Enyi Ye

Agency for Science, Technology and Research

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i-10 index

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Co-Authors

Zibiao Li

Agency for Science, Technology and Research

Xian Jun Loh

Agency for Science, Technology and Research

Ming‐Yong Han

Tianjin University

Karen Yuanting Tang

Agency for Science, Technology and Research

Jerry Zhi Xiong Heng

Agency for Science, Technology and Research

Qiang Zhu

Institute of Materials Research and Engineering

Houjuan Zhu

National University of Singapore

Michelle D. Regulacio

University of the Philippines Diliman

Yun‐Long Wu

Xiamen University

Ming Lin

Agency for Science, Technology and Research

Cooperative Institutions

Agency for Science, Technology and Research

203

Institute of Materials Research and Engineering

169

National University of Singapore

114

Nanyang Technological University

Chinese Academy of Sciences

University of Science and Technology of China

Singapore Polytechnic

Xiamen University

A*STAR Graduate Academy

Star Technology and Research (United States)

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Fabricating Dual-Functional Plasmonic–Magnetic Au@MgFe₂O₄ Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging

ACS Omega (2022)

Enhui Qiu Xiaofang Chen Da‐Peng Yang Michelle D. Regulacio Rufus Mart Ceasar R. Ramos

Bifunctional nanohybrids possessing both plasmonic and magnetic functionalities are of great interest for biomedical applications owing to their capability for simultaneous therapy and diagnostics. Herein, we fabricate a core-shell structured plasmonic-magnetic nanocomposite system that can serve as a dual-functional agent due to its combined photothermal therapeutic and magnetic resonance imaging (MRI) functions. The photothermal activity of the hybrid is attributed to its plasmonic Au core, which is capable of absorbing near-infrared (NIR) light and converting it into heat. Meanwhile, the magnetic MgFe2O4 shell exerts its ability to act as a MRI contrast agent. Our in vivo studies using tumor-bearing mice demonstrated the nanohybrids' excellent photothermal and MRI properties. As a photothermal therapeutic agent, the nanohybrids were able to dramatically shrink solid tumors in mice through NIR-induced hyperthermia. As T2-weighted MRI contrast agents, the nanohybrids were found capable of substantially reducing the MRI signal intensity of the tumor region at 10 min postinjection. With their dual plasmonic-magnetic functionality, these Au@MgFe2O4 nanohybrids hold great promise not only in the biomedical field but also in the areas of catalysis and optical sensing.

Plasmonic Nanoparticles

Photothermal effect

10.1021/acsomega.1c05486

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Citations (18)

Advances in photothermal nanomaterials for biomedical, environmental and energy applications

Nanoscale (2021)

Si Yin Tee Enyi Ye Choon Peng Teng Yūki Tanaka Karen Yuanting Tang

Highlights of various emerging inorganic photothermal nanomaterials and their up-to-date applications in photothermal therapy, photothermal sterilization, solar-driven steam generation and photothermal catalysis.

Nanomaterials

Photothermal effect

10.1039/d1nr04197e

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Citations (81)

Hierarchically Self-Assembled Supramolecular Host–Guest Delivery System for Drug Resistant Cancer Therapy

Biomacromolecules (2018)

Hongwei Cheng Xiaoshan Fan Xiaoyuan Wang Enyi Ye Xian Jun Loh

In this report, a new star-like copolymer β-CD-g-(PNIPAAm-b-POEGA)x, consisting of a β-CD core, grafted with temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and biocompatible poly(oligo(ethylene glycol) acrylate) (POEGA) in a block copolymer of the arms, was used to deliver chemotherapeutics to drug resistant cancer cells and tumors. The first step of the self-assembly process involves the encapsulation of chemotherapeutics through host–guest inclusion complexation between the β-cyclodextrin cavity and the anticancer drug. Next, the chain interaction of the PNIPAAm segment at elevated temperature drives the drug-loaded β-CD-g-(PNIPAAm-b-POEGA)x/PTX inclusion complex to hierarchically self-assemble into nanosized supramolecular assemblies at 37 °C, whereas the presence of poly(ethylene glycol) (PEG) chains in the distal end of the star-like copolymer arms impart enhanced stability to the self-assembled structure. More interestingly, this supramolecular host–guest nanocomplex promoted the enhanced cellular uptake of chemotherapeutics in MDR-1 up-regulated drug resistant cancer cells and exhibited high therapeutic efficacy for suppressing drug resistant tumor growth in an in vivo mouse model, due to the increased stability, improvement in aqueous solubility, enhanced cellular uptake, and partial membrane pump impairment by taking the advantage of PEGylation and supramolecular complex between this star-like copolymer and chemotherapeutics. This work signifies that temperature-sensitive PEGylated supramolecular nanocarriers with good biocompatibility are effective in combating MDR-1 mediated drug resistance in both in vitro and in vivo models, which is of significant importance for the advanced drug delivery platform designed to combat drug resistant cancer.

