Saeedeh Salimi

Zahedan University of Medical Sciences

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Mahnaz Rezaei

Zahedan University of Medical Sciences

Minoo Yaghmaei

Shahid Beheshti University of Medical Sciences

Mohsen Saravani

Zahedan University of Medical Sciences

Farzaneh Farajian‐Mashhadi

Zahedan University of Medical Sciences

Abbas Mohammadpour‐Gharehbagh

Zahedan University of Medical Sciences

Batool Teimoori

Zahedan University of Medical Sciences

Anoosh Naghavi

Zahedan University of Medical Sciences

Mojgan Mokhtari

Iran University of Medical Sciences

Mahnaz Sandoughi

Zahedan University of Medical Sciences

Marzieh Ghasemi

Zahedan University of Medical Sciences

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Zahedan University of Medical Sciences

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Tehran University of Medical Sciences

Iran University of Medical Sciences

Shahid Beheshti University of Medical Sciences

University of Tehran

Tabriz University of Medical Sciences

Hamedan University of Medical Sciences

Mashhad University of Medical Sciences

University of Sistan and Baluchestan

Isfahan University of Medical Sciences

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Lack of relationship between endothelial nitric oxide synthase gene 4b/a and T-786C polymorphisms with preeclampsia in southeast of Iran

Archives of Gynecology and Obstetrics (2011)

Saeedeh Salimi Anoosh Naghavi Mojgan Mokhtari Mehrangiz Noora Minoo Yaghmaei

Human genetics

10.1007/s00404-011-1952-4

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Citations (16)

Association of eNOS gene polymorphisms and systemic lupus erythematosus in southeast Iran

International Journal of Rheumatic Diseases (2014)

Mahnaz Sandoughi Saeedeh Salimi Zahra Zakeri Ebrahim Jahani Darbandi Mehdi Jahantigh

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with unknown etiology. Genetic and environmental factors play important roles in the pathogenesis of SLE. The primary objective of this study was to investigate the possible association of eNOS gene intron 4b/a, Glu298Asp and T-786C polymorphisms with SLE in southeast Iran populations.This was a case-control study comparing eNOS polymorphisms in 106 SLE patients and 196 age- and sex-matched healthy controls. The 4b/a, Glu298Asp and T-786C polymorphisms were analyzed using polymerase chain reaction and restriction fragment length polymorphism.Our findings indicated that the 4b/a polymorphism was associated with SLE, and the risk of SLE was 3.5- and 1.75-fold higher in patients with aa and ba genotypes than in patients with bb genotype. No association was observed between Glu298Asp and T-786C polymorphisms and SLE. There were no differences in eNOS gene polymorphisms between the Balouch and Fars population.Statistically significant differences were observed in genotypes and allele frequencies of 4b/a polymorphism between patients with SLE and healthy controls in southeast Iran.

Etiology

Pathogenesis

Gene polymorphism

10.1111/1756-185x.12510

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Citations (6)

MS278 THE RELEVANCE OF ANGIOTENSIN CONVERTING ENZYME AND ENDOTHELIAL NITRIC OXIDE SYNTHASE GLU298ASP GENE POLYMORPHISMS FOR SUSCEPTIBILITY TO CORONARY ARTERY DISEASE

Atherosclerosis Supplements (2010)

A.O. Naghavi Saeedeh Salimi Mohsen Firoozrai Sayed Mohammad Shafiee Ali Mohebbi

10.1016/s1567-5688(10)70779-0

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Citations (1)

Endothelial nitric oxide synthase gene Glu298Asp polymorphism in patients with coronary artery disease

Annals of Saudi Medicine (2010)

Saeedeh Salimi Mohsen Firoozrai Hamid Zand Alireza Nakhaee Sayed Mohammad Shafiee

