Chu-Hsu Lin

Fujian Medical University

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Hung‐Chih Hsu

Chang Gung Memorial Hospital

Chien‐Min Chen

Chiayi Chang Gung Memorial Hospital

M. Wójtowicz

ON Semiconductor (United States)

Kai-Hua Chen

Southern University of Science and Technology

A.K. Oki

Northrop Grumman (United States)

Y.C. Chou

Taipei City Hospital

J.M. Yang

Nantong University

B. R. Bennett

Virginia Tech

R. Lai

University of Connecticut

M. Barsky

Northrop Grumman (United States)

Cooperative Institutions

Northrop Grumman (United States)

Chang Gung University

Redondo Optics (United States)

Chang Gung Memorial Hospital

Northrop Grumman (United Kingdom)

Chiayi Chang Gung Memorial Hospital

National Taiwan University Hospital

National Taiwan University

Memorial Hospital of South Bend

Jet Propulsion Laboratory

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Manufacturable and Reliable 0.1 μm AlSb/InAs HEMT MMIC Technology for Ultra-Low Power Applications

2011 IEEE MTT-S International Microwave Symposium (2007)

Yeong-Chang Chou J.M. Yang Chu-Hsu Lin J. Lee M. Lange

This paper describes a manufacturable and reliable 0.1 μm AlSb/InAs MMIC technology for ultra-low power applications. AlSb/InAs HEMTs have been demonstrated with only one-tenth power dissipation of conventional InAlAs/InGaAs/InP HEMTs. The uniform DC and RF performance of AlSb/InAs HEMTs have been demonstrated on 3-inch GaAs substrates. The further demonstration of reliable AlSb/InAs HEMT technology warrants the successful insertion of AlSb/InAs HEMT MMICs for military and space applications with ultra-low power requirements.

Indium gallium arsenide

10.1109/mwsym.2007.380488

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Citations (14)

Hereditary Neuropathy with Liability to Pressure Palsies: A Report of Two Cases

Deleted Journal (2007)

Chu-Hsu Lin

Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal-dominant disorder characterized by self-limited, recurrent compressive mononeuropathies at common entrapment sites precipitated by trivial injuries. This disorder typically develops in early adulthood. Electrodiagnostic studies revealed diffuse mild demyelinating neuropathies with entrapment over common entrapment sites. Nerve biopsies frequently show segmental demyelination and thickening of the myelin sheath which is mostly caused by 1.5 Mb deletion of the 17p 11.2 site containing the peripheral myelin protein 22 (PMP22) gene on the 17(superscript th) chromosome. This report describes the clinical features, electrodiagnostic studies, and genetic studies of a Taiwanese family. Among the 5 members evaluated, 1 latent and 2 symptomatic cases had generally decreased nerve conduction velocities with further focally decreased conduction velocities or conduction blocks at common entrapment sites. Genetic studies demonstrated deletion of the Charcot-Marie-Tooth type IA sequences in 17p 11.2 in all 3 patients. Our case studies suggested that diagnosis of HNPP can be based on clinical suspicion, positive family history, and electrodiagnostic tests; however final confirmation should be based on genetic study.

Mononeuropathy

Entrapment Neuropathy

Entrapment

Nerve conduction study

10.6315/2007.35(1)06

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Muscle Pain Intensity and Pressure Pain Threshold Changes in Different Periods of Stroke Patients

American Journal of Physical Medicine & Rehabilitation (2013)

Chu-Hsu Lin Kai-Hua Chen Chia‐Hao Chang Chien‐Min Chen Ying Huang

Objective This study aimed to investigate the role of muscle pain in post-stroke pain syndromes. Design This cross-sectional–designed study enrolled 145 stroke patients at three different stroke duration periods (≤3 mos, 3 mos to 1 yr, and >1 yr) receiving inpatient or outpatient rehabilitation programs in a regional teaching hospital. Three common muscle tender points (two at the upper trapezius and one at the brachioradialis) and two relative periosteum points of the healthy and hemiparetic sides were identified for evaluation. Spontaneous pain intensity measured with the verbally reported numerical rating scale and pressure pain threshold were assessed. Associations between variables were analyzed. Results Among 145 subjects, 56 were women, and the mean ± SD age was 62.1 ± 13.2 yrs. The patients with stroke duration within 3 mos had the highest spontaneous muscle pain intensity and were most sensitive to pressure pain, with a prevalence of 48.3% of moderate to severe pain intensity (verbally reported numerical rating scale, 4–10) in the hemiparetic side. Spontaneous pain was more severe in the hemiparetic side than in the healthy side, but there were no obvious differences between the sides in the pressure pain threshold of the muscle or the periosteum. Conclusions In stroke patients, spontaneous muscle pain in the hemiparetic side is a common finding. Bilaterally symmetric changes of pressure pain threshold are probably caused by central sensitization mechanisms.