Cancer Therapy

10.1021/acs.biomac.7b01693

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Citations (58)

Carbon-based Nanomaterials

The Royal Society of Chemistry eBooks (2022)

Hong Chi Yaoguang Wang Zibiao Li Enyi Ye

Due to the full spectral absorption characteristics, versatile functionalization method, unique physical properties, biological compatibility, and high photothermal conversion efficiency, carbon-based nanomaterials are widely used in photothermal conversion. This chapter introduces the mechanism of photothermal conversion of carbon materials, shortlists and compares various hybrid carbon nanomaterials, and begins with the preparation of various carbon nanocomposites, with the properties of carbon dots, graphene, and carbon nanotube-supported metals, including semiconductors and polymer nanocomposites being of key interest. It then goes on to focus on photo-thermal catalytic conversion, seawater desalination, photothermal therapy, and photoacoustic/fluorescence imaging applications.

Nanomaterials

Carbon fibers

Surface Modification

Photothermal effect

10.1039/9781839165177-00305

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Citations (3)

Biomass-Derived Carbonaceous Materials: Recent Progress in Synthetic Approaches, Advantages, and Applications

ACS Sustainable Chemistry & Engineering (2019)

Da‐Peng Yang Zibiao Li Minghuan Liu Xiaoyan Zhang Lanying Li

Current energy shortages and environmental crises have compelled researchers to look for inexpensive and sustainable resources that can be obtained via environmentally friendly routes to produce novel functional materials. Biomass has been identified as one of the promising candidates given its availability in large quantities and renewable nature. Among the various feasible synthetic strategies, hydrothermal carbonization (HTC) has been admired for its energy efficiency and ability to synthesize carbonaceous materials for use in a wide range of applications. In this review, the different types of biomass and strategies available for the synthesis of carbon-based materials are discussed. Furthermore, factors influencing the efficiency of each strategy are analyzed and evaluated. Subsequently, the utilization of carbonaceous materials in environmental, catalytic, electrical, and biological applications are reviewed to further demonstrate their functionalities across different fields.

Hydrothermal Carbonization

Environmentally Friendly

Economic shortage

Carbon fibers

Renewable resource

10.1021/acssuschemeng.8b06030

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Citations (192)

Anisotropically branched metal nanostructures

Chemical Society Reviews (2015)

Enyi Ye Michelle D. Regulacio Shuang‐Yuan Zhang Xian Jun Loh Ming‐Yong Han

This tutorial review provides an essential introduction to colloidally prepared branched metal nanostructures and their utility in plasmonics, catalysis and biomedicine.

Biomedicine

10.1039/c5cs00213c

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Citations (165)

An experimental and theoretical investigation of the anisotropic branching in gold nanocrosses

Nanoscale (2015)

Enyi Ye Michelle D. Regulacio M. S. Bharathi Hui Pan Ming Lin

In this work, copper (Cu) species were used as reducing reagents in the colloidal preparation of novel cross-shaped gold (Au) nanostructures in oleylamine. The reduction rate can be controlled through an appropriate choice of Cu species to obtain Au nanocrosses of varying sizes. It was found that the presence of Cu species during the nucleation stage is crucial to the formation of a branched morphology. Further analysis revealed that the four primary branches of the Au nanocrosses grow along the <110> and <001> directions, and that secondary branched growth occurs along the <111> direction. First-principles calculations and phase-field models were used to rationalize the observed preferential branching and understand the morphological evolution of the nanocrosses. These unique cross-like Au nanostructures exhibit strong NIR absorption and remarkable plasmonic properties that make them promising materials for optical and biomedical applications.

Branching (polymer chemistry)

Oleylamine

Morphology

10.1039/c5nr07182h

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Citations (101)

Dual-Electric-Polarity Augmented Cyanoethyl Cellulose-Based Triboelectric Nanogenerator with Ultra-High Triboelectric Charge Density and Enhanced Moisture Resistance Performance

SSRN Electronic Journal (2022)

Nannan Wang Weihua Zhang Zibiao Li Sheng Wang Ady Suwardi

Moisture in environment can severely decrease the output of the solid-solid triboelectric nanogenerators (TENGs) which usually hinders their further practical applications. To solve this problem, we report a modified cellulose material that achieves ultra-high moisture resistance by acquiring universal dual-electric-polarity augmented property. This material shows enhanced contact electrification performance when contacted with different electrode materials. Results show that the electrical output of the TENG composed of cyanoethyl cellulose (CE-cellulose) with poly tetra fluoroethylene (PTFE) and nylon 11 (PA 11) increased by 4 and 8 times. Moreover, the triboelectric charge density (TECD) of CE-cellulose-PTFE based TENG at 95%RH is 533 μC/m2, which is a new record for the electrical output of TENG in high humidity environment. This work opens new avenues to the development of TENGs for energy harvesting and self-powered sensors under the real working conditions, especially in high humidity environments, even in the presence of water droplets.

Nanogenerator

Polarity (international relations)

10.2139/ssrn.4157498

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Citations (0)

Synthesis and studies on single crystal structure of [Ni(3,5-pdc)·H 2 O] (3,5-pdc=3,5-pyridinedicarboxylic acid)

Journal of Molecular Structure (2002)

Haitao Xu Nengwu Zheng Hanhui Xu Yonggang Wu Ruyi Yang

Coordination polymer

Hydrothermal reaction

Hydrothermal Synthesis

10.1016/s0022-2860(01)00858-4