ÜU

Ünal Uluca

Dicle University

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Effects of Gluten‐Free Diet on Quality of Life and Depression in Children With Celiac Disease

Journal of Pediatric Gastroenterology and Nutrition (2015)

Şeref Şimşek Gökhan Baysoy Salih Gençoğlan Ünal Uluca

The aim of this study was to investigate the level of depression and quality of life in children with celiac disease (CD). In addition, it aimed to examine the relations of depression level and life quality with adherence to a gluten-free diet (GFD).Twenty-five children with CD and 25 healthy controls were included. The Depression Scale for Children and the General Purpose Health-Related Quality of Life Scale for Children were performed on patients before and after receiving recommendations to follow a GFD.No significant differences were found in the depression scores between the patients and the control subjects (P > 0.05). In contrast, total scores and scores of the emotional well-being subscale of the measure of Quality of Life Scale for Children were significantly lower in patients with CD compared with the control group (P < 0.05). No significant improvements were observed in depression or life quality scores of the total subsample of celiac patients, all of whom received a recommendation to follow a GFD (P > 0.05). Significant decrease was observed in the depression scores, however, of celiac patients who were able to actually adhere to the GFD compared with nonadherent patients.CD negatively affected quality of life in children. Adherence to GFD was associated with reduction in depression symptoms. Improving the adherence of celiac patients to a GFD may have a favorable effect on their depression symptoms.

Depression

Gluten free

10.1097/mpg.0000000000000799

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Citations (50)

Rapid and Easy Diagnosis of Netherton Syndrome with Dermoscopy

Journal of Cutaneous Medicine and Surgery (2014)

Zeynep Meltem Akkurt Tuba Tunçel Erhan Ayhan Derya Uçmak Ünal Uluca

Background: Netherton syndrome is a rare autosomal recessive disease demonstrating ichthyosis linearis circumflexa, atopic findings, and hair shaft anomalies. Trichorrhexis invaginata is the pathognomonic hair shaft anomaly seen in this syndrome. Objective: In recent years, hair shaft anomalies have been described as “matchstick” and “golf tee” signs. We present a patient with Netherton syndrome diagnosed by the presence of matchstick and golf tee hairs in addition to trichorrhexis invaginata.

Pathognomonic

10.2310/7750.2013.13106

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Citations (13)

Akciğer tüberkülozlu çocuk hastalarin klinik ve laboratuvar özelliklerinin değerlendirilmesi The evaluation of the clinical and laboratory characteristics of children with pulmonary tuberculosis

Ünal Uluca Hadice Selimoğlu Tuba Tunçel Ali Güneş Müsemma Karabel

Objective: Pulmonary tuberculosis is an important health problem in pediatric patients. The aim of this study is to evaluate the epidemiological and clinical signs and treatment results of the children with pulmonary tuberculosis. Methods: Hospital records of 85 children with pulmonary tuberculosis which were diagnosis in Dicle University Medical Faculty, Pediatric Pulmonology Department, between the period of January 2008 and December 2013, were retrospectively reviewed. Results: Of 85 patients, 51.7% were girls with a mean age of 9.84±4.66 years (6 months-18 years). Ratio of patients that aged less than 5 years was 22.3%. The most prominent complaints were cough (81.2%), fever (55.2%), inappetence (47.1%), night sweats (38.8%), and weight lost (32.9 %). Sixty five of the patients (76.4 %) had a history of contact with adult patients with tuberculosis. BCG vaccine scarring was present in 70.6% of patients. Tuberculin skin test reactivity was present in 75.3%. Hilar lympadenomegaly (58.8%), primary focus-calsification (37.6%), and parenchymal infiltration (32.9%) were the most common radiographic findings. Conclusion: Pulmonary tuberculous is not a rare entity and remains an important infectious disease in children in our country. Early diagnosis and treatment of children with pulmonary tuberculosis is important to protect late symptoms and to prevent contamination of healthy people.

Pulmonology

Medical record

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Mean platelet volume in retinopathy of prematurity

Graefe s Archive for Clinical and Experimental Ophthalmology (2015)

Alparslan Şahin Ünal Uluca Fatih Mehmet Türkçü

Mean platelet volume

Neonatal Sepsis

10.1007/s00417-015-3046-7

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Citations (1)

Rhizomelic Chondrodysplasia Punctata Type 1 Caused by a Novel Mutation in the PEX7 Gene

Journal of Clinical Research in Pediatric Endocrinology (2015)

Abdullah Çim Salih Coşkun Orhan Görükmez Hatice Yüksel Ünal Uluca

ABS TRACTPeroxisomes are involved in various metabolic reactions.Rhizomelic chondrodysplasia punctata (RCDP) type 1 is one of the peroxisomal biogenesis disorders caused by mutations in the PEX7 gene and is inherited in an autosomal recessive manner.We present a nine-year-old boy with skeletal abnormalities and dysmorphic facial appearance.The patient was born to parents who were first cousins.Very-long-chain fatty acids and pristanic acid levels were in the normal range, but an elevated phytanic acid level was detected by gas chromatography/mass spectrometry.The PEX7 gene was sequenced in the patient and his parents.A novel homozygous mutation, c.192delT (p.F64Lfs*10), was identified in the patient and was present in heterozygosity in both parents.In conclusion, the clinical presentation and peroxisome profile of the patient suggest that this novel mutation leads to RCDP type 1.

