWOX tumor suppressor gene is lost or reduced in a large fraction of various cancers, including prostate cancer. We previously reported that Wwox overexpression induced apoptosis and suppressed prostate cancer growth in vitro and in vivo. In this study, pathways through which Wwox contributes to control of prostate cancer cell growth have been investigated. We found that Wwox interacts with Ap2γ and prevents it from entering the nucleus to bind the ERBB2 promoter region to activate transcription of ERBB2, a mediator of androgen receptor activity and prostate cancer cell growth at limiting androgen concentration. Ectopic expression of Wwox reduced ErbB2 protein expression in vitro and expression of Wwox protein inversely correlated with expression of ErbB2 protein in prostate cancer tissues. Furthermore, Wwox suppressed Ap2γ/ErbB2–induced prostate cancer cell growth and suppressed prostate-specific antigen secretion through interaction with Ap2γ and down-modulation of ErbB2, an effect that required functional androgen receptor. (Mol Cancer Res 2007;5(9):957–65)</div>

WWOX

Ectopic expression

10.1158/1541-7786.c.6542880.v1

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Holistic identification and assessment of environmental risks of arable land use in two grain producing areas of China

Ecosystem health and sustainability (2020)

Guanyi Yin Zhulu Lin Xilong Jiang Jin Sun Menglong Qiu

ABSTRACT Taking two typical grain producing areas of southern (Dongting Lake Region) and northern China (Shandong Province) as examples, this study used fault tree analysis and parametric estimation to provide a comparative analysis for environmental risks of intensive arable land use. The results show that (1) in the risks of eutrophication, toxicity, soil structure, greenhouse effect and air pollution, the greenhouse effect was the most prominent with the highest discharge; (2) the Dongting Lake Region discharged less pollutants annually than did Shandong Province, while surpassing Shandong in cumulative pollutant discharge in 2007-2018; (3) the spatial distribution of environmental risk in the Dongting Lake Region was mostly concentrated in the northern area, whereas that in Shandong Province displayed a scattered pattern; (4) in the Dongting Lake Region, Yueyang, Changde, and Yiyang were high environmental risk cities in 2007-2018, whereas in Shandong Province, Zaozhuang, Heze, Liaocheng, and Dezhou exhibited higher comprehensive environmental risk indexes in 2007-2008, while Rizhao replaced them in 2018. The results indicated that ago-production material use must be controlled, reasonable zoning for areas posing environmental risks must be employed and cities with high environmental risk must be dynamically monitored to prevent the intensification of environmental risks of arable land use.

Arable land

Environmental Pollution

10.1080/20964129.2020.1784043

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Citations (5)