Carine Bossenmeyer‐Pourié

Inserm

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Jean‐Louis Guéant

Inserm

Jean‐Luc Daval

Université de Lorraine

Grégory Pourié

Université de Lorraine

Violette Koziel

Délégation Centre-Est

Déborah Helle

Université de Lorraine

Jean‐Marc Alberto

Université de Lorraine

P Vert

Université de Lorraine

Rémy Umoret

Université de Lorraine

Rifki Chihab

Jacksonville College

Bernard Beck

Public Higher Medical Professional School in Opole

Cooperative Institutions

Inserm

163

Université de Lorraine

103

Centre National de la Recherche Scientifique

Centre Hospitalier Régional et Universitaire de Nancy

Nutrition-Génétique et Exposition aux Risques Environnementaux

Stress Environnementaux et Biosurveillance des Milieux Aquatiques

Université de Strasbourg

Sorbonne Université

Institut de génétique et de biologie moléculaire et cellulaire

Assistance Publique – Hôpitaux de Paris

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Increased homocysteinemia is associated with beneficial effects on body weight after long-term high-protein, low-fat diet in rats

Nutrition (2012)

Bernard Beck Carine Bossenmeyer‐Pourié Élise Jeannesson Sébastien Richy Jean‐Louis Guéant

Calorie

10.1016/j.nut.2011.12.015

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Citations (3)

Methyl Donor Deficiency Affects Fetal Programming of Gastric Ghrelin Cell Organization and Function in the Rat

American Journal Of Pathology (2009)

Carine Bossenmeyer‐Pourié Sébastien Blaise Grégory Pourié Catherine Tomasetto Sandra Audonnet

Weanling

10.2353/ajpath.2010.090153

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Citations (33)

Transient hypoxia may lead to neuronal proliferation in the developing mammalian brain: from apoptosis to cell cycle completion

Neuroscience (1999)

Carine Bossenmeyer‐Pourié R. Chihab Henri Schroeder J. Daval

Hypoxia

Viability assay

10.1016/s0306-4522(98)00565-x

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Citations (42)

Lack of Correlation Between the Effects of Transient Exposure to Glutamate and Those of Hypoxia/Reoxygenation in Immature Neurons In Vitro

Journal of Neurochemistry (1998)

Rifki Chihab Carine Bossenmeyer‐Pourié Jean Oillet Jean‐Luc Daval

Abstract: To assess the influence of brain immaturity on the effects of oxygen deprivation and the participation of excitotoxicity, the consequences of a 6‐h exposure to either hypoxia (95% N 2 /5% CO 2 ) or 100 µ M glutamate were studied in cultured fetal rat forebrain neurons taken at two maturational stages, i.e., 6 and 13 days in vitro. Cells were examined for their morphology, viability, energy metabolism reflected by 2‐ d ‐[ 3 H]deoxyglucose uptake, and protein synthesis assessed by [ 3 H]leucine incorporation. Apoptosis and necrosis were scored using the fluorescent dye 4,6‐diamidino‐2‐phenylindole. Whereas 6‐day‐old neurons responded to a 6‐h hypoxia by transient hypermetabolism, biphasic increase in protein synthesis, and cycloheximide‐sensitive apoptotic death within 72 h postexposure, glutamate did not affect cell characteristics by the same time. In 13‐day‐old neurons, hypoxia induced both apoptosis (8.2%) and necrosis (22.3%). At this age, glutamate definitely reduced energy metabolism (26%) and protein synthesis (17%) by the end of exposure. The percentage of necrotic neurons reached 40.7%, but the rate of apoptosis was unchanged compared with controls. Therefore, excitotoxicity cannot account for hypoxia‐induced injury in immature neurons, but its participation is suggested in older cells by the suppression of the necrotic component of hypoxia by glutamate receptor antagonists at 13 days.

