Rogéria de Souza Nunes

Universidade Federal de Sergipe

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Ana Amélia Moreira Lira

Universidade Federal de Sergipe

Víctor Hugo Vitorino Sarmento

Universidade Federal de Sergipe

Adriano Antunes de Souza Araújo

Universidade Federal de Sergipe

Juliana Gouveia Galvão

Universidade Federal de Sergipe

A. M. Costa

Universidade Federal de Sergipe

Adriana de Jesus Santos

Universidade Tiradentes

Guilherme Rodolfo Souza de Araújo

Universidade Federal de Sergipe

Sócrates C.H. Cavalcanti

Universidade Federal de Sergipe

Ellen Denise Prado Almeida

Universidade Federal de Sergipe

Péricles Barreto Alves

Universidade Federal de Sergipe

Cooperative Institutions

Universidade Federal de Sergipe

201

Universidade de São Paulo

Universidade Tiradentes

Instituto de Tecnologia e Pesquisa

Universidade Federal de Pernambuco

Universidade Estadual de Campinas (UNICAMP)

Universidade Federal do Piauí

Nanomed (Brazil)

Universidade Federal de São Paulo

Instituto de Ciências Farmacêuticas

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Microencapsulação do óleo essencial de Citrus sinensis (L) Osbeck pelo método da coacervação simples

J. K. M. C. Gonsalves A. M. Costa Damião Pergentino de Sousa Sócrates C.H. Cavalcanti Rogéria de Souza Nunes

Dengue, a major public health problem in the world, is transmitted by Aedes aegypti. The chemical control, mainly organophosphates, is one of the most effective. However, the resistance shows up as a major problem. A viable alternative vector control would be the use of monoterpenes or their complex mixtures (essential oils). Limonene, the main constituent of essential oil of Citrus sinensis, has strong larvicidal activity against larvae of Aedes aegypti. Therefore, the use of oil in the larvicidal control of Aedes aegypti proved to be adequate. However, the low stability of essential oil (volatility, oxidation of the constituents, among others), use direct disadvantage and needs to be microencapsulation. In this sense microcapsules were prepared by simple coacervation and characterized by FTIR. Chitosan was used as a polymer forming wall showed a degree of deacetylation of 87.31%, the yield of the process of formation of microcapsules was 82.81% and the encapsulation efficiency of the essential oil was 31.16%. With the spectroscopic characterization was possible to observe the cross-linking of chitosan by glutaraldehyde (formation of imine grouping - 1656 cm-1).

Citrus × sinensis

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Citations (7)

Study of pre-formulation and development of solid lipid nanoparticles containing perillyl alcohol

Journal of Thermal Analysis and Calorimetry (2019)

Mariana S. S. Cavendish Luciana Nalone Thallysson Carvalho Barbosa Raquel de Melo Barbosa Salvana Priscylla Manso Costa

Dispersity

Zeta potential

Solid lipid nanoparticle

10.1007/s10973-019-09080-0

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Citations (19)

Encapsulation of Citrus sinensis essential oil and R-limonene in lipid nanocarriers: A potential strategy for the treatment of leishmaniasis

International Journal of Pharmaceutics (2024)

Jeferson da Silva dos Santos Juliana Gouveia Galvão Marcos Rafael das Chagas Mendonça A. M. Costa Audrey R.S.T. Silva

Zeta potential

Nanocarriers

Viability assay

Surface charge

10.1016/j.ijpharm.2024.124464

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Citations (3)

Chitosan/pvp-based mucoadhesive membranes as a promising delivery system of betamethasone-17-valerate for aphthous stomatitis

Carbohydrate Polymers (2018)

