Manvi Aggarwal

Dr. Shroff’s Charity Eye Hospital

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Priyanka Mantri

Dr. D. Y. Patil Medical College, Hospital and Research Centre

Veena Sangwan

Dr. Shroff’s Charity Eye Hospital

Ozukhil Radhakrishnan

Bharati Vidyapeeth Deemed University

Abha Gour

Dr. Shroff’s Charity Eye Hospital

Rakesh Shankar Goud

Dr. D. Y. Patil Medical College, Hospital and Research Centre

Mudit Mittal

University of Technology Sydney

N. Charani Basena

Central Council for Research in Homoeopathy

Nabanita Debnath

Central Council for Research in Homoeopathy

Prashant Borde

Dr. Babasaheb Ambedkar Marathwada University

Ashi Khurana

Creative Commons

Cooperative Institutions

Dr. Shroff’s Charity Eye Hospital

Dr. D. Y. Patil Medical College, Hospital and Research Centre

Creative Commons

Central Council for Research in Homoeopathy

Christie's

L V Prasad Eye Institute

Sickle Cell Institute Chhattisgarh, Raipur

Dr. D.Y. Patil Vidyapeeth, Pune

Post Graduate Institute of Medical Education and Research

Sardar Patel Post Graduate Institute of Dental and Medical Sciences

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Antibiotic susceptibility pattern of bacterial isolates from microbial keratitis in North and Central India: A multi centric study

Indian Journal of Ophthalmology (2022)

Ashi Khurana Samrat Chatterjee Arpan Gandhi Prashant Borde Sanjay Chanda

This study was conducted to examine microbiological profile with their antibiotic sensitivity in cases of bacterial keratitis in north and central India to ensure appropriate use of antibiotics.The microbiology laboratory records of 228 patients with culture-proven bacterial keratitis from 1st January to 31st December 2019 were analyzed. Cultured bacterial isolates were subjected to antimicrobial susceptibility testing to antibiotics commonly used in the treatment of corneal ulcer. Chi-squared or Fisher's exact test were applied to check the significance of difference between the susceptibility levels of antibiotics.The prevalence of Staphylococcus aureus and Pseudomonas aeruginosa-induced keratitis was higher in northern India, whereas that by Streptococcus pneumoniae was more prevalent in central India. In central India, 100% of S. pneumoniae isolates were found to be sensitive to ceftriaxone compared to 79% in northern India (P = 0.017). In comparison to 67% of isolates from north India, 15% of S. aureus isolates from central India were found to be sensitive to ofloxacin (P = 0.009). Similarly, 23% of isolates from central India were found sensitive to amikacin compared to 65% of isolates from north India (P = 0.012). P. aeruginosa isolates from central India were found to be sensitive to ceftazidime in 63% of cases compared to 21% of isolates from north India (P = 0.034).Prevalence of bacteria and their susceptibility to antibiotics are not uniform across geography. Vancomycin remained the most effective drug in all gram-positive coccal infections. S. aureus susceptibility to amikacin was significantly greater in north India. P. aeruginosa showed less susceptibility as compared to previous reports.

Amikacin

Antibiotic sensitivity

10.4103/ijo.ijo_1438_22

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In vitro antimicrobial activity of nine homoeopathic preparations in different volumes against Staphylococcus aureus and Escherichia coli

Journal of Integrated Standardized Homoeopathy (2023)

V KumaraVel Mahadev Mondal Manvi Aggarwal Niharika Shaw Supriya Singh

Objective: The present study aims to evaluate the efficacy of antimicrobial activities of nine homoeopathic preparations through an in vitro study. Materials and Methods: The antimicrobial activity of nine homoeopathic preparations was evaluated through broth microdilution according to clinical and laboratory standards institute with slight modifications (M07-A10). Result: The mean and standard deviation of homoeopathic preparations against S. aureus and E. coli show lesser values than control and ethyl alcohol at lower volumes (10 μL and 15 μL, respectively). The broth microdilution assay provides the information that seven homoeopathic preparations exhibited significant results against S. aureus at 10 μL and eight homoeopathic preparations exhibited significant results against E. coli at 15 μL. Conclusion: The ultra-diluted homoeopathic preparations at different volumes especially lower volumes showed significant results against S. aureus (10 μL) and E. coli (15 μL) when compared to the negative control (91% ethyl alcohol). Further, in vivo studies may be carried out to confirm their mode and mechanism of action of homoeopathic preparations.