Excitotoxicity

Hypermetabolism

Hypoxia

10.1046/j.1471-4159.1998.71031177.x

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Citations (33)

Intracellular generation of free radicals and modifications of detoxifying enzymes in cultured neurons from the developing rat forebrain in response to transient hypoxia

Neuroscience (2001)

Valérie Lièvre Philippe Bécuwe Arnaud Bianchi Carine Bossenmeyer‐Pourié Violette Koziel

Dichlorofluorescein

Glutathione reductase

10.1016/s0306-4522(01)00189-0

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Citations (61)

CHANGES IN RNA AND PROTEIN SYNTHESIS FOLLOWING HYPOXIA/REOXYGENATION IN CULTURED CENTRAL NEURONS. 2225

Pediatric Research (1996)

Jean‐Luc Daval Carine Bossenmeyer‐Pourié Rifki Chihab Frédéric Nicolas P Vert

Hypoxia

10.1203/00006450-199604001-02250

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Citations (0)

Brain Susceptibility to Methyl Donor Deficiency: From Fetal Programming to Aging Outcome in Rats

International Journal of Molecular Sciences (2019)

Ziad Hassan David Coelho Tunay Kökten Jean‐Marc Alberto Rémy Umoret

Deficiencies in methyl donors, folate, and vitamin B12 are known to lead to brain function defects. Fetal development is the most studied but data are also available for such an impact in elderly rats. To compare the functional consequences of nutritional deficiency in young versus adult rats, we monitored behavioral outcomes of cerebellum and hippocampus circuits in the offspring of deficient mother rats and in adult rats fed a deficient diet from 2 to 8 months-of-age. We present data showing that the main deleterious consequences are found in young ages compared to adult ones, in terms of movement coordination and learning abilities. Moreover, we obtained sex and age differences in the deleterious effects on these functions and on neuronal layer integrity in growing young rats, while deficient adults presented only slight functional alterations without tissue damage. Actually, the cerebellum and the hippocampus develop and maturate according to different time lap windows and we demonstrate that a switch to a normal diet can only rescue circuits that present a long permissive window of time, such as the cerebellum, whereas the hippocampus does not. Thus, we argue, as others have, for supplements or fortifications given over a longer time than the developmental period.

Permissive

10.3390/ijms20225692

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Citations (15)

Differential Expression of AP-1-related Gene Products after Hypoxia/Reoxygenation in Cultured Central Neurons † 1859

Pediatric Research (1998)

Rifki Chihab Céline Ferry Carine Bossenmeyer‐Pourié Violette Koziel P Vert

Differential Expression of AP-1-related Gene Products after Hypoxia/Reoxygenation in Cultured Central Neurons † 1859

Hypoxia

10.1203/00006450-199804001-01882

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Folate and Vitamin B12 Gestational Deficiency Disturb Glucocorticoid Response in Hypothalamus Through N-Homocysteinilation of the Glucocorticoid Receptor

Arnaud Michel Tunay Kökten Lynda Saber Cherif Rémy Umoret Jean‐Marc Alberto

Vitamin B9(folate)/B12 deficiency is known to induce brain structural and/or functional retardations. Besides neural tube defects in case of major consequences, several mild deregulations also lead to deleterious effect after birth, and folate supplementation recommended in some countries usually stop at the end of the first trimester. Various hormonal receptors were shown to be deregulated in brain tissue under this context. The glucocorticoid receptor (GR) is particularly sensitive to epigenetic regulation and post-traductional modifications. In a mother-offspring rat model of vitamin B9/B12 deficiency, we investigated whether a prolonged folate supplementation could restore the GR signalization in the hypothalamus. Our data showed that a deficiency in folate and vitamin B12 during the in-utero and the early postnatal periods was associated with reduced GR expression inn the hypothalamus. We also described for the first time a new post-traductional modification of GR that impaired ligand binding and GR activation, leading to decreased the expression of one of the GR targets in the hypothalamus, AgRP. Moreover, this brain-impaired GR pathway was associated with behavioral perturbations during offspring growth. Importantly, perinatal and postnatal supplementation with folic acid helped restore GR mRNA level and activity in hypothalamus cells and improved behavioral deficits.

Folate receptor

10.20944/preprints202304.0383.v1

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Citations (1)

Effects of Hypothermia on Hypoxia-Induced Apoptosis in Cultured Neurons from Developing Rat Forebrain: Comparison with Preconditioning

Pediatric Research (2000)

Carine Bossenmeyer‐Pourié Violette Koziel Jean‐Luc Daval

Hypoxia

10.1203/00006450-200003000-00017

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Citations (79)