R. H. Sizilio Juliana Gouveia Galvão Gabriela G.G. Trindade Lícia Tairiny Santos Pina Luciana Nalone Andrade

Mucoadhesive membranes were proposed in this study as drug delivery system for betamethasone-17-valerate (BMV) in the treatment of recurrent aphthous stomatitis (RAS). The membranes were obtained by using the polymers chitosan (CHI) in both presence and absence of polyvinilpyrrolidone (PVP), following the solvent evaporation method. The presence of PVP in the membranes causes significant modifications in its thermal properties. Changes in the thermal events at 114 and 193 °C (related to BMV melting point), and losses in mass (39.38 and 30.68% for CH:PVP and CH:PVP-B, respectively), suggests the incorporation of BMV in these membranes. However, the morphological aspects of the membranes do not change after adding PVP and BMV. PVP causes changes in swelling ratios (>80%) of the membranes, and it is suggested that the reorganization of the polymer mesh was highlighted by the chemical interactions between the polymers leading to different percentages of BMV released ∼40% and ∼80% from CH-B and CH:PVP-B. BMV release profile follows Korsmeyer and Peppas model (n > 0.89) which suggests that the diffusion of the drug in the swollen matrix is driven by polymer relaxation. In addition, the membranes containing PVP (higher swelling ability) present high rates of tensile strength, and therefore, higher mucoadhesion. Moreover, given the results presented, the developed mucoadhesive membranes are a promising system to deliver BMV for the treatment of RAS.

Mucoadhesion

10.1016/j.carbpol.2018.02.079

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Citations (76)

Influence of concentration of hydroxyapatite surface modifier agent on bioactive composite characteristics

Ceramics International (2016)

Joyce Kelly M.C. Gonsalves Jamylle N. S. Ferro Emiliano Barreto Rogéria de Souza Nunes Mário E.G. Valério

Biocompatibility

Sponge

Stearic acid

10.1016/j.ceramint.2016.07.210

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Citations (12)

Caracterização da produtividade do funcho (Foeniculum vulgare Mill.) no sertão de Sergipe

Revista Brasileira de Plantas Medicinais (2011)

Luciana Marques de Carvalho I. R. de Oliveira Marcelo Augusto Gutiérrez Carnelossi Rogéria de Souza Nunes

Com o objetivo de avaliar a produtividade e qualidade do funcho (Foeniculum vulgare Mill.) produzido nas condições edafoclimáticas de Sergipe, foi conduzido cultivo orgânico de funcho em Frei Paulo-SE. Em junho de 2008 e de 2009, início do período de chuvas, foram instalados plantios por meio de mudas. Adicionalmente, em dezembro de 2010 foi realizada colheita de frutos a partir de plantas obtidas após poda drástica e rebrota. Foi realizada colheita de frutos e determinação da produtividade de dezembro a janeiro de 2008, 2009 e em dezembro de 2010. Verificou-se produtividade de 720 Kg.ha-1, no primeiro plantio e de 349 Kg.ha-1 no plantio de 2009. As plantas obtidas por rebrota em 2010 resultaram em produtividade de 589 Kg.ha-1. Sugere-se que a maior produtividade verificada no primeiro ano seja decorrente da maior precipitação média e conseqüente maior disponibilidade de água. A produtividade verificada nas plantas que rebrotaram em 2010 foi também superior a verificada em 2009, o que pode ser explicado tanto em função da maior precipitação, quanto em função do provável maior desenvolvimento das raízes e maior número de ramos após poda, devido à quebra da dominância apical. Esses dados sugerem importância da disponibilidade hídrica na determinação da produtividade na região e explicam a variação na produtividade verificada. A massa seca dos frutos (5, 29 g para 1000 frutos) e o alto teor de óleo essencial verificado (3,2%), assim como a composição do óleo, revelam a alta qualidade dos frutos produzidos na região.