Broth microdilution

10.25259/jish_51_2022

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EFFICACY OF HORIZONTAL STITCH IN EYES UNDERGOING MANUAL SMALL INCISION CATARACT SURGERY – A COMPARATIVE STUDY.

International journal of scientific research (2020)

Radhika Paranjpe Varsha Manade Megha Kotecha Priyanka Mantri Nikhil Toshniwal

Purpose: To determine whether eyes undergoing manual small incision cataract surgery (MSICS) have better uncorrected distance visual acuity (UCDVA) and lower postoperative astigmatism with a horizontal stitch compared to phacoemulsification and MSICS without this suture. Methods: Participants with uncomplicated cataract were offered phacoemulsification or MSICS. Those who opted for MSICS were randomly assigned to get the horizontal stitch at the end of the cataract surgery. The primary outcome measure was the UCDVA between three groups. Results: Seventy-five eyes of 75 patients were recruited, 25 in each group. At 6 weeks, 56% eyes in MSICS with horizontal stitch and 52% in phacoemulsification group had UCDVA of 6/6 compared to only 16% in MSICS group. The spherical equivalent for the MSICS group (-0.78 ± 0.76D) was significantly higher than MSICS with horizontal stitch (0.32 ± 0.30) and phacoemulsification (-0.28 ± 0.21) (p<0.05 for both), though there was no difference between the latter two groups. Conclusion: Adding a horizontal stitch to MSICS significantly improves uncorrected vision and reduces postoperative astigmatism and visual results are comparable to phacoemulsification.

Astigmatism

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“Visual outcome and postoperative complications of cataract surgery in patients with ocular surface disorders”

Journal of Cataract & Refractive Surgery (2024)

Manvi Aggarwal Abha Gour Nidhi Gupta Aastha Singh Veena Sangwan

To determine the visual outcome and postoperative complications of cataract surgery in patients with ocular surface disorders (OSDs).

10.1097/j.jcrs.0000000000001396

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Prevalence of dry eyes in patients with Type-2 diabetes mellitus

Indian Journal of Clinical and Experimental Ophthalmology (2020)

Rakesh Shankar Goud Manvi Aggarwal Ozukhil Radhakrishnan Priyanka Mantri Arpit Shah

To estimate the prevalence of dry eyes in patients with Type-2 diabetes mellitus and to compare various tests of dry eye. An analytical cross sectional study was conducted on 150 patients diagnosed with Type 2 diabetes mellitus. Dry eyes symptoms were assessed using Ocular surface disease index (OSDI) questionnaire and graded according to severity. The diagnosis was confirmed by positive Ocular surface staining pattern with fluorescein, Tear film breakup time test (TBUT) or Schirmers test. Severity of dry eyes was determined and prevalence calculated. The prevalence rate of dry eye disease among diabetics was calculated as 36% on the basis of Ocular surface disease index. Mild, moderate and severe dry eyes were present in 16%, 16% and 4% patients respectively. TBUT showed very good agreement with highest diagnostic accuracy. Schirmers test and Fluorescein test had good and moderate agreement respectively. Diabetes mellitus associated dry eye disease (DMDES) is the most frequent diabetic complication in clinical practice. Clinical trials are warranted to confirm the effects of the currently applied drugs in diabetes-associated DES for a better outcome in such patients. Our study can act as a stepping stone for larger multi-centric studies to gain more information about this largely unrecognized problem of diabetes associated dry eye disease.