Stroke

Brachioradialis

Periosteum

Hemiparesis

Intensity

10.1097/phm.0000000000000003

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Citations (14)

Texture Feature Analysis of Ultrasonic Images with Wryneck

International Conference on Biomedical Engineering and Biotechnology (2012)

Hsiao-Mei Chang Yayun Cheng Hong‐Ren Su Shang‐Hong Lai Chu-Hsu Lin

Torticollis, also called wryneck, is a clinical sign or symptom that could be the result of a variety of possible disorders. Among the etiologies, congenital muscular torticollis (CMT) with impairment of the sternocleidomastoid (SCM) is the most frequent cause of torticollis in infants. Infants with CMT have the symptom of head tilt to one side, which is often combined with rotation of the head to the opposite side. In this paper, we report a study on the analysis of the ultrasonic images on two sides of the neck for the CMT classification. To this end, we first apply an interactive ROI segmentation procedure, followed by the extraction of several different texture features for the classification of CMT type. We use three types of texture features, including gray-lever co-occurrence matrix, Laplacian of Gaussian, and Gabor features. In addition, three feature comparison methods, such as mutual information, Bhattacharyya Distance, and Kullback-Leibler divergence, are used to compute the distribution distances for different texture features and feed them into the support vector machine classifier for the CMT classification. Experimental results demonstrate the performance of the proposed image analysis and classification method on real ultrasonic images.

Bhattacharyya distance

Superimposition

Contextual image classification

Texture (cosmology)

10.1109/icbeb.2012.396

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Sub-mW Operation of InP HEMT X-Band Low-Noise Amplifiers for Low Power Applications

Chu-Hsu Lin X. B. Mei Y.C. Chou L. S. Lee J.M. Yang

For the first time, the sub-mW operation of InP HEMT X-band low-noise amplifiers on 4-inch InP wafer was demonstrated. With optimized non-alloyed ohmic contact, gate recess profile and epitaxial layer design, the InP HEMT achieves average peak transconductance of 1150 mS/mm at V _DS = 0.3 V. The mean current cut off frequency is above 150 GHz at V _DS = 0.3 V and I _DS = 150 mA/mm. The developed low power InP HEMTs enables the manufacturing of low-noise amplifiers for low power applications. The superior performance of X-band low-noise amplifiers was also demonstrated. Operating at a supply voltage of 0.25 V and drain current of 3.75 mA with DC power of 0.937 mW, the low noise amplifier exhibits noise figure of 1.6 dB and gain of 11 dB at frequencies from 6 to 12 GHz.

Transconductance

Ohmic contact

10.1109/csics.2009.5315662

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Citations (10)

Developmental profiles and mentality in preschool children with Prader-Willi syndrome: a preliminary study.

PubMed (2010)

Chien‐Min Chen Chia‐Ling Chen Jia‐Woei Hou Hung‐Chih Hsu Chia-Ying Chung

A majority of the children with Prader-Willi syndrome (PWS) have global developmental delay and mental delay. The aim of this study was to investigate the developmental profiles and mental assessments among preschool children with PWS.Ten children with PWS between the ages of 15 months to 6 years, and 11 children with typical development were enrolled. Developmental profiles in terms of their developmental quotient (DQ) for the eight domains of the Chinese Children Developmental Inventory (CCDI) and mental assessments in terms of intelligence quotient (IQ) and developmental index (DI) were carried out for all children.The DQs of all eight domains, including gross motor, fine motor, expressive language, concept comprehension, situation comprehension, self help, personal- social and general development, in the PWS group were lower than the DQs of the children from the typical development group (p < 0.01). Children with PWS had better DQs in the fine motor domain than in the gross motor domain and in the receptive language domain than in the expressive language domain. Furthermore, their verbal IQ were better than their performance IQ and their mental DI was better than their psychomotor DI.These findings suggest that the children with PWS show an uneven global developmental delay together with an uneven mental delay. The results of this study should allow clinicians to better understand the developmental functioning of children with PWS and this will help with the planning of treatment strategies.