BACKGROUND AND OBJECTIVES:Endo-derived nitric oxide (NO) is synthesized from L-arginine by endothelial nitric oxide synthase (NOS3). Since reduced NO synthesis in endothelial cells has been implicated in the development of coronary atherosclerosis, we investigated the association of NOS3 gene polymorphisms and coronary artery disease (CAD) in an Iranian population.SUBJECTS AND METHODS:We studied the NOS3 gene Glu298Asp polymorphism in 241 CAD patients with positive coronary angiograms (i.e., >50% stenosis affecting at least one coronary vessel) in Shahid Rajaee Heart Hospital and 261 control subjects without a history of symptomatic CAD. The NOS3 gene polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism. Lipid profile and other risk factors were also determined.RESULTS:The genotype frequencies of Glu298Asp polymorphism for Glu/Glu, Glu/Asp, and Asp/Asp were 61.3%, 32.2%, and 6.5%, respectively, in control subjects, and 46.5%, 42.7%, and 10.8% in CAD patients, respectively. The genotype frequencies differed significantly between the two groups (P=.003). The frequencies of the Asp alleles were 32.2% and 22.6% for CAD patients and control subjects, respectively; the difference between the two groups was statistically significant (P=.001; odds ratio=1.6). Plasma lipids, except HDL-C, were also significantly increased in the CAD groups.CONCLUSION:These results suggest that CAD is associated with Glu298Asp polymorphism of the NOS3 gene in our population and that this polymorphism is an independent risk factor for CAD.

Gene polymorphism

Coronary atherosclerosis

Genotype frequency

10.5144/0256-4947.59370

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Citations (15)

Lower Total Serum Protein, Albumin and Zinc in Depression in an Iranian Population

Journal of Medical Sciences(Faisalabad) (2008)

Saeedeh Salimi Mohsen Kianpoor Mahsa Abassi Mahdi Abdani E Sanee- Moghaddam

Depression

Serum Albumin

10.3923/jms.2008.587.590

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Association between TLR4 and TLR9 Gene Polymorphisms with Development of Pulmonary Tuberculosis in Zahedan, Southeastern Iran

The Scientific World JOURNAL (2013)

Danial Jahantigh Saeedeh Salimi Roya Alavi-Naini Abolfazl Emamdadi Hamid Owaysee Osquee

Some evidence suggests that a variety of genetic factors contribute to development of the tuberculosis (TB). TLR4 and TLR9 have been proposed as susceptibility genes for TB. This study was performed in 124 newly diagnosed TB cases and 149 healthy controls in a TB-endemic region of Iran. The TLR4 genes Asp299Gly, Thr399Ile, and TLR9 gene T-1486C polymorphisms were amplified by polymerase chain reaction (PCR) and then detected by PCR-restriction fragment length polymorphism (RFLP). The frequencies of the mutant alleles of TLR4 Arg299Gly, Thr399Ile, and TLR9 T-1486C polymorphisms were 0.8 versus 0.1, 5.6 versus 3, and 28.6 versus 25.2 in patients and controls, respectively, that were not significant. The synergic effect of TI,II/CC genotypes for TLR4 Thr399Ile and TLR9 T-1486C polymorphisms showed increased risk of PTB susceptibility. In conclusion, no significant relation was found between TLR4 and TLR9 polymorphisms alone and PTB. However, synergic effects of TLR4 Thr399Ile and TLR9-1486T/C polymorphisms might increase risk of PTB.

TLR9

10.1155/2013/534053

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Association of PvuII T> C and XbaI A> G Polymorphisms of Estrogen Receptor α Gene with Uterine Leiomyoma: A Case-Control Study

Gene Cell and Tissue (2018)

Mojgan Mokhtari Sepideh Zakerian Farzaneh Farajian‐Mashhadi Saeedeh Salimi

Background: Uterine leiomyomas (ULs) are benign tumors in the uterus that their growth and progression are stimulated by the estrogen hormone. In the current study, we aimed to determine if estrogen receptor α (ERα) polymorphisms could be used as the markers of the susceptibility to UL. Methods: The ERα gene polymorphisms of 154 UL women and 186 controls were genotyped by PCR or PCR-RFLP methods. Results: The frequency of ESRα PvuII T> C polymorphism genotypes did not differ among the women with leiomyoma and controls. However, the frequency of ESRα XbaI GG genotype was significantly higher than the frequency of AA genotype (27% vs 10%) in UL women and the UL risk was 4.1 folds greater in women carrying GG genotype (P < 0.0001). In the UL women, a higher frequency was observed for TG and CG haplotypes of ESRα PvuII/XbaI polymorphisms compared to TA haplotype and these haplotypes showed 3.2 and 1.5 folds increases in UL risk (P = 0.003 and P = 0.04, respectively). The frequency of CA haplotype was higher in controls, and the CA haplotype might have a potential to protect against UL (P = 0.04). Conclusions: The GG genotype of XbaI A> G polymorphism and TG and CG haplotypes of PvuII T> C / XbaI A> G polymorphisms could increase the risk of UL.