Chondrodysplasia punctata

Phytanic acid

Peroxisomal disorder

Zellweger syndrome

10.4274/jcrpe.1835

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Citations (3)

Bir üniversite hastanesindeki Acinetobacter baumannii suşlarinin antibiyotik duyarliliklari Antibiotic susceptibility of Acinetobacter baumannii strains in a university hospital

Recep Tekin Selvi Kelekçi Ünal Uluca

Objective: Nowadays nearly, Acinetobacter baumannii has become an incurable nosocomial infections’ pathogen due to its ability developing multiple resistance against antibiotics strains In our study, it was aimed to determine rates of resistance of A. baumannii strains isolated from various samples in the Dicle University Hospital. Methods: A. baumannii culture results of 270 patients that were followed in the Dicle University Medical Faculty Hospital between June 2010 and June 2011 were evaluated. Resistance rates of A. baumannii strains were cultured by conventional methods and BD Phoenix (BD Diagnostic Systems, Sparks, MD) automated system. Results: Our study included 82 (30.4%) female and 188 (69.6%) male. Resistance rates of A. baumannii strains were as follows: amikacin (76%), ampicillin / sulbactam (94%), aztreonam (96%), cefepime (95%), cefotaxime (98%), ceftazidime (95%), ciprofloxacin (93%), colistin (6%), gentamicin (94%), imipenem (87%), levofloxa cin (87%), meropenem (87%), piperacillin / tazobactam (92%), tetracycline (84%), trimethoprim / sulfamethoxazole (82%). Conclusions: A. baumannii strains isolated from our cultures have very high rate of resistance against antimicrobial agents except colistin. It should not be forgotten that antibiotic susceptibility may change from year to year in the regions, hospitals and even clinics, and resistance rates should be continuously monitored. When selecting empiric treatment, resistance rates of A. baumannii of that location should be considered until having culture results. In the infections caused by A. baumannii cultures and antibiograms should be repeated during treatment because that A. baumannii strains may change resistance ratio. J Clin Exp Invest 2013; 4 (3): 318-321

Acinetobacter baumannii

Colistin

Cefepime

Amikacin

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The spectrum of MEFV gene mutations and genotypes in Van province, the eastern region of Turkey, and report of a novel mutation (R361T)

Gene (2015)

Salih Coşkun Lokman Üstyol Yasemin Bayram Murat Bektaş Süleyman Gülşen

MEFV

Sanger sequencing

10.1016/j.gene.2015.02.059

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Citations (21)

Evaluation of the Mean Platelet Volume in Children with Juvenile Idiopathic Arthritis

Electronic Journal of General Medicine (2014)

Velat Şen Aydın Ece Ünal Uluca Ali Güneş İlhan Tan

Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory arthritis in children. Mean platelet volume (MPV) is an indicator of platelet size and has been investigated as an inflammation marker in several diseases. This study was designed to investigate the MPV values in patients with JIA and healthy subjects, and determine the correlation between MPV, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). The hospital records of a total of 40 children with JIA, diagnosed using the International League of Associations for Rheumatology (ILAR) criteria, and 40 healthy controls were enrolled into the study. White blood cell count (WBC), platelet count, CRP, ESR, and MPV levels were retrospectively recorded. Children with JIA had significantly higher MPV values (8.28±1.12 fL) compared to the control group (7.53±1.07 fL) (p=0.003). Significant correlations were found between MPV, ESR, and CRP in the JIA group (r=0.676, p<0.001 and r=0.430, p<0.006). In addition, a negative correlation was found between platelet count and MPV (r= -0.818, p<0.001) in JIA patients. There was no significant difference in WBC values between the patient and the control groups (p>0.05). Our results suggest that MPV levels may be a useful marker of inflammation and prognostic factor for atherosclerosis risk in pediatric JIA patients.

Mean platelet volume

Erythrocyte sedimentation rate

White blood cell

Complete blood count

10.15197/sabad.1.11.83

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Citations (1)

Evaluation of Neutrophil to Lymphocyte Ratio and Mean Platelet Volume in Inactive Hepatitis B Carriers

Mustafa Kemal Üniversitesi Tıp Dergisi (2015)

Ünal Uluca Velat Şen Ali Güneş İlhan Tan Fesih Aktar

Aim: The aim of this study was to investigate the neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) levels in children with inactive hepatitis B virus (HBV) carriers and to evaluate the possible association between NLR, MPV and inflammation status in HBV infection. Material and Method: Thirty inactive HBV carrier children and 32 age and gender matched healthy controls were enrolled as study group. Complete blood count parameters including white blood count, absolute neutrophil count and lymphocyte count, neutrophil to lymphocyte ratio and mean platelet volume were assessed in both study and the control groups. Results: There was no significant difference in the mean age of inactive HBV carriers (11.9±3.4 years) and the control subjects (11.0±2.7 years) (p=0.25). No significant differences were found in NLR (2.90±3.24 and 1.74±0.87, respectively, p=0.82) and MPV levels (7.9±1.0fL and 8.0±1.2fL, respectively, p=0.86) between inactive HBV carriers and the controls. MPV was found to be inversely correlated with platelet count in both patients and the control groups (r=-0.44, p=0.01; r=-0.36, p=0.04, respectively). A positive correlation was found between NLR and MPV (r=0.41, p=0.03) in patient group. Conclusion: NLR and MPV levels were not different in inactive HBV carrier children compared to the controls. Our results suggest that NLR and MPV values may not be appropriate for determining of chronicity and inflammation status in chronic HBV infection. Key words: Hepatitis B, chronic, neutrophil to lymphocyte ratio, mean platelet volume

Mean platelet volume

Absolute neutrophil count

White blood cell

Complete blood count

Hepatitis B

10.17944/mkutfd.75063

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Citations (5)

Fasciola hepatica infestation in Turkish children

Gazzetta Medica Italiana Archivio per le Scienze Mediche (2017)

Yavuz Tokgöz Müsemma Karabel Gökhan Baysoy Cemil Göya Mutalip Çiçek

Fasciola

10.23736/s0393-3660.17.03430-1

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Citations (0)