Pediatric ophthalmology

10.18231/j.ijceo.2020.062

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A study of the prevalence of age related macular degeneration and its risk factors

Indian Journal of Clinical and Experimental Ophthalmology (2020)

Rakesh Shankar Goud Priyanka Mantri Ozukhil Radhakrishnan Manvi Aggarwal Mayur Patil

Age related macular degeneration (ARMD) is one of the leading causes of visual impairment in individuals more than 50 years of age. Aim of this study was to know the prevalence and various socio demographic risk factors associated with ARMD. We studied 300 patients attending Ophthalmology OPD of a Tertiary Care Hospital in Western Maharashtra. Risk factors such as age, sex, smoking, Body Mass Index (BMI), and family history of ARMD were studied. Diagnosis of ARMD was confirmed on Fundus Fluorescein Angiography (FFA) and Optical Coherence Tomography(OCT). Out of 300 patients studied, 24 (8.0%) had ARMD. Increasing age was found to be a significant risk factor for ARMD. In our study, we found that there were 83.3% females as compared to 16.7% males. There was no statistically significant association found between Body Mass Index and ARMD in our study. Among patients with ARMD, 4 (16.7%) were smokers and 20 (83.3%) were non-smokers and this was not found to be statistically significant. Family history was found to be a significant risk factor for development of ARMD. Increasing age, female sex and family history of ARMD were significant risk factors associated with development of ARMD.

Fundus (uterus)

10.18231/j.ijceo.2020.043

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Butterfly rash with periodontitis: A diagnostic dilemma

Contemporary Clinical Dentistry (2012)

Pallavi Vashisth Manvi Aggarwal Mudit Mittal Swati Dwivedi Deepesh Jaiswal

Rashes can occur in any part of the body. But rash which appears on face has got both psychological and cosmetic effect on the patient. Rashes on face can sometimes be very challenging to physicians and dermatologists and those associated with oral manifestations pose a challenge to dentists. Butterfly rash is a red flat facial rash involving the malar region bilaterally and the bridge of the nose. The presence of a butterfly rash is generally a sign of lupus erythematosus (LE), but it can also include a plethora of conditions. The case presented here is of a female with butterfly rash along with typical bright red discoloration of gingiva. The clinical, histopathological and biochemical investigations suggested the presence of rosacea.

10.4103/0976-237x.103637

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Dealing With Pericylindrical Melts in Keratoprosthesis: Tenon Patch Graft to the Rescue

Cornea (2024)

Nikunj Patel Manvi Aggarwal Mayur Shirish Jain Abha Gour Veena Sangwan

Purpose: The aim of this study was to describe the outcomes of autologous Tenon patch graft in the management of Auro keratoprosthesis–related pericylindrical corneal melt. Methods: We report 3 cases of sterile pericylindrical corneal melt in patients with Auro keratoprosthesis implantation after a mean duration of 5 years (1.5–8 years). Case 1 was a patient with severe graft-versus-host disease. Cases 2 and 3 were cases of chemical injury. All these cases of sterile pericylindrical corneal melt (4–6 mm) underwent autologous Tenon patch graft. The technique included freshening of the edges around the melt, followed by measuring the size of the defect. A Tenon graft harvested from the patient's own eye was used to seal the defect and act as a scaffold. The Tenon patch graft was spread over the melt and held in place by the application of fibrin glue and/or interrupted 10-0 nylon sutures. A bandage contact lens was then placed on the eye. Results: Tenon patch graft was well taken in all patients. The mean duration of epithelial healing was 1 month. Globe integrity was well maintained with no postoperative complications at a mean follow-up duration of 12 months (6–18 months). Conclusions: Corneal melt is one of the most dreaded complications of KPro because its occurrence could threaten visual prognosis and globe integrity. Autologous Tenon patch is a simple yet innovative and effective option to steer such eyes away from potentially dreadful complications.

Mortise and tenon

Keratoprosthesis

10.1097/ico.0000000000003501

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Role of impression cytology in ocular surface disorders

IP International Journal of Ocular Oncology and Oculoplasty (2020)

Rupali Maheshgauri Aishwarya Thakre Manvi Aggarwal Priyanka Mantri Asim Naik

Role of impression cytology in ocular surface disorders - IJOOO- Print ISSN No: - 2581-5024 Online ISSN No:- 2581-5016 Article DOI No:- 10.18231/j.ijooo.2020.008, IP International Journal of Ocular Oncology and Oculoplasty-IP Int J Ocul Oncol Oculoplasty

Impression

10.18231/j.ijooo.2020.008

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Citations (2)

Counterfeiting Medical Devices: A Global Threat

Journal of Pharmacovigilance and Drug Research (2023)

Manvi Aggarwal Arti . Thakkar Jyoti Sinha

10.53411/jpadr.2023.4.3.1

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