Behnaz Najafi

Tehran University of Medical Sciences

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Amir Hossein Abdolghaffari

Islamic Azad University Medical Branch of Tehran

Saied Goodarzi

Tehran University of Medical Sciences

Seyede Nargess Sadati Lamardi

Tehran University of Medical Sciences

Zahra Tofighi

Tehran University of Medical Sciences

Hassan Vatandoost

Tehran University of Medical Sciences

Mahnaz Khanavi

Tehran University of Medical Sciences

Abbas Hadjiakhoondi

Tehran University of Medical Sciences

Mahshad Marvi

Tehran University of Medical Sciences

Saeed Tavakoli

Academic Center for Education, Culture and Research

Mohammad Reza Abai

Tehran University of Medical Sciences

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Tehran University of Medical Sciences

University of Tehran

Academic Center for Education, Culture and Research

Iranian Research Institute of Plant Protection

Institute of Medicinal Plant Development

Universal Scientific Education and Research Network

Islamic Azad University Pharmaceutical Sciences Branch

Pharmaceutical Sciences Research Center

Jahrom University of Medical Sciences

Vector (United States)

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Isoimperatorin alleviates acetic acid–induced colitis in rats

Asian Pacific Journal of Tropical Biomedicine (2024)

Saied Goodarzi Amir Hossein Abdolghaffari Behnaz Najafi M Pirali Hamedani Saeed Tavakoli

Objective: To investigate the effect of isoimperatorin on histopathological and biochemical changes in acetic acid-induced colitis rats. Methods: Colitis was induced by intracolonic administration of acetic acid solution (4% v/v ) in rats. Rats were divided into six groups including the sham group, the negative control group, the dexamethasone-treated group, and the groups treated with isoimperatorin (0.1, 1, and 10 mg/kg/d by gavage). The treatments were administered for three days and then colonic status was assessed by macroscopic, histopathological, and biochemical analyses. Results: Isoimperatorin significantly alleviated colonic damage in a dose-dependent manner and improved histological changes in rats with acetic acid-induced colitis. It also significantly reduced myeloperoxidase, TNF-α, IL-1β, and malodialdehyde levels. Conclusions: Isoimperatorin alleviates acetic acid-induced colitis in rats and may be a potential therapeutic agent for the treatment of colitis.

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10.4103/apjtb.apjtb_851_23

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Chemical Constitute and Larvicidal Activity of Fractions of Ajuga chamaecistus tomentella Plant against Malaria Vector Anopheles stephensi.

DOAJ (DOAJ: Directory of Open Access Journals) (2017)

Mahnaz Khanavi Behnaz Najafi Seyede Nargess Sadati Lamardi Mohammad Reza Abai Hassan Vatandoost

The genus Ajuga, belongs to Lamiaceae family, is one of the exclusive subspecies in the flora of Iran. The plants of this genus are used traditionally for treatment of joints pain, gout, jaundice, and as insecticide.larvicidal activity of methanol 80% extract and partition fractions of hexane, chloroform, and ethyl acetate obtained from aerial parts of Ajuga chamaecistus subspecies tomentella against malaria vector An. stephensi was evaluated. Phytochemical study of active fraction was analyzed using column chromatography and spectroscopy.According to the results, among different fractions, hexane fraction has the most larvicidal activity with mortality rate of 100% in concentration of 102 ppm and LC50 of 95.66ppm. The structure of compound 1, main phytoecdysteroid compound separated from hexane fraction, was determined to be ajugalide-E.The results suggested that the hexane fraction of Ajuga chamaecistus subsp tomentella could be used as a natural and biodegradable insecticide.

Anopheles stephensi

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Hexane

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