Foeniculum

10.1590/s1516-05722011000500004

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Citations (0)

The action modes of Lippia sidoides (Cham) essential oil as penetration enhancers on snake skin

Journal of Thermal Analysis and Calorimetry (2009)

M. B. Brito Gabriela Borin Barin Adriano Antunes de Souza Araújo Damião Pergentino de Sousa Sócrates C.H. Cavalcanti

Penetration (warfare)

10.1007/s10973-008-9669-8

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Citations (11)

Praziquantel-Solid Lipid Nanoparticles Produced by Supercritical Carbon Dioxide Extraction: Physicochemical Characterization, Release Profile, and Cytotoxicity

Molecules (2019)

Luciana Nalone Andrade Daniele M. L. Oliveira Marco V. Chaud Thais Alves Marcelo Nery

Solid lipid nanoparticles (SLNs) can be produced by various methods, but most of them are difficult to scale up. Supercritical fluid (SCF) is an important tool to produce micro/nanoparticles with a narrow size distribution and high encapsulation efficiency. The aim of this work was to produce cetyl palmitate SLNs using SCF to be loaded with praziquantel (PZQ) as an insoluble model drug. The mean particle size (nm), polydispersity index (PdI), zeta potential, and encapsulation efficiency (EE) were determined on the freshly prepared samples, which were also subject of Differential Scanning Calorimetry (DSC), Fourier-Transform Infrared Spectroscopy (FTIR), drug release profile, and in vitro cytotoxicity analyses. PZQ-SLN exhibited a mean size of ~25 nm, PdI ~ 0.5, zeta potential ~-28 mV, and EE 88.37%. The DSC analysis demonstrated that SCF reduced the crystallinity of cetyl palmitate and favored the loading of PZQ into the lipid matrices. No chemical interaction between the PZQ and cetyl palmitate was revealed by FTIR analysis, while the release or PZQ from SLN followed the Weibull model. PZQ-SLN showed low cytotoxicity against fibroblasts cell lines. This study demonstrates that SCF may be a suitable scale-up procedure for the production of SLN, which have shown to be an appropriate carrier for PZQ.

Zeta potential

Solid lipid nanoparticle

Supercritical Carbon Dioxide

Dispersity

10.3390/molecules24213881

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Citations (48)

Microemulsions formed by PPG-5-CETETH-20 at low concentrations for transdermal delivery of nifedipine: Structural and in vitro study

Colloids and Surfaces B Biointerfaces (2022)

Guilherme Rodolfo Souza de Araújo Givalda Mendonça da Cruz Macieira Dayane Xavier de Oliveira Saulo Santos Matos Quesia Nery dos Santos

Microemulsion

Penetration (warfare)

Lipophilicity

10.1016/j.colsurfb.2022.112474

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Citations (11)

Bilayer Mucoadhesive Buccal Film for Mucosal Ulcers Treatment: Development, Characterization, and Single Study Case

Pharmaceutics (2020)

Thais Alves Alesssandra C. Rios Katiusca da Silva Pontes Décio Luís Portella Norberto Aranha

The formation of mucosal ulcers is an end result of epithelial damage, and it occurs due to some specific causes, such as trauma, aphthous stomatitis, lichen planus and lichenoid reactions, cytotoxic effects of chemotherapy and radiation, and drug-induced hypersensitivity reactions and malignant settings. This study focused on films for target drug delivery with respect to the treatment of the diseases of the oral mucosa, specifically mucositis. The results of a single clinical study as a pre-experimental design was performed and followed up to the outcome until 30 days. The polymeric film was prepared in a mucoadhesive bilayer structure: the basal layer with lidocaine HCl had a faster release than the apical layer with benzydamine HCl and N-acetyl-cysteine. Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), and SEM characterized the physical-chemical and morphological properties. The cell viability and cytotoxicity were evaluated in cell line MCF7. The transport mechanism of the solvent (swelling) and the drugs in the basal or apical layer (drug release) was explained with mathematical models. To evaluate the effect of movement inside the mouth, the folding endurance was determined. The mucoadhesive bilayer film is biologically safe and stimulates cellular proliferation. A single study in vivo demonstrated the therapeutic effect of the mucoadhesive bilayer film in buccal mucositis.

Mucositis

Mucoadhesion

10.3390/pharmaceutics12070657

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Citations (41)