Estrogen receptor alpha

Uterine Leiomyoma

10.5812/ijhrba.79616

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Citations (2)

Impact of HOTAIR variants on preeclampsia susceptibility based on blood and placenta and in silico analysis

IUBMB Life (2019)

Abbas Mohammadpour‐Gharehbagh Danial Jahantigh Mohsen Saravani Mahdiyeh Harati‐Sadegh Rostam Maruie‐Milan

Abstract HOX transcript antisense RNA (HOTAIR) as a lncRNA involves in epigenetic regulation of various genes. Several studies have been suggested the effects of HOTAIR polymorphisms on different diseases. The aim of the present study was to evaluate the effect of maternal and placental HOTAIR polymorphisms on risk of preeclampsia (PE). The maternal blood of 203 preeclamptic and 202 nonpreeclamptic pregnant women as well as the placentas of 87 of preeclamptic and 95 nonpreeclamptic pregnant women were genotyped for HOTAIR polymorphisms. There was no association between maternal and placental HOTAIR polymorphisms (rs12826786, rs920778, and rs1899663) and PE risk. However, the maternal rs4759314AG and dominant model genotypes were associated with increased risk of PE. The maternal and placental HOTAIR rs10783618 polymorphism was associated with PE risk in recessive and allelic models. Haplotype analysis showed that, the maternal CTGAT and CCTAT and placental CTGAT haplotypes were significantly higher and maternal CTGAC, TCTAT, and TTGAT and placental CTGAC haplotypes were significantly lower in PE women. In silico analysis revealed that HOTAIR rs1899663 had a main effect on the secondary structure of mRNA, however, HOTAIR rs4759314 variant had potential alteration of splicing. In conclusion, the maternal and placental HOTAIR rs10783618 polymorphism might increase PE susceptibility. © 2019 IUBMB Life, 71(9):1367–1381, 2019

HOTAIR

10.1002/iub.2095

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Citations (23)

Association of H19 rs3741219 polymorphism with the susceptibility to uterine leiomyomas

Gene Reports (2020)

Farahnaz Farzaneh Saeedeh Salimi Maryam Razavi Mahnaz Rezaei Mohsen Saravani

SNP

Genetic Association

Uterine Leiomyoma

10.1016/j.genrep.2020.100623

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Citations (3)

Association of the osteopontin rs1126616 polymorphism and a higher serum osteopontin level with lupus nephritis

Biomedical Reports (2016)

Saeedeh Salimi Mehrangiz Noora Sima Nabizadeh Mahnaz Rezaei HOSSAIN SHAHRAKI

Osteopontin (OPN) is a chemokine-like glycoprotein that has a prominent role in regulating inflammation and immunity. OPN polymorphisms and elevated OPN levels are associated with systemic lupus erythematosus (SLE) in several populations. The aim of present study was to evaluate the association between the OPN rs1126616 polymorphism and OPN level with SLE susceptibility. A total of 163 SLE patients and 180 age‑, gender‑ and ethnically matched controls were genotyped for the rs1126616 polymorphism by the polymerase chain reaction‑restriction fragment length polymorphism method. Serum OPN levels were assayed by the enzyme‑linked immunosorbent assay. There was no association between the OPN rs1126616 C/T polymorphism and SLE. The frequency of the OPN rs1126616 CT genotype was significantly higher in SLE patients with nephritis compared to SLE patients without nephritis and controls. Additionally, the frequency of TT genotypes was higher in SLE patients with nephritis compared to controls. The serum OPN levels were significantly higher in SLE patients compared to controls (50.6±22 vs. 35.6±15.8 ng/ml, P<0.001). Increased serum OPN levels were observed in SLE patients with lupus nephritis and joint symptoms. There was no correlation between OPN levels and the OPN rs1126616 polymorphism. The present data suggest that the CT and TT genotypes of the OPN rs1126616 polymorphism could be a risk factor for lupus nephritis. The OPN level is associated with SLE and certain SLE manifestations. However, there was no association between the OPN rs1126616 C/T polymorphism and SLE susceptibility.

Osteopontin

Nephritis

10.3892/br.2016.589

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Citations (24)