Gross motor skill

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Progressive Schottky junction reaction induced degradation in Pt-sunken gate InP HEMT MMICs for high reliability applications

Y.C. Chou D. Leung M. Biedenbender D. Buttari D. Eng

Reliability performance of 0.1-μm Pt-sunken gate InP HEMT MMICs on 4-inch InP substrates was evaluated under elevated temperature life testing. The primary degradation mechanism was observed to be the progressive Schottky junction reaction with the Schottky barrier InAlAs and the InGaAs channel. Despite the progressive Schottky junction reaction with the InAlAs and InGaAs materials, the lifetest at T _ambient of 280°C projects the median-time-to-failure exceeding 1×10 ⁶ hours at T _channel of 125°C. This result indicates that the promising initial reliability performance was achieved on Pt-sunken gate InP HEMT MMICs on 4-inch InP substrates.

Degradation

10.1109/irps.2010.5488728

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Citations (1)

InGaAs/InAlAs/InP power hemt with an improved ohimc contact and an extremely high operating voltage

X. B. Mei D. Farkas Wen Luo Chu-Hsu Lin L. J. Lee

An InGaAs/InAlAs/InP HEMT has been fabricated with 0.15 mum EBL gate, double gate recess and improved Ohmic contact. While maintaining a peak transconductance (Gmp) in excess of 1000 mS/mm, an onstate burnout voltage exceeding 8 V and an operating drain voltage of 5 V have been achieved. A loadpull measurement at 40 GHz was conducted. An output power density of 471 mW/mm, a power-added efficiency of 38% and a power gain of 8 dB were demonstrated, making this technology attractive for power applications at millimeter wave frequencies.

Transconductance

Ohmic contact

Power density

Indium gallium arsenide

Power-added efficiency

Extremely high frequency

10.1109/iciprm.2009.5012479

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Citations (4)

The effect of sequential combination of mirror therapy and robot-assisted therapy on motor function, daily function, and self-efficacy after stroke

Scientific Reports (2023)

Chen Yen-Wei Kuan‐yi Li Chu-Hsu Lin Pei-Hsuan Hung Hui-Tzu Lai

Abstract Robot-assisted therapy and mirror therapy are both effective in promoting upper limb function after stroke and combining these two interventions might yield greater therapeutic effects. We aimed to examine whether using mirror therapy as a priming strategy would augment therapeutic effects of robot-assisted therapy. Thirty-seven chronic stroke survivors (24 male/13 female; age = 49.8 ± 13.7 years) were randomized to receive mirror therapy or sham mirror therapy prior to robot-assisted therapy. All participants received 18 intervention sessions (60 min/session, 3 sessions/week). Outcome measures were evaluated at baseline and after the 18-session intervention. Motor function was assessed using Fugl-Meyer Assessment and Wolf Motor Function Test. Daily function was assessed using Nottingham Extended Activities of Daily Living Scale. Self-efficacy was assessed using Stroke Self-Efficacy Questionnaires and Daily Living Self-Efficacy Scale. Data was analyzed using mixed model analysis of variance. Both groups demonstrated statistically significant improvements in measures of motor function and daily function, but no significant between-group differences were found. Participants who received mirror therapy prior to robot-assisted therapy showed greater improvements in measures of self-efficacy, compared with those who received sham mirror therapy. Our findings suggest that sequentially combined mirror therapy with robot-assisted therapy could be advantageous for enhancing self-efficacy post-stroke. Trial registration : ClinicalTrials.gov Identifier: NCT03917511. Registered on 17/04/2019, https://clinicaltrials.gov/ct2/show/ NCT03917511.

Stroke

Repeated measures design

10.1038/s41598-023-43981-3

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Citations (7)

0.1 um n+-InAs-AlSb-InAs HEMT MMIC Technology for Phased-Array Applications

Chu-Hsu Lin Y.C. Chou M. D. Lange J.M. Yang M. Nishimoto

-A 0.1 mum n+-InAs-AlSb-InAs MMIC technology was developed for phased-array applications requiring ultralow power consumption. An n doped cap layer was utilized to provide lower access resistance and to reduce detrimental effects of cap layer etching during the process. As a result, the performance and manufacturability can be enhanced. In this work, we have demonstrated excellent DC and RF uniformity on both devices and low-noise amplifiers (LNA) using 0.1 mum n ⁺ -InAs-AlSb-InAs HEMTs on 3-inch GaAs substrates. In addition, the LNAs also demonstrate excellent RF performance while operating at ultralow power (~1 mW). This accomplishment is crucial for phased-array applications requiring ultralow power dissipation.

10.1109/csics07.2007.48

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Citations (2)